Detailed information for compound 620902

Basic information

Technical information
  • TDR Targets ID: 620902
  • Name: tert-butyl 2-[3-(3,4-dimethoxyphenyl)-4-methy l-2-oxochromen-6-yl]oxyacetate
  • MW: 426.459 | Formula: C24H26O7
  • H donors: 0 H acceptors: 2 LogP: 4.28 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)c1c(=O)oc2c(c1C)cc(cc2)OCC(=O)OC(C)(C)C
  • InChi: 1S/C24H26O7/c1-14-17-12-16(29-13-21(25)31-24(2,3)4)8-10-18(17)30-23(26)22(14)15-7-9-19(27-5)20(11-15)28-6/h7-12H,13H2,1-6H3
  • InChiKey: NYULXCIXLIIHJO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • tert-butyl 2-[3-(3,4-dimethoxyphenyl)-4-methyl-2-oxo-chromen-6-yl]oxyacetate
  • 2-[[3-(3,4-dimethoxyphenyl)-4-methyl-2-oxo-6-chromenyl]oxy]acetic acid tert-butyl ester
  • 2-[3-(3,4-dimethoxyphenyl)-2-keto-4-methyl-chromen-6-yl]oxyacetic acid tert-butyl ester
  • tert-butyl 2-[3-(3,4-dimethoxyphenyl)-4-methyl-2-oxo-chromen-6-yl]oxyethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.0161 0.0389
Brugia malayi MH1 domain containing protein 0.0027 0.0031 0.0075
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.014 0.0338
Loa Loa (eye worm) hypothetical protein 0.0025 0.0019 0.0046
Echinococcus multilocularis lamin dm0 0.0055 0.0191 0.0331
Echinococcus multilocularis mothers against decapentaplegic 5 0.005 0.0161 0.0279
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.006 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0105 0.0486 0.1176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0304 0.212
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0188 0.0968 0.3136
Echinococcus multilocularis smad 0.005 0.0161 0.0279
Plasmodium falciparum thioredoxin reductase 0.0541 0.3038 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0188 0.0968 0.2858
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.005 0.0162 0.2143
Onchocerca volvulus 0.0032 0.0057 0.0421
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0137 0.0673 0.2159
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.005 0.0162 0.105
Schistosoma mansoni hypothetical protein 0.0032 0.006 0.006
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0137 0.0673 0.1168
Echinococcus multilocularis tumor protein p63 0.1007 0.5762 1
Loa Loa (eye worm) hypothetical protein 0.0253 0.1348 0.3264
Schistosoma mansoni hypothetical protein 0.0038 0.0095 0.0095
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.005 0.0087
Trichomonas vaginalis disulfide oxidoreductase, putative 0.005 0.0162 0.105
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.005 0.0162 0.0391
Leishmania major hypothetical protein, conserved 0.005 0.0162 0.0076
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0101 0.0176
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.0161 0.0389
Schistosoma mansoni smad1 5 8 and 0.005 0.0161 0.0161
Brugia malayi glutamate synthase 0.005 0.0162 0.0391
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0046 0.014 0.014
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.005 0.0162 0.028
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0188 0.0968 0.168
Schistosoma mansoni tar DNA-binding protein 0.0379 0.2089 0.2089
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0188 0.0968 0.3136
Echinococcus multilocularis GPCR, family 2 0.0032 0.006 0.0103
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0188 0.0968 0.2858
Plasmodium falciparum glutathione reductase 0.0541 0.3038 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.006 0.0144
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0188 0.0968 0.3136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0086 0.0478
Schistosoma mansoni smad 0.005 0.0161 0.0161
Trypanosoma cruzi trypanothione reductase, putative 0.0188 0.0968 0.3136
Schistosoma mansoni intermediate filament proteins 0.0055 0.0191 0.0191
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.005 0.0162 0.028
Schistosoma mansoni hypothetical protein 0.0043 0.0125 0.0125
Brugia malayi PHD-finger family protein 0.0027 0.003 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.0509 0.3663
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0188 0.0968 0.2803
Echinococcus granulosus microtubule associated protein 2 0.067 0.379 0.6578
Echinococcus granulosus lamin 0.0055 0.0191 0.0331
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0057 0.0204 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0345 0.2432
Loa Loa (eye worm) programmed cell death 8 0.005 0.0162 0.0391
Echinococcus granulosus thioredoxin glutathione reductase 0.0546 0.3065 0.5319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.014 0.0883
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0138 0.0677 0.1638
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0188 0.0968 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0102 0.0467 0.1477
Echinococcus granulosus TGF beta signal transducer SmadC 0.005 0.0161 0.0279
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0188 0.0968 0.3136
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0191 0.0462
Plasmodium vivax ferrodoxin reductase, putative 0.005 0.0162 0.0351
Echinococcus multilocularis protein patched 0.0045 0.0134 0.0233
Brugia malayi Thioredoxin reductase 0.0541 0.3038 0.7354
Trichomonas vaginalis glutamate synthase, putative 0.005 0.0162 0.105
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0022 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0379 0.2089 0.2089
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0469 0.1135
