Detailed information for compound 620692

Basic information

Technical information
  • TDR Targets ID: 620692
  • Name: 6-[[5-butan-2-ylsulfanyl-4-(2,5-dimethylpheny l)-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2 ,4-dione
  • MW: 385.483 | Formula: C19H23N5O2S
  • H donors: 2 H acceptors: 6 LogP: 4.22 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(Sc1nnc(n1c1cc(C)ccc1C)Cc1cc(O)nc(n1)O)C
  • InChi: 1S/C19H23N5O2S/c1-5-13(4)27-19-23-22-16(9-14-10-17(25)21-18(26)20-14)24(19)15-8-11(2)6-7-12(15)3/h6-8,10,13H,5,9H2,1-4H3,(H2,20,21,25,26)
  • InChiKey: CJTJSYJBYUTTAL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[[4-(2,5-dimethylphenyl)-5-sec-butylsulfanyl-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione
  • 6-[[4-(2,5-dimethylphenyl)-5-(sec-butylthio)-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione
  • 6-[[4-(2,5-dimethylphenyl)-5-(sec-butylthio)-1,2,4-triazol-3-yl]methyl]uracil

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis set domain proteins, putative 0.0258 0.2774 0.2771
Entamoeba histolytica hypothetical protein 0.0074 0.0685 0.0644
Schistosoma mansoni cpg binding protein 0.006 0.0526 0.0528
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0067 0.0121
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0292 0.0511
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0071 0.0145
Onchocerca volvulus 0.0023 0.0116 0.0265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.0039
Schistosoma mansoni nuclear hormone receptor 0.0083 0.0788 0.0806
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0071 0.0145
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0292 0.4008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0294 0.0914
Brugia malayi Bromodomain containing protein 0.0039 0.0293 0.0913
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.2922 0.2918
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0067 0.0121
Loa Loa (eye worm) hypothetical protein 0.0039 0.0294 0.0914
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0039 0.0294 0.0282
Schistosoma mansoni DNA polymerase eta 0.0019 0.0067 0.0041
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0178 0.1862 0.1944
Loa Loa (eye worm) hypothetical protein 0.0129 0.1308 0.4421
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0294 0.028
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0071 0.0045
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0292 0.055
Schistosoma mansoni zinc finger protein 0.0023 0.0116 0.0093
Loa Loa (eye worm) DR-78 0.0039 0.0294 0.0914
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0067 0.0207
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0083 0.0788 0.0805
Loa Loa (eye worm) hypothetical protein 0.0083 0.0788 0.2625
Loa Loa (eye worm) hypothetical protein 0.0072 0.0667 0.2206
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0116 0.0275
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0294 0.028
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0428 0.1255
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0187 0.1971 0.6714
Schistosoma mansoni cpg binding protein 0.0065 0.0587 0.0592
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0071 0.0145
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0043 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0582 0.181
Schistosoma mansoni microtubule-associated protein tau 0.0728 0.8098 0.8559
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0071 0.0045
Echinococcus granulosus dnaJ subfamily B 0.0848 0.9456 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.015 0.0129
Brugia malayi tailless protein 0.0039 0.0294 0.0914
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0043 0.0039
Onchocerca volvulus Protein ultraspiracle homolog 0.0083 0.0788 0.2728
Leishmania major ADP-ribosylation factor GTPase activating protein 1, putative 0.0025 0.0133 0.0328
Brugia malayi TAR-binding protein 0.0252 0.2705 0.925
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0071 0.0145
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0233 0.0217
Echinococcus granulosus microtubule associated protein 2 0.0728 0.8098 0.8559
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0083 0.0788 0.0805
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0043 0.0048
Loa Loa (eye worm) hypothetical protein 0.0093 0.0899 0.3008
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0055 0.0091
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0205 0.0186
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0071 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1866 0.1862
Schistosoma mansoni RAR-like nuclear receptor 0.0083 0.0788 0.0806
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.043 0.0425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.0039
Brugia malayi Cathepsin L-like precursor 0.0017 0.0043 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.043 0.0426
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0292 0.0227
Echinococcus granulosus nuclear receptor nhr 48 0.0039 0.0294 0.028
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0033 0.0004
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0294 0.0282
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.1444 0.449
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0233 0.1785
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0365 0.1159
Toxoplasma gondii cathepsin CPL 0.0017 0.0043 0.0125
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0043 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0365 0.0356
