Detailed information for compound 620865

Basic information

Technical information
  • TDR Targets ID: 620865
  • Name: [3-(4-chlorophenyl)-4-methyl-2-oxochromen-6-y l] N,N-diethylcarbamate
  • MW: 385.841 | Formula: C21H20ClNO4
  • H donors: 0 H acceptors: 2 LogP: 4.58 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)Oc1ccc2c(c1)c(C)c(c(=O)o2)c1ccc(cc1)Cl)CC
  • InChi: 1S/C21H20ClNO4/c1-4-23(5-2)21(25)26-16-10-11-18-17(12-16)13(3)19(20(24)27-18)14-6-8-15(22)9-7-14/h6-12H,4-5H2,1-3H3
  • InChiKey: POUFWUWYWWWOMS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [3-(4-chlorophenyl)-4-methyl-2-oxo-chromen-6-yl] N,N-diethylcarbamate
  • N,N-diethylcarbamic acid [3-(4-chlorophenyl)-4-methyl-2-oxo-6-chromenyl] ester
  • N,N-diethylcarbamic acid [3-(4-chlorophenyl)-2-keto-4-methyl-chromen-6-yl] ester
  • ZINC04340781

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0059 0.0138 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0389 0.3496
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0059 0.0138 0.0123
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0042 0.0373
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1628 0.7896 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0059 0.0138 0.0324
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0042 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.024 0.2159
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0007 0.0003
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0059 0.0138 0.0439
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0042 0.0373
Loa Loa (eye worm) hypothetical protein 0.0033 0.0007 0.0014
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0223 0.0946 0.2971
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.005 0.0091 0.0166
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.005 0.0091 0.0269
Plasmodium vivax thioredoxin reductase, putative 0.0642 0.3021 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0223 0.0946 1
Echinococcus multilocularis smad 0.0068 0.0184 0.0563
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0059 0.0138 0.1241
Leishmania major hypothetical protein, conserved 0.0059 0.0138 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.024 0.2154
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0059 0.0138 0.0457
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0091 0.0817
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0059 0.0138 0.1241
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0059 0.0138 0.1068
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0354 0.0726
Loa Loa (eye worm) hypothetical protein 0.004 0.0042 0.0087
Echinococcus granulosus GPCR family 2 0.0033 0.0007 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0673 0.3171 0.3167
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0223 0.0946 0.3037
Schistosoma mansoni smad 0.0068 0.0184 0.0178
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0059 0.0138 0.0324
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0059 0.0138 0.0324
Brugia malayi beta-lactamase family protein 0.004 0.0042 0.0075
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0042 0.0087
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0148 0.0576 0.1795
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0059 0.0138 0.1068
Onchocerca volvulus 0.0059 0.0138 0.1195
Entamoeba histolytica hypothetical protein 0.0076 0.0223 0.1936
Toxoplasma gondii thioredoxin reductase 0.0642 0.3021 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0091 0.0817
Echinococcus granulosus thioredoxin glutathione reductase 0.0648 0.305 0.9618
Schistosoma mansoni hypothetical protein 0.0033 0.0007 0.0001
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0059 0.0138 0.0418
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0059 0.0138 0.1068
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0223 0.0946 0.196
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0059 0.0138 0.0418
Schistosoma mansoni hypothetical protein 0.0076 0.0223 0.0217
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0223 0.0946 0.3037
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0148 0.0576 0.1795
Loa Loa (eye worm) hypothetical protein 0.004 0.0042 0.0087
Brugia malayi RNA recognition motif domain containing protein 0.0673 0.3171 0.6597
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0059 0.0138 0.0457
Echinococcus granulosus smad 0.0068 0.0184 0.0563
Loa Loa (eye worm) MH1 domain-containing protein 0.0068 0.0184 0.0383
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0059 0.0138 0.1241
Echinococcus granulosus tar DNA binding protein 0.0673 0.3171 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0223 0.0946 0.3037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0282 0.2537
Echinococcus multilocularis GPCR, family 2 0.0033 0.0007 0.0003
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.005 0.0091 0.0166
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0059 0.0138 0.1241
Leishmania major NADH dehydrogenase, putative 0.0059 0.0138 0.0324
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0223 0.0946 0.3037
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0223 0.0946 1
Plasmodium falciparum glutathione reductase 0.0642 0.3021 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0223 0.0946 0.3037
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0148 0.0576 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.1095 0.1341
Toxoplasma gondii NADPH-glutathione reductase 0.0223 0.0946 0.3132
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0059 0.0138 0.0418
Trichomonas vaginalis esterase, putative 0.004 0.0042 0.0373
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0059 0.0138 0.0123
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0042 0.0036
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0059 0.0138 0.0457
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0007 0.0003
