Detailed information for compound 620876

Basic information

Technical information
  • TDR Targets ID: 620876
  • Name: [3-(3,4-dimethoxyphenyl)-4-methyl-2-oxochrome n-7-yl] 2-methylpropanoate
  • MW: 382.406 | Formula: C22H22O6
  • H donors: 0 H acceptors: 2 LogP: 4.2 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)c1c(=O)oc2c(c1C)ccc(c2)OC(=O)C(C)C
  • InChi: 1S/C22H22O6/c1-12(2)21(23)27-15-7-8-16-13(3)20(22(24)28-18(16)11-15)14-6-9-17(25-4)19(10-14)26-5/h6-12H,1-5H3
  • InChiKey: DENILZSDCVMSEI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [3-(3,4-dimethoxyphenyl)-4-methyl-2-oxo-chromen-7-yl] 2-methylpropanoate
  • 2-methylpropanoic acid [3-(3,4-dimethoxyphenyl)-4-methyl-2-oxo-7-chromenyl] ester
  • 2-methylpropionic acid [3-(3,4-dimethoxyphenyl)-2-keto-4-methyl-chromen-7-yl] ester
  • ZINC04340133

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0319 0.0924 0.1236
Brugia malayi MH2 domain containing protein 0.1713 0.5748 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0085 0.0114 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0163 0.0386 0.4042
Schistosoma mansoni smad1 5 8 and 0.0117 0.0225 0.0225
Loa Loa (eye worm) latrophilin receptor protein 2 0.0135 0.0288 0.0498
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0319 0.0924 0.0924
Brugia malayi RNA recognition motif domain containing protein 0.0919 0.3002 0.5221
Echinococcus granulosus smad 0.0117 0.0225 0.0299
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0319 0.0924 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0092 0.0138 0.0083
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0319 0.0924 0.1042
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.2333 0.7893 1
Schistosoma mansoni smad 0.0052 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0058 0.002 0.0032
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0319 0.0924 0.2803
Loa Loa (eye worm) RNA binding protein 0.0919 0.3002 0.5221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0524 0.557
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0117 0.0225 0.0299
Mycobacterium tuberculosis Putative ferredoxin reductase 0.2099 0.7083 0.8958
Giardia lamblia GTOR 0.0273 0.0766 0.8045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0233 0.0628 0.672
Loa Loa (eye worm) hypothetical protein 0.0065 0.0047 0.0079
Loa Loa (eye worm) glutathione reductase 0.092 0.3005 0.5226
Brugia malayi hypothetical protein 0.0108 0.0195 0.0336
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0092 0.0138 0.0237
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0085 0.0114 0.0314
Loa Loa (eye worm) hypothetical protein 0.0146 0.0327 0.0566
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0085 0.0114 0.1037
Loa Loa (eye worm) thioredoxin reductase 0.092 0.3005 0.5226
Loa Loa (eye worm) phosphatidylinositol 3 0.0092 0.0138 0.0237
Brugia malayi MH2 domain containing protein 0.0117 0.0225 0.0389
Loa Loa (eye worm) programmed cell death 8 0.0085 0.0114 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0163 0.0386 0.4042
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0068 0.0056 0.0073
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0135 0.0288 0.0384
Echinococcus granulosus mothers against decapentaplegic 5 0.0117 0.0225 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147 0.0331 0.344
Onchocerca volvulus 0.0146 0.0327 0.4632
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.2099 0.7083 0.8958
Schistosoma mansoni hypothetical protein 0.0291 0.083 0.083
Schistosoma mansoni tar DNA-binding protein 0.0919 0.3002 0.3002
Mycobacterium tuberculosis Probable dehydrogenase 0.2099 0.7083 0.8958
Trichomonas vaginalis glutamate synthase, putative 0.0085 0.0114 0.1037
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0085 0.0114 0.1037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0138 0.1302
Schistosoma mansoni glutamate synthase 0.0085 0.0114 0.0114
Schistosoma mansoni tar DNA-binding protein 0.0919 0.3002 0.3002
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0092 0.0138 0.0083
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0319 0.0924 0.2803
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0319 0.0924 0.2803
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0273 0.0766 0.2255
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0135 0.0288 0.0384
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0319 0.0924 0.2803
Giardia lamblia NADH oxidase lateral transfer candidate 0.0319 0.0924 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0319 0.0924 0.2803
Brugia malayi cytoplasmic intermediate filament protein 0.0075 0.0082 0.014
Trypanosoma cruzi target of rapamycin kinase 3 0.0217 0.0573 0.1589
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0319 0.0924 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0085 0.0114 0.0151
Schistosoma mansoni glutamate synthase 0.0085 0.0114 0.0114
Schistosoma mansoni cellular tumor antigen P53 0.0255 0.0704 0.0704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0273 0.0766 0.8248
Schistosoma mansoni hypothetical protein 0.0108 0.0195 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0524 0.557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0273 0.0766 0.8248