Brugia malayi hypothetical protein 0.0044 0.0347 0.1097
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0067 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0071 0.0067
Brugia malayi conserved hypotetical protein 0.0039 0.0294 0.0914
Echinococcus granulosus cpg binding protein 0.0065 0.0587 0.0591
Trypanosoma brucei unspecified product 0.0019 0.0067 0.0207
Loa Loa (eye worm) hypothetical protein 0.0093 0.0899 0.3008
Loa Loa (eye worm) hypothetical protein 0.0083 0.0788 0.2625
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0048 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0582 0.181
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0145
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0083 0.0788 0.0805
Onchocerca volvulus Huntingtin homolog 0.0129 0.1308 0.4631
Plasmodium vivax vivapain-2 0.0017 0.0043 0.0217
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0161 0.0417
Loa Loa (eye worm) hypothetical protein 0.0041 0.0313 0.0981
Schistosoma mansoni lipoxygenase 0.0178 0.1862 0.1945
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0313 0.0301
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0071 0.0046
Echinococcus granulosus ADP ribosylation factor GTPase activating 0.0025 0.0133 0.011
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0071 0.0046
Echinococcus multilocularis ecdysone induced protein 78C 0.0083 0.0788 0.0805
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0083 0.0788 0.2625
Brugia malayi Cathepsin L-like precursor 0.0017 0.0043 0.0049
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.2677 0.2809
Echinococcus granulosus geminin 0.0179 0.1877 0.196
Schistosoma mansoni nuclear receptor 0.0039 0.0294 0.0282
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0067 0.0121
Echinococcus multilocularis nuclear receptor nhr 48 0.0039 0.0294 0.028
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.021 0.0627
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0071 0.0046
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0896 1 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0043 0.0049
Entamoeba histolytica ARF GTPase activating protein, putative 0.0025 0.0133 0.009
Leishmania major cathepsin L-like protease 0.0065 0.0582 0.1738
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.0313 0.0301
Echinococcus multilocularis cysteine protease 0.0017 0.0043 0.0015
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0025 0.0133 0.0358
Brugia malayi hypothetical protein 0.0041 0.0313 0.0981
Brugia malayi beta-NAC-like protein 0.0074 0.0685 0.2268
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Brugia malayi hypothetical protein 0.0019 0.0071 0.0145
Brugia malayi ecdysone receptor 0.0039 0.0294 0.0914
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0071 0.0046
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.0294 0.0916
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0071 0.0046
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0233 0.0216
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0043 0.0039
Onchocerca volvulus 0.0034 0.0233 0.0694
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0526 0.1718
Loa Loa (eye worm) hypothetical protein 0.0039 0.0294 0.0914
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0067 0.013
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0071 0.0046
Echinococcus granulosus expressed protein 0.0378 0.4126 0.4346
Echinococcus granulosus cathepsin l1 0.0017 0.0043 0.0015
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0083 0.0788 0.0806
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0029 0.0003
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0627 0.2066
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1866 0.1862
Loa Loa (eye worm) hypothetical protein 0.0032 0.021 0.0627
Brugia malayi Doublecortin family protein 0.0041 0.0313 0.0981
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0071 0.0045
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0266 0.0251
Brugia malayi hypothetical protein 0.0018 0.0051 0.0077
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0116 0.0275
Brugia malayi nuclear hormone receptor 0.0039 0.0294 0.0914
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0071 0.0046
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0161 0.0501
Loa Loa (eye worm) hypothetical protein 0.0027 0.0161 0.0456
Treponema pallidum fructose-bisphosphate aldolase 0.0896 1 1
Echinococcus multilocularis cpg binding protein 0.0065 0.0587 0.0591
Onchocerca volvulus Huntingtin homolog 0.0129 0.1308 0.4631
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0116 0.0181
Schistosoma mansoni tar DNA-binding protein 0.0252 0.2705 0.2839
Echinococcus multilocularis geminin 0.0179 0.1877 0.196
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0292 0.0279
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0145
Leishmania major cathepsin L-like protease 0.0017 0.0043 0.0048
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0294 0.0282
Echinococcus multilocularis microtubule associated protein 2 0.0728 0.8098 0.8559
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0294 0.0282
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0049
Mycobacterium ulcerans hypothetical protein 0.0157 0.1624 0.3309
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.2922 0.2918
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0116 0.0073
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.015 0.0128
Schistosoma mansoni coup transcription factor 0.0083 0.0788 0.0806
