Detailed information for compound 620890

Basic information

Technical information
  • TDR Targets ID: 620890
  • Name: 3-(3,4-dimethoxyphenyl)-7-(2-methylprop-2-eno xy)chromen-2-one
  • MW: 352.381 | Formula: C21H20O5
  • H donors: 0 H acceptors: 1 LogP: 4.73 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)c1cc2ccc(cc2oc1=O)OCC(=C)C
  • InChi: 1S/C21H20O5/c1-13(2)12-25-16-7-5-15-9-17(21(22)26-19(15)11-16)14-6-8-18(23-3)20(10-14)24-4/h5-11H,1,12H2,2-4H3
  • InChiKey: BBBDBEKMCJAACQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(3,4-dimethoxyphenyl)-7-(2-methylprop-2-enoxy)-2-chromenone
  • 3-(3,4-dimethoxyphenyl)-7-(2-methylprop-2-enoxy)coumarin
  • ZINC01317664

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0128
Echinococcus multilocularis thioredoxin glutathione reductase 0.0263 0.2984 0.3712
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0024 0.0055 0.0184
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0091 0.087 0.2936
Echinococcus multilocularis tar DNA binding protein 0.0194 0.2145 0.2664
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0093 0.0899 0.2998
Schistosoma mansoni intermediate filament proteins 0.0029 0.0117 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0434 0.4826
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0066 0.0729
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0899 1
Echinococcus granulosus tumor protein p63 0.0672 0.8012 1
Schistosoma mansoni Smad4 0.0025 0.0066 0.0051
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0066 0.0155
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0091 0.087 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0194 0.2145 0.5041
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0093 0.0899 0.2998
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0024 0.0055 0.0607
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0024 0.0055 0.0049
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0024 0.0055 0.0445
Plasmodium vivax thioredoxin reductase, putative 0.0261 0.2965 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0024 0.0055 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0666 0.7408
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0091 0.087 0.1069
Schistosoma mansoni lamin 0.0029 0.0117 0.0102
Mycobacterium tuberculosis Probable dehydrogenase 0.0596 0.7071 0.8964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0607 0.6753
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0024 0.0055 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0375 0.4171
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0024 0.0055 0.046
Trichomonas vaginalis apoptosis inducing factor, putative 0.0024 0.0055 0.0607
Echinococcus multilocularis smad 0.0025 0.0066 0.0064
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0064 0.0165
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0024 0.0055 0.0133
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0066 0.0051
Loa Loa (eye worm) glutathione reductase 0.0261 0.2965 0.6967
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0024 0.0055 0.0133
Leishmania major phosphatidylinositol 3-kinase, putative 0.0031 0.0142 0.043
Schistosoma mansoni glutamate synthase 0.0024 0.0055 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0434 0.4826
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0055 0.0607
Echinococcus multilocularis lamin 0.0029 0.0117 0.0127
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0091 0.087 1
Mycobacterium tuberculosis Probable reductase 0.0596 0.7071 0.8964
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0375 0.4171
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0374 0.4161
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0024 0.0055 0.0093
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0064 0.0165
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0024 0.0055 0.0133
Echinococcus multilocularis glutamate synthase 0.0024 0.0055 0.0049
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0024 0.0055 0.0049
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0596 0.7071 0.8964
Schistosoma mansoni tar DNA-binding protein 0.0194 0.2145 0.2133
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0091 0.087 0.2899
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0091 0.087 0.2803
Loa Loa (eye worm) phosphatidylinositol 3 0.0093 0.0899 0.2114
Schistosoma mansoni tar DNA-binding protein 0.0194 0.2145 0.2133
Schistosoma mansoni smad1 5 8 and 0.0025 0.0066 0.0051
Leishmania major hypothetical protein, conserved 0.0024 0.0055 0.0133
Echinococcus granulosus Smad4 0.0025 0.0066 0.0064
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0968 0.0954
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0093 0.0899 0.2998
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0031 0.0142 0.0127
Entamoeba histolytica hypothetical protein 0.0072 0.0638 0.7048
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0024 0.0055 0.0184
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0091 0.087 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0666 0.7408
Mycobacterium ulcerans monoxygenase 0.0024 0.0055 0.046
Schistosoma mansoni hypothetical protein 0.0024 0.0055 0.0039
Trypanosoma cruzi trypanothione reductase, putative 0.0091 0.087 0.2899
Entamoeba histolytica hypothetical protein 0.0072 0.0638 0.7048
Brugia malayi MH1 domain containing protein 0.0025 0.0066 0.012
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0091 0.087 0.2899
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0066 0.0576 0.1322
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0055 0.0607
