Detailed information for compound 620653

Basic information

Technical information
  • TDR Targets ID: 620653
  • Name: 6-[[4-(4-fluorophenyl)-5-[(4-methylphenyl)met hylsulfanyl]-1,2,4-triazol-3-yl]methyl]-1H-py rimidine-2,4-dione
  • MW: 423.463 | Formula: C21H18FN5O2S
  • H donors: 2 H acceptors: 6 LogP: 4.12 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)n1c(SCc2ccc(cc2)C)nnc1Cc1cc(O)nc(n1)O
  • InChi: 1S/C21H18FN5O2S/c1-13-2-4-14(5-3-13)12-30-21-26-25-18(10-16-11-19(28)24-20(29)23-16)27(21)17-8-6-15(22)7-9-17/h2-9,11H,10,12H2,1H3,(H2,23,24,28,29)
  • InChiKey: MQMKXBSSZBPIQV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[[4-(4-fluorophenyl)-5-[(4-methylphenyl)methylthio]-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione
  • 6-[[4-(4-fluorophenyl)-5-[(4-methylbenzyl)thio]-1,2,4-triazol-3-yl]methyl]uracil

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0049 0.5
Schistosoma mansoni tar DNA-binding protein 0.0253 0.2694 0.285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0083 0.0785 0.2612
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0116 0.0181
Onchocerca volvulus Bile acid receptor homolog 0.0083 0.0785 0.2722
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1867 0.1855
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0116 0.014
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0325 0.101
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0266 0.0253
Brugia malayi Cathepsin L-like precursor 0.0017 0.0041 0.004
Schistosoma mansoni nuclear receptor nhr-48 0.0039 0.0292 0.0282
Loa Loa (eye worm) hypothetical protein 0.0044 0.0345 0.109
Loa Loa (eye worm) hypothetical protein 0.0151 0.1549 0.5254
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0029 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0083 0.0785 0.0809
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0041 0.0026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0134
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0581 0.059
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0083 0.0785 0.2612
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0067 0.0121
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0611 0.0623
Loa Loa (eye worm) hypothetical protein 0.0101 0.0986 0.3305
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0068 0.0134
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0048 0.0019
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0044 0.0345 0.0338
Loa Loa (eye worm) ICD-1 protein 0.0074 0.0679 0.2246
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0041 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0041 0.0026
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0266 0.0238
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0314 1
Schistosoma mansoni cpg binding protein 0.007 0.0633 0.0647
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.021 0.0194
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0049 0.0306
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0903 1 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0068 0.0039
Toxoplasma gondii exonuclease III APE 0.0039 0.0292 0.2148
Echinococcus multilocularis nuclear receptor nhr 48 0.0039 0.0292 0.0264
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Schistosoma mansoni hypothetical protein 0.0189 0.1971 0.2077
Loa Loa (eye worm) hypothetical protein 0.0039 0.0292 0.0908
Schistosoma mansoni ap endonuclease 0.0039 0.0292 0.0282
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0314 0.0304
Loa Loa (eye worm) hypothetical protein 0.0186 0.194 0.6603
Loa Loa (eye worm) hypothetical protein 0.0073 0.0667 0.2205
Echinococcus granulosus neuropeptide receptor A26 0.0517 0.5664 0.6025
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0048 0.0022
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0041 0.004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0083 0.0785 0.0809
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0116 0.014
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0067 0.0052
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0314 0.0975
Echinococcus granulosus nuclear receptor nhr 48 0.0039 0.0292 0.0281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0572 0.1777
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0041 0.0026
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.009 0.0209
Brugia malayi nuclear receptor RXR 0.0039 0.0292 0.0908
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0038 0.0019
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.0292 0.0919
Brugia malayi Cathepsin L-like precursor 0.0017 0.0041 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Loa Loa (eye worm) hypothetical protein 0.0039 0.0292 0.0908
Loa Loa (eye worm) hypothetical protein 0.0023 0.0116 0.0299
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0068 0.0039
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0292 0.055
Brugia malayi hypothetical protein 0.0018 0.0051 0.0077
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1867 0.1855
Echinococcus multilocularis microtubule associated protein 2 0.0723 0.7975 0.7974
Loa Loa (eye worm) hypothetical protein 0.0039 0.0292 0.0908
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0067 0.0078
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0055 0.0091
Brugia malayi TAR-binding protein 0.0253 0.2694 0.9211
Loa Loa (eye worm) hypothetical protein 0.0039 0.0292 0.0908
Echinococcus multilocularis geminin 0.0189 0.1971 0.1949
Loa Loa (eye worm) hypothetical protein 0.0069 0.0627 0.2065
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.1444 0.449
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0025 0.0129 0.0344
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0903 1 1
Brugia malayi tailless protein 0.0039 0.0292 0.0908
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0287 0.0277
