Detailed information for compound 620730

Basic information

Technical information
  • TDR Targets ID: 620730
  • Name: ethyl 2-[[5-[(2,6-dioxo-3H-pyrimidin-4-yl)met hyl]-4-(3-methylphenyl)-1,2,4-triazol-3-yl]su lfanyl]acetate
  • MW: 401.44 | Formula: C18H19N5O4S
  • H donors: 2 H acceptors: 7 LogP: 2.81 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CSc1nnc(n1c1cccc(c1)C)Cc1cc(O)nc(n1)O
  • InChi: 1S/C18H19N5O4S/c1-3-27-16(25)10-28-18-22-21-14(8-12-9-15(24)20-17(26)19-12)23(18)13-6-4-5-11(2)7-13/h4-7,9H,3,8,10H2,1-2H3,(H2,19,20,24,26)
  • InChiKey: UZNOCEKLQWJVJX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[5-[(2,6-dioxo-3H-pyrimidin-4-yl)methyl]-4-(3-methylphenyl)-1,2,4-triazol-3-yl]thio]acetic acid ethyl ester
  • 2-[[5-[(2,6-diketo-3H-pyrimidin-4-yl)methyl]-4-(3-methylphenyl)-1,2,4-triazol-3-yl]thio]acetic acid ethyl ester
  • ethyl 2-[[5-[(2,6-dioxo-3H-pyrimidin-4-yl)methyl]-4-(3-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]ethanoate
  • ZINC04061376

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0062 0.055 0.196
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0313 0.0643
Trypanosoma cruzi transcription factor btf3, putative 0.007 0.0646 0.1857
Entamoeba histolytica heat shock protein 90, putative 0.0068 0.0619 0.0615
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0089 0.0301
Schistosoma mansoni tar DNA-binding protein 0.0259 0.2806 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.055 0.1947
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0131 0.0126
Brugia malayi Steroid receptor seven-up type 2 0.0062 0.055 0.1947
Echinococcus multilocularis FTZ F1 alpha 0.0062 0.055 0.1947
Brugia malayi ecdysteroid receptor 0.0062 0.055 0.1947
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0062 0.055 0.1947
Trypanosoma brucei heat shock protein, putative 0.0068 0.0619 0.178
Brugia malayi beta-lactamase family protein 0.0038 0.0286 0.1005
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0062 0.055 0.1947
Loa Loa (eye worm) hypothetical protein 0.0038 0.0286 0.102
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0313 0.0894
Plasmodium falciparum heat shock protein 90, putative 0.0028 0.0164 0.2479
Toxoplasma gondii heat shock protein 75, putative 0.0028 0.0164 0.2479
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0313 0.0894
Loa Loa (eye worm) steroid hormone receptor 0.0062 0.055 0.196
Echinococcus granulosus bloom syndrome protein 0.0021 0.0089 0.0301
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.0779
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0646 0.0642
Schistosoma mansoni thyroid hormone receptor 0.0062 0.055 0.1947
Leishmania major heat shock protein 83-1 0.0068 0.0619 0.178
Echinococcus multilocularis thyroid hormone receptor alpha 0.0062 0.055 0.1947
Onchocerca volvulus 0.0038 0.0286 0.1093
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0313 0.0894
Loa Loa (eye worm) endoplasmin 0.0068 0.0619 0.2206
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.006 0.0197
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0286 0.1005
Loa Loa (eye worm) RNA binding protein 0.0259 0.2806 1
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0021 0.006
Brugia malayi ecdysone receptor 0.0029 0.0179 0.0622
Schistosoma mansoni endoplasmin 0.0068 0.0619 0.2193
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.089 1 1
Echinococcus multilocularis endoplasmin 0.0054 0.0462 0.1632
Brugia malayi intermediate filament protein 0.0029 0.0176 0.0612
Schistosoma mansoni heat shock protein 0.0028 0.0164 0.0568
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0286 0.0586
Loa Loa (eye worm) hypothetical protein 0.0038 0.0286 0.102
Loa Loa (eye worm) hypothetical protein 0.0029 0.0179 0.0637
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0313 0.1102
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0313 0.0894
Loa Loa (eye worm) hypothetical protein 0.0062 0.055 0.196
Schistosoma mansoni zinc finger protein 0.0029 0.0179 0.0622
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0048 0.009
Giardia lamblia Grp94/Hsp90 0.0054 0.0462 0.0458
Brugia malayi conserved hypotetical protein 0.0029 0.0179 0.0622
Toxoplasma gondii exonuclease III APE 0.0019 0.006 0.0859
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0286 0.0586
Trypanosoma cruzi heat shock protein 90, putative 0.0054 0.0462 0.1324
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0435 0.4807 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0131 0.0263
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.0779
Trypanosoma cruzi heat shock protein 85, putative 0.0068 0.0619 0.178
Trypanosoma brucei heat shock protein, putative 0.0068 0.0619 0.178
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0089 0.0301
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0286 0.102
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.2762 0.2758
