Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0111 | 0.0492 |
Mycobacterium tuberculosis | Probable reductase | 0.0084 | 0.0621 | 0.2991 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.1833 | 0.369 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0111 | 0.0492 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0201 | 0.1833 | 0.369 |
Schistosoma mansoni | apoferritin-2 | 0.0025 | 0.001 | 0.0014 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.011 | 0.0107 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0111 | 0.0492 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0064 | 0.041 | 0.0819 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0158 | 0.0312 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0111 | 1 |
Schistosoma mansoni | ferritin | 0.0025 | 0.001 | 0.0014 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0064 | 0.041 | 0.0406 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0094 | 0.0718 | 0.3466 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0111 | 0.142 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0145 | 0.1251 | 0.2516 |
Schistosoma mansoni | tar DNA-binding protein | 0.0504 | 0.4961 | 1 |
Brugia malayi | RNA binding protein | 0.0504 | 0.4961 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0504 | 0.4961 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0504 | 0.4961 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0037 | 0.0137 | 0.0134 |
Schistosoma mansoni | bromodomain containing protein | 0.0061 | 0.0384 | 0.0767 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0111 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0111 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0201 | 0.1833 | 0.3694 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0111 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0111 | 0.0216 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.0132 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0043 | 0.0193 | 0.0388 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.041 | 0.0819 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0504 | 0.4961 | 1 |
Echinococcus granulosus | ferritin | 0.0025 | 0.001 | 0.0007 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0064 | 0.041 | 0.0406 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0.0132 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0149 | 0.0293 |
Brugia malayi | MH2 domain containing protein | 0.0024 | 0.0004 | 0.0007 |
Schistosoma mansoni | ferritin | 0.0025 | 0.001 | 0.0014 |
Echinococcus multilocularis | GPCR, family 2 | 0.0064 | 0.041 | 0.0406 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0138 | 0.1174 | 0.2366 |
Schistosoma mansoni | intermediate filament proteins | 0.008 | 0.0576 | 0.1154 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0094 | 0.0718 | 0.3466 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0177 | 0.035 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0201 | 0.1833 | 0.3694 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0111 | 0.0492 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.0501 | 0.101 |
Schistosoma mansoni | lamin | 0.008 | 0.0576 | 0.1154 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0064 | 0.041 | 0.0826 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0064 | 0.041 | 0.0826 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.0132 | 0.0259 |
Echinococcus multilocularis | musashi | 0.008 | 0.0576 | 0.0572 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0111 | 0.0224 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.0348 | 0.0344 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.0134 | 0.027 |
Brugia malayi | MH1 domain containing protein | 0.0024 | 0.0004 | 0.0007 |
Echinococcus granulosus | intermediate filament protein | 0.008 | 0.0576 | 0.0572 |
Schistosoma mansoni | ferritin | 0.0025 | 0.001 | 0.0014 |
Brugia malayi | MH1 domain containing protein | 0.0024 | 0.0004 | 0.0007 |
Echinococcus multilocularis | tar DNA binding protein | 0.0504 | 0.4961 | 0.4959 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0084 | 0.0621 | 0.2991 |
Echinococcus multilocularis | lamin | 0.008 | 0.0576 | 0.0572 |
Echinococcus multilocularis | lamin dm0 | 0.008 | 0.0576 | 0.0572 |
Brugia malayi | MH2 domain containing protein | 0.0024 | 0.0004 | 0.0007 |
Loa Loa (eye worm) | RNA binding protein | 0.0504 | 0.4961 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.008 | 0.0576 | 0.1154 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0111 | 1 |
Brugia malayi | intermediate filament protein | 0.008 | 0.0576 | 0.116 |
Schistosoma mansoni | tar DNA-binding protein | 0.0504 | 0.4961 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1174 | 0.2361 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0037 | 0.0132 | 0.0597 |
Echinococcus multilocularis | ferritin | 0.0025 | 0.001 | 0.0007 |
Loa Loa (eye worm) | TAR-binding protein | 0.0504 | 0.4961 | 1 |
Brugia malayi | glutathione reductase | 0.0037 | 0.0132 | 0.0267 |
Echinococcus granulosus | GPCR family 2 | 0.0064 | 0.041 | 0.0406 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0084 | 0.0621 | 0.2991 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0064 | 0.041 | 0.0406 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0111 | 0.0216 |
Schistosoma mansoni | ferritin | 0.0025 | 0.001 | 0.0014 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0359 | 0.3462 | 0.6975 |