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0041 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0292 0.0908
Echinococcus granulosus GPCR family 2 0.0032 0.021 0.0194
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0087 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Brugia malayi ecdysone receptor 0.0039 0.0292 0.0908
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0067 0.0121
Schistosoma mansoni zinc finger protein 0.0024 0.0118 0.0097
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0287 0.0273
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0292 0.0828
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.2922 0.2912
Brugia malayi hypothetical protein 0.004 0.0302 0.0942
Schistosoma mansoni hypothetical protein 0.004 0.0306 0.0297
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0039 0.0292 0.0264
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0068 0.0039
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0041 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0083 0.0785 0.2612
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0134
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0161 0.2029
Entamoeba histolytica ARF GTPase activating protein, putative 0.0025 0.0129 0.0088
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0306 0.0296
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0572 0.1777
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0134
Brugia malayi steroid hormone receptor 0.0083 0.0785 0.2612
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0273 0.2922 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0611 0.1217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0041 0.0026
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.2422 0.8269
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0068 0.0134
Leishmania major cathepsin L-like protease 0.0064 0.0572 0.1704
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0292 0.0909
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0195
Leishmania major basic transcription factor 3a, putative 0.0074 0.0679 0.2042
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0083 0.0785 0.0808
Echinococcus multilocularis ecdysone induced protein 78C 0.0083 0.0785 0.0758
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0116 0.0275
Schistosoma mansoni inositol monophosphatase 0.0041 0.0314 0.0305
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0287 0.0222
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0041 0.0026
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0161 0.2029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0116 0.0181
Onchocerca volvulus 0.004 0.0306 0.0972
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0116 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.1883 0.1871
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1444 0.4441
Echinococcus granulosus ecdysone induced protein 78C 0.0083 0.0785 0.0808
Entamoeba histolytica hypothetical protein 0.0019 0.0068 0.0027
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0509 0.1509
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0186 0.194 0.6603
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0116 0.014
Leishmania major cathepsin L-like protease 0.0017 0.0041 0.0039
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0986 0.3305
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0287 0.0277
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0067 0.0052
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0068 0.0134
Echinococcus granulosus microtubule associated protein 2 0.0723 0.7975 0.8495
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0083 0.0785 0.2612
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0041 0.0026
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0068 0.0039
Schistosoma mansoni nuclear receptor 0.0039 0.0292 0.0282
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0273 0.2922 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0234 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0068 0.0054
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0083 0.0785 0.0758
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0041 0.0026
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0292 0.0264
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0039 0.0292 0.0282
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0068 0.0043
Schistosoma mansoni microtubule-associated protein tau 0.0723 0.7975 0.8495
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0902 0.9993 1
Schistosoma mansoni hypothetical protein 0.0069 0.0627 0.064
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0068 0.0039
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0292 0.4047
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0087 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0424 0.0423
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0067 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0424 0.0422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0041 0.0026
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0049 0.0042
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0292 0.0908
Onchocerca volvulus 0.0151 0.1549 0.5518
Schistosoma mansoni hypothetical protein 0.0051 0.0419 0.0418
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0068 0.0043
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0048 0.0022
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0287 0.0892
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0029 0.0003
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0314 0.0285
Trypanosoma brucei ISWI complex protein 0.0016 0.0028 0.0087
Leishmania major cathepsin L-like protease 0.0064 0.0572 0.1704
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0302 0.0292
Brugia malayi Cathepsin L-like precursor 0.0017 0.0041 0.004