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0195 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0217 0.0573 0.611
Plasmodium vivax thioredoxin reductase, putative 0.092 0.3005 1
Brugia malayi Smad1 0.0117 0.0225 0.0389
Brugia malayi MH1 domain containing protein 0.0117 0.0225 0.0389
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0085 0.0114 0.1037
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0085 0.0114 0.0195
Onchocerca volvulus 0.0141 0.0308 0.4362
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0085 0.0114 0.0151
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0319 0.0924 0.3029
Entamoeba histolytica hypothetical protein 0.0108 0.0195 0.1235
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0319 0.0924 0.2803
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0085 0.0114 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147 0.0331 0.3432
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0092 0.0138 0.0083
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0273 0.0766 0.2255
Loa Loa (eye worm) MH1 domain-containing protein 0.0117 0.0225 0.0389
Toxoplasma gondii thioredoxin reductase 0.092 0.3005 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0319 0.0924 0.2803
Schistosoma mansoni sulfide quinone reductase 0.0085 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0075
Brugia malayi Intermediate filament tail domain containing protein 0.0141 0.0308 0.0533
Plasmodium falciparum thioredoxin reductase 0.0319 0.0924 0.2803
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0273 0.0766 0.1024
Echinococcus granulosus intermediate filament protein 0.0141 0.0308 0.0411
Schistosoma mansoni hypothetical protein 0.0085 0.0114 0.0114
Echinococcus granulosus tumor protein p63 0.1743 0.5853 0.784
Echinococcus granulosus glutamate synthase 0.0085 0.0114 0.0151
Loa Loa (eye worm) TAR-binding protein 0.0919 0.3002 0.5221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0162 0.038 0.398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0217 0.0573 0.611
Trichomonas vaginalis glutathione reductase, putative 0.0319 0.0924 1
Toxoplasma gondii selenide, water dikinase 0.0085 0.0114 0.0314
Entamoeba histolytica hypothetical protein 0.0108 0.0195 0.1235
Schistosoma mansoni smad1 5 8 and 0.0117 0.0225 0.0225
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.2099 0.7083 0.8958
Schistosoma mansoni lamin 0.0141 0.0308 0.0308
Schistosoma mansoni tar DNA-binding protein 0.0919 0.3002 0.3002
Echinococcus multilocularis Smad4 0.0117 0.0225 0.0299
Loa Loa (eye worm) transcription factor SMAD2 0.1713 0.5748 1
Schistosoma mansoni microtubule-associated protein tau 0.2209 0.7464 0.7464
Trichomonas vaginalis mercuric reductase, putative 0.0319 0.0924 1
Schistosoma mansoni smad 0.0117 0.0225 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0524 0.557
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0085 0.0114 0.0151
Toxoplasma gondii target of rapamycin (TOR), putative 0.0203 0.0524 0.1687
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147 0.0331 0.3432
Trichomonas vaginalis set domain proteins, putative 0.024 0.065 0.6968
Echinococcus multilocularis smad 0.0117 0.0225 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0138 0.1302
Loa Loa (eye worm) hypothetical protein 0.0056 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0068 0.0056 0.0095
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0092 0.0138 0.0138
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0273 0.0766 0.2255
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0319 0.0924 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0319 0.0924 0.2803
Schistosoma mansoni tar DNA-binding protein 0.0919 0.3002 0.3002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0138 0.1302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0217 0.0573 0.611
Loa Loa (eye worm) hypothetical protein 0.0255 0.0704 0.1222
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0234 0.0632 0.1096
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0092 0.0138 0.0083
Loa Loa (eye worm) hypothetical protein 0.0426 0.1296 0.2253
Trichomonas vaginalis apoptosis inducing factor, putative 0.0085 0.0114 0.1037
Schistosoma mansoni tar DNA-binding protein 0.0919 0.3002 0.3002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0135 0.0288 0.0384
Brugia malayi intermediate filament protein 0.0141 0.0308 0.0533
Leishmania major phosphatidylinositol 3-kinase, putative 0.0092 0.0138 0.0083
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0085 0.0114 0.0195
Trypanosoma cruzi trypanothione reductase, putative 0.0319 0.0924 0.2803
Loa Loa (eye worm) intermediate filament protein 0.0141 0.0308 0.0533
Schistosoma mansoni Smad4 0.0117 0.0225 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0524 0.557
Brugia malayi Latrophilin receptor protein 2 0.0135 0.0288 0.0498
Echinococcus multilocularis tumor protein p63 0.1743 0.5853 0.784
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0273 0.0766 0.2255
Schistosoma mansoni glutamate synthase 0.0085 0.0114 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147 0.0331 0.344
