Detailed information for compound 620602

Basic information

Technical information
  • TDR Targets ID: 620602
  • Name: 2-[[5-[(2,6-dioxo-3H-pyrimidin-4-yl)methyl]-4 -phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-(4-met hoxyphenyl)acetamide
  • MW: 464.497 | Formula: C22H20N6O4S
  • H donors: 3 H acceptors: 7 LogP: 3.03 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)CSc1nnc(n1c1ccccc1)Cc1cc(O)nc(n1)O
  • InChi: 1S/C22H20N6O4S/c1-32-17-9-7-14(8-10-17)23-20(30)13-33-22-27-26-18(28(22)16-5-3-2-4-6-16)11-15-12-19(29)25-21(31)24-15/h2-10,12H,11,13H2,1H3,(H,23,30)(H2,24,25,29,31)
  • InChiKey: WGROTBZKBQPARX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[5-[(2,6-dioxo-3H-pyrimidin-4-yl)methyl]-4-phenyl-1,2,4-triazol-3-yl]thio]-N-(4-methoxyphenyl)acetamide
  • 2-[[5-[(2,6-diketo-3H-pyrimidin-4-yl)methyl]-4-phenyl-1,2,4-triazol-3-yl]thio]-N-(4-methoxyphenyl)acetamide
  • 2-[[5-[(2,6-dioxo-3H-pyrimidin-4-yl)methyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-(4-methoxyphenyl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni smad 0.0051 0.0117 0.0108
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0019 0.001
Echinococcus multilocularis musashi 0.011 0.0322 0.0313
Brugia malayi MH2 domain containing protein 0.0023 0.0019 0.0035
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0146 0.0137
Loa Loa (eye worm) Smad1 0.0051 0.0117 0.0371
Trichomonas vaginalis glucose transporter, putative 0.0032 0.005 0.0252
Schistosoma mansoni tar DNA-binding protein 0.0855 0.2914 0.2908
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0212 0.0679 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0064 0.2759
Echinococcus granulosus lamin 0.011 0.0322 0.0313
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0041 0.1445
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0046 0.9446
Brugia malayi latrophilin 2 splice variant baaae 0.0176 0.0552 0.1868
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.005 0.1844
Trichomonas vaginalis sugar transporter, putative 0.0032 0.005 0.0252
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0048 0.0277
Brugia malayi MH1 domain containing protein 0.0051 0.0117 0.0371
Echinococcus granulosus tumor protein p63 0.1746 0.6013 0.601
Echinococcus multilocularis smad 0.0051 0.0117 0.0108
Schistosoma mansoni hypothetical protein 0.0102 0.0294 0.0286
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0154 0.0145
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0027 0.0033 0.0388
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0212 0.0679 1
Echinococcus granulosus expressed protein 0.0027 0.0033 0.0024
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0041 0.0111
Leishmania major protein kinase, putative 0.0031 0.0048 0.1781
Echinococcus granulosus TGF beta signal transducer SmadC 0.0051 0.0117 0.0108
Schistosoma mansoni ferritin light chain 0.0027 0.0033 0.0024
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0019 0.001
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0041 0.0224
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0041 0.0224
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0041 1
Plasmodium vivax SET domain protein, putative 0.0061 0.0154 0.101
Plasmodium falciparum thioredoxin reductase 0.0084 0.0231 0.1552
Mycobacterium tuberculosis Probable dehydrogenase 0.0191 0.0604 0.8896
Loa Loa (eye worm) hypothetical protein 0.0176 0.0552 0.1868
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.0294 0.0286
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0154 0.0145
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0019 0.0063
Schistosoma mansoni intermediate filament proteins 0.011 0.0322 0.0313
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0019 0.0177
Plasmodium falciparum protein kinase 6 0.0432 0.1443 1
Brugia malayi cytoplasmic intermediate filament protein 0.0059 0.0145 0.0467
Schistosoma mansoni hypothetical protein 0.0081 0.0223 0.0214
Schistosoma mansoni Smad4 0.0023 0.0019 0.001
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0223 0.0738
Echinococcus granulosus thioredoxin glutathione reductase 0.0084 0.0233 0.0224
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0048 0.0277
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0048 0.004
Trypanosoma cruzi hexose transporter 0.0032 0.005 0.2153
Mycobacterium tuberculosis Probable reductase 0.0191 0.0604 0.8896
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0064 0.2474
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0041 0.1445
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0048 0.0277
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0019 0.0461