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0042 0.0373
Toxoplasma gondii selenide, water dikinase 0.0059 0.0138 0.0457
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0059 0.0138 0.0123
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0006 0.0019
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0223 0.0946 1
Loa Loa (eye worm) transcription factor SMAD2 0.1003 0.4804 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0117 0.0427 0.3835
Toxoplasma gondii target of rapamycin (TOR), putative 0.011 0.0389 0.1288
Schistosoma mansoni sulfide quinone reductase 0.0059 0.0138 0.0132
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0042 0.0373
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0223 0.0946 0.3119
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.005 0.0091 0.0166
Loa Loa (eye worm) thioredoxin reductase 0.0642 0.3021 0.6288
Schistosoma mansoni Smad4 0.0068 0.0184 0.0178
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0223 0.0946 0.3037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.0278 0.2498
Leishmania major phosphatidylinositol 3-kinase, putative 0.005 0.0091 0.0166
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0061 0.0149 0.0362
Loa Loa (eye worm) hypothetical protein 0.004 0.0042 0.0087
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0059 0.0138 0.0123
Mycobacterium tuberculosis Probable dehydrogenase 0.1465 0.7088 0.8971
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0059 0.0138 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.024 0.2159
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0059 0.0138 0.1068
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0059 0.0138 0.1241
Schistosoma mansoni glutamate synthase 0.0059 0.0138 0.0132
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.005 0.0091 0.0269
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0059 0.0138 0.0123
Leishmania major hypothetical protein, conserved 0.0059 0.0138 0.0324
Brugia malayi MH1 domain containing protein 0.0068 0.0184 0.0371
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.024 0.2154
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0148 0.0576 0.1795
Loa Loa (eye worm) phosphatidylinositol 3 0.005 0.0091 0.0189
Echinococcus multilocularis tumor protein p63 0.0371 0.168 0.529
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0389 0.3496
Onchocerca volvulus 0.004 0.0042 0.0323
Brugia malayi glutathione reductase 0.0642 0.3021 0.6284
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0059 0.0138 0.1241
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0059 0.0138 0.0276
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0223 0.0946 0.2803
Loa Loa (eye worm) hypothetical protein 0.0038 0.0033 0.0069
Loa Loa (eye worm) MH2 domain-containing protein 0.0068 0.0184 0.0383
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.005 0.0091 0.0178
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0059 0.0138 0.0324
Onchocerca volvulus 0.004 0.0042 0.0323
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0059 0.0138 0.0418
Loa Loa (eye worm) Smad1 0.0068 0.0184 0.0383
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0223 0.0946 0.3037
Echinococcus multilocularis tar DNA binding protein 0.0673 0.3171 1
Leishmania major trypanothione reductase 0.0642 0.3021 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0042 0.0087
Trypanosoma cruzi trypanothione reductase, putative 0.0642 0.3021 1
Trichomonas vaginalis glutamate synthase, putative 0.0059 0.0138 0.1241
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1465 0.7088 0.8971
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0223 0.0946 0.3037
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0059 0.0138 0.0457
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0148 0.0576 0.1802
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0223 0.0946 0.0941
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0223 0.0946 0.3037
Mycobacterium tuberculosis Probable reductase 0.1465 0.7088 0.8971
Brugia malayi MH1 domain containing protein 0.0038 0.0033 0.0057
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0059 0.0138 0.0418
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0223 0.0217
Loa Loa (eye worm) hypothetical protein 0.004 0.0042 0.0087
Trichomonas vaginalis apoptosis inducing factor, putative 0.0059 0.0138 0.1241
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0223 0.0946 0.2971
Brugia malayi Thioredoxin reductase 0.0642 0.3021 0.6284
Brugia malayi MH2 domain containing protein 0.0068 0.0184 0.0371
Plasmodium falciparum thioredoxin reductase 0.0223 0.0946 0.2803
Schistosoma mansoni tar DNA-binding protein 0.0673 0.3171 0.3167
Echinococcus multilocularis mothers against decapentaplegic 5 0.0068 0.0184 0.0563
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0148 0.0576 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0091 0.0817
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0223 0.0946 0.3037
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0138 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0042 0.0378
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0138 0.0324
Onchocerca volvulus 0.0256 0.1113 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.005 0.0091 0.0166
Schistosoma mansoni glutamate synthase 0.0059 0.0138 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0282 0.2537
Leishmania major phosphatidylinositol 3-related kinase, putative 0.005 0.0091 0.0166
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0163 0.0654 0.1352
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0223 0.0946 0.3037
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0193 0.0391
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0223 0.0946 0.3132
Leishmania major hypothetical protein, conserved 0.0059 0.0138 0.0324