Echinococcus granulosus transcription factor btf3 0.0074 0.0679 0.0695
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0083 0.0785 0.0758
Brugia malayi hypothetical protein 0.0151 0.1549 0.5254
Onchocerca volvulus Huntingtin homolog 0.013 0.1308 0.4637
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0314 0.0556
Entamoeba histolytica hypothetical protein, conserved 0.0025 0.0129 0.0088
Mycobacterium ulcerans hypothetical protein 0.0023 0.0116 0.014
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0292 0.0908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0572 0.1777
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0067 0.004
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0302 0.0273
Echinococcus granulosus geminin 0.0189 0.1971 0.2076
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0116 0.014
Loa Loa (eye worm) hypothetical protein 0.0044 0.0345 0.109
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0067 0.0207
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0287 0.0259
Brugia malayi Cathepsin L-like precursor 0.0017 0.0041 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1867 0.1855
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0116 0.0076
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0265 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0068 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0424 0.0396
Schistosoma mansoni nuclear receptor 0.0039 0.0292 0.0282
Echinococcus multilocularis RUN 0.004 0.0306 0.0278
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0306 0.0278
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0287 0.0812
Brugia malayi Nuclear hormone receptor-like 1 0.0083 0.0785 0.2612
Echinococcus granulosus dna polymerase kappa 0.0019 0.0067 0.004
Entamoeba histolytica hypothetical protein 0.0019 0.0068 0.0027
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0611 0.1181
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0572 0.1704
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0067 0.013
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1444 0.4441
Loa Loa (eye worm) doublecortin family protein 0.004 0.0306 0.0958
Brugia malayi nuclear receptor NHR-88 0.0039 0.0292 0.0908
Schistosoma mansoni zinc finger protein 0.0039 0.0292 0.0282
Loa Loa (eye worm) hypothetical protein 0.013 0.1308 0.4421
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0424 0.1364
Trichomonas vaginalis set domain proteins, putative 0.026 0.2775 0.2764
Loa Loa (eye worm) hypothetical protein 0.0039 0.0292 0.0908
Schistosoma mansoni hypothetical protein 0.0189 0.1971 0.2077
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0419 0.1349
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.1624 0.3336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0041 0.0026
Trypanosoma brucei transcription factor BTF3, putative 0.0074 0.0679 0.2111
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Schistosoma mansoni hypothetical protein 0.0021 0.009 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1867 0.1855
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0068 0.0134
Loa Loa (eye worm) DR-78 0.0039 0.0292 0.0908
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0611 0.1829
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0067 0.0037
Loa Loa (eye worm) hypothetical protein 0.0083 0.0785 0.2612
Mycobacterium ulcerans hypothetical protein 0.0158 0.1624 0.3309
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0068 0.0041
Loa Loa (eye worm) hypothetical protein 0.004 0.0306 0.0958
Onchocerca volvulus 0.0051 0.0419 0.1386
Loa Loa (eye worm) RNA binding protein 0.0253 0.2694 0.9211
Schistosoma mansoni coup transcription factor 0.0083 0.0785 0.0809
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0627 0.2065
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0195
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0611 0.0584
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Echinococcus multilocularis expressed protein 0.0375 0.4063 0.4049
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0044 0.0014
Loa Loa (eye worm) cysteine protease 0.0017 0.0041 0.004
Onchocerca volvulus 0.0039 0.0292 0.0919
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0044 0.0015
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0292 0.0281
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0137 0.1389 0.1455
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0265 0.0494
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0345 0.0338
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0611 0.0622
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1199 0.4042
Loa Loa (eye worm) hypothetical protein 0.0032 0.021 0.0626
Schistosoma mansoni hypothetical protein 0.0848 0.9382 1
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0068 0.0041
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0067 0.013
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0083 0.0785 0.0809
Leishmania major ADP-ribosylation factor GTPase activating protein 1, putative 0.0025 0.0129 0.0315
Loa Loa (eye worm) hypothetical protein 0.0039 0.0292 0.0908
Schistosoma mansoni tar DNA-binding protein 0.0253 0.2694 0.285
Loa Loa (eye worm) hypothetical protein 0.0083 0.0785 0.2612
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0083 0.0785 0.2612
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0325 0.0931
Schistosoma mansoni bromodomain containing protein 0.0069 0.0622 0.0635
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0069
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0903 1 1
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0292 0.0282
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0044 0.0345 0.109
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0067 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0068 0.0041
Onchocerca volvulus 0.0052 0.0434 0.1438