Echinococcus granulosus FTZ F1 alpha 0.0083 0.0788 0.0805
Leishmania major cathepsin L-like protease 0.0017 0.0043 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.0039
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.0313 0.0301
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0426 0.1247
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0048 0.0021
Brugia malayi hypothetical protein 0.0039 0.0294 0.0914
Echinococcus granulosus RUN 0.0041 0.0313 0.0301
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0292 0.0909
Loa Loa (eye worm) ICD-1 protein 0.0074 0.0685 0.2268
Loa Loa (eye worm) doublecortin family protein 0.0041 0.0313 0.0981
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0365 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0083 0.0788 0.2625
Brugia malayi Pre-SET motif family protein 0.0034 0.0233 0.0704
Schistosoma mansoni hypothetical protein 0.0051 0.0428 0.0424
Echinococcus granulosus dna polymerase kappa 0.0019 0.0067 0.004
Brugia malayi hypothetical protein 0.0039 0.0294 0.0914
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0582 0.1738
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0083 0.0788 0.2625
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0896 1 1
Toxoplasma gondii hypothetical protein 0.0048 0.0394 0.3201
Loa Loa (eye worm) hypothetical protein 0.0039 0.0294 0.0914
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0067 0.013
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0579 0.0583
Brugia malayi nuclear receptor RXR 0.0044 0.0347 0.1097
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0116 0.0073
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.009 0.0209
Loa Loa (eye worm) hypothetical protein 0.0044 0.0347 0.1097
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.3217 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0294 0.028
Schistosoma mansoni transcription factor btf3 0.0074 0.0685 0.0697
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0071 0.0045
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0083 0.0788 0.0805
Loa Loa (eye worm) ctsf protein 0.0017 0.0043 0.0049
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0116 0.014
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.2922 0.2918
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0083 0.0788 0.0806
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0071 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0083 0.0788 0.2625
Trypanosoma brucei ADP-ribosylation factor GTPase activating protein 1, putative 0.0025 0.0133 0.0413
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0083 0.0788 0.2625
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0294 0.028
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1866 0.1862
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0292 0.4008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0582 0.181
Echinococcus granulosus GPCR family 2 0.0032 0.021 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Entamoeba histolytica hypothetical protein 0.0019 0.0071 0.0028
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0325 0.0931
Loa Loa (eye worm) hypothetical protein 0.0187 0.1971 0.6714
Brugia malayi hypothetical protein 0.015 0.155 0.5256
Loa Loa (eye worm) hypothetical protein 0.015 0.155 0.5256
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0083 0.0788 0.2625
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0029 0.0091
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0294 0.028
Entamoeba histolytica transcription factor BTF3, putative 0.0074 0.0685 0.0644
Brugia malayi hypothetical protein 0.0041 0.0313 0.0981
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1219 0.4113
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0043 0.0039
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0266 0.0251
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0067 0.0037
Loa Loa (eye worm) nuclear hormone receptor 0.0039 0.0294 0.0914
Giardia lamblia Fructose-bisphosphate aldolase 0.0896 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0083 0.0788 0.0806
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0093 0.0221
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0067 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0083 0.0788 0.2625
Echinococcus multilocularis zinc finger protein 0.0023 0.0116 0.0092
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0083 0.0788 0.0806
Echinococcus multilocularis expressed protein 0.0378 0.4126 0.4346
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0067 0.004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0896 1 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0029 0.0003
Entamoeba histolytica hypothetical protein, conserved 0.0025 0.0133 0.009
Loa Loa (eye worm) hypothetical protein 0.0083 0.0788 0.2625
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1866 0.1862
Trypanosoma cruzi transcription factor btf3, putative 0.0074 0.0685 0.206
Schistosoma mansoni hypothetical protein 0.0848 0.9456 1
Echinococcus granulosus tar DNA binding protein 0.0252 0.2705 0.2838
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0896 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1866 0.1862
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0685 0.0681
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0043 0.0049
Schistosoma mansoni lipoxygenase 0.0104 0.1031 0.1064
Brugia malayi hypothetical protein 0.0027 0.0161 0.0456
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0043 0.0039