Echinococcus multilocularis thioredoxin glutathione reductase 0.0648 0.305 0.9618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0148 0.0576 0.5177
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0059 0.0138 0.0418
Onchocerca volvulus 0.0054 0.0115 0.0982
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0059 0.0138 0.0418
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0148 0.0576 0.0571
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0068 0.0184 0.0563
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0223 0.0946 1
Treponema pallidum NADH oxidase 0.0223 0.0946 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0117 0.0427 0.3835
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0059 0.0138 0.0324
Brugia malayi hypothetical protein 0.0076 0.0223 0.0453
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0042 0.0113
Schistosoma mansoni disulfide oxidoreductase 0.0059 0.0138 0.0132
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0059 0.0138 0.0324
Brugia malayi MH2 domain containing protein 0.1003 0.4804 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0148 0.0576 0.1189
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0068 0.0184 0.0178
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0354 0.0726
Loa Loa (eye worm) programmed cell death 8 0.0059 0.0138 0.0288
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0148 0.0576 0.1795
Mycobacterium tuberculosis Probable oxidoreductase 0.1628 0.7896 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0389 0.3496
Schistosoma mansoni sulfide quinone reductase 0.0059 0.0138 0.0132
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0007 0.0003
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1465 0.7088 0.8971
Brugia malayi TAR-binding protein 0.0673 0.3171 0.6597
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0223 0.0946 0.3037
Schistosoma mansoni hypothetical protein 0.0033 0.0007 0.0001
Trichomonas vaginalis mercuric reductase, putative 0.0223 0.0946 0.8502
Loa Loa (eye worm) hypothetical protein 0.0103 0.0354 0.0737
Onchocerca volvulus 0.004 0.0042 0.0323
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0223 0.0946 0.3037
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0007 0.0003
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0148 0.0576 0.1795
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0223 0.0686
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0059 0.0138 0.1068
Loa Loa (eye worm) hypothetical protein 0.0059 0.0138 0.0288
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0059 0.0138 0.0123
Loa Loa (eye worm) MH2 domain-containing protein 0.1003 0.4804 1
Mycobacterium ulcerans glutamate synthase subunit beta 0.0059 0.0138 0.1068
Brugia malayi RNA binding protein 0.0673 0.3171 0.6597
Trichomonas vaginalis PIKK family atypical protein kinase 0.0148 0.0576 0.5177
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0163 0.0654 0.1352
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1628 0.7896 1
Brugia malayi MH1 domain containing protein 0.0068 0.0184 0.0371
Loa Loa (eye worm) RNA binding protein 0.0673 0.3171 0.6601
Trypanosoma brucei NADH dehydrogenase 0.0059 0.0138 0.0324
Trypanosoma cruzi NADH dehydrogenase, putative 0.0059 0.0138 0.0324
Mycobacterium ulcerans monoxygenase 0.0059 0.0138 0.1068
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.024 0.2154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.0278 0.2498
Mycobacterium ulcerans hypothetical protein 0.0059 0.0138 0.1068
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0148 0.0576 0.1802
Echinococcus granulosus mothers against decapentaplegic 5 0.0068 0.0184 0.0563
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0223 0.0946 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0091 0.0817
Entamoeba histolytica hypothetical protein 0.0076 0.0223 0.1936
Brugia malayi beta-lactamase family protein 0.004 0.0042 0.0075
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0007 0.0002
Brugia malayi glutamate synthase 0.0059 0.0138 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0469 0.4218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0117 0.0427 0.3835
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0118 0.0427 0.1295
Echinococcus granulosus Smad4 0.0068 0.0184 0.0563
Mycobacterium ulcerans NADH dehydrogenase 0.0059 0.0138 0.1068
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0354 0.0737
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0042 0.0075
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1465 0.7088 0.8971
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0059 0.0138 0.0324
Trichomonas vaginalis glutamate synthase, putative 0.0059 0.0138 0.1241
Plasmodium vivax ferrodoxin reductase, putative 0.0059 0.0138 0.0439
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0059 0.0138 0.1241
Plasmodium falciparum glutathione reductase 0.0223 0.0946 0.2803
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0059 0.0138 0.0418
Loa Loa (eye worm) TAR-binding protein 0.0673 0.3171 0.6601
Loa Loa (eye worm) hypothetical protein 0.0032 0.0006 0.0012
Brugia malayi MH2 domain containing protein 0.0068 0.0184 0.0371
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1465 0.7088 0.8971
Schistosoma mansoni smad1 5 8 and 0.0068 0.0184 0.0178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0117 0.0427 0.3835
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0059 0.0138 0.1241
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0059 0.0138 0.0276
Loa Loa (eye worm) nuclear factor I 0.0038 0.0033 0.0069
Brugia malayi MH1 domain containing protein 0.0038 0.0033 0.0057
Giardia lamblia NADH oxidase lateral transfer candidate 0.0223 0.0946 1
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0059 0.0138 0.0123
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0042 0.0373
Trichomonas vaginalis set domain proteins, putative 0.0256 0.1113 1
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0059 0.0138 0.1068