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1759 0.1756
Brugia malayi hypothetical protein 0.0146 0.1512 0.5381
Plasmodium vivax heat shock protein 90, putative 0.0028 0.0164 0.2479
Echinococcus multilocularis dna polymerase eta 0.0041 0.0313 0.1102
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0286 0.0282
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.006 0.0213
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0313 0.0894
Leishmania major heat shock protein 83-1 0.0068 0.0619 0.178
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0192 0.0668
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0286 0.1005
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0062 0.055 0.196
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0089 0.0301
Loa Loa (eye worm) hypothetical protein 0.0025 0.0131 0.0466
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0313 0.0894
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.006 0.0159
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0313 0.1102
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0059 1
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0179 0.0622
Trypanosoma cruzi transcription factor btf3, putative 0.007 0.0646 0.1857
Brugia malayi TAR-binding protein 0.0259 0.2806 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0089 0.0244
Trypanosoma cruzi heat shock protein 85, putative 0.0054 0.0462 0.1324
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0059 0.0851
Loa Loa (eye worm) hypothetical protein 0.0029 0.0179 0.0637
Trypanosoma cruzi Heat shock protein 83, putative 0.0068 0.0619 0.178
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.1556 0.4493
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0016
Treponema pallidum heat shock protein 90 0.0054 0.0462 0.0458
Leishmania major hypothetical protein, conserved 0.0052 0.0445 0.1276
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0313 0.0894
Loa Loa (eye worm) hypothetical protein 0.0062 0.055 0.196
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0089 0.0244
Echinococcus granulosus dna polymerase kappa 0.0041 0.0313 0.1102
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0219 0.0764
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0048 0.009
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0286 0.1005
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.2762 0.2758
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0317 0.3458 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0179 0.0622
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2248 0.8011
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.006 0.1204
Leishmania major heat shock protein 83-1 0.0068 0.0619 0.178
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0062 0.055 0.2118
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.089 1 1
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0028 0.0164 0.0568
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0286 0.1004
Trypanosoma cruzi heat shock protein 85, putative 0.0068 0.0619 0.178
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.055 0.1947
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0445 0.1276
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0313 0.1102
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0355 0.1015
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0179 0.0637
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0062 0.055 0.1947
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1759 0.1756
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0131 0.0263
Schistosoma mansoni DNA helicase recq1 0.0021 0.0089 0.0301
Echinococcus multilocularis lamin 0.0029 0.0176 0.0612
Trypanosoma brucei heat shock protein 90, putative 0.0068 0.0619 0.178
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0192 0.0668
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0089 0.0301
Loa Loa (eye worm) hypothetical protein 0.0041 0.0313 0.1116
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0286 0.0586
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0179 0.0622
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0435 0.4807 1
Mycobacterium ulcerans beta-lactamase 0.0038 0.0286 0.0586
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0059 0.0114
Leishmania major heat shock protein 83-1 0.0068 0.0619 0.178
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0089 0.0317
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.055 0.1947
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0179 0.0622
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0313 0.0894
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.0179 0.0622
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.1556 0.4493
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0179 0.0622
Leishmania major heat shock protein 83-1 0.0068 0.0619 0.178
Loa Loa (eye worm) hypothetical protein 0.0021 0.0089 0.0317
