Detailed information for compound 620882

Basic information

Technical information
  • TDR Targets ID: 620882
  • Name: 7-methoxy-3-(4-methoxyphenyl)chromen-2-one
  • MW: 282.291 | Formula: C17H14O4
  • H donors: 0 H acceptors: 1 LogP: 3.49 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1cc2ccc(cc2oc1=O)OC
  • InChi: 1S/C17H14O4/c1-19-13-6-3-11(4-7-13)15-9-12-5-8-14(20-2)10-16(12)21-17(15)18/h3-10H,1-2H3
  • InChiKey: FLTZDSVIFBIENN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-methoxy-3-(4-methoxyphenyl)-2-chromenone
  • 7-methoxy-3-(4-methoxyphenyl)coumarin
  • ZINC00058064
  • ST056234

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0153 0.0935 0.3061
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0041 0.0125 0.0143
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0041 0.0125 0.0143
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0136 0.0316
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0041 0.0125 0.0143
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0046 0.0161 0.0125
Schistosoma mansoni tar DNA-binding protein 0.0395 0.2682 0.267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0136 0.0812 0.8668
Schistosoma mansoni glutamate synthase 0.0041 0.0125 0.0107
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0041 0.0125 0.1169
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0108 0.0613 0.1986
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0468 0.4917
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0112 0.0642 0.1494
Loa Loa (eye worm) Smad1 0.0042 0.0136 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0612 0.648
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0046 0.0161 0.0478
Entamoeba histolytica hypothetical protein 0.0076 0.0381 0.4579
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0041 0.0125 0.0143
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0136 0.0812 1
Loa Loa (eye worm) glutathione reductase 0.0441 0.3014 0.7017
Brugia malayi hypothetical protein 0.0076 0.0381 0.0888
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0153 0.0935 0.2803
Trichomonas vaginalis glutamate synthase, putative 0.0041 0.0125 0.1169
Loa Loa (eye worm) thioredoxin reductase 0.0441 0.3014 0.7017
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0125 0.1169
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0153 0.0935 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0161 0.1563
Loa Loa (eye worm) hypothetical protein 0.0102 0.057 0.1328
Leishmania major trypanothione reductase 0.0441 0.3014 1
Trypanosoma cruzi trypanothione reductase, putative 0.0153 0.0935 0.3061
Echinococcus granulosus tar DNA binding protein 0.0395 0.2682 0.3564
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0561 0.5929
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0085
Brugia malayi RNA binding protein 0.0395 0.2682 0.6244
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0038 0.0231
Toxoplasma gondii target of rapamycin (TOR), putative 0.0101 0.0561 0.1815
Mycobacterium tuberculosis Probable oxidoreductase 0.1118 0.7901 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0153 0.0935 0.2803
Loa Loa (eye worm) hypothetical protein 0.0069 0.0329 0.0765
Schistosoma mansoni smad1 5 8 and 0.0042 0.0136 0.0119
Echinococcus multilocularis smad 0.0042 0.0136 0.0159
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0337 0.0784
Trypanosoma cruzi NADH dehydrogenase, putative 0.0041 0.0125 0.0358
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0153 0.0935 1
Schistosoma mansoni smad1 5 8 and 0.0042 0.0136 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0153 0.0935 0.3061
Brugia malayi Bromodomain containing protein 0.0037 0.0101 0.0235
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0056 0.0239 0.074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.049 0.5148
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0395 0.2682 0.6244
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1005 0.7091 0.8958
Brugia malayi MH1 domain containing protein 0.0042 0.0136 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.036 0.3741
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0361 0.375
Loa Loa (eye worm) hypothetical protein 0.0028 0.0032 0.0074
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0153 0.0935 0.3061
Brugia malayi Thioredoxin reductase 0.0441 0.3014 0.7017
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0153 0.0935 0.3061
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0153 0.0935 0.1042
Plasmodium falciparum glutathione reductase 0.0153 0.0935 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0561 0.5929
Schistosoma mansoni tar DNA-binding protein 0.0395 0.2682 0.267
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0136 0.0812 0.1891
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0561 0.5929
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0041 0.0125 0.1349
Schistosoma mansoni glutamate synthase 0.0041 0.0125 0.0107
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0041 0.0125 0.0358
Loa Loa (eye worm) hypothetical protein 0.0032 0.0065 0.0152
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0084 0.009
Entamoeba histolytica hypothetical protein 0.0076 0.0381 0.4579
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0136 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0561 0.5929