Schistosoma mansoni polycystin 1-related 0.004 0.0306 0.0297
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0572 0.1704
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0306 0.4264
Echinococcus multilocularis dna polymerase eta 0.0019 0.0067 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0083 0.0785 0.2612
Echinococcus multilocularis cpg binding protein 0.007 0.0633 0.0606
Giardia lamblia Fructose-bisphosphate aldolase 0.0903 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0039 0.0292 0.0282
Onchocerca volvulus 0.0083 0.0785 0.2722
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0314 0.03
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0041 0.0026
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0434 0.0434
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0306 0.0296
Entamoeba histolytica transcription factor BTF3, putative 0.0074 0.0679 0.0641
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0325 0.0931
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0041 0.0026
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0292 0.0253
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0068 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0572 0.1777
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0314 0.03
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0068 0.0054
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0083 0.0785 0.0808
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0068 0.0041
Loa Loa (eye worm) hypothetical protein 0.0093 0.09 0.3008
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.3216 1
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0161 0.0501
Brugia malayi orphan nuclear receptor NR2E1 0.0039 0.0292 0.0908
Loa Loa (eye worm) hypothetical protein 0.0039 0.0292 0.0908
Loa Loa (eye worm) hypothetical protein 0.0039 0.0292 0.0908
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1867 0.1855
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0069
Schistosoma mansoni retinoic acid receptor RXR 0.0083 0.0785 0.0809
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0234 0.022
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0083 0.0785 0.0809
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0068 0.0054
Brugia malayi hypothetical protein 0.0028 0.0161 0.0456
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.2922 0.2912
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0083 0.0785 0.0808
Brugia malayi nuclear receptor NHR-88 0.0083 0.0785 0.2612
Toxoplasma gondii cathepsin CPL 0.0017 0.0041 0.0093
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0068 0.0043
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0083 0.0785 0.0808
Trypanosoma brucei ADP-ribosylation factor GTPase activating protein 1, putative 0.0025 0.0129 0.04
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0153 0.0132
Echinococcus granulosus expressed protein 0.0375 0.4063 0.4313
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.043 0.0403
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0292 0.0511
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0572 0.1777
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0428 0.1255
Echinococcus multilocularis ADP ribosylation factor GTPase activating 0.0025 0.0129 0.01
Plasmodium vivax GTP-ase activating protein for Arf containing protein 0.0025 0.0129 0.153
Loa Loa (eye worm) hypothetical protein 0.0083 0.0785 0.2612
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0306 0.0278
Trichomonas vaginalis arf-GTPase activating protein, putative 0.0025 0.0129 0.0114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0903 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0083 0.0785 0.2612
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0068 0.0054
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0039 0.0292 0.0908
Brugia malayi hypothetical protein 0.013 0.1308 0.4421
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0325 0.0931
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0083 0.0785 0.0758
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0068 0.0043
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0287 0.0276
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0044 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0083 0.0785 0.2612
Brugia malayi Pre-SET motif family protein 0.0229 0.2422 0.8269
Loa Loa (eye worm) hypothetical protein 0.0044 0.0345 0.109
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0176 0.1832 0.1928
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0176 0.1832 0.181
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0068 0.0134
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0068 0.0043
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0581 0.0554
Brugia malayi conserved hypotetical protein 0.0039 0.0292 0.0908
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0029 0.0003
Plasmodium vivax SET domain protein, putative 0.0034 0.0234 0.3148
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0083 0.0785 0.0758
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0134
Brugia malayi nuclear hormone receptor 0.0039 0.0292 0.0908
Echinococcus multilocularis cysteine protease 0.0017 0.0041 0.0011
Toxoplasma gondii histone lysine methyltransferase SET1 0.0125 0.1253 1
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0068 0.0043
Onchocerca volvulus Glucosylceramidase homolog 0.0179 0.1867 0.6678
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0903 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0679 0.0665
Brugia malayi RNA binding protein 0.0253 0.2694 0.9211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0041 0.0026
Echinococcus granulosus dnaJ subfamily B 0.0848 0.9382 1
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0679 0.0665
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0083 0.0785 0.2612
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0041 0.0026