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0179 0.0622
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0445 0.6872
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1862 0.1859
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0021 0.0077
Trypanosoma cruzi heat shock protein 90, putative 0.004 0.0303 0.0864
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0089 0.0244
Loa Loa (eye worm) hypothetical protein 0.0087 0.0842 0.3
Toxoplasma gondii Hsp90 domain-containing protein 0.0028 0.0164 0.2479
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.089 1 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0219 0.0779
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0062 0.055 0.196
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0062 0.055 0.1947
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0286 0.0586
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0179 0.0622
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0179 0.0622
Onchocerca volvulus 0.0038 0.0286 0.1093
Schistosoma mansoni steroid hormone receptor ad4bp 0.0062 0.055 0.1947
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0028 0.0164 0.0568
Loa Loa (eye worm) hypothetical protein 0.0029 0.0179 0.0637
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.089 1 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0021 0.0049
Mycobacterium ulcerans hypothetical protein 0.0025 0.0131 0.0263
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0286 0.0586
Loa Loa (eye worm) heat shock protein 75 0.0028 0.0164 0.0583
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0089 0.1315
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0021 0.0049
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0062 0.055 0.1947
Echinococcus granulosus tar DNA binding protein 0.0259 0.2806 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.055 0.1947
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0059 0.0114
Echinococcus multilocularis heat shock protein 90 0.0054 0.0462 0.1632
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.055 0.1947
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0131 0.0126
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.006 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0062 0.055 0.1947
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.055 0.1947
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0089 0.0084
Schistosoma mansoni tar DNA-binding protein 0.0259 0.2806 1
Loa Loa (eye worm) ICD-1 protein 0.007 0.0646 0.2302
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0313 0.0309
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0286 0.0586
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0021 0.006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0179 0.0637
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0176 0.0612
Leishmania major DNA polymerase eta, putative 0.0041 0.0313 0.0894
Schistosoma mansoni nuclear receptor 0.0029 0.0179 0.0622
Echinococcus granulosus FTZ F1 alpha 0.0062 0.055 0.1947
Leishmania major heat shock protein 83-1 0.0068 0.0619 0.178
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0192 0.0668
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.089 1 1
Leishmania major heat shock protein 83-1 0.0068 0.0619 0.178
Brugia malayi steroid hormone receptor 0.0062 0.055 0.1947
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.0179 0.0622
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0062 0.055 0.1947
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0313 0.0894
Brugia malayi hypothetical protein 0.0038 0.0286 0.1004
Plasmodium vivax SET domain protein, putative 0.003 0.0192 0.2918
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0131 0.0263
Onchocerca volvulus 0.0029 0.0176 0.0666
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0062 0.055 0.1947
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0445 0.1276
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0192 0.0668
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0313 0.0894
Plasmodium vivax heat shock protein, putative 0.0028 0.0164 0.2479
Trypanosoma brucei heat shock protein, putative 0.0068 0.0619 0.178
Trypanosoma brucei unspecified product 0.0028 0.0169 0.0475
Trichomonas vaginalis esterase, putative 0.0038 0.0286 0.0282
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0462 0.0458
Entamoeba histolytica hypothetical protein 0.0038 0.0286 0.0281
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0021 0.0049
Echinococcus multilocularis lamin dm0 0.0029 0.0176 0.0612
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0021 0.0035
Trypanosoma brucei unspecified product 0.0041 0.0313 0.0894
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0169 0.0475
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0131 0.0263
Schistosoma mansoni retinoic acid receptor RXR 0.0062 0.055 0.1947
Leishmania major heat shock protein 83-1 0.0068 0.0619 0.178
