Detailed information for compound 620861

Basic information

Technical information
  • TDR Targets ID: 620861
  • Name: [3-(3,4-dimethoxyphenyl)-4-methyl-2-oxochrome n-6-yl] acetate
  • MW: 354.353 | Formula: C20H18O6
  • H donors: 0 H acceptors: 2 LogP: 3.15 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)c1c(=O)oc2c(c1C)cc(cc2)OC(=O)C
  • InChi: 1S/C20H18O6/c1-11-15-10-14(25-12(2)21)6-8-16(15)26-20(22)19(11)13-5-7-17(23-3)18(9-13)24-4/h5-10H,1-4H3
  • InChiKey: GSKNROPWNODRFQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [3-(3,4-dimethoxyphenyl)-4-methyl-2-oxo-chromen-6-yl] acetate
  • acetic acid [3-(3,4-dimethoxyphenyl)-4-methyl-2-oxo-6-chromenyl] ester
  • acetic acid [3-(3,4-dimethoxyphenyl)-2-keto-4-methyl-chromen-6-yl] ester
  • [3-(3,4-dimethoxyphenyl)-4-methyl-2-oxo-chromen-6-yl] ethanoate
  • ZINC04340693

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii thioredoxin reductase 0.0294 0.2989 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0089 0.0166
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0671 0.7079 0.8969
Trichomonas vaginalis glutamate synthase, putative 0.0027 0.0089 0.0921
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0027 0.0089 0.0108
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0027 0.0089 0.0166
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0162 0.0249
Brugia malayi intermediate filament protein 0.0053 0.0374 0.0739
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0187 0.2011
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0027 0.0089 0.0108
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0027 0.0089 0.0108
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0027 0.0089 0.0921
Schistosoma mansoni hypothetical protein 0.0038 0.0203 0.0196
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0148 0.0185
Plasmodium vivax glutathione reductase, putative 0.0294 0.2989 1
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0027 0.0089 0.0108
Loa Loa (eye worm) hypothetical protein 0.0052 0.0363 0.0718
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0374 0.0739
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0746 0.7892 1
Loa Loa (eye worm) programmed cell death 8 0.0027 0.0089 0.0166
Onchocerca volvulus 0.0053 0.0374 0.3322
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0746 0.7892 1
Giardia lamblia GTOR 0.0045 0.0288 0.3135
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0288 0.0941
Echinococcus granulosus Smad4 0.0032 0.0148 0.0185
Schistosoma mansoni lamin 0.0053 0.0374 0.0367
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0341 0.0674
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0007 0.0023
Plasmodium falciparum thioredoxin reductase 0.0102 0.0902 0.2803
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0102 0.0902 0.117
Entamoeba histolytica hypothetical protein 0.0038 0.0203 0.6991
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0089 0.0921
Mycobacterium tuberculosis Probable reductase 0.0671 0.7079 0.8969
Loa Loa (eye worm) transcription factor SMAD2 0.0477 0.497 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0075 0.0608 0.1212
Loa Loa (eye worm) hypothetical protein 0.0106 0.0946 0.1892
Echinococcus granulosus glutamate synthase 0.0027 0.0089 0.0108
Schistosoma mansoni glutamate synthase 0.0027 0.0089 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0023
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0102 0.0902 0.3019
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0027 0.0089 0.0276
Schistosoma mansoni smad 0.0032 0.0148 0.0141
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0288 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0027 0.0089 0.0108
Brugia malayi MH2 domain containing protein 0.0032 0.0148 0.0285
Echinococcus multilocularis tumor protein p63 0.0724 0.7655 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0061 0.0607
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0027 0.0089 0.0166
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0027 0.0089 0.0276
Loa Loa (eye worm) thioredoxin reductase 0.0294 0.2989 0.6007
Echinococcus multilocularis lamin dm0 0.0053 0.0374 0.048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0162 0.1727
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0027 0.0089 0.0105
Schistosoma mansoni hypothetical protein 0.0034 0.0169 0.0162
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0089 0.0921
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0105 0.0198
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0288 0.0367
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0341 0.0674
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0027 0.0089 0.0105
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0148 0.0285
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0102 0.0902 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0162 0.1727
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0087 0.0891
Trichomonas vaginalis glutathione reductase, putative 0.0102 0.0902 1
Mycobacterium ulcerans dehydrogenase 0.0027 0.0089 0.0921
Echinococcus granulosus thioredoxin glutathione reductase 0.0296 0.301 0.3927
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0671 0.7079 0.8969
