Detailed information for compound 620855

Basic information

Technical information
  • TDR Targets ID: 620855
  • Name: prop-2-enyl 2-[3-(4-methoxyphenyl)-4-methyl-2 -oxochromen-6-yl]oxyacetate
  • MW: 380.391 | Formula: C22H20O6
  • H donors: 0 H acceptors: 2 LogP: 3.97 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOC(=O)COc1ccc2c(c1)c(C)c(c(=O)o2)c1ccc(cc1)OC
  • InChi: 1S/C22H20O6/c1-4-11-26-20(23)13-27-17-9-10-19-18(12-17)14(2)21(22(24)28-19)15-5-7-16(25-3)8-6-15/h4-10,12H,1,11,13H2,2-3H3
  • InChiKey: YECYDKJVCGHURM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • allyl 2-[3-(4-methoxyphenyl)-4-methyl-2-oxo-chromen-6-yl]oxyacetate
  • 2-[[3-(4-methoxyphenyl)-4-methyl-2-oxo-6-chromenyl]oxy]acetic acid allyl ester
  • 2-[2-keto-3-(4-methoxyphenyl)-4-methyl-chromen-6-yl]oxyacetic acid allyl ester
  • prop-2-enyl 2-[3-(4-methoxyphenyl)-4-methyl-2-oxo-chromen-6-yl]oxyethanoate
  • ZINC04340616

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0187 0.0948 0.3098
Echinococcus multilocularis smad 0.0051 0.0123 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0491 0.5037
Schistosoma mansoni glutamate synthase 0.0048 0.0105 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0484 0.4963
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0425 0.4316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0149 0.0716 0.7477
Loa Loa (eye worm) MH1 domain-containing protein 0.0051 0.0123 0.0282
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0048 0.0105 0.0264
Entamoeba histolytica hypothetical protein 0.0038 0.0041 0.0149
Loa Loa (eye worm) hypothetical protein 0.0039 0.0049 0.0111
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0048 0.0105 0.0135
Trypanosoma cruzi trypanothione reductase, putative 0.0182 0.0917 0.2993
Trichomonas vaginalis glutathione reductase, putative 0.0182 0.0917 0.9661
Echinococcus multilocularis serine protein kinase ATM 0.0035 0.0027 0.0007
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0182 0.0917 0.2803
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0467 0.2654 0.6059
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0048 0.0105 0.0264
Schistosoma mansoni fkbp-rapamycin associated protein 0.0035 0.0027 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.0657 0.684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0149 0.0716 0.7477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0149 0.0716 0.7477
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0048 0.0105 0.0264
Loa Loa (eye worm) phosphatidylinositol 3 0.0187 0.0948 0.2164
Loa Loa (eye worm) hypothetical protein 0.0035 0.0023 0.0052
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0048 0.0105 0.0851
Schistosoma mansoni tar DNA-binding protein 0.0467 0.2654 0.2638
Schistosoma mansoni lamin 0.0058 0.0163 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0063 0.0193 0.1803
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0048 0.0105 0.0264
Plasmodium falciparum thioredoxin reductase 0.0524 0.3 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0156 0.0357
Loa Loa (eye worm) MH2 domain-containing protein 0.0051 0.0123 0.0282
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0048 0.0105 0.0135
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0048 0.0105 0.0135
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0063 0.0193 0.0277
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0048 0.0105 0.0135
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0187 0.0948 0.3098
Trypanosoma cruzi NADH dehydrogenase, putative 0.0048 0.0105 0.0264
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0048 0.0105 0.0851
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0182 0.0917 0.2993
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0062
Brugia malayi Bromodomain containing protein 0.0076 0.0275 0.0627
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0048 0.0105 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0159 0.0782 0.8197
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0051 0.0123 0.0101
Brugia malayi glutathione reductase 0.0524 0.3 0.6848
Plasmodium falciparum glutathione reductase 0.0182 0.0917 0.2803
Entamoeba histolytica hypothetical protein 0.0038 0.0041 0.0149
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0048 0.0105 0.0264
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0063 0.0193 0.0277
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0187 0.0948 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0182 0.0917 0.2993
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0063 0.0193 0.0171
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0048 0.0105 0.0851
Loa Loa (eye worm) transcription factor SMAD2 0.0751 0.4381 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0048 0.0105 0.0851
Schistosoma mansoni tar DNA-binding protein 0.0467 0.2654 0.2638
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0133 0.0624 0.1423
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0425 0.4327
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0048 0.0105 0.0135
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0187 0.0948 0.1505
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0048 0.0105 0.0264
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0034 0.0018
Echinococcus multilocularis mothers against decapentaplegic 5 0.0051 0.0123 0.0164
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0051 0.0123 0.0164
Schistosoma mansoni tar DNA-binding protein 0.0467 0.2654 0.2638