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0048 0.004
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.0294 0.0286
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0191 0.0604 0.8896
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0154 0.1554
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.0512 0.351
Toxoplasma gondii protein kinase, putative 0.0288 0.094 1
Plasmodium falciparum hexose transporter 0.0102 0.0294 0.1989
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0064 0.0384
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0154 0.0145
Brugia malayi Pre-SET motif family protein 0.0428 0.1429 0.4889
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0041 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0041 1
Echinococcus multilocularis Smad4 0.0051 0.0117 0.0108
Brugia malayi Sugar transporter family protein 0.0102 0.0294 0.0982
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0084 0.0231 0.3338
Loa Loa (eye worm) transcription factor SMAD2 0.0745 0.2531 0.8682
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0223 0.0738
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0041 0.1769
Loa Loa (eye worm) hypothetical protein 0.0051 0.0117 0.0374
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0064 0.0591
Trichomonas vaginalis glucose transporter, putative 0.0032 0.005 0.0252
Echinococcus multilocularis mothers against decapentaplegic 5 0.0051 0.0117 0.0108
Leishmania major glucose transporter, lmgt2 0.0032 0.005 0.1844
Loa Loa (eye worm) hypothetical protein 0.0061 0.0154 0.0498
Echinococcus multilocularis GPCR, family 2 0.0081 0.0223 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.005 0.0252
Schistosoma mansoni glucose transport protein 0.0102 0.0294 0.0286
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0046 0.023
Brugia malayi RNA recognition motif domain containing protein 0.0855 0.2914 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0014 0.0018
Loa Loa (eye worm) RNA binding protein 0.0855 0.2914 1
Echinococcus granulosus mothers against decapentaplegic 6 0.0023 0.0019 0.001
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0048 0.0426
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0048 0.0277
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0041 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0019 0.3187
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0046 0.0037
Schistosoma mansoni Smad4 0.0051 0.0117 0.0108
Schistosoma mansoni lamin 0.011 0.0322 0.0313
Schistosoma mansoni smad1 5 8 and 0.0051 0.0117 0.0108
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0041 0.1445
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.006
Schistosoma mansoni hypothetical protein 0.0081 0.0223 0.0214
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0223 0.0214
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0048 0.1781
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0019 0.0461
Brugia malayi MH1 domain containing protein 0.0051 0.0117 0.0371
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.005 0.1844
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0041 0.1769
Brugia malayi MH1 domain containing protein 0.0028 0.0038 0.0099
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0046 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0041 0.1445
Loa Loa (eye worm) thioredoxin reductase 0.0084 0.0231 0.0766
Brugia malayi Calcitonin receptor-like protein seb-1 0.0257 0.0835 0.2843
Loa Loa (eye worm) MH1 domain-containing protein 0.0051 0.0117 0.0371
Trypanosoma brucei glucose transporter 2A 0.0032 0.005 0.1844
Schistosoma mansoni hypothetical protein 0.0081 0.0223 0.0214
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0136
Trypanosoma brucei glucose transporter, putative 0.0032 0.005 0.1844
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0855 0.2914 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0191 0.0604 0.8896
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0042 0.0033
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0019 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0048 0.004
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0019 0.011
Schistosoma mansoni glucose transport protein 0.0102 0.0294 0.0286
Echinococcus granulosus ferritin 0.0027 0.0033 0.0024
Schistosoma mansoni protein kinase 0.0031 0.0048 0.004
Echinococcus multilocularis mothers against decapentaplegic 6 0.0023 0.0019 0.001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.011 0.0322 0.1078
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0154 0.0145
Schistosoma mansoni Smad4 0.0023 0.0019 0.001
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0041 1