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0089 0.0276
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0027 0.0089 0.2937
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0027 0.0089 0.0166
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0148 0.0185
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0027 0.0089 0.0921
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0288 0.0941
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0288 0.0281
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0288 0.0962
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0187 0.0605
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0027 0.0089 0.0921
Schistosoma mansoni smad1 5 8 and 0.0032 0.0148 0.0141
Mycobacterium ulcerans monoxygenase 0.0027 0.0089 0.0921
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0187 0.2011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0902 0.3002
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0374 0.0739
Brugia malayi glutathione reductase 0.0294 0.2989 0.6007
Loa Loa (eye worm) glutathione reductase 0.0294 0.2989 0.6007
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0027 0.0089 0.0108
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0089 0.0276
Brugia malayi hypothetical protein 0.0038 0.0203 0.0395
Schistosoma mansoni tar DNA-binding protein 0.0261 0.2632 0.2627
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0102 0.0902 0.1804
Plasmodium falciparum glutathione reductase 0.0294 0.2989 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0288 0.0941
Brugia malayi MH2 domain containing protein 0.0032 0.0148 0.0285
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0102 0.0902 0.3002
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0102 0.0902 0.3002
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0027 0.0089 0.0166
Trypanosoma cruzi NADH dehydrogenase, putative 0.0027 0.0089 0.0276
Loa Loa (eye worm) hypothetical protein 0.0053 0.0374 0.0739
Brugia malayi glutamate synthase 0.0027 0.0089 0.0166
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0027 0.0089 0.0276
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0027 0.0089 0.0921
Loa Loa (eye worm) TAR-binding protein 0.0261 0.2632 0.529
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0089 0.0276
Echinococcus multilocularis Smad4 0.0032 0.0148 0.0185
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0203 0.0257
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0341 0.0674
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0288 0.0367
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0102 0.0902 1
Brugia malayi Thioredoxin reductase 0.0294 0.2989 0.6007
Echinococcus multilocularis lamin 0.0053 0.0374 0.048
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0288 0.0941
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0902 0.3002
Echinococcus multilocularis tar DNA binding protein 0.0261 0.2632 0.3433
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0102 0.0902 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0288 0.0565
Leishmania major hypothetical protein, conserved 0.0027 0.0089 0.0276
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0027 0.0089 0.0108
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0027 0.0089 0.0921
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0027 0.0089 0.2937
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0187 0.0627
Echinococcus multilocularis glutamate synthase 0.0027 0.0089 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0061 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0288 0.3135
Trypanosoma brucei unspecified product 0.0019 0.0007 0.0023
Schistosoma mansoni tar DNA-binding protein 0.0261 0.2632 0.2627
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0115 0.1208
Schistosoma mansoni sulfide quinone reductase 0.0027 0.0089 0.0082
Loa Loa (eye worm) hypothetical protein 0.0034 0.0169 0.0326
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0027 0.0089 0.0921
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0746 0.7892 1
Loa Loa (eye worm) Smad1 0.0032 0.0148 0.0285
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0102 0.0902 0.3019
Toxoplasma gondii NADPH-glutathione reductase 0.0102 0.0902 0.2803
Trichomonas vaginalis glutamate synthase, putative 0.0027 0.0089 0.0921
Schistosoma mansoni smad1 5 8 and 0.0032 0.0148 0.0141
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0027 0.0089 0.0108
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0902 0.3002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0162 0.1727
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0102 0.0902 0.0896
Entamoeba histolytica hypothetical protein 0.0038 0.0203 0.6991
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0671 0.7079 0.8969
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0162 0.1727
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.009 0.0924
Loa Loa (eye worm) RNA binding protein 0.0261 0.2632 0.529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0061 0.0607
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0294 0.2989 0.3781
Loa Loa (eye worm) hypothetical protein 0.005 0.0341 0.0674