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0075 0.0082 0.014
Schistosoma mansoni lamin 0.0141 0.0308 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147 0.0331 0.344
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0426 0.1296 0.2253
Echinococcus granulosus TGF beta signal transducer SmadC 0.0117 0.0225 0.0299
Echinococcus multilocularis microtubule associated protein 2 0.2209 0.7464 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0928 0.3031 0.406
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0319 0.0924 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0085 0.0114 0.1037
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.2099 0.7083 0.8958
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0319 0.0924 0.2803
Echinococcus granulosus GPCR family 2 0.0135 0.0288 0.0384
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0113 0.0214 0.0344
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0319 0.0924 0.2803
Brugia malayi hypothetical protein 0.0146 0.0327 0.0566
Echinococcus multilocularis glutamate synthase 0.0085 0.0114 0.0151
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0319 0.0924 1
Echinococcus granulosus Smad4 0.0117 0.0225 0.0299
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0234 0.0632 0.1096
Brugia malayi TAR-binding protein 0.0919 0.3002 0.5221
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0085 0.0114 0.1037
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0195 0.0258
Plasmodium falciparum glutathione reductase 0.0319 0.0924 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0085 0.0114 0.1037
Trypanosoma cruzi trypanothione reductase, putative 0.092 0.3005 1
Echinococcus granulosus lamin dm0 0.0141 0.0308 0.0411
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0085 0.0114 0.1037
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0426 0.1296 0.2253
Loa Loa (eye worm) hypothetical protein 0.0085 0.0114 0.0195
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.092 0.3005 0.3716
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0217 0.0573 0.1589
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0319 0.0924 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0138 0.1302
Mycobacterium tuberculosis Probable oxidoreductase 0.2333 0.7893 1
Entamoeba histolytica hypothetical protein 0.0108 0.0195 0.1235
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0319 0.0924 0.2803
Echinococcus granulosus tar DNA binding protein 0.0919 0.3002 0.402
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0085 0.0114 0.0195
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0273 0.0766 0.1024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0319 0.0924 0.2803
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0085 0.0114 0.0314
Schistosoma mansoni disulfide oxidoreductase 0.0085 0.0114 0.0114
Brugia malayi MH1 domain containing protein 0.0117 0.0225 0.0389
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0319 0.0924 0.1606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0273 0.0766 0.8248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147 0.0331 0.3432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0138 0.1302
Echinococcus multilocularis tar DNA binding protein 0.0919 0.3002 0.402
Loa Loa (eye worm) nuclear factor I 0.0065 0.0045 0.0075
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0273 0.0766 0.0766
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0919 0.3002 0.5221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0163 0.0386 0.4042
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0085 0.0114 0.0151
Echinococcus multilocularis musashi 0.0141 0.0308 0.0411
Treponema pallidum NADH oxidase 0.0319 0.0924 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0085 0.0114 0.1037
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0085 0.0114 0.0151
Loa Loa (eye worm) hypothetical protein 0.0141 0.0308 0.0533
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0319 0.0924 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0162 0.038 0.398
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0135 0.0288 0.0384
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0085 0.0114 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147 0.0331 0.344
Echinococcus multilocularis lamin dm0 0.0141 0.0308 0.0411
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0085 0.0114 0.0151
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0273 0.0766 0.133
Brugia malayi latrophilin 2 splice variant baaae 0.0291 0.083 0.1441
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0273 0.0766 0.2255
Schistosoma mansoni smad1 5 8 and 0.0117 0.0225 0.0225
Brugia malayi Calcitonin receptor-like protein seb-1 0.0426 0.1296 0.2253
Loa Loa (eye worm) Smad1 0.0117 0.0225 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.0435 0.4582
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0319 0.0924 0.2803
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0092 0.0138 0.0183
Echinococcus granulosus microtubule associated protein 2 0.2209 0.7464 1
Brugia malayi MH2 domain containing protein 0.0117 0.0225 0.0389
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.2099 0.7083 0.8958
