TDR Targets

Basic information

Technical information

TDR Targets ID: 620911
Name: 5-[[4-(4-methoxyphenyl)piperazin-1-yl]-(3-met hylphenyl)methyl]-2-methyl-[1,3]thiazolo[2,3- e][1,2,4]triazol-6-ol
MW: 449.568 | Formula: C24H27N5O2S
H donors: 1 H acceptors: 3 LogP: 4.72 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)N1CCN(CC1)C(c1sc2n(c1O)nc(n2)C)c1cccc(c1)C
InChi: 1S/C24H27N5O2S/c1-16-5-4-6-18(15-16)21(22-23(30)29-24(32-22)25-17(2)26-29)28-13-11-27(12-14-28)19-7-9-20(31-3)10-8-19/h4-10,15,21,30H,11-14H2,1-3H3
InChiKey: QKNNKSIJQCZOCL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-[[4-(4-methoxyphenyl)piperazin-1-yl]-(3-methylphenyl)methyl]-2-methyl-thiazolo[2,3-e][1,2,4]triazol-6-ol
5-[[4-(4-methoxyphenyl)-1-piperazinyl]-(3-methylphenyl)methyl]-2-methyl-6-thiazolo[2,3-e][1,2,4]triazolol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0168	0.0378
Echinococcus multilocularis	glutamate synthase	0.0063	0.0146	0.0331
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0239	0.0954	0.3043
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0239	0.0954	0.3043
Mycobacterium tuberculosis	Probable reductase	0.1571	0.7092	0.8972
Loa Loa (eye worm)	pyridine nucleotide-disufhide oxidoreductase	0.0063	0.0146	0.0329
Trypanosoma cruzi	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.0063	0.0146	0.0334
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0239	0.0954	0.3016
Schistosoma mansoni	sulfide quinone reductase	0.0063	0.0146	0.01
Brugia malayi	glutathione reductase	0.0689	0.3027	0.6791
Echinococcus granulosus	mothers against decapentaplegic 5	0.0068	0.0167	0.04
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0063	0.0146	0.0334
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0063	0.0146	0.0483
Onchocerca volvulus		0.0249	0.1003	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0119	0.0404	0.4027
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0063	0.0146	0.0269
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0239	0.0954	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.0313	0.0647
Mycobacterium ulcerans	NADH dehydrogenase	0.0063	0.0146	0.1096
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0694	0.3054	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.015	0.0545	0.5436
Toxoplasma gondii	selenide, water dikinase	0.0063	0.0146	0.0483
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0081	0.0227	0.2267
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0175	0.0662	0.1437
Schistosoma mansoni	hypothetical protein	0.0063	0.0146	0.01
Schistosoma mansoni	smad1 5 8 and	0.0068	0.0167	0.0121
Trypanosoma cruzi	NADH dehydrogenase, putative	0.0063	0.0146	0.0334
Plasmodium vivax	glutathione reductase, putative	0.0689	0.3027	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.1571	0.7092	0.8972
Trypanosoma cruzi	trypanothione reductase, putative	0.0239	0.0954	0.3043
Schistosoma mansoni	glutamate synthase	0.0063	0.0146	0.01
Echinococcus multilocularis	Smad4	0.0068	0.0167	0.04
Loa Loa (eye worm)	intermediate filament protein	0.0054	0.0102	0.0229
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0239	0.0954	0.3043
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0081	0.0227	0.2262
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0063	0.0146	0.1458
Loa Loa (eye worm)	nuclear factor I	0.0038	0.0027	0.0062
Loa Loa (eye worm)	TAR-binding protein	0.0671	0.2947	0.6631
Mycobacterium leprae	PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE)	0.0063	0.0146	0.0127
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.015	0.0545	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0097	0.0219
Schistosoma mansoni	tar DNA-binding protein	0.0671	0.2947	0.2914
Trichomonas vaginalis	PIKK family atypical protein kinase	0.009	0.0267	0.2664
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0063	0.0146	0.0331
Echinococcus multilocularis	sulfide:quinone oxidoreductase	0.0063	0.0146	0.0331
Echinococcus multilocularis	apoptosis inducing factor 1 mitochondrial	0.0063	0.0146	0.0331
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0047	0.0467
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.015	0.0545	0.1673
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0239	0.0954	0.2803
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0081	0.0227	0.2267
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0239	0.0954	0.3043
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0089	0.0263	0.2623
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0068	0.0167	0.04
Schistosoma mansoni	smad1 5 8 and	0.0068	0.0167	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0105
Trichomonas vaginalis	mercuric reductase, putative	0.0239	0.0954	0.9509
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0063	0.0146	0.1458
Onchocerca volvulus		0.0054	0.0102	0.0575
Echinococcus multilocularis	smad	0.0068	0.0167	0.04
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0239	0.0954	0.2097
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0105
Echinococcus multilocularis	lamin dm0	0.0054	0.0102	0.0183
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0112	0.0372	0.1081
Brugia malayi	RNA recognition motif domain containing protein	0.0671	0.2947	0.661
Trichomonas vaginalis	esterase, putative	0.0042	0.0047	0.0467
Schistosoma mansoni	glutamate synthase	0.0063	0.0146	0.01
Echinococcus multilocularis	tumor protein p63	0.0392	0.166	0.5365
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0239	0.0954	0.3043