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0027 0.0089 0.0108
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0027 0.0089 0.0921
Echinococcus granulosus tar DNA binding protein 0.0261 0.2632 0.3433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0162 0.1727
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0089 0.0276
Brugia malayi MH1 domain containing protein 0.0032 0.0148 0.0285
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0902 0.3002
Schistosoma mansoni glutamate synthase 0.0027 0.0089 0.0082
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0089 0.0299
Echinococcus multilocularis smad 0.0032 0.0148 0.0185
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0148 0.0141
Echinococcus granulosus lamin dm0 0.0053 0.0374 0.048
Plasmodium vivax thioredoxin reductase, putative 0.0294 0.2989 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0027 0.0089 0.2937
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0187 0.0605
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0102 0.0902 0.2803
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0027 0.0089 0.0276
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0027 0.0089 0.0921
Treponema pallidum NADH oxidase 0.0102 0.0902 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0007 0.0023
Trypanosoma cruzi trypanothione reductase, putative 0.0102 0.0902 0.3002
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0007 0.0023
Entamoeba histolytica hypothetical protein 0.0038 0.0203 0.6991
Schistosoma mansoni sulfide quinone reductase 0.0027 0.0089 0.0082
Mycobacterium tuberculosis Probable oxidoreductase 0.0746 0.7892 1
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0027 0.0089 0.0108
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0027 0.0089 0.0299
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0288 0.0962
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0089 0.0921
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0023
Trypanosoma cruzi trypanothione reductase, putative 0.0294 0.2989 1
Trypanosoma brucei NADH dehydrogenase 0.0027 0.0089 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0187 0.2011
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0023
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0027 0.0089 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0216 0.2332
Mycobacterium ulcerans hypothetical protein 0.0027 0.0089 0.0921
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0102 0.0902 0.3002
Schistosoma mansoni smad1 5 8 and 0.0032 0.0148 0.0141
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0027 0.0089 0.0921
Schistosoma mansoni glutamate synthase 0.0027 0.0089 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0061 0.0607
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0075 0.0089
Brugia malayi RNA recognition motif domain containing protein 0.0261 0.2632 0.529
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0288 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0288 0.3135
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0027 0.0089 0.0108
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0102 0.0902 0.3002
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0671 0.7079 0.8958
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0089 0.0299
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0027 0.0089 0.0921
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0027 0.0089 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0023
Trypanosoma cruzi NADH dehydrogenase, putative 0.0027 0.0089 0.0276
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0028 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0126 0.1326
Giardia lamblia NADH oxidase lateral transfer candidate 0.0102 0.0902 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0007 0.0023
Schistosoma mansoni tar DNA-binding protein 0.0261 0.2632 0.2627
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0102 0.0902 0.3019
Brugia malayi Smad1 0.0032 0.0148 0.0285
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0203 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0023
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0102 0.0902 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.009 0.0924
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0102 0.0902 0.3019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0061 0.0603
Mycobacterium ulcerans glutamate synthase subunit beta 0.0027 0.0089 0.0921
Echinococcus multilocularis thioredoxin glutathione reductase 0.0296 0.301 0.3927
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0105 0.0198
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0102 0.0902 0.1135
Entamoeba histolytica hypothetical protein 0.0038 0.0203 0.6991
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0023
Entamoeba histolytica thioredoxin reductase, putative 0.0027 0.0089 0.2937
Leishmania major NADH dehydrogenase, putative 0.0027 0.0089 0.0276
Schistosoma mansoni cellular tumor antigen P53 0.0106 0.0946 0.094
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0102 0.0902 0.2803
Brugia malayi TAR-binding protein 0.0261 0.2632 0.529
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0102 0.0902 0.2803