Mycobacterium tuberculosis Probable reductase 0.2099 0.7083 0.8958
Trypanosoma brucei trypanothione reductase 0.092 0.3005 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0117 0.0225 0.0299
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0319 0.0924 0.2803
Echinococcus granulosus lamin 0.0141 0.0308 0.0411
Schistosoma mansoni intermediate filament proteins 0.0141 0.0308 0.0308
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0092 0.0138 0.0183
Brugia malayi Thioredoxin reductase 0.092 0.3005 0.5226
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.055 0.0953
Loa Loa (eye worm) hypothetical protein 0.0138 0.0299 0.0518
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.2333 0.7893 1
Onchocerca volvulus 0.0141 0.0308 0.4362
Echinococcus multilocularis GPCR, family 2 0.0135 0.0288 0.0384
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0319 0.0924 0.2803
Loa Loa (eye worm) hypothetical protein 0.0291 0.083 0.1441
Schistosoma mansoni hypothetical protein 0.0135 0.0288 0.0288
Echinococcus multilocularis lamin 0.0141 0.0308 0.0411
Schistosoma mansoni hypothetical protein 0.0135 0.0288 0.0288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0075 0.0602
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0129 0.0268 0.0533
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0217 0.0573 0.1589
Brugia malayi Pre-SET motif family protein 0.0211 0.055 0.0953
Schistosoma mansoni Smad4 0.0052 0.0002 0.0002
Plasmodium falciparum thioredoxin reductase 0.092 0.3005 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0319 0.0924 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0319 0.0924 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0319 0.0924 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0085 0.0114 0.1037
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0085 0.0114 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0217 0.0573 0.611
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0085 0.0114 0.0314
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0319 0.0924 0.2803
Onchocerca volvulus 0.0085 0.0114 0.1599
Loa Loa (eye worm) phosphatidylinositol 3 0.0273 0.0766 0.133
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0195 0.0195
Leishmania major trypanothione reductase 0.092 0.3005 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0217 0.0573 0.611
Brugia malayi RNA binding protein 0.0919 0.3002 0.5221
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0319 0.0924 0.1236
Toxoplasma gondii NADPH-glutathione reductase 0.0319 0.0924 0.3029
Brugia malayi MH1 domain containing protein 0.0065 0.0045 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0524 0.557
Schistosoma mansoni Smad4 0.0052 0.0002 0.0002
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0141 0.0308 0.0533
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0085 0.0114 0.0151
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0273 0.0766 0.2255
Schistosoma mansoni hypothetical protein 0.0135 0.0288 0.0288
Plasmodium vivax glutathione reductase, putative 0.092 0.3005 1
Onchocerca volvulus 0.0255 0.0704 1
Brugia malayi glutathione reductase 0.092 0.3005 0.5226
Schistosoma mansoni hypothetical protein 0.0135 0.0288 0.0288
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0085 0.0114 0.0314
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0135 0.0288 0.0498
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0085 0.0114 0.1037
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0092 0.0138 0.0083
Schistosoma mansoni sulfide quinone reductase 0.0085 0.0114 0.0114
Loa Loa (eye worm) MH2 domain-containing protein 0.1713 0.5748 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.2333 0.7893 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0117 0.0225 0.0225
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0085 0.0114 0.0151
Onchocerca volvulus 0.024 0.065 0.9234
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0085 0.0114 0.0151
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0085 0.0114 0.0151
Brugia malayi MH1 domain containing protein 0.0065 0.0045 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0455 0.4807
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0068 0.0056 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0524 0.557
Loa Loa (eye worm) hypothetical protein 0.0135 0.0288 0.0498
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0273 0.0766 1
Trichomonas vaginalis glutamate synthase, putative 0.0085 0.0114 0.1037
Entamoeba histolytica hypothetical protein 0.0108 0.0195 0.1235
Brugia malayi glutamate synthase 0.0085 0.0114 0.0195
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0225 0.0389
Echinococcus multilocularis thioredoxin glutathione reductase 0.0928 0.3031 0.406
Loa Loa (eye worm) hypothetical protein 0.0065 0.0047 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0524 0.557
Plasmodium falciparum glutathione reductase 0.092 0.3005 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0273 0.0766 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.0631 0.0664

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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