Schistosoma mansoni smad1 5 8 and 0.0042 0.0136 0.0119
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0136 0.0812 0.2653
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1118 0.7901 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.057 0.1328
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0136 0.0812 0.1063
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0046 0.0161 0.0192
Toxoplasma gondii NADPH-glutathione reductase 0.0153 0.0935 0.3061
Echinococcus multilocularis musashi 0.0028 0.0036 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0116 0.0669 0.7105
Mycobacterium tuberculosis Probable dehydrogenase 0.1005 0.7091 0.8958
Loa Loa (eye worm) transcription factor SMAD2 0.0618 0.4296 1
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0041 0.0125 0.1349
Brugia malayi hypothetical protein 0.0151 0.0921 0.2145
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0153 0.0935 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0561 0.5929
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0136 0.0119
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1005 0.7091 0.8958
Brugia malayi glutathione reductase 0.0441 0.3014 0.7017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.036 0.3741
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0041 0.0125 0.0358
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0041 0.0125 0.0143
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0041 0.0125 0.0143
Loa Loa (eye worm) hypothetical protein 0.0041 0.0125 0.029
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0041 0.0125 0.0358
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0381 0.0365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0418 0.4365
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0041 0.0125 0.0143
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0136 0.0812 0.238
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1118 0.7901 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0136 0.0812 0.8668
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0136 0.0812 0.2653
Toxoplasma gondii thioredoxin reductase 0.0441 0.3014 1
Echinococcus multilocularis glutamate synthase 0.0041 0.0125 0.0143
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0161 0.0374
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0112 0.0642 0.1494
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0612 0.648
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0153 0.0935 0.2803
Schistosoma mansoni bromodomain containing protein 0.0062 0.0276 0.026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0033 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0361 0.375
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0065 0.0064
Schistosoma mansoni sulfide quinone reductase 0.0041 0.0125 0.0107
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0017 0.004
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1005 0.7091 0.8958
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0041 0.0125 0.0358
Schistosoma mansoni glutamate synthase 0.0041 0.0125 0.0107
Onchocerca volvulus 0.0041 0.0125 0.0962
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0153 0.0935 0.3061
Echinococcus granulosus glutamate synthase 0.0041 0.0125 0.0143
Loa Loa (eye worm) hypothetical protein 0.0042 0.0131 0.0306
Echinococcus multilocularis thioredoxin glutathione reductase 0.0443 0.3033 0.4033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0612 0.648
Echinococcus multilocularis Smad4 0.0042 0.0136 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0561 0.5929
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0064 0.0296 0.0929
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0041 0.0125 0.0358
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0153 0.0935 0.3061
Schistosoma mansoni intermediate filament proteins 0.0028 0.0036 0.0019
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0041 0.0125 0.0358
Loa Loa (eye worm) hypothetical protein 0.0155 0.0953 0.2219
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0041 0.0125 0.0358
Echinococcus multilocularis tumor protein p63 0.1061 0.7495 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0161 0.1563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0612 0.648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0161 0.1563
Brugia malayi glutamate synthase 0.0041 0.0125 0.029
Loa Loa (eye worm) hypothetical protein 0.007 0.0337 0.0784
Plasmodium falciparum glutathione reductase 0.0441 0.3014 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0136 0.0812 0.1063
Echinococcus granulosus Smad4 0.0042 0.0136 0.0159
Schistosoma mansoni hypothetical protein 0.0032 0.0065 0.0048
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0041 0.0125 0.0143
Brugia malayi intermediate filament protein 0.0028 0.0036 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.036 0.3741
Brugia malayi MH2 domain containing protein 0.0042 0.0136 0.0316
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0041 0.0125 0.1169
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0041 0.0125 0.029
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0125 0.1169
Schistosoma mansoni hypothetical protein 0.0032 0.0065 0.0048
Entamoeba histolytica disulphide oxidoreductase, putative 0.0041 0.0125 0.1349
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0125 0.1169