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0091 0.087 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0064 0.0032
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0117 0.0274
Echinococcus multilocularis musashi 0.0029 0.0117 0.0127
Brugia malayi hypothetical protein 0.0232 0.2612 0.6124
Mycobacterium ulcerans dehydrogenase 0.0024 0.0055 0.046
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0142 0.0334
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0024 0.0055 0.005
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0024 0.0055 0.0049
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.042 0.0986
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0024 0.0055 0.0184
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0024 0.0055 0.0049
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0091 0.087 0.2899
Echinococcus multilocularis Smad4 0.0025 0.0066 0.0064
Loa Loa (eye worm) hypothetical protein 0.0098 0.0968 0.2274
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0117 0.0274
Loa Loa (eye worm) thioredoxin reductase 0.0261 0.2965 0.6967
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0024 0.0055 0.046
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0091 0.087 0.2899
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0024 0.0055 0.0093
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0091 0.087 0.1086
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0093 0.0899 0.2998
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0375 0.4171
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0024 0.0055 0.005
Echinococcus granulosus glutamate synthase 0.0024 0.0055 0.0049
Giardia lamblia GTOR 0.0093 0.0899 1
Brugia malayi TAR-binding protein 0.0194 0.2145 0.5023
Giardia lamblia Glutamate synthase 0.0024 0.0055 0.0445
Loa Loa (eye worm) transcription factor SMAD2 0.0366 0.4255 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0031 0.0142 0.043
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0024 0.0055 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0899 1
Mycobacterium ulcerans glutamate synthase subunit beta 0.0024 0.0055 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0441 0.4901
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0638 0.0624
Echinococcus granulosus thioredoxin glutathione reductase 0.0263 0.2984 0.3712
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0662 0.7887 1
Brugia malayi RNA binding protein 0.0194 0.2145 0.5023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0274
Schistosoma mansoni survival motor neuron protein 0.0047 0.0342 0.0327
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0596 0.7071 0.8964
Loa Loa (eye worm) Smad1 0.0025 0.0066 0.0155
Schistosoma mansoni sulfide quinone reductase 0.0024 0.0055 0.0039
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0066 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0607 0.6753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0607 0.6753
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0024 0.0055 0.0133
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0093 0.0899 0.2085
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0055 0.0133
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0064 0.0032
Echinococcus granulosus intermediate filament protein 0.0029 0.0117 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0666 0.7408
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.042 0.0954
Schistosoma mansoni glutamate synthase 0.0024 0.0055 0.0039
Trichomonas vaginalis glutamate synthase, putative 0.0024 0.0055 0.0607
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0093 0.0899 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0091 0.087 0.2899
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0091 0.087 1
Leishmania major hypothetical protein, conserved 0.0024 0.0055 0.0133
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0024 0.0055 0.0445
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0638 0.0779
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0055 0.0133
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0064 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0194 0.2145 0.2133
Echinococcus granulosus tar DNA binding protein 0.0194 0.2145 0.2664
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0064 0.0215
Trypanosoma cruzi target of rapamycin kinase 3 0.0074 0.0667 0.221
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0015 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0733 0.8147
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0024 0.0055 0.046
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0024 0.0055 0.0128
Schistosoma mansoni smad 0.0025 0.0066 0.0051
Leishmania major hypothetical protein, conserved 0.0024 0.0055 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0375 0.4171
Brugia malayi RNA recognition motif domain containing protein 0.0194 0.2145 0.5023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0142 0.1579
Brugia malayi hypothetical protein 0.0025 0.0064 0.0115
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0211 0.0461
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0091 0.087 0.2899
Entamoeba histolytica thioredoxin reductase, putative 0.0024 0.0055 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0441 0.4901
Loa Loa (eye worm) programmed cell death 8 0.0024 0.0055 0.0128
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0142 0.043
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0091 0.087 0.2899
Brugia malayi MH2 domain containing protein 0.0366 0.4255 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0069 0.0607 0.2049
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0036