Schistosoma mansoni tar DNA-binding protein 0.0855 0.2914 0.2908
Brugia malayi TAR-binding protein 0.0855 0.2914 1
Echinococcus granulosus General substrate transporter 0.0088 0.0244 0.0236
Schistosoma mansoni smad 0.0023 0.0019 0.001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0223 0.0214
Onchocerca volvulus 0.011 0.0322 0.1875
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0027 0.0033 0.0388
Trypanosoma brucei glucose transporter, putative 0.0032 0.005 0.1844
Plasmodium vivax glutathione reductase, putative 0.0084 0.0231 0.1552
Entamoeba histolytica protein kinase, putative 0.0031 0.0048 1
Brugia malayi glutathione reductase 0.0084 0.0231 0.0766
Echinococcus multilocularis tumor protein p63 0.1746 0.6013 0.601
Onchocerca volvulus 0.0061 0.0154 0.0833
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0154 0.0145
Trypanosoma brucei glucose transporter, putative 0.0032 0.005 0.1844
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0041 0.1769
Trichomonas vaginalis set domain proteins, putative 0.0487 0.1635 1
Toxoplasma gondii thioredoxin reductase 0.0084 0.0231 0.2388
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0223 0.0738
Schistosoma mansoni microtubule-associated protein tau 0.2893 1 1
Brugia malayi Thioredoxin reductase 0.0084 0.0231 0.0766
Echinococcus granulosus mothers against decapentaplegic 5 0.0051 0.0117 0.0108
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0048 0.0277
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0048 0.0136
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0053 0.0124 0.0116
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0048 0.004
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0048 0.0136
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0048 0.0277
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0048 0.004
Schistosoma mansoni smad1 5 8 and 0.0051 0.0117 0.0108
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0428 0.1429 0.4889
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0048 0.0136
Echinococcus granulosus tar DNA binding protein 0.0855 0.2914 0.2908
Brugia malayi Intermediate filament tail domain containing protein 0.011 0.0322 0.1078
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0046 0.0582
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0064 0.0384
Trypanosoma brucei trypanothione reductase 0.0084 0.0231 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0041 0.0032
Mycobacterium ulcerans bacterioferritin BfrB 0.0027 0.0033 0.7583
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0046 0.0037
Plasmodium falciparum glutathione reductase 0.0029 0.0041 0.0224
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0191 0.0604 0.8896
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0019 0.2737
Echinococcus multilocularis tar DNA binding protein 0.0855 0.2914 0.2908
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.005 0.1844
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0051 0.0117 0.0108
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.0294 0.0286
Trypanosoma brucei glucose transporter, putative 0.0032 0.005 0.1844
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0257 0.0835 0.2843
Loa Loa (eye worm) sugar transporter 0.0102 0.0294 0.0982
Plasmodium vivax CDK-related protein kinase 6, putative 0.0432 0.1443 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0009 0.0025
Entamoeba histolytica hypothetical protein 0.0023 0.0019 0.2586
Trypanosoma brucei glucose transporter 1E 0.0032 0.005 0.1844
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.0294 0.3062
Schistosoma mansoni ferritin 0.0027 0.0033 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0041 0.1769
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0048 0.004
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.0512 0.5403
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0041 0.0224
Loa Loa (eye worm) hypothetical protein 0.0081 0.0223 0.0738
Brugia malayi MH2 domain containing protein 0.0051 0.0117 0.0371
Schistosoma mansoni tar DNA-binding protein 0.0855 0.2914 0.2908
Loa Loa (eye worm) glutathione reductase 0.0084 0.0231 0.0766
Treponema pallidum NADH oxidase 0.0029 0.0041 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.0294 0.0286
Echinococcus granulosus intermediate filament protein 0.011 0.0322 0.0313
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0041 0.1769
Brugia malayi MH2 domain containing protein 0.0051 0.0117 0.0371
Plasmodium falciparum protein kinase 7 0.0288 0.094 0.6497
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0046 0.0129
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0059 0.0145 0.0467