Onchocerca volvulus 0.0083 0.0788 0.2728
Trichomonas vaginalis arf-GTPase activating protein, putative 0.0025 0.0133 0.0128
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1866 0.1862
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0071 0.0045
Loa Loa (eye worm) hypothetical protein 0.0039 0.0294 0.0914
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0043 0.0039
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0313 0.0301
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0071 0.0045
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0294 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1913 0.191
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0049 0.0042
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0071 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0582 0.181
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0193
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0071 0.0045
Onchocerca volvulus 0.0041 0.0313 0.0987
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1219 0.4113
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1444 0.4441
Onchocerca volvulus Bile acid receptor homolog 0.0083 0.0788 0.2728
Schistosoma mansoni bromodomain containing protein 0.0068 0.062 0.0628
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0029 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0347 0.1097
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1444 0.4441
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0294 0.0289
Echinococcus multilocularis tar DNA binding protein 0.0252 0.2705 0.2838
Schistosoma mansoni hypothetical protein 0.0179 0.1877 0.1961
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.117 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0347 0.1097
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.021 0.0192
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0043 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.043 0.0426
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0294 0.028
Brugia malayi hypothetical protein 0.0129 0.1308 0.4421
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0582 0.181
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0083 0.0788 0.0805
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0043 0.0039
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0043 0.0217
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0292 0.0828
Onchocerca volvulus 0.0039 0.0294 0.0916
Loa Loa (eye worm) hypothetical protein 0.0039 0.0294 0.0914
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0233 0.0217
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0025 0.0133 0.0358
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0071 0.0145
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0044 0.0347 0.0338
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0067 0.0207
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0033 0.0005
Loa Loa (eye worm) hypothetical protein 0.0039 0.0294 0.0914
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0038 0.0019
Plasmodium vivax vivapain-2 0.0017 0.0043 0.0217
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.3217 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0071 0.0145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0582 0.181
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0582 0.1738
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0116 0.014
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0347 0.1097
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0252 0.2705 0.925
Loa Loa (eye worm) hypothetical protein 0.0083 0.0788 0.2625
Loa Loa (eye worm) hypothetical protein 0.0039 0.0294 0.0914
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0048 0.0021
Onchocerca volvulus 0.015 0.155 0.5515
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0071 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0083 0.0788 0.2625
Schistosoma mansoni cpg binding protein 0.0065 0.0587 0.0592
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0067 0.0062
Brugia malayi nuclear receptor NHR-67 0.0039 0.0294 0.0914
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Onchocerca volvulus Glucosylceramidase homolog 0.0178 0.1866 0.6674
Toxoplasma gondii NAC domain-containing protein 0.0074 0.0685 0.5749
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0043 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0043 0.0039
Loa Loa (eye worm) hypothetical protein 0.0044 0.0347 0.1097
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.015 0.0128
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0896 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0582 0.181
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0069
Brugia malayi nuclear hormone receptor 0.0083 0.0788 0.2625
Loa Loa (eye worm) hypothetical protein 0.0041 0.0321 0.101
Loa Loa (eye worm) TAR-binding protein 0.0252 0.2705 0.925
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0083 0.0788 0.0806
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0039 0.0294 0.0282
Schistosoma mansoni hypothetical protein 0.0021 0.009 0.0065
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0043 0.0039
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0069
Echinococcus multilocularis thyroid hormone receptor alpha 0.0083 0.0788 0.0805
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0985 0.3306
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0803 0.8943 0.9456
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0116 0.014