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1867 0.1855
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0903 1 1
Leishmania major cathepsin L-like protease 0.0017 0.0041 0.0039
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0195
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0441 0.4809 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0083 0.0785 0.2612
Plasmodium falciparum ADP-ribosylation factor GTPase-activating protein, putative 0.0025 0.0129 0.153
Entamoeba histolytica ARF GTPase activating protein, putative 0.0025 0.0129 0.0088
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.2635 0.2786
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0287 0.0891
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0067 0.0207
Onchocerca volvulus 0.0023 0.0116 0.0275
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0153 0.0124
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0041 0.004
Brugia malayi hypothetical protein 0.0039 0.0292 0.0908
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0134
Onchocerca volvulus 0.0039 0.0292 0.0919
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.043 0.043
Brugia malayi Bromodomain containing protein 0.0039 0.0293 0.0913
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0067 0.0121
Schistosoma mansoni RAR-like nuclear receptor 0.0083 0.0785 0.0809
Brugia malayi hypothetical protein 0.004 0.0306 0.0958
Schistosoma mansoni lipoxygenase 0.0103 0.1014 0.1054
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0068 0.0039
Loa Loa (eye worm) hypothetical protein 0.0039 0.0294 0.0916
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0083 0.0785 0.2612
Plasmodium falciparum basic transcription factor 3b, putative 0.0074 0.0679 1
Entamoeba histolytica hypothetical protein 0.004 0.0302 0.0262
Echinococcus granulosus thyroid hormone receptor alpha 0.0039 0.0292 0.0281
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0116 0.014
Entamoeba histolytica hypothetical protein 0.004 0.0302 0.0262
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0161 0.0417
Loa Loa (eye worm) hypothetical protein 0.013 0.1308 0.4421
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0069
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0068 0.0134
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0903 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0292 0.0828
Loa Loa (eye worm) hypothetical protein 0.0083 0.0785 0.2612
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0083 0.0785 0.2612
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0302 0.0291
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0038 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0253 0.2694 0.285
Toxoplasma gondii hypothetical protein 0.0048 0.0394 0.2983
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0044 0.0345 0.0317
Loa Loa (eye worm) hypothetical protein 0.0052 0.0434 0.1399
Schistosoma mansoni cpg binding protein 0.0064 0.057 0.0579
Brugia malayi MH2 domain containing protein 0.012 0.1199 0.4042
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1867 0.1855
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0572 0.1777
Loa Loa (eye worm) TAR-binding protein 0.0253 0.2694 0.9211
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0292 0.0264
Brugia malayi hypothetical protein 0.0019 0.0068 0.0134
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0314 0.2323
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0041 0.0012
Brugia malayi PHD-finger family protein 0.0029 0.018 0.0521
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.2922 0.2912
Loa Loa (eye worm) fibroinase 0.0017 0.0041 0.004
Onchocerca volvulus 0.004 0.0306 0.0972
Echinococcus multilocularis dnaJ subfamily B 0.0848 0.9382 0.9387
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0083 0.0785 0.0809
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0287 0.0276
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0041 0.0039
Brugia malayi Latrophilin receptor protein 2 0.0032 0.021 0.0626
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0153 0.0133
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0068 0.0039
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0067 0.0121
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0314 0.03
Brugia malayi hypothetical protein 0.0093 0.09 0.3008
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0611 0.1181
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0083 0.0785 0.2612
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0345 0.109
Schistosoma mansoni rab6-interacting 0.004 0.0306 0.0297
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0572 0.1777
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0441 0.4809 1
Echinococcus granulosus zinc finger protein 0.0024 0.0118 0.0095
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0306 0.4264
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0292 0.0264
Brugia malayi Inositol-1 0.0041 0.0314 0.0983
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0572 0.1704
Brugia malayi nuclear hormone receptor family member odr-7 0.0039 0.0292 0.0908
Entamoeba histolytica hypothetical protein 0.0074 0.0679 0.0641
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0038 0.0019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0067 0.013
Schistosoma mansoni cpg binding protein 0.007 0.0633 0.0647
Echinococcus granulosus ADP ribosylation factor GTPase activating 0.0025 0.0129 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0083 0.0785 0.2612
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0068 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0572 0.1777
Brugia malayi hypothetical protein 0.0248 0.2635 0.9007
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0161 0.2029
Loa Loa (eye worm) nuclear receptor NHR-67 0.0039 0.0292 0.0908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0572 0.1777