Brugia malayi MH2 domain containing protein 0.0025 0.0066 0.012
Brugia malayi hypothetical protein 0.0149 0.1592 0.3718
Loa Loa (eye worm) hypothetical protein 0.0054 0.042 0.0986
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0044 0.0299 0.0961
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0055 0.0607
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0024 0.0055 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0899 1
Plasmodium vivax glutathione reductase, putative 0.0261 0.2965 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0596 0.7071 0.8964
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0093 0.0899 0.1106
Brugia malayi Smad1 0.0025 0.0066 0.012
Echinococcus granulosus lamin 0.0029 0.0117 0.0127
Trichomonas vaginalis mercuric reductase, putative 0.0091 0.087 0.9677
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0596 0.7071 0.8958
Toxoplasma gondii NADPH-glutathione reductase 0.0091 0.087 0.2936
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0015 0.0036
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0024 0.0055 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0374 0.4161
Echinococcus granulosus smad 0.0025 0.0066 0.0064
Onchocerca volvulus 0.0098 0.0968 0.5939
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0024 0.0055 0.046
Schistosoma mansoni tar DNA-binding protein 0.0194 0.2145 0.2133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0666 0.7408
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0064 0.0165
Loa Loa (eye worm) hypothetical protein 0.0037 0.0211 0.0495
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0024 0.0055 0.0049
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0261 0.2965 0.3747
Mycobacterium ulcerans ferredoxin reductase 0.0024 0.0055 0.046
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0024 0.0055 0.0607
Entamoeba histolytica hypothetical protein 0.0072 0.0638 0.7048
Plasmodium falciparum thioredoxin reductase 0.0261 0.2965 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0024 0.0055 0.0184
Onchocerca volvulus 0.0149 0.1592 1
Toxoplasma gondii selenide, water dikinase 0.0024 0.0055 0.0184
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0066 0.0155
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0662 0.7887 1
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0055 0.0133
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0091 0.087 0.2899
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0024 0.0055 0.0133
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0024 0.0055 0.0049
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0091 0.087 0.0857
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0091 0.087 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0024 0.0055 0.0133
Loa Loa (eye worm) TAR-binding protein 0.0194 0.2145 0.5041
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0093 0.0899 0.2998
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0374 0.4161
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0055 0.0607
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0091 0.087 0.2803
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0091 0.087 0.2899
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0117 0.0239
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0024 0.0055 0.046
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0024 0.0055 0.005
Schistosoma mansoni tar DNA-binding protein 0.0194 0.2145 0.2133
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.05 0.5555
Schistosoma mansoni sulfide quinone reductase 0.0024 0.0055 0.0039
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0091 0.087 0.2899
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.2612 0.3247
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0066 0.0064
Schistosoma mansoni disulfide oxidoreductase 0.0024 0.0055 0.0039
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0039 0.0233 0.0739
Mycobacterium ulcerans NADH dehydrogenase 0.0024 0.0055 0.046
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0024 0.0055 0.0607
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0093 0.0899 0.2998
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0142 0.043
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0031 0.0142 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0441 0.4901
Plasmodium falciparum thioredoxin reductase 0.0091 0.087 0.2803
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.042 0.0954
Schistosoma mansoni hypothetical protein 0.0047 0.0342 0.0327
Mycobacterium ulcerans hypothetical protein 0.0024 0.0055 0.046
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0091 0.087 0.2899
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0091 0.087 0.2899
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0091 0.087 0.2899
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0055 0.0607
Trichomonas vaginalis glutamate synthase, putative 0.0024 0.0055 0.0607
Trypanosoma cruzi NADH dehydrogenase, putative 0.0024 0.0055 0.0133
Loa Loa (eye worm) MH2 domain-containing protein 0.0366 0.4255 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.011 0.0259
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0024 0.0055 0.0133
Schistosoma mansoni smad1 5 8 and 0.0025 0.0066 0.0051
Mycobacterium tuberculosis Probable oxidoreductase 0.0662 0.7887 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0091 0.087 0.2017
Onchocerca volvulus 0.0029 0.0117 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0524 0.5829
Loa Loa (eye worm) hypothetical protein 0.0149 0.1592 0.3741
Brugia malayi MH2 domain containing protein 0.0025 0.0066 0.012