Loa Loa (eye worm) hypothetical protein 0.0062 0.055 0.196
Schistosoma mansoni lamin 0.0029 0.0176 0.0612
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0179 0.0623
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0021
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0355 0.1015
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0219 0.0764
Entamoeba histolytica hypothetical protein 0.0038 0.0286 0.0281
Leishmania major hypothetical protein, conserved 0.0038 0.0286 0.0815
Onchocerca volvulus Huntingtin homolog 0.0121 0.123 0.4758
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0062 0.055 0.1947
Loa Loa (eye worm) hypothetical protein 0.0062 0.055 0.196
Brugia malayi beta-lactamase 0.0038 0.0286 0.1005
Schistosoma mansoni DNA polymerase eta 0.0041 0.0313 0.1102
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0062 0.055 0.1947
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0062 0.055 0.1947
Loa Loa (eye worm) hypothetical protein 0.016 0.1668 0.5942
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0179 0.0622
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0462 0.0458
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0089 0.1315
Entamoeba histolytica hypothetical protein 0.0038 0.0286 0.0281
Schistosoma mansoni ap endonuclease 0.0019 0.006 0.0197
Trypanosoma brucei heat shock protein, putative 0.0068 0.0619 0.178
Loa Loa (eye worm) hypothetical protein 0.0029 0.0176 0.0627
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0179 0.0622
Loa Loa (eye worm) hypothetical protein 0.0038 0.0286 0.102
Loa Loa (eye worm) TAR-binding protein 0.0259 0.2806 1
Leishmania major heat shock protein 83-1 0.0068 0.0619 0.178
Onchocerca volvulus Huntingtin homolog 0.0121 0.123 0.4758
Loa Loa (eye worm) hypothetical protein 0.0025 0.0131 0.0466
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0355 0.1015
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0355 0.1015
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0021 0.0263
Giardia lamblia Heat shock protein HSP 90-alpha 0.0068 0.0619 0.0615
Schistosoma mansoni ap endonuclease 0.0019 0.006 0.0197
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0169 0.0475
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0062 0.055 0.196
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.006 0.0159
Plasmodium vivax heat shock protein 86, putative 0.0068 0.0619 0.9581
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.006 0.0055
Leishmania major heat shock protein, putative 0.0028 0.0164 0.0461
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0219 0.0764
Leishmania major heat shock protein 83-1 0.0068 0.0619 0.178
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0062 0.055 0.1947
Echinococcus multilocularis ecdysone induced protein 78C 0.0062 0.055 0.1947
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0116 0.0396
Loa Loa (eye worm) hypothetical protein 0.0029 0.0179 0.0637
Onchocerca volvulus 0.0025 0.0131 0.049
Onchocerca volvulus 0.0029 0.0176 0.0666
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0286 0.1004
Brugia malayi nuclear receptor NHR-88 0.0062 0.055 0.1947
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0131 0.0366
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0054 0.0462 0.1324
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0021 0.0049
Trypanosoma cruzi heat shock protein, putative 0.0028 0.0164 0.0461
Plasmodium vivax basic transcription factor 3b, putative 0.007 0.0646 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0313 0.0894
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.0179 0.0637
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0179 0.0622
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0313 0.1102
Brugia malayi Pre-SET motif family protein 0.003 0.0192 0.0668
Echinococcus granulosus dna polymerase eta 0.0041 0.0313 0.1102
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0445 0.6872
Loa Loa (eye worm) hypothetical protein 0.0028 0.017 0.0606
Schistosoma mansoni hypothetical protein 0.0038 0.0286 0.1004
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0286 0.0815
Trypanosoma cruzi heat shock protein 90, putative 0.0068 0.0619 0.178
Loa Loa (eye worm) hypothetical protein 0.0029 0.0179 0.0637
Trypanosoma brucei unspecified product 0.0028 0.0169 0.0475
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0259 0.2806 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0021 0.006
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0021 0.006
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0089 0.0301
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0028 0.0164 0.0618
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1759 0.1756
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.2762 0.984
Leishmania major heat shock protein 83-1 0.0068 0.0619 0.178
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.1556 0.4493