Echinococcus granulosus tumor protein p63 0.1045 0.617 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0063 0.0193 0.0559
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1195 0.7083 0.8958
Echinococcus multilocularis microtubule associated protein 2 0.0674 0.3913 0.6329
Brugia malayi intermediate filament protein 0.0058 0.0163 0.0372
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0048 0.0105 0.0851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0425 0.4327
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0039 0.0052 0.0083
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0023 0.0052
Echinococcus multilocularis lamin 0.0058 0.0163 0.0228
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0027 0.0062
Schistosoma mansoni smad1 5 8 and 0.0051 0.0123 0.0101
Schistosoma mansoni hypothetical protein 0.0075 0.0267 0.0245
Loa Loa (eye worm) hypothetical protein 0.0072 0.0248 0.0567
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1195 0.7083 0.8958
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0182 0.0917 0.2993
Schistosoma mansoni tar DNA-binding protein 0.0467 0.2654 0.2638
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1195 0.7083 0.8958
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0048 0.0105 0.0851
Toxoplasma gondii selenide, water dikinase 0.0048 0.0105 0.0264
Echinococcus multilocularis glutamate synthase 0.0048 0.0105 0.0135
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0048 0.0105 0.0851
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0182 0.0917 0.2803
Trypanosoma brucei NADH dehydrogenase 0.0048 0.0105 0.0264
Echinococcus granulosus tar DNA binding protein 0.0467 0.2654 0.4281
Treponema pallidum NADH oxidase 0.0182 0.0917 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0182 0.0917 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.018 0.0257
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0187 0.0948 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0187 0.0948 0.2164
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0052 0.0266
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0182 0.0917 0.1042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.0657 0.684
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0182 0.0917 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0048 0.0105 0.0851
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0048 0.0105 0.0851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0149 0.0716 0.7477
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0048 0.0105 0.0264
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0182 0.0917 0.2993
Loa Loa (eye worm) hypothetical protein 0.0109 0.0477 0.109
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0182 0.0917 1
Brugia malayi MH2 domain containing protein 0.0051 0.0123 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.0657 0.684
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0182 0.0917 0.0896
Echinococcus granulosus serine protein kinase ATM 0.0035 0.0027 0.0007
Echinococcus granulosus microtubule associated protein 2 0.0674 0.3913 0.6329
Brugia malayi glutamate synthase 0.0048 0.0105 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0425 0.4327
Echinococcus granulosus smad 0.0051 0.0123 0.0164
Onchocerca volvulus 0.0058 0.0163 0.0861
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0182 0.0917 0.2803
Brugia malayi RNA binding protein 0.0467 0.2654 0.6059
Echinococcus granulosus mothers against decapentaplegic 5 0.0051 0.0123 0.0164
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0182 0.0917 0.2993
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0948 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1329 0.7895 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0048 0.0105 0.0264
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0041 0.0029
Entamoeba histolytica hypothetical protein 0.0038 0.0041 0.0149
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0182 0.0917 0.2993
Loa Loa (eye worm) TAR-binding protein 0.0467 0.2654 0.6059
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0484 0.4963
Echinococcus multilocularis tumor protein p63 0.1045 0.617 1
Schistosoma mansoni smad 0.0051 0.0123 0.0101
Onchocerca volvulus 0.0158 0.0772 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.0657 0.684
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0041 0.0029
Plasmodium vivax glutathione reductase, putative 0.0524 0.3 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0035 0.0027 0.0004
Echinococcus granulosus TGF beta signal transducer SmadC 0.0051 0.0123 0.0164
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0105 0.0264
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0267 0.0609
Schistosoma mansoni sulfide quinone reductase 0.0048 0.0105 0.0083
Trichomonas vaginalis apoptosis inducing factor, putative 0.0048 0.0105 0.0851
Trypanosoma cruzi trypanothione reductase, putative 0.0524 0.3 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0048 0.0105 0.0264
Plasmodium falciparum thioredoxin reductase 0.0182 0.0917 0.2803
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0187 0.0948 0.3098
Loa Loa (eye worm) hypothetical protein 0.0038 0.0044 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0491 0.5037
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0034 0.0018
Leishmania major phosphatidylinositol 3-kinase, putative 0.0063 0.0193 0.0303
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0048 0.0105 0.0264