Plasmodium falciparum glutathione reductase 0.0084 0.0231 0.1552
Leishmania major glucose transporter, lmgt3 0.0032 0.005 0.1844
Echinococcus multilocularis lamin dm0 0.011 0.0322 0.0313
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0041 0.1769
Trypanosoma cruzi trypanothione reductase, putative 0.0084 0.0231 1
Plasmodium falciparum thioredoxin reductase 0.0029 0.0041 0.0224
Leishmania major glucose transporter, lmgt1 0.0032 0.005 0.1844
Echinococcus multilocularis thioredoxin glutathione reductase 0.0084 0.0233 0.0224
Echinococcus granulosus smad 0.0051 0.0117 0.0108
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0191 0.0604 0.8896
Loa Loa (eye worm) nuclear factor I 0.0028 0.0038 0.0099
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0048 0.0244
Mycobacterium ulcerans bacterioferritin BfrA 0.0027 0.0033 0.7583
Mycobacterium tuberculosis Probable oxidoreductase 0.0212 0.0679 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0154 0.0145
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0041 0.1445
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0041 0.1445
Entamoeba histolytica protein kinase, putative 0.0031 0.0048 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0051 0.0117 0.0371
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0009 0.0379
Schistosoma mansoni tar DNA-binding protein 0.0855 0.2914 0.2908
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0009 0.0003
Brugia malayi Smad1 0.0051 0.0117 0.0371
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0041 0.1769
Brugia malayi MH1 domain containing protein 0.0028 0.0038 0.0099
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0041 0.0224
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0041 0.1445
Schistosoma mansoni tar DNA-binding protein 0.0855 0.2914 0.2908
Echinococcus multilocularis General substrate transporter 0.0088 0.0244 0.0236
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0048 0.004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0019 0.0035
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0257 0.0835 0.2843
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0048 0.0277
Echinococcus granulosus GPCR family 2 0.0081 0.0223 0.0214
Loa Loa (eye worm) hypothetical protein 0.011 0.0322 0.1078
Trypanosoma brucei glucose transporter, putative 0.0032 0.005 0.1844
Brugia malayi mothers against decapentaplegic homolog 3 0.0023 0.0019 0.0035
Schistosoma mansoni glucose transport protein 0.0102 0.0294 0.0286
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0041 0.0345
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0042 0.0033
Schistosoma mansoni ferritin 0.0027 0.0033 0.0024
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0041 0.0198
Loa Loa (eye worm) intermediate filament protein 0.011 0.0322 0.1078
Trypanosoma brucei glucose transporter, putative 0.0032 0.005 0.1844
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0048 0.004
Brugia malayi RNA binding protein 0.0855 0.2914 1
Loa Loa (eye worm) hypothetical protein 0.0256 0.0829 0.2823
Schistosoma mansoni hypothetical protein 0.0176 0.0552 0.0543
Echinococcus granulosus lamin dm0 0.011 0.0322 0.0313
Schistosoma mansoni cellular tumor antigen P53 0.0256 0.0829 0.0821
Loa Loa (eye worm) hypothetical protein 0.0108 0.0315 0.1054
Plasmodium vivax thioredoxin reductase, putative 0.0084 0.0231 0.1552
Schistosoma mansoni ferritin 0.0027 0.0033 0.0024
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0041 0.0032
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0041 0.0032
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0019 0.0071
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0099
Trichomonas vaginalis sugar transporter, putative 0.0032 0.005 0.0252
Trypanosoma cruzi hexose transporter, putative 0.0032 0.005 0.2153
Brugia malayi MH2 domain containing protein 0.0745 0.2531 0.8682
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.0294 0.0286
Loa Loa (eye worm) hypothetical protein 0.0053 0.0124 0.0398
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0019 0.0035
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.0294 0.0286
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0041 0.1769
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0294 0.1755
Brugia malayi intermediate filament protein 0.011 0.0322 0.1078
Onchocerca volvulus 0.0256 0.0829 0.5013
Schistosoma mansoni ferritin light chain 0.0027 0.0033 0.0024
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.0294 0.0286
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0064 0.2474
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0053 0.0124 0.0116