Loa Loa (eye worm) beta-lactamase 0.0038 0.0286 0.102
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0179 0.0677
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0286 0.1004
Echinococcus granulosus heat shock protein 90 0.0068 0.0619 0.2193
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0192 0.2918
Loa Loa (eye worm) hypothetical protein 0.003 0.0192 0.0683
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0089 0.0301
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0062 0.055 0.1947
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0179 0.0622
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.055 0.1947
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0176 0.0627
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.2762 0.2758
Leishmania major heat shock protein 83-1 0.0068 0.0619 0.178
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0131 0.0451
Loa Loa (eye worm) DR-78 0.0029 0.0179 0.0637
Onchocerca volvulus 0.0029 0.0179 0.0677
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0176 0.0627
Brugia malayi Muscleblind-like protein 0.016 0.1668 0.5936
Loa Loa (eye worm) hypothetical protein 0.0052 0.0445 0.1587
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0179 0.0622
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0131 0.0451
Toxoplasma gondii heat shock protein HSP90 0.0068 0.0619 0.9581
Loa Loa (eye worm) hypothetical protein 0.0029 0.0179 0.0637
Brugia malayi beta-lactamase family protein 0.0038 0.0286 0.1005
Brugia malayi Hsp90 protein 0.0028 0.0164 0.0568
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0062 0.055 0.196
Schistosoma mansoni hypothetical protein 0.0024 0.0116 0.0396
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0131 0.0126
Giardia lamblia Heat shock protein HSP 90-alpha 0.0054 0.0462 0.0458
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0131 0.0263
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0286 0.0586
Echinococcus granulosus endoplasmin 0.0054 0.0462 0.1632
Mycobacterium ulcerans hypothetical protein 0.0167 0.1749 0.3632
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0179 0.0622
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0286 0.0586
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0021 0.0049
Onchocerca volvulus 0.024 0.258 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0179 0.0622
Schistosoma mansoni tar DNA-binding protein 0.0259 0.2806 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0179 0.0622
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.2762 0.2758
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0313 0.0894
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0131 0.0263
Echinococcus granulosus heat shock protein 90 0.0054 0.0462 0.1632
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.055 0.1947
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0445 0.1276
Brugia malayi nuclear receptor NHR-88 0.0029 0.0179 0.0622
Echinococcus multilocularis musashi 0.0029 0.0176 0.0612
Loa Loa (eye worm) hypothetical protein 0.0029 0.0179 0.0637
Onchocerca volvulus 0.0038 0.0286 0.1093
Schistosoma mansoni lamin 0.0029 0.0176 0.0612
Brugia malayi nuclear receptor RXR 0.0029 0.0179 0.0622
Plasmodium falciparum endoplasmin, putative 0.0042 0.0321 0.493
Mycobacterium ulcerans hypothetical protein 0.0038 0.0286 0.0586
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0054 0.0462 0.0952
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0021 0.006
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0089 0.0084
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0313 0.0643
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0021 0.0263
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0313 0.0894
Trypanosoma brucei Heat shock protein 83, putative 0.0068 0.0619 0.178
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.1749 0.3632
Mycobacterium tuberculosis Conserved protein 0.0038 0.0286 0.0586
Echinococcus granulosus ecdysone induced protein 78C 0.0062 0.055 0.1947
Plasmodium falciparum basic transcription factor 3b, putative 0.007 0.0646 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0023 0.0084
Schistosoma mansoni heat shock protein 0.0068 0.0619 0.2193
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0219 0.0764
Echinococcus multilocularis muscleblind protein 0.016 0.1668 0.5936
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.2762 0.984
Leishmania major DNA polymerase kappa, putative 0.0041 0.0313 0.0894
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0179 0.0622
Brugia malayi hypothetical protein 0.0034 0.0233 0.0817
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0089 0.0084
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0192 0.0668
Mycobacterium leprae Probable lipase LipE 0.0038 0.0286 0.0586
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0313 0.0894
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0445 0.6872