Onchocerca volvulus 0.0153 0.0743 0.9557
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0163 0.0372
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0524 0.3 0.3716
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0149 0.0717 0.2112
Loa Loa (eye worm) glutathione reductase 0.0524 0.3 0.6848
Echinococcus granulosus intermediate filament protein 0.0058 0.0163 0.0228
Schistosoma mansoni sulfide quinone reductase 0.0048 0.0105 0.0083
Schistosoma mansoni intermediate filament proteins 0.0058 0.0163 0.014
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0048 0.0105 0.0135
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0048 0.0105 0.0241
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0023 0.0052
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0048 0.0105 0.0264
Schistosoma mansoni microtubule-associated protein tau 0.0674 0.3913 0.3899
Entamoeba histolytica thioredoxin reductase, putative 0.0048 0.0105 0.0851
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1329 0.7895 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0149 0.0716 0.7477
Schistosoma mansoni smad1 5 8 and 0.0051 0.0123 0.0101
Loa Loa (eye worm) programmed cell death 8 0.0048 0.0105 0.0241
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0048 0.0105 0.0851
Brugia malayi hypothetical protein 0.0038 0.0041 0.0093
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0477 0.109
Brugia malayi Bromodomain containing protein 0.0039 0.0048 0.011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0491 0.5037
Schistosoma mansoni lamin 0.0058 0.0163 0.014
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0027 0.0062
Loa Loa (eye worm) hypothetical protein 0.0158 0.0772 0.1763
Trichomonas vaginalis glutamate synthase, putative 0.0048 0.0105 0.0851
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0117 0.0976
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0048 0.0105 0.0135
Echinococcus granulosus thioredoxin glutathione reductase 0.0528 0.3022 0.4879
Brugia malayi Smad1 0.0051 0.0123 0.0282
Entamoeba histolytica hypothetical protein 0.0038 0.0041 0.0149
Trypanosoma brucei trypanothione reductase 0.0524 0.3 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0121 0.055 0.5673
Brugia malayi hypothetical protein 0.0158 0.0772 0.1763
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0149 0.0717 0.232
Schistosoma mansoni hypothetical protein 0.0048 0.0105 0.0083
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0078 0.0284 0.0864
Loa Loa (eye worm) phosphatidylinositol 3 0.0063 0.0193 0.0441
Loa Loa (eye worm) hypothetical protein 0.0043 0.0075 0.0172
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0182 0.0917 0.2993
Loa Loa (eye worm) hypothetical protein 0.0153 0.0743 0.1696
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0182 0.0917 0.2093
Schistosoma mansoni smad1 5 8 and 0.0051 0.0123 0.0101
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0187 0.0948 0.0927
Schistosoma mansoni Smad4 0.0051 0.0123 0.0101
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0477 0.109
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0048 0.0105 0.0135
Giardia lamblia NADH oxidase lateral transfer candidate 0.0182 0.0917 0.9629
Mycobacterium tuberculosis Probable dehydrogenase 0.1195 0.7083 0.8958
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0035 0.0027 0.0007
Echinococcus granulosus lamin 0.0058 0.0163 0.0228
Loa Loa (eye worm) MH2 domain-containing protein 0.0751 0.4381 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0023 0.0052
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1195 0.7083 0.8958
Toxoplasma gondii thioredoxin reductase 0.0524 0.3 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0182 0.0917 0.2803
Loa Loa (eye worm) Smad1 0.0051 0.0123 0.0282
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0063 0.0193 0.0559
Brugia malayi Thioredoxin reductase 0.0524 0.3 0.6848
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0063 0.0193 0.0303
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0048 0.0105 0.0135
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1329 0.7895 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0574 0.594
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.018 0.0257
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0063 0.0193 0.0559
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0182 0.0917 0.2803
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0163 0.0372
Trichomonas vaginalis mercuric reductase, putative 0.0182 0.0917 0.9661
Echinococcus granulosus lamin dm0 0.0058 0.0163 0.0228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0063 0.0193 0.1803
Echinococcus multilocularis musashi 0.0058 0.0163 0.0228
Loa Loa (eye worm) hypothetical protein 0.0039 0.0052 0.0118
Onchocerca volvulus 0.0058 0.0163 0.0861
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.0657 0.684
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0133 0.0624 0.1423
Plasmodium vivax thioredoxin reductase, putative 0.0524 0.3 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0041 0.0018
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0182 0.0917 0.2993
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0182 0.0917 0.2993
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0048 0.0105 0.0851
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0187 0.0948 0.2911
Toxoplasma gondii target of rapamycin (TOR), putative 0.0139 0.0657 0.2119
Trichomonas vaginalis glutamate synthase, putative 0.0048 0.0105 0.0851