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0582 0.1738
Loa Loa (eye worm) hypothetical protein 0.0129 0.1308 0.4421
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.021 0.0192
Onchocerca volvulus 0.0025 0.0133 0.0327
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0313 0.0301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0083 0.0788 0.2625
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.0039
Loa Loa (eye worm) hypothetical protein 0.0039 0.0294 0.0916
Entamoeba histolytica hypothetical protein 0.0019 0.0071 0.0028
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0145
Echinococcus multilocularis dna polymerase eta 0.0019 0.0067 0.004
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0044 0.0347 0.0337
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0043 0.0217
Schistosoma mansoni tar DNA-binding protein 0.0252 0.2705 0.2839
Loa Loa (eye worm) hypothetical protein 0.0052 0.0443 0.143
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0083 0.0788 0.0806
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.021 0.0192
Echinococcus granulosus ecdysone induced protein 78C 0.0083 0.0788 0.0805
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0443 0.044
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0292 0.0828
Onchocerca volvulus 0.0041 0.0313 0.0987
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.0039
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0985 0.3306
Onchocerca volvulus 0.0051 0.0428 0.1408
Loa Loa (eye worm) hypothetical protein 0.0039 0.0294 0.0914
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0294 0.028
Brugia malayi nuclear receptor NHR-88 0.0039 0.0294 0.0914
Schistosoma mansoni survival motor neuron protein 0.0051 0.0428 0.0424
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0145
Echinococcus granulosus thyroid hormone receptor alpha 0.0039 0.0294 0.028
Loa Loa (eye worm) fibroinase 0.0017 0.0043 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.0039
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0083 0.0788 0.0805
Plasmodium falciparum ADP-ribosylation factor GTPase-activating protein, putative 0.0025 0.0133 0.1579
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0083 0.0788 0.0805
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0896 1 1
Schistosoma mansoni hypothetical protein 0.0068 0.0627 0.0635
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0252 0.2705 0.2839
Schistosoma mansoni thyroid hormone receptor 0.0083 0.0788 0.0806
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0039 0.0294 0.028
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0582 0.1738
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0294 0.028
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0071 0.0045
Loa Loa (eye worm) hypothetical protein 0.0044 0.0347 0.1097
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.1974 0.1971
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0083 0.0788 0.2625
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0071 0.0067
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0071 0.0045
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0029 0.0091
Brugia malayi PXA domain containing protein 0.0019 0.0071 0.0145
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0067 0.0041
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0043 0.0217
Loa Loa (eye worm) hypothetical protein 0.0041 0.0313 0.0981
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0145
Schistosoma mansoni loxhd1 0.0041 0.0313 0.0302
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0071 0.0045
Brugia malayi hypothetical protein 0.025 0.2677 0.9156
Schistosoma mansoni ap endonuclease 0.0039 0.0292 0.028
Leishmania major cathepsin L-like protease 0.0017 0.0043 0.0048
Schistosoma mansoni polycystin 1-related 0.0041 0.0313 0.0302
Echinococcus granulosus tumor protein p63 0.0357 0.3889 0.4095
Loa Loa (eye worm) hypothetical protein 0.0068 0.0627 0.2066
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0161 0.1156
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0294 0.0913
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0067 0.0207
Schistosoma mansoni eyes absent homolog 0.0093 0.0899 0.0924
Leishmania major cathepsin L-like protease 0.0017 0.0043 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0083 0.0788 0.2625
Leishmania major cathepsin L-like protease 0.0065 0.0582 0.1738
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Brugia malayi hypothetical protein 0.0019 0.0071 0.0145
Echinococcus granulosus survival motor neuron protein 1 0.025 0.2677 0.2809
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0029 0.0003
Schistosoma mansoni zinc finger protein 0.0039 0.0294 0.0282
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0294 0.0914
Brugia malayi hypothetical protein 0.0044 0.0347 0.1097
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0083 0.0788 0.2625
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0116 0.014
Echinococcus multilocularis transcription factor btf3 0.0074 0.0685 0.0696
Brugia malayi Cathepsin L-like precursor 0.0017 0.0043 0.0049
Echinococcus granulosus transcription factor btf3 0.0074 0.0685 0.0696
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0271 0.2922 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.0039
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0071 0.0145
Loa Loa (eye worm) hypothetical protein 0.0039 0.0294 0.0914
Loa Loa (eye worm) hypothetical protein 0.0039 0.0294 0.0914
Loa Loa (eye worm) hypothetical protein 0.01 0.0985 0.3306