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0191 0.0462
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0047 0.0144 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.0673 0.4899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.014 0.0883
Trichomonas vaginalis disulfide oxidoreductase, putative 0.005 0.0162 0.105
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0095 0.0165
Brugia malayi Pre-SET motif family protein 0.0222 0.1171 0.2835
Trichomonas vaginalis disulfide oxidoreductase, putative 0.005 0.0162 0.105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0303 0.2115
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0134 0.0233
Echinococcus multilocularis microtubule associated protein 2 0.067 0.379 0.6578
Entamoeba histolytica hypothetical protein 0.0038 0.0095 0.1122
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0046 0.014 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.0509 0.3663
Loa Loa (eye worm) hypothetical protein 0.0054 0.0185 0.0448
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0167 0.0167
Toxoplasma gondii selenide, water dikinase 0.005 0.0162 0.0463
Schistosoma mansoni smad1 5 8 and 0.005 0.0161 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.0467 0.3351
Schistosoma mansoni hypothetical protein 0.0032 0.006 0.006
Schistosoma mansoni lamin 0.0055 0.0191 0.0191
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0162 0.0463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0345 0.2432
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0188 0.0968 0.3136
Brugia malayi RNA binding protein 0.0379 0.2089 0.5055
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.005 0.0162 0.0463
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.005 0.0162 0.105
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.1171 0.2835
Loa Loa (eye worm) hypothetical protein 0.0042 0.0117 0.0283
Entamoeba histolytica glutamate synthase beta subunit, putative 0.005 0.0162 0.2143
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.005 0.0162 0.028
Schistosoma mansoni patched 1 0.0045 0.0134 0.0134
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0105 0.0486 0.7121
Leishmania major hypothetical protein, conserved 0.005 0.0162 0.0076
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.005 0.0162 0.0463
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1372 0.7903 1
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0162 0.0463
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.005 0.0162 0.028
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0137 0.0673 0.2159
Brugia malayi MH1 domain containing protein 0.005 0.0161 0.0389
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.006 0.0103
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0866 0.4939 0.8572
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.005 0.0162 0.028
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.005 0.0162 0.0463
Entamoeba histolytica thioredoxin reductase, putative 0.005 0.0162 0.2143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.0467 0.3351
Brugia malayi MH1 domain containing protein 0.0027 0.0031 0.0075
Loa Loa (eye worm) phosphatidylinositol 3 0.0137 0.0673 0.1629
Schistosoma mansoni glutamate synthase 0.005 0.0162 0.0162
Brugia malayi hypothetical protein 0.0253 0.1348 0.3264
Trichomonas vaginalis glutathione reductase, putative 0.0188 0.0968 0.7118
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0065 0.025 0.0755
Onchocerca volvulus 0.0147 0.0733 0.5423
Onchocerca volvulus 0.0055 0.0191 0.1414
Echinococcus granulosus sulfide:quinone oxidoreductase 0.005 0.0162 0.028
Trypanosoma brucei NADH dehydrogenase 0.005 0.0162 0.0463
Schistosoma mansoni cellular tumor antigen P53 0.0147 0.0733 0.0733
Brugia malayi glutathione reductase 0.0541 0.3038 0.7354
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.005 0.0162 0.028
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0188 0.0968 0.168
Echinococcus multilocularis expressed conserved protein 0.0099 0.0448 0.0778
Giardia lamblia NADH oxidase lateral transfer candidate 0.0188 0.0968 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.005 0.0161 0.0279
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0188 0.0968 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.0509 0.3663
Brugia malayi Pre-SET motif family protein 0.0032 0.0057 0.0138
Trichomonas vaginalis apoptosis inducing factor, putative 0.005 0.0162 0.105
Schistosoma mansoni hypothetical protein 0.0032 0.006 0.006
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0015 0.0026
Echinococcus granulosus mothers against decapentaplegic 5 0.005 0.0161 0.0279
Brugia malayi RNA recognition motif domain containing protein 0.0379 0.2089 0.5055
Brugia malayi Smad1 0.005 0.0161 0.0389
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.005 0.0162 0.2143
Schistosoma mansoni hypothetical protein 0.0032 0.006 0.006
Treponema pallidum NADH oxidase 0.0188 0.0968 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.005 0.0162 0.105
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.005 0.0162 0.2143
Loa Loa (eye worm) hypothetical protein 0.0147 0.0733 0.1773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0304 0.212
Schistosoma mansoni hypothetical protein 0.0023 0.0003 0.0003
Loa Loa (eye worm) glutathione reductase 0.0541 0.3038 0.7354
Entamoeba histolytica hypothetical protein 0.0038 0.0095 0.1122
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0188 0.0968 0.2858