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.015	0.0545	0.1673
Plasmodium vivax	type II NADH:ubiquinone oxidoreductase, putative	0.0063	0.0146	0.0334
Schistosoma mansoni	sulfide quinone reductase	0.0063	0.0146	0.01
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0239	0.0954	0.2803
Leishmania major	2,4-dienoyl-coa reductase fadh1, putative	0.0063	0.0146	0.0334
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0219	0.0864	0.1943
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.0086	0.0858
Brugia malayi	glutamate synthase	0.0063	0.0146	0.0269
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.1746	0.79	1
Echinococcus granulosus	Smad4	0.0068	0.0167	0.04
Loa Loa (eye worm)	MH1 domain-containing protein	0.0068	0.0167	0.0376
Schistosoma mansoni	smad1 5 8 and	0.0068	0.0167	0.0121
Brugia malayi	intermediate filament protein	0.0054	0.0102	0.0169
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0063	0.0146	0.1458
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0047	0.0467
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.1746	0.79	1
Schistosoma mansoni	Smad4	0.0068	0.0167	0.0121
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0112	0.0368	0.3671
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0239	0.0954	0.3151
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0068	0.0167	0.04
Schistosoma mansoni	hypothetical protein	0.0068	0.0168	0.0122
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.015	0.0545	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0062	0.0141	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0027	0.0062
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0239	0.0954	0.3043
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0128	0.0444	0.4429
Mycobacterium leprae	THIOREDOXIN TRXC (TRX) (MPT46)	0.0063	0.0146	0.0127
Leishmania major	hypothetical protein, conserved	0.0063	0.0146	0.0334
Echinococcus granulosus	tar DNA binding protein	0.0671	0.2947	0.9644
Entamoeba histolytica	hypothetical protein	0.0112	0.0372	0.5655
Schistosoma mansoni	tar DNA-binding protein	0.0671	0.2947	0.2914
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0112	0.0368	0.3671
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0112	0.0368	0.3671
Trypanosoma brucei	trypanothione reductase	0.0689	0.3027	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.0086	0.0858
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0239	0.0954	0.3043
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0239	0.0954	0.0911
Mycobacterium tuberculosis	NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase)	0.0063	0.0146	0.0127
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0239	0.0954	0.3043
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0112	0.0368	0.3671
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0119	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0102	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0105
Trichomonas vaginalis	PIKK family atypical protein kinase	0.015	0.0545	0.5436
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0119	0.0404	0.4027
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.015	0.0545	0.1673
Brugia malayi	Smad1	0.0068	0.0167	0.0316
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0081	0.0227	0.2267
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0063	0.0146	0.0483
Brugia malayi	Thioredoxin reductase	0.0689	0.3027	0.6791
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.1571	0.7092	0.8972
Brugia malayi	MH1 domain containing protein	0.0068	0.0167	0.0316
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0239	0.0954	0.3043
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0063	0.0146	0.0331
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0068	0.0167	0.0121
Trypanosoma brucei	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.0063	0.0146	0.0334
Plasmodium falciparum	glutathione reductase	0.0689	0.3027	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0239	0.0954	0.3043
Mycobacterium ulcerans	hypothetical protein	0.0063	0.0146	0.1096
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.1571	0.7092	0.8972
Trypanosoma cruzi	2,4-dienoyl-coa reductase-like protein, putative	0.0063	0.0146	0.0334
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0239	0.0954	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0063	0.0146	0.1458
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0097	0.0303	0.3019
Echinococcus multilocularis	NADPH:adrenodoxin oxidoreductase	0.0063	0.0146	0.0331
Brugia malayi	beta-lactamase	0.0042	0.0047	0.0044
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0047	0.0044
Loa Loa (eye worm)	transcription factor SMAD2	0.0996	0.4445	1
Echinococcus granulosus	intermediate filament protein	0.0054	0.0102	0.0183
Echinococcus granulosus	sulfide:quinone oxidoreductase	0.0063	0.0146	0.0331
Loa Loa (eye worm)	hypothetical protein	0.01	0.0313	0.0705
Schistosoma mansoni	intermediate filament proteins	0.0054	0.0102	0.0055
Brugia malayi	hypothetical protein	0.0112	0.0372	0.078
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.015	0.0545	0.1657
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.0086	0.0858
Mycobacterium ulcerans	dehydrogenase	0.0063	0.0146	0.1096
Echinococcus multilocularis	pyridine nucleotide disulfide oxidoreductase	0.0063	0.0146	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0105
Loa Loa (eye worm)	glutathione reductase	0.0689	0.3027	0.6811