Schistosoma mansoni nuclear hormone receptor 0.0083 0.0785 0.0809
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0292 0.0281
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0083 0.0785 0.0758
Schistosoma mansoni tar DNA-binding protein 0.0253 0.2694 0.285
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0572 0.1704
Leishmania major DNA polymerase kappa, putative 0.0019 0.0067 0.0121
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0068 0.0134
Loa Loa (eye worm) hypothetical protein 0.0047 0.0384 0.1228
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0067 0.0121
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0029 0.0091
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0068 0.0041
Brugia malayi hypothetical protein 0.004 0.0306 0.0958
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Loa Loa (eye worm) hypothetical protein 0.0083 0.0785 0.2612
Leishmania major cathepsin L-like protease 0.0017 0.0041 0.0039
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0041 0.0176
Schistosoma mansoni thyroid hormone receptor 0.0083 0.0785 0.0809
Brugia malayi hypothetical protein 0.0039 0.0292 0.0908
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0083 0.0785 0.0809
Brugia malayi PXA domain containing protein 0.0019 0.0068 0.0134
Brugia malayi Cathepsin L-like precursor 0.0017 0.0041 0.004
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0068 0.0043
Entamoeba histolytica hypothetical protein 0.004 0.0302 0.0262
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0039 0.0292 0.0264
Leishmania major cathepsin L-like protease 0.0064 0.0572 0.1704
Loa Loa (eye worm) hypothetical protein 0.0039 0.0292 0.0908
Loa Loa (eye worm) hypothetical protein 0.004 0.0306 0.0958
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1199 0.4042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0572 0.1777
Schistosoma mansoni inositol monophosphatase 0.0041 0.0314 0.0305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0041 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0068 0.0054
Echinococcus granulosus RUN 0.004 0.0306 0.0296
Loa Loa (eye worm) inositol-1 0.0041 0.0314 0.0983
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0049 0.0306
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0044 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0041 0.0026
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0253 0.2694 0.9211
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0287 0.0247
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0067 0.0041
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0067 0.0038
Brugia malayi hypothetical protein 0.0044 0.0345 0.109
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0067 0.0207
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0068 0.0054
Loa Loa (eye worm) hypothetical protein 0.0044 0.0345 0.109
Brugia malayi hypothetical protein 0.0019 0.0068 0.0134
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0038 0.0019
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0068 0.0041
Toxoplasma gondii ARF1-directed GTPase-activating protein, putative 0.0025 0.0129 0.0812
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0083 0.0785 0.2612
Loa Loa (eye worm) hypothetical protein 0.0248 0.2635 0.9007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0424 0.0396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0041 0.0026
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0314 0.0896
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0068 0.0043
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0287 0.0259
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0611 0.0623
Treponema pallidum fructose-bisphosphate aldolase 0.0903 1 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0068 0.0043
Onchocerca volvulus 0.026 0.2775 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0785 0.2612
Plasmodium vivax basic transcription factor 3b, putative 0.0074 0.0679 1
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0107 0.0268
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0067 0.0207
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0299 0.3216 1
Trypanosoma cruzi transcription factor btf3, putative 0.0074 0.0679 0.2042
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0067 0.0121
Toxoplasma gondii NAC domain-containing protein 0.0074 0.0679 0.5308
Echinococcus multilocularis FTZ F1 alpha 0.0083 0.0785 0.0758
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0205 0.0188
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0417 0.1221
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0292 0.0908
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0292 0.0227
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0611 0.1181
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0068 0.0134
Brugia malayi RNA recognition motif domain containing protein 0.0253 0.2694 0.9211
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0041 0.0012
Loa Loa (eye worm) hypothetical protein 0.0083 0.0785 0.2612
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0069
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0986 0.3305
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.0292 0.0919
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0068 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0679 0.0665
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0441 0.4809 1
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0292 0.0282
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0292 0.0909
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0424 0.0423
Schistosoma mansoni arf gtpase-activating protein 0.0025 0.0129 0.0108
Schistosoma mansoni ap endonuclease 0.0039 0.0292 0.0282
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0306 0.0278
Loa Loa (eye worm) hypothetical protein 0.0023 0.0116 0.0299