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0279 0.0676
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0541 0.3038 0.3716
Brugia malayi hypothetical protein 0.0038 0.0095 0.023
Plasmodium falciparum glutathione reductase 0.0188 0.0968 0.2803
Echinococcus granulosus lamin dm0 0.0055 0.0191 0.0331
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.014 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.0467 0.3351
Echinococcus multilocularis musashi 0.0055 0.0191 0.0331
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1234 0.7096 0.8958
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0057 0.0115
Loa Loa (eye worm) hypothetical protein 0.0045 0.0134 0.0325
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0188 0.0968 0.3056
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0188 0.0968 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0137 0.0673 1
Loa Loa (eye worm) Smad1 0.005 0.0161 0.0389
Mycobacterium tuberculosis Probable reductase 0.1234 0.7096 0.8958
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0188 0.0968 0.3136
Schistosoma mansoni hypothetical protein 0.005 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0026 0.0022 0.0053
Leishmania major trypanothione reductase 0.0541 0.3038 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.014 0.0883
Trypanosoma brucei trypanothione reductase 0.0541 0.3038 1
Brugia malayi MH2 domain containing protein 0.0728 0.4131 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.006 0.0103
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.1348 0.234
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.005 0.0162 0.028
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0254 0.0441
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.005 0.0162 0.0463
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.005 0.0162 0.0076
Trypanosoma brucei hypothetical protein, conserved 0.005 0.0162 0.0463
Brugia malayi CHE-14 protein 0.0045 0.0134 0.0325
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0029 0.0039 0.0058
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0188 0.0968 0.3136
Loa Loa (eye worm) hypothetical protein 0.007 0.0279 0.0676
Brugia malayi MH2 domain containing protein 0.005 0.0161 0.0389
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.0167 0.0289
Schistosoma mansoni sulfide quinone reductase 0.005 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0131 0.0636 0.154
Echinococcus multilocularis tar DNA binding protein 0.0379 0.2089 0.3624
Echinococcus multilocularis glutamate synthase 0.005 0.0162 0.028
Loa Loa (eye worm) RNA binding protein 0.0379 0.2089 0.5055
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0003 0.0007
Echinococcus multilocularis Niemann Pick C1 protein 0.0105 0.0486 0.0843
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0188 0.0968 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.035 0.2468
Entamoeba histolytica hypothetical protein 0.0038 0.0095 0.1122
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.005 0.0162 0.0463
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.005 0.0162 0.0463
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.005 0.0162 0.0076
Schistosoma mansoni glutamate synthase 0.005 0.0162 0.0162
Trichomonas vaginalis glutamate synthase, putative 0.005 0.0162 0.105
Entamoeba histolytica hypothetical protein 0.0038 0.0095 0.1122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.0467 0.3351
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.005 0.0162 0.0391
Schistosoma mansoni TGF-beta signal transducer Smad2 0.005 0.0161 0.0161
Mycobacterium tuberculosis Probable dehydrogenase 0.1234 0.7096 0.8958
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.005 0.0162 0.0463
Schistosoma mansoni survival motor neuron protein 0.0052 0.0172 0.0172
Trypanosoma cruzi NADH dehydrogenase, putative 0.005 0.0162 0.0463
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0075
Trypanosoma cruzi trypanothione reductase, putative 0.0541 0.3038 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.0391 0.278
Trichomonas vaginalis mercuric reductase, putative 0.0188 0.0968 0.7118
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.005 0.0162 0.0391
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0026 0.0022 0.0038
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0095 0.0165
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0191 0.0462
Leishmania major NADH dehydrogenase, putative 0.005 0.0162 0.0076
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0046 0.014 0.0242
Echinococcus granulosus expressed conserved protein 0.0099 0.0448 0.0778
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.005 0.0162 0.0463
Loa Loa (eye worm) TAR-binding protein 0.0379 0.2089 0.5055
Leishmania major hypothetical protein, conserved 0.005 0.0162 0.0076
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0188 0.0968 0.3136
Brugia malayi MH2 domain containing protein 0.005 0.0161 0.0389
Loa Loa (eye worm) hypothetical protein 0.005 0.0162 0.0391
Loa Loa (eye worm) hypothetical protein 0.0045 0.0132 0.032
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0046 0.014 0.0242
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.0167 0.0289
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0137 0.0673 0.1629
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0304 0.212
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1234 0.7096 0.8958
