TDR Targets

Basic information

Technical information

TDR Targets ID: 620792
Name: 5-[[4-(4-fluorophenyl)piperazin-1-yl]-(2-meth ylphenyl)methyl]-2-methyl-[1,3]thiazolo[2,3-e ][1,2,4]triazol-6-ol
MW: 437.533 | Formula: C23H24FN5OS
H donors: 1 H acceptors: 3 LogP: 4.85 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)N1CCN(CC1)C(c1sc2n(c1O)nc(n2)C)c1ccccc1C
InChi: 1S/C23H24FN5OS/c1-15-5-3-4-6-19(15)20(21-22(30)29-23(31-21)25-16(2)26-29)28-13-11-27(12-14-28)18-9-7-17(24)8-10-18/h3-10,20,30H,11-14H2,1-2H3
InChiKey: RXBHVEPSUDXYIG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-[[4-(4-fluorophenyl)piperazin-1-yl]-(2-methylphenyl)methyl]-2-methyl-thiazolo[2,3-e][1,2,4]triazol-6-ol
5-[[4-(4-fluorophenyl)-1-piperazinyl]-(2-methylphenyl)methyl]-2-methyl-6-thiazolo[2,3-e][1,2,4]triazolol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	lamin	0.0026	0.0284	0.0811
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0091	0.1187	0.3385
Echinococcus multilocularis	lamin	0.0026	0.0284	0.0307
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0016	0.0135	0.1134
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.001	0.0051	0.0055
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.001	0.0051	0.0055
Schistosoma mansoni	blooms syndrome DNA helicase	0.0018	0.0174	0.0497
Echinococcus granulosus	tumor protein p63	0.0672	0.9272	1
Schistosoma mansoni	tar DNA-binding protein	0.0258	0.3508	1
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0016	0.0137	0.1156
Trypanosoma brucei	PAB1-binding protein , putative	0.0014	0.0112	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0094	0.0102
Brugia malayi	hypothetical protein	0.0131	0.1744	0.1987
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.001	0.0051	0.0059
Schistosoma mansoni	hypothetical protein	0.0027	0.0289	0.0825
Brugia malayi	RNA binding protein	0.0258	0.3508	0.3997
Loa Loa (eye worm)	TAR-binding protein	0.0258	0.3508	0.3997
Echinococcus granulosus	intermediate filament protein	0.0026	0.0284	0.0307
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0284	0.0324
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0114	0.013
Trichomonas vaginalis	DNA helicase recq1, putative	0.0023	0.0243	0.0243
Plasmodium falciparum	ataxin-2 like protein, putative	0.0014	0.0112	0.5486
Echinococcus granulosus	lamin	0.0026	0.0284	0.0307
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0091	0.1187	0.3385
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0027	0.0289	0.033
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1187	0.1353
Schistosoma mansoni	tar DNA-binding protein	0.0258	0.3508	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0091	0.1187	0.1281
Loa Loa (eye worm)	RNA binding protein	0.0258	0.3508	0.3997
Brugia malayi	Pre-SET motif family protein	0.0636	0.8776	1
Schistosoma mansoni	hypothetical protein	0.0006	0.0004	0.0012
Trypanosoma cruzi	PAB1-binding protein , putative	0.0014	0.0112	1
Schistosoma mansoni	cellular tumor antigen P53	0.0098	0.1286	0.3666
Onchocerca volvulus		0.0098	0.1286	0.1286
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0258	0.3508	0.3997
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0087	0.01
Onchocerca volvulus		0.0091	0.1187	0.1187
Toxoplasma gondii	LsmAD domain-containing protein	0.0014	0.0112	0.0939
Echinococcus granulosus	bloom syndrome protein	0.0023	0.0243	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0087	0.01
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0278	0.0316
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0051	0.0433
Echinococcus multilocularis	tar DNA binding protein	0.0258	0.3508	0.3784
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.001	0.0051	0.0055
Echinococcus multilocularis	tumor protein p63	0.0672	0.9272	1
Schistosoma mansoni	lamin	0.0026	0.0284	0.0811
Echinococcus granulosus	tar DNA binding protein	0.0258	0.3508	0.3784
Trichomonas vaginalis	DNA helicase recq, putative	0.0013	0.0091	0.0091
Entamoeba histolytica	recQ family helicase, putative	0.0013	0.0091	1
Onchocerca volvulus		0.0026	0.0284	0.0284
Schistosoma mansoni	tar DNA-binding protein	0.0258	0.3508	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0112	0.0127
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0284	0.0324
Onchocerca volvulus		0.0026	0.0284	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0118	0.1559	0.1776
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1286	0.1465
Echinococcus multilocularis	musashi	0.0026	0.0284	0.0307
Leishmania major	hypothetical protein, conserved	0.0014	0.0112	1
Brugia malayi	RNA recognition motif domain containing protein	0.0258	0.3508	0.3997
Echinococcus multilocularis	survival motor neuron protein 1	0.0131	0.1744	0.1881
Schistosoma mansoni	DNA helicase recq1	0.001	0.0051	0.0146
Schistosoma mansoni	tar DNA-binding protein	0.0258	0.3508	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0091	0.1187	0.1281
Trichomonas vaginalis	set domain proteins, putative	0.0724	1	1
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0051	0.0059
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0091	0.8158
Echinococcus granulosus	survival motor neuron protein 1	0.0131	0.1744	0.1881
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0284	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0284	0.0324
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0091	0.1187	1
Brugia malayi	hypothetical protein	0.0009	0.0042	0.0048
Schistosoma mansoni	survival motor neuron protein	0.0027	0.0289	0.0825
Brugia malayi	intermediate filament protein	0.0026	0.0284	0.0324
Brugia malayi	hypothetical protein	0.0014	0.0112	0.0127
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0051	0.0433
Plasmodium vivax	SET domain protein, putative	0.0091	0.1187	1
Loa Loa (eye worm)	RecQ helicase	0.0023	0.0243	0.0277
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0091	0.8158
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0006	0.0004	0.0004
Schistosoma mansoni	DNA helicase recq5	0.001	0.0051	0.0146
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0088	0.1141	0.123
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0091	0.1187	0.1281
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1744	0.1987
Trypanosoma cruzi	PAB1-binding protein , putative	0.0014	0.0112	1
Echinococcus multilocularis	bloom syndrome protein	0.0023	0.0243	0.0262
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0114	0.013
Trichomonas vaginalis	DNA helicase recq, putative	0.0023	0.0243	0.0243
Schistosoma mansoni	tar DNA-binding protein	0.0258	0.3508	1
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0006	0.0004	0.0004
Giardia lamblia	Sgs1 DNA helicase, putative	0.001	0.0051	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0091	0.1187	0.3385
Echinococcus granulosus	lamin dm0	0.0026	0.0284	0.0307
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0284	0.0324
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0636	0.8776	1
Brugia malayi	TAR-binding protein	0.0258	0.3508	0.3997
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0091	0.8158
Brugia malayi	Pre-SET motif family protein	0.0091	0.1187	0.1353
Plasmodium vivax	ataxin-2 like protein, putative	0.0014	0.0112	0.0939
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0094	0.0102
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0051	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0094	0.0107
Echinococcus multilocularis	lamin dm0	0.0026	0.0284	0.0307
Plasmodium falciparum	ataxin-2 like protein, putative	0.0014	0.0112	0.5486
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.0203	1
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.001	0.0051	0.2527
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.001	0.0051	0.0055
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0091	0.1187	0.3385
Brugia malayi	Bloom's syndrome protein homolog	0.0023	0.0243	0.0277
Onchocerca volvulus		0.0027	0.0289	0.0289

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 620792