Trichomonas vaginalis endoplasmin, putative 0.0042 0.0321 0.0316
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0089 0.0301
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0219 0.0764
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1759 0.1756
Trypanosoma brucei heat shock protein 84, putative 0.0028 0.0164 0.0461
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0089 0.0301
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0286 0.1005
Mycobacterium ulcerans lipase LipD 0.0038 0.0286 0.0586
Schistosoma mansoni heat shock protein 0.0068 0.0619 0.2193
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0054 0.0462 0.1632
Brugia malayi hypothetical protein 0.0121 0.123 0.4373
Loa Loa (eye worm) hypothetical protein 0.0038 0.0286 0.102
Brugia malayi nuclear receptor NHR-67 0.0029 0.0179 0.0622
Toxoplasma gondii hypothetical protein 0.0051 0.043 0.6628
Onchocerca volvulus 0.0029 0.0179 0.0677
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.3458 1
Brugia malayi hypothetical protein 0.0087 0.0842 0.2988
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0059 0.0851
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0062 0.055 0.196
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0286 0.0815
Loa Loa (eye worm) hypothetical protein 0.0087 0.0842 0.3
Schistosoma mansoni nuclear receptor 0.0029 0.0179 0.0622
Loa Loa (eye worm) hypothetical protein 0.0029 0.0179 0.0637
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0062 0.055 0.1947
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0286 0.0282
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.006 0.0159
Leishmania major basic transcription factor 3a, putative 0.007 0.0646 0.1857
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.089 1 1
Schistosoma mansoni intermediate filament proteins 0.0029 0.0176 0.0612
Loa Loa (eye worm) hypothetical protein 0.0038 0.0286 0.102
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.1759 0.6815
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0062 0.055 0.1947
Entamoeba histolytica transcription factor BTF3, putative 0.007 0.0646 0.0642
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0313 0.0894
Brugia malayi hypothetical protein 0.0029 0.0179 0.0622
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0313 0.0894
Entamoeba histolytica hypothetical protein 0.007 0.0646 0.0642
Leishmania major heat shock protein 83-1 0.0068 0.0619 0.178
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0211
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.2762 0.2758
Toxoplasma gondii ABC1 family protein 0.0038 0.0286 0.439
Loa Loa (eye worm) TOPoisomerase family member 0.0014 0.0005 0.0016
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0313 0.0643
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0321 0.0316
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0313 0.1102
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0131 0.0366
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0286 0.0586
Trypanosoma cruzi heat shock protein 85, putative 0.0068 0.0619 0.178
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0313 0.0894
Brugia malayi nuclear hormone receptor 0.0062 0.055 0.1947
Plasmodium falciparum heat shock protein 90, putative 0.0028 0.0164 0.2479
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.0779
Brugia malayi nuclear receptor RXR 0.0033 0.0219 0.0764
Mycobacterium ulcerans heat shock protein 90 0.0054 0.0462 0.0952
Brugia malayi beta-NAC-like protein 0.007 0.0646 0.2289
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0313 0.0309
Onchocerca volvulus 0.0146 0.1512 0.5854
Brugia malayi RNA recognition motif domain containing protein 0.0259 0.2806 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0313 0.0894
Echinococcus multilocularis transcription factor btf3 0.007 0.0646 0.2289
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.055 0.1947
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0313 0.1116
Toxoplasma gondii heat shock protein 90, putative 0.0068 0.0619 0.9581
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0179 0.0622
Echinococcus multilocularis heat shock protein 90 0.0068 0.0619 0.2193
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0131 0.0263
Loa Loa (eye worm) hypothetical protein 0.0062 0.055 0.196
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.006 0.0197
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.0313 0.0894
Schistosoma mansoni thyroid hormone receptor 0.0062 0.055 0.1947
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0054 0.0462 0.0952
Echinococcus granulosus muscleblind protein 0.016 0.1668 0.5936
Loa Loa (eye worm) hypothetical protein 0.0029 0.0179 0.0637
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0131 0.0366
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0006 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0313 0.0894
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0179 0.0637