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0254 0.0441
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0101 0.0176
Loa Loa (eye worm) MH2 domain-containing protein 0.0728 0.4131 1
Schistosoma mansoni Smad4 0.005 0.0161 0.0161
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0188 0.0968 0.2803
Echinococcus multilocularis lamin 0.0055 0.0191 0.0331
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0026 0.0022 0.0038
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.005 0.0162 0.0463
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.005 0.0162 0.028
Schistosoma mansoni glutamate synthase 0.005 0.0162 0.0162
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1234 0.7096 0.8958
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0046 0.014 0.0389
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0057 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0117 0.0556 0.4016
Echinococcus granulosus intermediate filament protein 0.0055 0.0191 0.0331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.035 0.2468
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0137 0.0673 0.1168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.0673 0.4899
Loa Loa (eye worm) hypothetical protein 0.0025 0.0019 0.0046
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.006 0.0144
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0137 0.0673 0.0673
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.005 0.0162 0.0391
Loa Loa (eye worm) hypothetical protein 0.0026 0.0025 0.0061
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0025 0.0043
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0134 0.0325
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0022 0.0038
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0046 0.014 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.0467 0.3351
Schistosoma mansoni disulfide oxidoreductase 0.005 0.0162 0.0162
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0188 0.0968 0.1042
Brugia malayi Bromodomain containing protein 0.0082 0.0353 0.0853
Echinococcus multilocularis Niemann Pick C1 protein 0.015 0.075 0.1301
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.0495 0.0495
Schistosoma mansoni smad1 5 8 and 0.005 0.0161 0.0161
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.005 0.0162 0.0463
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.005 0.0162 0.028
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0469 0.1135
Echinococcus granulosus smad 0.005 0.0161 0.0279
Echinococcus multilocularis thioredoxin glutathione reductase 0.0546 0.3065 0.5319
Schistosoma mansoni hypothetical protein 0.007 0.0279 0.0279
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1372 0.7903 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.0673 0.4899
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0188 0.0968 0.3136
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0057 0.0099
Plasmodium vivax glutathione reductase, putative 0.0541 0.3038 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0167 0.0403
Echinococcus granulosus tumor protein p63 0.1007 0.5762 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.006 0.0144
Trichomonas vaginalis disulfide oxidoreductase, putative 0.005 0.0162 0.105
Echinococcus multilocularis protein dispatched 1 0.0051 0.0172 0.0298
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.005 0.0162 0.0463
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0469 0.1135
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.0144
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0137 0.0673 0.2159
Schistosoma mansoni hypothetical protein 0.0043 0.0125 0.0125
Entamoeba histolytica disulphide oxidoreductase, putative 0.005 0.0162 0.2143
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0188 0.0968 0.2858
Trypanosoma cruzi target of rapamycin kinase 3 0.0109 0.051 0.1616
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0188 0.0968 0.3136
Schistosoma mansoni hypothetical protein 0.0043 0.0125 0.0125
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0188 0.0968 0.3136
Loa Loa (eye worm) transcription factor SMAD2 0.0728 0.4131 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1234 0.7096 0.8958
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0015 0.0026
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0134 0.0233
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.005 0.0162 0.028
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0137 0.0673 0.1841
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1372 0.7903 1
Onchocerca volvulus 0.0052 0.0172 0.1271
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0188 0.0968 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0109 0.051 0.1616
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0022 0.0053
Loa Loa (eye worm) hypothetical protein 0.0029 0.0039 0.0095
Schistosoma mansoni bromodomain containing protein 0.007 0.0277 0.0277
Echinococcus granulosus Niemann Pick C1 protein 0.015 0.075 0.1301
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.005 0.0162 0.0463
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.005 0.0162 0.0351
Brugia malayi Bromodomain containing protein 0.0042 0.0117 0.0282
Loa Loa (eye worm) hypothetical protein 0.0028 0.0034 0.0082
Echinococcus granulosus glutamate synthase 0.005 0.0162 0.028
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.006 0.0103
Schistosoma mansoni hypothetical protein 0.0052 0.0172 0.0172