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0083 0.0788 0.0805
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0043 0.0015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0365 0.0356
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0161 0.2011
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0292 0.0908
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0071 0.0067
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0161 0.2011
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0033 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0116 0.03
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0071 0.0045
Echinococcus granulosus dna polymerase eta 0.0019 0.0067 0.004
Brugia malayi Pre-SET motif family protein 0.0227 0.2421 0.827
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0161 0.2011
Schistosoma mansoni tar DNA-binding protein 0.0252 0.2705 0.2839
Brugia malayi CXXC zinc finger family protein 0.006 0.0526 0.1718
Brugia malayi nuclear hormone receptor family member odr-7 0.0039 0.0294 0.0914
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0985 0.3306
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0178 0.1862 0.1944
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0519 0.1539
Loa Loa (eye worm) hypothetical protein 0.0047 0.0382 0.1219
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0325 0.101
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0347 0.0338
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0043 0.0048
Schistosoma mansoni tar DNA-binding protein 0.0252 0.2705 0.2839
Brugia malayi ecdysteroid receptor 0.0083 0.0788 0.2625
Loa Loa (eye worm) steroid hormone receptor 0.0083 0.0788 0.2625
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0292 0.0288
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0043 0.0049
Brugia malayi MH2 domain containing protein 0.0121 0.1219 0.4113
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0071 0.0045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0896 1 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0294 0.0833
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0039 0.0294 0.0914
Echinococcus granulosus zinc finger protein 0.0023 0.0116 0.0092
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0071 0.0046
Plasmodium falciparum basic transcription factor 3b, putative 0.0074 0.0685 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0039 0.0294 0.028
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.021 0.0627
Loa Loa (eye worm) hypothetical protein 0.0083 0.0788 0.2625
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0294 0.0289
Schistosoma mansoni nuclear receptor 0.0039 0.0294 0.0282
Echinococcus multilocularis tumor protein p63 0.0357 0.3889 0.4095
Leishmania major DNA polymerase kappa, putative 0.0019 0.0067 0.0121
Onchocerca volvulus 0.0052 0.0443 0.1462
Loa Loa (eye worm) hypothetical protein 0.0044 0.0347 0.1097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0083 0.0788 0.2625
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0325 0.0931
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0292 0.0909
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0582 0.181
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0083 0.0788 0.2625
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0116 0.0181
Entamoeba histolytica ARF GTPase activating protein, putative 0.0025 0.0133 0.009
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.0313 0.4328
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0071 0.0145
Echinococcus multilocularis cysteine protease 0.0017 0.0043 0.0015
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0043 0.0015
Echinococcus multilocularis dnaJ subfamily B 0.0848 0.9456 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0788 0.2625
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0193
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0048 0.002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0292 0.0828
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0049 0.0303
Onchocerca volvulus 0.0258 0.2774 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.0116 0.014
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0067 0.0023
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0292 0.0288
Brugia malayi nuclear hormone receptor family member nhr-6 0.0039 0.0294 0.0914
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0116 0.014
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.2421 0.827
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0582 0.181
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0071 0.0145
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0033 0.0004
Trypanosoma cruzi transcription factor btf3, putative 0.0074 0.0685 0.206
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0071 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0083 0.0788 0.2625
Leishmania major cathepsin L-like protease 0.0065 0.0582 0.1738
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0067 0.0121
Brugia malayi Latrophilin receptor protein 2 0.0032 0.021 0.0627
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.043 0.0425
Loa Loa (eye worm) nuclear receptor NHR-67 0.0039 0.0294 0.0914
Brugia malayi steroid hormone receptor 0.0083 0.0788 0.2625
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0071 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0207
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0071 0.0046