Schistosoma mansoni hypothetical protein 0.007 0.0337 0.032
Echinococcus granulosus tumor protein p63 0.1061 0.7495 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0041 0.0125 0.029
Entamoeba histolytica hypothetical protein 0.0076 0.0381 0.4579
Schistosoma mansoni sulfide quinone reductase 0.0041 0.0125 0.0107
Entamoeba histolytica thioredoxin reductase, putative 0.0041 0.0125 0.1349
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.057 0.1328
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0036 0.0085
Schistosoma mansoni tar DNA-binding protein 0.0395 0.2682 0.267
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0041 0.0125 0.029
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0381 0.0487
Giardia lamblia GTOR 0.0136 0.0812 0.8491
Echinococcus granulosus GPCR family 2 0.0032 0.0065 0.0064
Echinococcus multilocularis tar DNA binding protein 0.0395 0.2682 0.3564
Loa Loa (eye worm) MH2 domain-containing protein 0.0618 0.4296 1
Loa Loa (eye worm) RNA binding protein 0.0395 0.2682 0.6244
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0041 0.0125 0.0358
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0065 0.0064
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0153 0.0935 0.3061
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0046 0.0161 0.0478
Trichomonas vaginalis mercuric reductase, putative 0.0153 0.0935 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0046 0.0161 0.0478
Loa Loa (eye worm) hypothetical protein 0.004 0.0118 0.0275
Echinococcus multilocularis lamin 0.0028 0.0036 0.0025
Trypanosoma brucei NADH dehydrogenase 0.0041 0.0125 0.0358
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0153 0.0935 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0136 0.0812 0.1891
Plasmodium falciparum thioredoxin reductase 0.0441 0.3014 1
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0041 0.0125 0.1349
Mycobacterium tuberculosis Probable reductase 0.1005 0.7091 0.8958
Onchocerca volvulus 0.0151 0.0921 0.9649
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0041 0.0125 0.0358
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.004
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0153 0.0935 0.2803
Brugia malayi MH1 domain containing protein 0.0042 0.0136 0.0316
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0153 0.0935 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0046 0.0161 0.0192
Brugia malayi RNA recognition motif domain containing protein 0.0395 0.2682 0.6244
Trypanosoma cruzi trypanothione reductase, putative 0.0441 0.3014 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0153 0.0935 0.2803
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0136 0.0316
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1005 0.7091 0.8958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0361 0.375
Echinococcus granulosus lamin dm0 0.0028 0.0036 0.0025
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0084 0.009
Schistosoma mansoni cellular tumor antigen P53 0.0155 0.0953 0.0938
Trichomonas vaginalis apoptosis inducing factor, putative 0.0041 0.0125 0.1169
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0136 0.0812 0.238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0161 0.1563
Schistosoma mansoni hypothetical protein 0.0032 0.0065 0.0048
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0041 0.0125 0.0143
Treponema pallidum NADH oxidase 0.0153 0.0935 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0136 0.0812 0.2653
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0041 0.0125 0.1349
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0136 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0095 0.0846
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0161 0.0374
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0136 0.0812 0.0797
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0153 0.0935 1
Schistosoma mansoni hypothetical protein 0.0041 0.0125 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0418 0.4365
Loa Loa (eye worm) hypothetical protein 0.0151 0.0921 0.2145
Schistosoma mansoni hypothetical protein 0.0032 0.0065 0.0048
Trypanosoma brucei trypanothione reductase 0.0441 0.3014 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0153 0.0935 0.2803
Brugia malayi Bromodomain containing protein 0.0073 0.0359 0.0835
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0041 0.0125 0.029
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0153 0.0935 0.3061
Brugia malayi MH2 domain containing protein 0.0618 0.4296 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0125 0.1169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0612 0.648
Trichomonas vaginalis glutathione reductase, putative 0.0153 0.0935 1
Entamoeba histolytica hypothetical protein 0.0076 0.0381 0.4579
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0036 0.0085
Toxoplasma gondii selenide, water dikinase 0.0041 0.0125 0.0358
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0041 0.0125 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0412 0.4302
Schistosoma mansoni lamin 0.0028 0.0036 0.0019
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0041 0.0125 0.0358
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0036 0.0085
Giardia lamblia NADH oxidase lateral transfer candidate 0.0153 0.0935 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0108 0.0613 0.1986