Echinococcus granulosus Niemann Pick C1 protein 0.0105 0.0486 0.0843
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0025 0.0043
Onchocerca volvulus 0.005 0.0162 0.1196
Trichomonas vaginalis disulfide oxidoreductase, putative 0.005 0.0162 0.105
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0042 0.0102
Trichomonas vaginalis set domain proteins, putative 0.0253 0.1351 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.014 0.0883
Plasmodium vivax thioredoxin reductase, putative 0.0541 0.3038 1
Onchocerca volvulus Huntingtin homolog 0.0131 0.0636 0.4708
Giardia lamblia GTOR 0.0137 0.0673 0.6344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.014 0.0883
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0188 0.0968 0.0968
Onchocerca volvulus Huntingtin homolog 0.0131 0.0636 0.4708
Brugia malayi TAR-binding protein 0.0379 0.2089 0.5055
Schistosoma mansoni tar DNA-binding protein 0.0379 0.2089 0.2089
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0172 0.0416
Echinococcus granulosus Smad4 0.005 0.0161 0.0279
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0188 0.0968 0.2343
Loa Loa (eye worm) hypothetical protein 0.0078 0.0325 0.0787
Loa Loa (eye worm) nuclear factor I 0.0027 0.0031 0.0075
Onchocerca volvulus 0.0253 0.1351 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0046 0.014 0.0389
Plasmodium falciparum thioredoxin reductase 0.0188 0.0968 0.2803
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0095 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0134 0.0845
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.0467 0.3351
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0015 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0379 0.2089 0.2089
Loa Loa (eye worm) hypothetical protein 0.0055 0.0194 0.0469
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1234 0.7096 0.8958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.0467 0.3351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.0509 0.3663
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.005 0.0162 0.0463
Brugia malayi hypothetical protein 0.0131 0.0636 0.154
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0022 0.0038
Entamoeba histolytica glutamate synthase beta subunit, putative 0.005 0.0162 0.2143
Echinococcus granulosus tar DNA binding protein 0.0379 0.2089 0.3624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0409 0.291
Brugia malayi intermediate filament protein 0.0055 0.0191 0.0462
Brugia malayi MH1 domain containing protein 0.005 0.0161 0.0389
Onchocerca volvulus 0.0055 0.0191 0.1414
Toxoplasma gondii NADPH-glutathione reductase 0.0188 0.0968 0.3136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.035 0.2468
Mycobacterium tuberculosis Probable oxidoreductase 0.1372 0.7903 1
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0042 0.0102
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.005 0.0162 0.105
Toxoplasma gondii thioredoxin reductase 0.0541 0.3038 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.005 0.0162 0.0463
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.1348 0.234
Schistosoma mansoni tar DNA-binding protein 0.0379 0.2089 0.2089
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0109 0.051 0.1277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0304 0.212
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0188 0.0968 0.3136
Loa Loa (eye worm) hypothetical protein 0.0131 0.0636 0.154
Loa Loa (eye worm) thioredoxin reductase 0.0541 0.3038 0.7354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0303 0.2115
Echinococcus granulosus GPCR family 2 0.0032 0.006 0.0103
Loa Loa (eye worm) hypothetical protein 0.0102 0.0469 0.1135
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.005 0.0162 0.028
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0137 0.0673 0.2159
Schistosoma mansoni lamin 0.0055 0.0191 0.0191
Schistosoma mansoni fkbp-rapamycin associated protein 0.0026 0.0022 0.0022
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0188 0.0968 0.3056
Brugia malayi Niemann-Pick C1 protein precursor 0.0105 0.0486 0.1176
Schistosoma mansoni microtubule-associated protein tau 0.067 0.379 0.379
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0138 0.0677 0.1638
Trypanosoma cruzi NADH dehydrogenase, putative 0.005 0.0162 0.0463
Echinococcus multilocularis Smad4 0.005 0.0161 0.0279
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0188 0.0968 1
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.005 0.0162 0.0351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0303 0.2115
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0379 0.2089 0.5055
Loa Loa (eye worm) hypothetical protein 0.0055 0.0191 0.0462
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0134 0.0233
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0137 0.0673 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0039 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.0509 0.3663
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0137 0.0673 0.1841
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0188 0.0968 0.3136
Trichomonas vaginalis disulfide oxidoreductase, putative 0.005 0.0162 0.105
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0022 0.0053
Schistosoma mansoni sulfide quinone reductase 0.005 0.0162 0.0162
Schistosoma mansoni hypothetical protein 0.0043 0.0125 0.0125

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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