Brugia malayi hypothetical protein 0.0033 0.0219 0.0764
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0131 0.0263
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0179 0.0622
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0089 0.1315
Schistosoma mansoni coup transcription factor 0.0062 0.055 0.1947
Entamoeba histolytica hypothetical protein 0.0038 0.0286 0.0281
Loa Loa (eye worm) hypothetical protein 0.0121 0.123 0.4382
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0286 0.0282
Schistosoma mansoni tar DNA-binding protein 0.0259 0.2806 1
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.2762 0.2758
Loa Loa (eye worm) hypothetical protein 0.0121 0.123 0.4382
Trypanosoma brucei heat shock protein, putative 0.0068 0.0619 0.178
Echinococcus granulosus transcription factor btf3 0.007 0.0646 0.2289
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0179 0.0622
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0164 0.0159
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0313 0.1102
Leishmania major heat shock protein 83-1 0.0068 0.0619 0.178
Echinococcus granulosus heat shock protein 0.0068 0.0619 0.2193
Brugia malayi Endoplasmin precursor 0.0068 0.0619 0.2193
Plasmodium falciparum heat shock protein 90 0.0068 0.0619 0.9581
Brugia malayi hypothetical protein 0.0033 0.0219 0.0764
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0062 0.055 0.1947
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0021 0.006
Onchocerca volvulus Bile acid receptor homolog 0.0062 0.055 0.2118
Loa Loa (eye worm) hypothetical protein 0.0029 0.0179 0.0637
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.0779
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0435 0.4807 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0211
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0023 0.0067
Brugia malayi tailless protein 0.0029 0.0179 0.0622
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.3458 1
Giardia lamblia Fructose-bisphosphate aldolase 0.089 1 1
Leishmania major heat shock protein 83-1 0.0068 0.0619 0.178
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0286 0.1005
Loa Loa (eye worm) hypothetical protein 0.016 0.1668 0.5942
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0089 0.0084
Echinococcus multilocularis muscleblind protein 1 0.016 0.1668 0.5936
Loa Loa (eye worm) hypothetical protein 0.0038 0.0286 0.102
Trypanosoma brucei heat shock protein, putative 0.0068 0.0619 0.178
Brugia malayi heat shock protein 90 0.0068 0.0619 0.2193
Loa Loa (eye worm) hypothetical protein 0.0029 0.0179 0.0637
Onchocerca volvulus 0.003 0.0192 0.0727
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0021 0.006
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.006 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0646 0.0642
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0116 0.0396
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0021 0.006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0048 0.009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.055 0.1947
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.006 0.0115
Mycobacterium tuberculosis Conserved protein 0.0038 0.0286 0.0586
Brugia malayi hypothetical protein 0.0052 0.0445 0.1573
Entamoeba histolytica heat shock protein 90, putative 0.0068 0.0619 0.0615
Echinococcus multilocularis tar DNA binding protein 0.0259 0.2806 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0211
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0179 0.0622
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0062 0.055 0.196
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0062 0.055 0.196
Loa Loa (eye worm) hypothetical protein 0.0025 0.0131 0.0466
Treponema pallidum fructose-bisphosphate aldolase 0.089 1 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.006 0.0197
Onchocerca volvulus 0.0062 0.055 0.2118
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0062 0.055 0.1947
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0462 0.0458
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0286 0.0586
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0646 0.0642
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0021 0.0263
Loa Loa (eye worm) hypothetical protein 0.0029 0.0179 0.0637
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1862 0.1859
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.006 0.0859
Echinococcus multilocularis heat shock protein 0.0068 0.0619 0.2193
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0054 0.0462 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0062 0.055 0.1947
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.089 1 1
Leishmania major mitochondrial DNA polymerase beta 0.0317 0.3458 1
Echinococcus granulosus intermediate filament protein 0.0029 0.0176 0.0612
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0192 0.0668