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0066 0.0064
Onchocerca volvulus 0.0047 0.0342 0.1866
Trypanosoma cruzi trypanothione reductase, putative 0.0261 0.2965 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0342 0.077
Echinococcus granulosus lamin dm0 0.0029 0.0117 0.0127
Plasmodium falciparum glutathione reductase 0.0091 0.087 0.2803
Trypanosoma brucei trypanothione reductase 0.0261 0.2965 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0596 0.7071 0.8964
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0091 0.087 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0142 0.1579
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0093 0.0899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0142 0.1579
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0024 0.0055 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0607 0.6753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0142 0.1579
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0662 0.7887 1
Echinococcus multilocularis lamin dm0 0.0029 0.0117 0.0127
Schistosoma mansoni hypothetical protein 0.0037 0.0211 0.0196
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0024 0.0055 0.0445
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0031 0.0142 0.0159
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0142 0.0299
Schistosoma mansoni hypothetical protein 0.0072 0.0638 0.0624
Giardia lamblia Thioredoxin reductase 0.0024 0.0055 0.0445
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0093 0.0899 0.1106
Treponema pallidum NADH oxidase 0.0091 0.087 1
Trypanosoma brucei NADH dehydrogenase 0.0024 0.0055 0.0133
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0091 0.087 0.1069
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0024 0.0055 0.0445
Toxoplasma gondii thioredoxin reductase 0.0261 0.2965 1
Brugia malayi hypothetical protein 0.0072 0.0638 0.147
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0638 0.0779
Loa Loa (eye worm) RNA binding protein 0.0194 0.2145 0.5041
Entamoeba histolytica hypothetical protein 0.0072 0.0638 0.7048
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.2612 0.3247
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0091 0.087 0.2899
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0066 0.0064
Leishmania major NADH dehydrogenase, putative 0.0024 0.0055 0.0133
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0015 0.017
Trichomonas vaginalis glutathione reductase, putative 0.0091 0.087 0.9677
Schistosoma mansoni glutamate synthase 0.0024 0.0055 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0607 0.6753
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0024 0.0055 0.0049
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0093 0.0899 0.0886
Giardia lamblia NADH oxidase lateral transfer candidate 0.0091 0.087 0.9672
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0091 0.087 0.2899
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0024 0.0055 0.0133
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0031 0.0142 0.0159
Entamoeba histolytica disulphide oxidoreductase, putative 0.0024 0.0055 0.0445
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0074 0.0667 0.221
Loa Loa (eye worm) hypothetical protein 0.0232 0.2612 0.6138
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0031 0.0142 0.043
Trypanosoma cruzi NADH dehydrogenase, putative 0.0024 0.0055 0.0133
Schistosoma mansoni smad1 5 8 and 0.0025 0.0066 0.0051
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0024 0.0055 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0142 0.1579
Brugia malayi glutathione reductase 0.0261 0.2965 0.6956
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0024 0.0055 0.0049
Brugia malayi intermediate filament protein 0.0029 0.0117 0.0239
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0024 0.0055 0.005
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0055 0.0607
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0024 0.0055 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0666 0.7408
Echinococcus multilocularis tumor protein p63 0.0672 0.8012 1
Leishmania major hypothetical protein, conserved 0.0025 0.0064 0.0165
Leishmania major trypanothione reductase 0.0261 0.2965 1
Brugia malayi glutamate synthase 0.0024 0.0055 0.0093
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0024 0.0055 0.005
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0024 0.0055 0.0607
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0091 0.087 1
Schistosoma mansoni lamin 0.0029 0.0117 0.0102
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0024 0.0055 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0607 0.6753
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0066 0.0576 0.1322
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0024 0.0055 0.0049
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0024 0.0055 0.046
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0024 0.0055 0.005
Brugia malayi MH1 domain containing protein 0.0025 0.0066 0.012
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0024 0.0055 0.0184
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0074 0.0667 0.221
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0091 0.087 0.2899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0607 0.6753
Plasmodium falciparum glutathione reductase 0.0261 0.2965 1
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0024 0.0055 0.0049
Brugia malayi Thioredoxin reductase 0.0261 0.2965 0.6956
Onchocerca volvulus 0.0029 0.0117 0.0404

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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