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0049 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0685 0.0681
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0438 0.4809 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.021 0.0192
Loa Loa (eye worm) hypothetical protein 0.0023 0.0116 0.03
Toxoplasma gondii ARF1-directed GTPase-activating protein, putative 0.0025 0.0133 0.0908
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0067 0.0121
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0294 0.028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0582 0.181
Schistosoma mansoni hypothetical protein 0.0041 0.0313 0.0302
Loa Loa (eye worm) hypothetical protein 0.0023 0.0116 0.03
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0083 0.0788 0.0805
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0083 0.0788 0.2728
Entamoeba histolytica ARF GTPase activating protein, putative 0.0025 0.0133 0.009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0074 0.0047
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.0294 0.0916
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0067 0.0207
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0365 0.0357
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.0039
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0438 0.4809 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0038 0.0019
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0294 0.0833
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0071 0.0045
Plasmodium vivax basic transcription factor 3b, putative 0.0074 0.0685 1
Schistosoma mansoni arf gtpase-activating protein 0.0025 0.0133 0.0111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0365 0.0357
Echinococcus multilocularis ADP ribosylation factor GTPase activating 0.0025 0.0133 0.011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0083 0.0788 0.2625
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0071 0.0046
Loa Loa (eye worm) hypothetical protein 0.0039 0.0294 0.0914
Trypanosoma cruzi ADP-ribosylation factor GTPase activating protein 1, putative 0.0025 0.0133 0.0328
Leishmania major DNA polymerase eta, putative 0.0019 0.0067 0.0121
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0071 0.0046
Trypanosoma brucei ISWI complex protein 0.0016 0.0028 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.0039
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.0313 0.4328
Schistosoma mansoni hypothetical protein 0.0179 0.1877 0.1961
Echinococcus multilocularis FTZ F1 alpha 0.0083 0.0788 0.0805
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0428 0.1379
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.2922 0.2918
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0083 0.0788 0.0805
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.2922 0.2918
Schistosoma mansoni rab6-interacting 0.0041 0.0313 0.0302
Loa Loa (eye worm) hypothetical protein 0.0039 0.0294 0.0914
Brugia malayi orphan nuclear receptor NR2E1 0.0039 0.0294 0.0914
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1624 0.3337
Echinococcus multilocularis RUN 0.0041 0.0313 0.0301
Brugia malayi Steroid receptor seven-up type 2 0.0083 0.0788 0.2625
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0145
Loa Loa (eye worm) cysteine protease 0.0017 0.0043 0.0049
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0083 0.0788 0.0805
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0292 0.025
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.3217 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0294 0.0914
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0685 0.0681
Brugia malayi Bromodomain containing protein 0.008 0.0755 0.2509
Brugia malayi nuclear receptor NHR-88 0.0083 0.0788 0.2625
Trypanosoma cruzi ADP-ribosylation factor GTPase activating protein 1, putative 0.0025 0.0133 0.0328
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0033 0.0004
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0116 0.014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0083 0.0788 0.0805
Schistosoma mansoni steroid hormone receptor ad4bp 0.0083 0.0788 0.0806
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1866 0.1862
Onchocerca volvulus 0.0039 0.0294 0.0916
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0294 0.028
Onchocerca volvulus 0.006 0.0526 0.1767
Brugia malayi PHD-finger family protein 0.0029 0.0177 0.0512
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.3217 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0071 0.0067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0043 0.0039
Leishmania major basic transcription factor 3a, putative 0.0074 0.0685 0.206
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0294 0.0289
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0294 0.028
Toxoplasma gondii exonuclease III APE 0.0039 0.0292 0.2305
Entamoeba histolytica hypothetical protein 0.0019 0.0071 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0582 0.181
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0579 0.0583
Brugia malayi Nuclear hormone receptor-like 1 0.0083 0.0788 0.2625
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0292 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0083 0.0788 0.0805
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0128 0.1296 0.1344
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0313 0.0301
Leishmania major hypothetical protein, conserved 0.0027 0.0161 0.0417
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0116 0.014
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0043 0.0015