Brugia malayi Cathepsin L-like precursor 0.0017 0.0041 0.004
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0986 0.3305
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.2922 0.2912
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.043 0.0429
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.2922 0.2912
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0083 0.0785 0.0809
Loa Loa (eye worm) hypothetical protein 0.0039 0.0292 0.0908
Loa Loa (eye worm) hypothetical protein 0.0028 0.0161 0.0456
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.021 0.0182
Echinococcus granulosus cathepsin l1 0.0017 0.0041 0.0012
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0083 0.0785 0.0808
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0287 0.0812
Plasmodium vivax vivapain-2 0.0017 0.0041 0.0176
Brugia malayi photoreceptor-specific nuclear receptor 0.0083 0.0785 0.2612
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0161 0.0417
Loa Loa (eye worm) ctsf protein 0.0017 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0051 0.043 0.1387
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0083 0.0785 0.0808
Echinococcus multilocularis zinc finger protein 0.0024 0.0118 0.0089
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0083 0.0785 0.2612
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0116 0.0275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0041 0.0026
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0068 0.0134
Brugia malayi hypothetical protein 0.0044 0.0345 0.109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0041 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.021 0.0626
Echinococcus granulosus tar DNA binding protein 0.0253 0.2694 0.2849
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0287 0.0273
Leishmania major mitochondrial DNA polymerase beta 0.0299 0.3216 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0903 1 1
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0087 0.0201
Loa Loa (eye worm) nuclear hormone receptor 0.0039 0.0292 0.0908
Entamoeba histolytica hypothetical protein 0.0019 0.0068 0.0027
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0041 0.0011
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0116 0.014
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0068 0.0041
Plasmodium vivax vivapain-2 0.0017 0.0041 0.0176
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0903 1 1
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.2635 0.2615
Brugia malayi nuclear receptor NHR-67 0.0039 0.0292 0.0908
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0292 0.0281
Entamoeba histolytica ARF GTPase activating protein, putative 0.0025 0.0129 0.0088
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0048 0.002
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0029 0.0001
Schistosoma mansoni survival motor neuron protein 0.0051 0.0419 0.0418
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0287 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Leishmania major cathepsin L-like protease 0.0017 0.0041 0.0039
Echinococcus multilocularis tar DNA binding protein 0.0253 0.2694 0.2675
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0292 0.0278
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0134
Echinococcus multilocularis cysteine protease 0.0017 0.0041 0.0011
Brugia malayi nuclear receptor RXR 0.0044 0.0345 0.109
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0292 0.0264
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0041 0.0176
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0116 0.0076
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0116 0.0275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0083 0.0785 0.2612
Schistosoma mansoni DNA polymerase eta 0.0019 0.0067 0.0041
Loa Loa (eye worm) hypothetical protein 0.0023 0.0116 0.0299
Brugia malayi PXA domain containing protein 0.0019 0.0068 0.0134
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0039 0.0292 0.0908
Echinococcus granulosus FTZ F1 alpha 0.0083 0.0785 0.0808
Trypanosoma brucei unspecified product 0.0019 0.0067 0.0207
Brugia malayi Bromodomain containing protein 0.0081 0.0757 0.2517
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0041 0.0176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0041 0.0026
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0068 0.0041
Brugia malayi ecdysteroid receptor 0.0083 0.0785 0.2612
Onchocerca volvulus 0.0064 0.057 0.1936
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0287 0.0812
Schistosoma mansoni loxhd1 0.004 0.0306 0.0297
Echinococcus multilocularis neuropeptide receptor A26 0.0517 0.5664 0.5655
Trypanosoma cruzi ADP-ribosylation factor GTPase activating protein 1, putative 0.0025 0.0129 0.0315
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0068 0.0039
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0292 0.0278
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0025 0.0129 0.0344
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0068 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0253 0.2694 0.285
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0161 0.1077
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0116 0.0299
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0041 0.004
Echinococcus granulosus neuropeptide s receptor 0.0517 0.5664 0.6025
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0067 0.0041
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0424 0.1364
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0067 0.0037
Loa Loa (eye worm) hypothetical protein 0.0039 0.0292 0.0908
Trypanosoma cruzi ADP-ribosylation factor GTPase activating protein 1, putative 0.0025 0.0129 0.0315
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.021 0.0194
Schistosoma mansoni eyes absent homolog 0.0093 0.09 0.0932