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0048 0.0105 0.0241
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0182 0.0917 0.2993
Trypanosoma brucei hypothetical protein, conserved 0.0048 0.0105 0.0264
Schistosoma mansoni cellular tumor antigen P53 0.0153 0.0743 0.0722
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0048 0.0105 0.0135
Plasmodium falciparum glutathione reductase 0.0524 0.3 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.0657 0.684
Schistosoma mansoni tar DNA-binding protein 0.0467 0.2654 0.2638
Schistosoma mansoni glutamate synthase 0.0048 0.0105 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0948 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0048 0.0105 0.0241
Leishmania major trypanothione reductase 0.0524 0.3 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.0657 0.684
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0182 0.0917 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0035 0.0027 0.0007
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0048 0.0105 0.0241
Mycobacterium tuberculosis Probable oxidoreductase 0.1329 0.7895 1
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0048 0.0105 0.0264
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0182 0.0917 0.2993
Loa Loa (eye worm) RNA binding protein 0.0467 0.2654 0.6059
Schistosoma mansoni glutamate synthase 0.0048 0.0105 0.0083
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0182 0.0917 0.2993
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0182 0.0917 0.2803
Schistosoma mansoni disulfide oxidoreductase 0.0048 0.0105 0.0083
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0048 0.0105 0.0264
Brugia malayi MH1 domain containing protein 0.0051 0.0123 0.0282
Toxoplasma gondii NADPH-glutathione reductase 0.0182 0.0917 0.2993
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0182 0.0917 0.2993
Loa Loa (eye worm) hypothetical protein 0.0075 0.0267 0.0609
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0048 0.0105 0.0135
Brugia malayi RNA recognition motif domain containing protein 0.0467 0.2654 0.6059
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0182 0.0917 1
Schistosoma mansoni hypothetical protein 0.0038 0.0041 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0425 0.4316
Brugia malayi TAR-binding protein 0.0467 0.2654 0.6059
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0048 0.0105 0.0851
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0063 0.0193 0.0559
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0187 0.0948 0.3098
Echinococcus granulosus glutamate synthase 0.0048 0.0105 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0063 0.0193 0.1803
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0048 0.0105 0.0851
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0182 0.0917 0.1454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0425 0.4316
Echinococcus multilocularis lamin dm0 0.0058 0.0163 0.0228
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0048 0.0105 0.0851
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0182 0.0917 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0063 0.0193 0.1803
Echinococcus multilocularis Smad4 0.0051 0.0123 0.0164
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0477 0.109
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0182 0.0917 1
Brugia malayi MH2 domain containing protein 0.0751 0.4381 1
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0163 0.0372
Loa Loa (eye worm) hypothetical protein 0.0048 0.0105 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0425 0.4327
Loa Loa (eye worm) hypothetical protein 0.0041 0.0063 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0063 0.0193 0.1803
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0088 0.0349 0.1084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0948 1
Echinococcus granulosus Smad4 0.0051 0.0123 0.0164
Mycobacterium tuberculosis Probable reductase 0.1195 0.7083 0.8958
Echinococcus multilocularis thioredoxin glutathione reductase 0.0528 0.3022 0.4879
Giardia lamblia GTOR 0.0187 0.0948 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0048 0.0105 0.0264
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1195 0.7083 0.8958
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0182 0.0917 0.1454
Loa Loa (eye worm) hypothetical protein 0.0058 0.0163 0.0372
Brugia malayi MH2 domain containing protein 0.0051 0.0123 0.0282
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0187 0.0948 0.2911
Schistosoma mansoni bromodomain containing protein 0.0064 0.0202 0.018
Entamoeba histolytica disulphide oxidoreductase, putative 0.0048 0.0105 0.0851
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0182 0.0917 0.2803
Brugia malayi MH1 domain containing protein 0.0051 0.0123 0.0282
Echinococcus multilocularis tar DNA binding protein 0.0467 0.2654 0.4281
Trypanosoma cruzi target of rapamycin kinase 3 0.0149 0.0717 0.232
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0048 0.0105 0.0135
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0187 0.0948 0.1505
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0105 0.0264
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0048 0.0105 0.0851
Loa Loa (eye worm) thioredoxin reductase 0.0524 0.3 0.6848
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0063 0.0193 0.0441

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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