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0027 0.0033 0.7583
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0019 0.0071
Schistosoma mansoni protein kinase 0.0031 0.0048 0.004
Echinococcus multilocularis ferritin 0.0027 0.0033 0.0024
Trypanosoma cruzi hexose transporter, putative 0.0032 0.005 0.2153
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0046 0.0037
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0041 0.1445
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0046 0.0037
Echinococcus multilocularis mothers against decapentaplegic 2 0.0023 0.0019 0.001
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0027 0.0033 0.0388
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0223 0.0214
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0046 0.0129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0154 0.0145
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0014 0.0018
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.0512 0.351
Loa Loa (eye worm) TAR-binding protein 0.0855 0.2914 1
Plasmodium vivax hexose transporter 0.0102 0.0294 0.1989
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0064 0.2474
Trypanosoma cruzi hexose transporter, putative 0.0032 0.005 0.2153
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0048 0.0277
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0041 0.0345
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0041 0.8589
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0212 0.0679 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0009 0.0379
Loa Loa (eye worm) MH2 domain-containing protein 0.0745 0.2531 0.8682
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0019 0.001
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0051 0.0117 0.0108
Schistosoma mansoni protein kinase 0.0031 0.0048 0.004
Schistosoma mansoni apoferritin-2 0.0027 0.0033 0.0024
Loa Loa (eye worm) hypothetical protein 0.0031 0.0046 0.0129
Brugia malayi Pre-SET motif family protein 0.0061 0.0154 0.0498
Trichomonas vaginalis sugar transporter, putative 0.0032 0.005 0.0252
Loa Loa (eye worm) hypothetical protein 0.0023 0.0019 0.0035
Echinococcus multilocularis microtubule associated protein 2 0.2893 1 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0041 0.1769
Brugia malayi Cam kinase protein 1 0.0031 0.0048 0.0136
Schistosoma mansoni hypothetical protein 0.0081 0.0223 0.0214
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0041 1
Treponema pallidum bacterioferrin (TpF1) 0.0027 0.0033 0.7583
Trichomonas vaginalis ferritin, putative 0.0027 0.0033 0.015
Schistosoma mansoni lamin 0.011 0.0322 0.0313
Echinococcus granulosus mothers against decapentaplegic 2 0.0023 0.0019 0.001
Echinococcus multilocularis expressed protein 0.0027 0.0033 0.0024
Echinococcus granulosus Smad4 0.0051 0.0117 0.0108
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0019 0.0822
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0048 0.0426
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0041 0.0198
Loa Loa (eye worm) hypothetical protein 0.0051 0.0117 0.0374
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.0294 0.0286
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0041 0.0504
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.005 0.0252
Echinococcus multilocularis lamin 0.011 0.0322 0.0313
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0064 0.2759
Loa Loa (eye worm) hypothetical protein 0.0031 0.0046 0.0129
Trypanosoma brucei glucose transporter, putative 0.0032 0.005 0.1844
Leishmania major trypanothione reductase 0.0084 0.0231 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0023 0.0019 0.0035
Onchocerca volvulus 0.0487 0.1635 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0019 0.3187
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0048 0.0277
Trypanosoma brucei glucose transporter, putative 0.0032 0.005 0.1844
Onchocerca volvulus 0.011 0.0322 0.1875
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0048 0.0426
Schistosoma mansoni ferritin 0.0027 0.0033 0.0024
Loa Loa (eye worm) hypothetical protein 0.0257 0.0835 0.2843
Loa Loa (eye worm) MH2 domain-containing protein 0.0023 0.0019 0.0035
Schistosoma mansoni apoferritin-2 0.0027 0.0033 0.0024
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0223 0.0214
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0048 0.004
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.005 0.1844
Schistosoma mansoni smad1 5 8 and 0.0051 0.0117 0.0108
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0191 0.0604 0.8896

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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