Schistosoma mansoni | tar DNA-binding protein | 0.0504 | 0.4961 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0111 | 0.0492 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0111 | 0.0107 |
Schistosoma mansoni | tar DNA-binding protein | 0.0504 | 0.4961 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0111 | 0.0224 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.0348 | 0.0344 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0039 | 0.0149 | 0.0145 |
Echinococcus multilocularis | tumor protein p63 | 0.0991 | 1 | 1 |
Echinococcus granulosus | lamin | 0.008 | 0.0576 | 0.0572 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0111 | 0.0216 |
Schistosoma mansoni | ferritin light chain | 0.0025 | 0.001 | 0.0014 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0084 | 0.0621 | 0.2991 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0064 | 0.041 | 0.0406 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.2052 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.041 | 0.0819 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0359 | 0.3462 | 0.6975 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0037 | 0.0137 | 0.0134 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0111 | 0.0216 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0111 | 0.0492 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0111 | 0.0107 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.0132 | 0.0267 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.0132 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0134 | 0.0263 |
Schistosoma mansoni | apoferritin-2 | 0.0025 | 0.001 | 0.0014 |
Echinococcus multilocularis | expressed protein | 0.0025 | 0.001 | 0.0007 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0111 | 0.0224 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0111 | 0.0492 |
Echinococcus granulosus | tar DNA binding protein | 0.0504 | 0.4961 | 0.4959 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0111 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0561 | 0.1123 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0084 | 0.0621 | 0.2991 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0025 | 0.001 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.0132 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.0132 | 0.0259 |
Onchocerca volvulus | 0.008 | 0.0576 | 0.4077 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0111 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.008 | 0.0576 | 0.116 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0111 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0111 | 0.0216 |
Leishmania major | trypanothione reductase | 0.0037 | 0.0132 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0111 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0111 | 0.0492 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0094 | 0.0718 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0359 | 0.3462 | 0.6977 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.0132 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0111 | 0.142 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0111 | 0.0492 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0025 | 0.001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0111 | 0.0216 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.041 | 0.0819 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0111 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0458 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0576 | 0.1154 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0084 | 0.0621 | 0.2991 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0135 | 0.0264 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0111 | 0.0492 |
Onchocerca volvulus | 0.0145 | 0.1251 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0111 | 0.0216 |
Brugia malayi | Smad1 | 0.0024 | 0.0004 | 0.0007 |
Echinococcus granulosus | expressed protein | 0.0025 | 0.001 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1251 | 0.2516 |
Loa Loa (eye worm) | intermediate filament protein | 0.008 | 0.0576 | 0.1154 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0111 | 0.0216 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0094 | 0.0718 | 0.3466 |
Schistosoma mansoni | ferritin light chain | 0.0025 | 0.001 | 0.0014 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0084 | 0.0621 | 0.8628 |
Brugia malayi | TAR-binding protein | 0.0504 | 0.4961 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.0132 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0111 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0111 | 0.0224 |
Onchocerca volvulus | 0.008 | 0.0576 | 0.4077 | |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.041 | 0.0819 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.041 | 0.0819 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0134 | 0.0263 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0111 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.0132 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.008 | 0.0576 | 0.0572 |
Schistosoma mansoni | lamin | 0.008 | 0.0576 | 0.1154 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.011 | 0.0107 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0039 | 0.0149 | 0.0145 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0043 | 0.0193 | 0.0381 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0111 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.1174 | 0.2361 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.