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0041 0.0125 0.0143
Schistosoma mansoni lamin 0.0028 0.0036 0.0019
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0041 0.0125 0.1169
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0041 0.0125 0.0358
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1118 0.7901 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0038 0.009
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0125 0.1169
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0381 0.0487
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0017 0.004
Echinococcus granulosus smad 0.0042 0.0136 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0561 0.5929
Schistosoma mansoni disulfide oxidoreductase 0.0041 0.0125 0.0107
Plasmodium vivax thioredoxin reductase, putative 0.0441 0.3014 1
Echinococcus multilocularis GPCR, family 2 0.0032 0.0065 0.0064
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0065 0.0152
Loa Loa (eye worm) TAR-binding protein 0.0395 0.2682 0.6244
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0251 0.0313
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0153 0.0935 0.3061
Loa Loa (eye worm) programmed cell death 8 0.0041 0.0125 0.029
Brugia malayi MH2 domain containing protein 0.0042 0.0136 0.0316
Schistosoma mansoni smad 0.0042 0.0136 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0136 0.0812 0.8668
Echinococcus multilocularis lamin dm0 0.0028 0.0036 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0361 0.375
Schistosoma mansoni tar DNA-binding protein 0.0395 0.2682 0.267
Brugia malayi Smad1 0.0042 0.0136 0.0316
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0065 0.0152
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0441 0.3014 0.3716
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0153 0.0935 0.0919
Trichomonas vaginalis glutamate synthase, putative 0.0041 0.0125 0.1169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0161 0.1563
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0041 0.0125 0.0143
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0136 0.0812 0.2653
Plasmodium vivax glutathione reductase, putative 0.0441 0.3014 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0251 0.0313
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0041 0.0125 0.0358
Leishmania major phosphatidylinositol 3-kinase, putative 0.0046 0.0161 0.0125
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0125 0.0358
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0153 0.0935 0.1227
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0136 0.0159
Schistosoma mansoni hypothetical protein 0.0076 0.0381 0.0365
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0153 0.0935 0.3061
Loa Loa (eye worm) hypothetical protein 0.0037 0.0101 0.0236
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0041 0.0125 0.1349
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0153 0.0935 0.3061
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0153 0.0935 0.3061
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0153 0.0935 1
Schistosoma mansoni Smad4 0.0042 0.0136 0.0119
Echinococcus granulosus thioredoxin glutathione reductase 0.0443 0.3033 0.4033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0418 0.4365
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0065 0.0152
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0136 0.0159
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0041 0.0125 0.0358
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0125 0.1169
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0029 0.0038 0.0071
Schistosoma mansoni tar DNA-binding protein 0.0395 0.2682 0.267
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0136 0.0812 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0153 0.0935 0.3061
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0153 0.0935 1
Onchocerca volvulus 0.0155 0.0953 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1005 0.7091 0.8958
Plasmodium falciparum thioredoxin reductase 0.0153 0.0935 0.2803
Trypanosoma cruzi NADH dehydrogenase, putative 0.0041 0.0125 0.0358
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.057 0.1328
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0108 0.0613 0.1689
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0041 0.0125 0.1169
Echinococcus granulosus lamin 0.0028 0.0036 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0125 0.0358
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0041 0.0125 0.0358
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0046 0.0161 0.0478
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0065 0.0064
Brugia malayi PHD-finger family protein 0.0024 0.0007 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0125 0.0358
Echinococcus granulosus intermediate filament protein 0.0028 0.0036 0.0025
Brugia malayi TAR-binding protein 0.0395 0.2682 0.6244
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0065 0.0064
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0153 0.0935 0.2176
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0412 0.4302
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0153 0.0935 0.1227
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0046 0.0161 0.0144

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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