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0083 0.0785 0.2612
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0195
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0044 0.0345 0.0337
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0611 0.4753
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0041 0.0026
Leishmania major hypothetical protein, conserved 0.0028 0.0161 0.0417
Leishmania major DNA polymerase eta, putative 0.0019 0.0067 0.0121
Brugia malayi nuclear hormone receptor family member nhr-6 0.0039 0.0292 0.0908
Loa Loa (eye worm) hypothetical protein 0.0039 0.0292 0.0908
Onchocerca volvulus 0.0034 0.0234 0.0706
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0041 0.0026
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0068 0.0041
Schistosoma mansoni transcription factor btf3 0.0074 0.0679 0.0696
Echinococcus multilocularis neuropeptide s receptor 0.0517 0.5664 0.5655
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0041 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0068 0.0043
Onchocerca volvulus 0.0025 0.0129 0.0322
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0044 0.0014
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0067 0.013
Schistosoma mansoni steroid hormone receptor ad4bp 0.0083 0.0785 0.0809
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0314 0.0896
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1975 0.1963
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0041 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0116 0.014
Leishmania major cathepsin L-like protease 0.0017 0.0041 0.0039
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0068 0.0039
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0234 0.1671
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0116 0.0299
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0083 0.0785 0.0758
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0314 0.0274
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0029 0.0091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0424 0.0423
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0234 0.022
Echinococcus multilocularis GPCR, family 2 0.0032 0.021 0.0182
Brugia malayi beta-NAC-like protein 0.0074 0.0679 0.2246
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0116 0.0299
Brugia malayi Doublecortin family protein 0.004 0.0306 0.0958
Loa Loa (eye worm) steroid hormone receptor 0.0083 0.0785 0.2612
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1975 0.1963
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0041 0.0026
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.0891
Brugia malayi Steroid receptor seven-up type 2 0.0083 0.0785 0.2612
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0041 0.0026
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.021 0.0626
Brugia malayi Pre-SET motif family protein 0.0034 0.0234 0.0707
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0083 0.0785 0.2612
Echinococcus multilocularis thyroid hormone receptor alpha 0.0083 0.0785 0.0758
Echinococcus multilocularis transcription factor btf3 0.0074 0.0679 0.0652
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0292 0.0281
Echinococcus multilocularis tumor protein p63 0.0354 0.3829 0.3814
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0314 0.0896
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0083 0.0785 0.2612
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0041 0.0026
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0083 0.0785 0.0808
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0067 0.0078
Loa Loa (eye worm) hypothetical protein 0.0044 0.0345 0.109
Schistosoma mansoni rab6-interacting 0.004 0.0306 0.0297
Schistosoma mansoni lipoxygenase 0.0176 0.1832 0.1929
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0345 0.109
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0287 0.0259
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.2922 0.2912
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.3216 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0083 0.0785 0.2722
Loa Loa (eye worm) hypothetical protein 0.0093 0.09 0.3008
Brugia malayi CXXC zinc finger family protein 0.0064 0.057 0.1869
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0083 0.0785 0.2612
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0424 0.0422
Echinococcus granulosus dna polymerase eta 0.0019 0.0067 0.004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.021 0.0182
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0039 0.0292 0.0281
Loa Loa (eye worm) hypothetical protein 0.0042 0.0321 0.101
Onchocerca volvulus Huntingtin homolog 0.013 0.1308 0.4637
Brugia malayi nuclear hormone receptor 0.0083 0.0785 0.2612
Schistosoma mansoni hypothetical protein 0.004 0.0302 0.0292
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0572 0.1777
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0083 0.0785 0.2722
Echinococcus granulosus cpg binding protein 0.007 0.0633 0.0646
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0068 0.0134
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0306 0.0296
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0292 0.0828
Entamoeba histolytica hypothetical protein 0.004 0.0302 0.0262
Trypanosoma cruzi transcription factor btf3, putative 0.0074 0.0679 0.2042
Echinococcus granulosus tumor protein p63 0.0354 0.3829 0.4063
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0068 0.0134
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0068 0.0043
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.057 0.1869
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0287 0.0276
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0041 0.0011
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0292 0.4047

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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