Loa Loa (eye worm) hypothetical protein 0.007 0.0193 0.0403
Brugia malayi beta-lactamase 0.004 0.0042 0.0075
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0059 0.0138 0.0324
Mycobacterium ulcerans ferredoxin reductase 0.0059 0.0138 0.1068
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0059 0.0138 0.0324
Loa Loa (eye worm) phosphatidylinositol 3 0.0148 0.0576 0.1199
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.007 0.0191 0.0503
Plasmodium falciparum thioredoxin reductase 0.0642 0.3021 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.005 0.0091 0.0085
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0059 0.0138 0.1068
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0059 0.0138 0.0324
Schistosoma mansoni hypothetical protein 0.0033 0.0007 0.0001
Schistosoma mansoni hypothetical protein 0.0059 0.0138 0.0132
Trypanosoma brucei hypothetical protein, conserved 0.0059 0.0138 0.0324
Trichomonas vaginalis glutathione reductase, putative 0.0223 0.0946 0.8502
Trypanosoma cruzi target of rapamycin kinase 3 0.0118 0.0427 0.1295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0282 0.2537
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0118 0.0427 0.1295
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0007 0.0014
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0059 0.0138 0.0418
Echinococcus granulosus tumor protein p63 0.0371 0.168 0.529
Schistosoma mansoni glutamate synthase 0.0059 0.0138 0.0132
Schistosoma mansoni smad1 5 8 and 0.0068 0.0184 0.0178
Giardia lamblia GTOR 0.0148 0.0576 0.5421
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0059 0.0138 0.0439
Trypanosoma cruzi NADH dehydrogenase, putative 0.0059 0.0138 0.0324
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0673 0.3171 0.6601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0148 0.0576 0.5177
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.024 0.2159
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0223 0.0946 0.3037
Echinococcus multilocularis glutamate synthase 0.0059 0.0138 0.0418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0117 0.0427 0.3835
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0059 0.0138 0.0123
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0223 0.0686
Brugia malayi Smad1 0.0068 0.0184 0.0371
Schistosoma mansoni tar DNA-binding protein 0.0673 0.3171 0.3167
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0223 0.0946 0.3037
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0389 0.3496
Schistosoma mansoni smad1 5 8 and 0.0068 0.0184 0.0178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0336 0.3017
Trypanosoma brucei trypanothione reductase 0.0642 0.3021 1
Trypanosoma cruzi trypanothione reductase, putative 0.0223 0.0946 0.3037
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0059 0.0138 0.1241
Schistosoma mansoni tar DNA-binding protein 0.0673 0.3171 0.3167
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0059 0.0138 0.0123
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1628 0.7896 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0068 0.0184 0.0563
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0223 0.0946 0.2803
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0059 0.0138 0.0418
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0059 0.0138 0.0418
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0059 0.0138 0.0457
Schistosoma mansoni hypothetical protein 0.007 0.0193 0.0188
Plasmodium vivax glutathione reductase, putative 0.0642 0.3021 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0042 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0389 0.3496
Loa Loa (eye worm) beta-lactamase 0.004 0.0042 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.032 0.2876
Entamoeba histolytica hypothetical protein 0.0076 0.0223 0.1936
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1465 0.7088 0.8971
Mycobacterium ulcerans dehydrogenase 0.0059 0.0138 0.1068
Loa Loa (eye worm) glutathione reductase 0.0642 0.3021 0.6288
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0007 0.0002
Entamoeba histolytica hypothetical protein 0.0076 0.0223 0.1936
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0223 0.0946 0.3119
Loa Loa (eye worm) hypothetical protein 0.004 0.0042 0.0087
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.0959 0.1997
Loa Loa (eye worm) hypothetical protein 0.0054 0.0115 0.0239
Echinococcus multilocularis Smad4 0.0068 0.0184 0.0563
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0223 0.0946 0.3037
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0059 0.0138 0.1241
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0389 0.3496
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0642 0.3021 0.3793
Brugia malayi Pre-SET motif family protein 0.0225 0.0959 0.1987
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0223 0.0946 0.1152
Toxoplasma gondii ABC1 family protein 0.004 0.0042 0.0138
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0148 0.0576 0.1795
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0389 0.3496
Schistosoma mansoni tar DNA-binding protein 0.0673 0.3171 0.3167
Plasmodium vivax hypothetical protein, conserved 0.004 0.0042 0.0119
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0223 0.0946 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0091 0.0817
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0115 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.024 0.2159
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0059 0.0138 0.0288
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0059 0.0138 0.0123
Schistosoma mansoni hypothetical protein 0.0033 0.0007 0.0001
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0059 0.0138 0.0418
Echinococcus granulosus glutamate synthase 0.0059 0.0138 0.0418

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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