Schistosoma mansoni lamin 0.0053 0.0374 0.0367
Brugia malayi MH2 domain containing protein 0.0477 0.497 1
Brugia malayi RNA binding protein 0.0261 0.2632 0.529
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0148 0.0185
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0902 0.3002
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0075 0.0089
Leishmania major hypothetical protein, conserved 0.0027 0.0089 0.0276
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0023
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0027 0.0089 0.2937
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0148 0.0185
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0102 0.0902 1
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0027 0.0089 0.0299
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0374 0.0739
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0102 0.0902 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0075 0.0608 0.1212
Mycobacterium tuberculosis Probable dehydrogenase 0.0671 0.7079 0.8969
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0027 0.0089 0.0105
Plasmodium falciparum thioredoxin reductase 0.0294 0.2989 1
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0027 0.0089 0.0105
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0148 0.0285
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0089 0.0921
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0061 0.0603
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0027 0.0089 0.0105
Leishmania major hypothetical protein, conserved 0.0027 0.0089 0.0276
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0027 0.0089 0.0921
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0187 0.2011
Giardia lamblia Thioredoxin reductase 0.0027 0.0089 0.0921
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0027 0.0089 0.0921
Echinococcus granulosus tumor protein p63 0.0724 0.7655 1
Mycobacterium ulcerans NADH dehydrogenase 0.0027 0.0089 0.0921
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0288 0.3135
Schistosoma mansoni tar DNA-binding protein 0.0261 0.2632 0.2627
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0187 0.2011
Onchocerca volvulus 0.0053 0.0374 0.3322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0061 0.0607
Schistosoma mansoni tar DNA-binding protein 0.0261 0.2632 0.2627
Echinococcus multilocularis musashi 0.0053 0.0374 0.048
Echinococcus granulosus smad 0.0032 0.0148 0.0185
Trichomonas vaginalis mercuric reductase, putative 0.0102 0.0902 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0089 0.0921
Echinococcus granulosus lamin 0.0053 0.0374 0.048
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0027 0.0089 0.2937
Mycobacterium ulcerans ferredoxin reductase 0.0027 0.0089 0.0921
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.0115
Schistosoma mansoni intermediate filament proteins 0.0053 0.0374 0.0367
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0102 0.0902 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0102 0.0902 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0162 0.1727
Trichomonas vaginalis apoptosis inducing factor, putative 0.0027 0.0089 0.0921
Trypanosoma brucei trypanothione reductase 0.0294 0.2989 1
Schistosoma mansoni hypothetical protein 0.0027 0.0089 0.0082
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0203 0.0257
Loa Loa (eye worm) MH2 domain-containing protein 0.0477 0.497 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0023
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0027 0.0089 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.009 0.0924
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0902 0.3002
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0288 0.0565
Giardia lamblia Glutamate synthase 0.0027 0.0089 0.0921
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0162 0.1727
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0261 0.2632 0.529
Brugia malayi MH1 domain containing protein 0.0032 0.0148 0.0285
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0102 0.0902 0.117
Leishmania major trypanothione reductase 0.0294 0.2989 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0089 0.0921
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0102 0.0902 0.3002
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0671 0.7079 0.8969
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0087 0.0891
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0169 0.0326
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0102 0.0902 0.3002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0023
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0089 0.0299
Entamoeba histolytica disulphide oxidoreductase, putative 0.0027 0.0089 0.2937
Onchocerca volvulus 0.0106 0.0946 1
Schistosoma mansoni disulfide oxidoreductase 0.0027 0.0089 0.0082
Plasmodium falciparum glutathione reductase 0.0102 0.0902 0.2803
Schistosoma mansoni Smad4 0.0032 0.0148 0.0141
Echinococcus granulosus intermediate filament protein 0.0053 0.0374 0.048
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.0115

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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