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0083 0.0788 0.0806
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0044 0.0347 0.0337
Loa Loa (eye worm) hypothetical protein 0.0083 0.0788 0.2625
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0067 0.013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0083 0.0788 0.2625
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0044 0.0347 0.1097
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0043 0.0015
Loa Loa (eye worm) hypothetical protein 0.0023 0.0116 0.03
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0039 0.0294 0.0914
Brugia malayi Cathepsin L-like precursor 0.0017 0.0043 0.0049
Schistosoma mansoni thyroid hormone receptor 0.0083 0.0788 0.0806
Plasmodium vivax GTP-ase activating protein for Arf containing protein 0.0025 0.0133 0.1579
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0116 0.0275
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0083 0.0788 0.2625
Brugia malayi nuclear receptor RXR 0.0039 0.0294 0.0914
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0365 0.0356
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0083 0.0788 0.2625
Brugia malayi RNA recognition motif domain containing protein 0.0252 0.2705 0.925
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0271 0.2922 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0294 0.0914
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0069
Brugia malayi hypothetical protein 0.0093 0.0899 0.3008
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0071 0.0045
Echinococcus multilocularis GPCR, family 2 0.0032 0.021 0.0192
Loa Loa (eye worm) histone methyltransferase 0.002 0.0074 0.0154
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0161 0.0417
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0365 0.0356
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0071 0.0145
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0071 0.0046
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0043 0.0016
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0067 0.0078
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0294 0.0914
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0896 1 1
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0294 0.0282
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.2922 0.2918
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0116 0.0073
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0038 0.0019
Loa Loa (eye worm) RNA binding protein 0.0252 0.2705 0.925
Schistosoma mansoni rab6-interacting 0.0041 0.0313 0.0302
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0049 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0069
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0067 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0071 0.0046
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0071 0.0046
Brugia malayi photoreceptor-specific nuclear receptor 0.0083 0.0788 0.2625
Leishmania major cathepsin L-like protease 0.0017 0.0043 0.0048
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0325 0.0931
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0039 0.0294 0.028
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0292 0.0279
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0067 0.0121
Brugia malayi RNA binding protein 0.0252 0.2705 0.925
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0067 0.013
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0294 0.0833
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0365 0.1159
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0067 0.004
Plasmodium vivax SET domain protein, putative 0.0034 0.0233 0.3105
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0193
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.1974 0.1971
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0896 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0038 0.0019
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0074 0.0047
Loa Loa (eye worm) hypothetical protein 0.025 0.2677 0.9156
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0067 0.0062
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0116 0.03
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0067 0.004
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0071 0.0045
Schistosoma mansoni ap endonuclease 0.0039 0.0292 0.028
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0438 0.4809 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0116 0.03
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0294 0.0251
Schistosoma mansoni nuclear receptor nhr-48 0.0039 0.0294 0.0282
Loa Loa (eye worm) hypothetical protein 0.0051 0.043 0.1384
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0083 0.0788 0.2625
Brugia malayi Cathepsin L-like precursor 0.0017 0.0043 0.0049
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0043 0.0049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0043 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.0039
Trypanosoma brucei transcription factor BTF3, putative 0.0074 0.0685 0.213
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0294 0.028
Loa Loa (eye worm) hypothetical protein 0.0083 0.0788 0.2625
Brugia malayi PXA domain containing protein 0.0019 0.0071 0.0145
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0071 0.0045
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0071 0.0045

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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