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0192 0.0668
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0169 0.0475
Trypanosoma brucei heat shock protein, putative 0.0068 0.0619 0.178
Schistosoma mansoni nuclear hormone receptor 0.0062 0.055 0.1947
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.006 0.0159
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0246 0.265 0.5509
Leishmania major heat shock protein 83-1 0.0068 0.0619 0.178
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0028 0.0164 0.0159
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1759 0.1756
Brugia malayi RNA binding protein 0.0259 0.2806 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0131 0.0263
Schistosoma mansoni tar DNA-binding protein 0.0259 0.2806 1
Schistosoma mansoni transcription factor btf3 0.007 0.0646 0.2289
Plasmodium vivax endoplasmin, putative 0.0068 0.0619 0.9581
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0131 0.0263
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0179 0.0677
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0089 0.1315
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0313 0.0309
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0219 0.0764
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0062 0.055 0.1947
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.006 0.0055
Trichomonas vaginalis heat shock protein, putative 0.0068 0.0619 0.0615
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.006 0.0055
Schistosoma mansoni endoplasmin 0.0068 0.0619 0.2193
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0131 0.0451
Trypanosoma brucei heat shock protein, putative 0.0068 0.0619 0.178
Mycobacterium tuberculosis Conserved protein 0.0038 0.0286 0.0586
Brugia malayi Pre-SET motif family protein 0.0211 0.2248 0.8007
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0445 0.6872
Onchocerca volvulus Protein ultraspiracle homolog 0.0062 0.055 0.2118
Brugia malayi photoreceptor-specific nuclear receptor 0.0062 0.055 0.1947
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0089 0.0084
Trypanosoma brucei transcription factor BTF3, putative 0.007 0.0646 0.1857
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0131 0.0263
Schistosoma mansoni DNA helicase recq5 0.0021 0.0089 0.0301
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.0779
Loa Loa (eye worm) heat shock protein 90 0.0068 0.0619 0.2206
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0062 0.055 0.1947
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0286 0.0815
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0021 0.0263
Echinococcus granulosus lamin 0.0029 0.0176 0.0612
Echinococcus granulosus lamin dm0 0.0029 0.0176 0.0612
Giardia lamblia DINP protein human, muc B family 0.0041 0.0313 0.0309
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0211
Toxoplasma gondii NAC domain-containing protein 0.007 0.0646 1
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1759 0.1756
Trichomonas vaginalis set domain proteins, putative 0.024 0.258 0.2576
Trypanosoma brucei heat shock protein 90, putative 0.0068 0.0619 0.178
Leishmania major heat shock protein 83-1 0.0068 0.0619 0.178
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0286 0.0282
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.089 1 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.055 0.196
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0062 0.055 0.1947
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.006 0.0859
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0286 0.439
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.006 0.0055
Loa Loa (eye worm) RecQ helicase 0.0021 0.0089 0.0317
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1759 0.1756
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0313 0.0643
Schistosoma mansoni RAR-like nuclear receptor 0.0062 0.055 0.1947
Loa Loa (eye worm) hypothetical protein 0.0146 0.1512 0.5388
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.055 0.1947
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.055 0.1947
Schistosoma mansoni eyes absent homolog 0.0087 0.0842 0.2988
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.089 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0466 0.1337
Loa Loa (eye worm) hypothetical protein 0.0062 0.055 0.196
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0006 0.0005
Brugia malayi nuclear hormone receptor 0.0029 0.0179 0.0622
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0048 0.009
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0286 0.0282
Brugia malayi hypothetical protein 0.0029 0.0179 0.0622
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0313 0.1102
Brugia malayi isocitrate dehydrogenase 0.0015 0.0021 0.006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0211

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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