Toxoplasma gondii	NADH dehydrogenase (NDH2-II)	0.0063	0.0146	0.0483
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0047	0.0467
Mycobacterium tuberculosis	Probable oxidoreductase	0.1746	0.79	1
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprB	0.0063	0.0146	0.1096
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0119	0.0404	0.4027
Echinococcus granulosus	glutamate synthase	0.0063	0.0146	0.0331
Trichomonas vaginalis	glutamate synthase, putative	0.0063	0.0146	0.1458
Loa Loa (eye worm)	thioredoxin reductase	0.0689	0.3027	0.6811
Echinococcus granulosus	lamin dm0	0.0054	0.0102	0.0183
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0112	0.0368	0.3671
Brugia malayi	TAR-binding protein	0.0671	0.2947	0.661
Schistosoma mansoni	hypothetical protein	0.0112	0.0372	0.0327
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.015	0.0545	0.1172
Echinococcus multilocularis	lamin	0.0054	0.0102	0.0183
Onchocerca volvulus		0.0063	0.0146	0.104
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.0063	0.0146	0.0334
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0068	0.0167	0.04
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.005	0.0086	0.0131
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0063	0.0146	0.0331
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0119	0.0404	0.4027
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0239	0.0954	1
Echinococcus granulosus	lamin	0.0054	0.0102	0.0183
Trichomonas vaginalis	glutathione reductase, putative	0.0239	0.0954	0.9509
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0112	0.0368	0.3671
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0689	0.3027	0.3795
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0063	0.0146	0.1458
Mycobacterium ulcerans	NADH dehydrogenase Ndh	0.0063	0.0146	0.1096
Trichomonas vaginalis	apoptosis inducing factor, putative	0.0063	0.0146	0.1458
Mycobacterium tuberculosis	Possible dehydrogenase/reductase	0.0063	0.0146	0.0127
Plasmodium vivax	NAD(P)H-dependent glutamate synthase, putative	0.0063	0.0146	0.0334
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.005	0.0086	0.0132
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0671	0.2947	0.6631
Loa Loa (eye worm)	Smad1	0.0068	0.0167	0.0376
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0119	0.0405	0.12
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0063	0.0146	0.1458
Brugia malayi	MH2 domain containing protein	0.0996	0.4445	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0101	0.0318	0.3168
Giardia lamblia	GTOR	0.015	0.0545	0.4941
Plasmodium vivax	thioredoxin reductase, putative	0.0689	0.3027	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0112	0.0368	0.1216
Schistosoma mansoni	lamin	0.0054	0.0102	0.0055
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.0086	0.0858
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.005	0.0086	0.0132
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0239	0.0954	0.3043
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0105
Schistosoma mansoni	tar DNA-binding protein	0.0671	0.2947	0.2914
Plasmodium falciparum	thioredoxin reductase	0.0689	0.3027	1
Leishmania major	hypothetical protein, conserved	0.0063	0.0146	0.0334
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.005	0.0086	0.0132
Trypanosoma cruzi	2,4-dienoyl-coa reductase fadh1, putative	0.0063	0.0146	0.0334
Leishmania major	2,4-dienoyl-coa reductase-like protein	0.0063	0.0146	0.0334
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0071	0.0181	0.0451
Trichomonas vaginalis	glutamate synthase, putative	0.0063	0.0146	0.1458
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0047	0.0105
Trypanosoma brucei	hypothetical protein, conserved	0.0063	0.0146	0.0334
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0063	0.0146	0.1096
Trichomonas vaginalis	dihydrolipoamide dehydrogenase, putative	0.0063	0.0146	0.1458
Trichomonas vaginalis	PIKK family atypical protein kinase	0.009	0.0267	0.2664
Trichomonas vaginalis	set domain proteins, putative	0.0249	0.1003	1
Toxoplasma gondii	NADPH-glutathione reductase	0.0239	0.0954	0.3151
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0239	0.0954	0.1155
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.005	0.0086	0.0039
Leishmania major	trypanothione reductase	0.0689	0.3027	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0063	0.0146	0.0334
Mycobacterium ulcerans	ferredoxin reductase	0.0063	0.0146	0.1096
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0175	0.0662	0.1437
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0239	0.0954	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.1746	0.79	1
Mycobacterium leprae	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.0063	0.0146	0.0127
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0239	0.0954	0.3043
Brugia malayi	Intermediate filament tail domain containing protein	0.0054	0.0102	0.0169
Entamoeba histolytica	hypothetical protein	0.0112	0.0372	0.5655
Plasmodium falciparum	glutathione reductase	0.0239	0.0954	0.2803
Loa Loa (eye worm)	MH2 domain-containing protein	0.0068	0.0167	0.0376
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0239	0.0954	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0105
Trichomonas vaginalis	PIKK family atypical protein kinase	0.015	0.0545	0.5436
Mycobacterium tuberculosis	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.0063	0.0146	0.0127
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.0313	0.0647
Trypanosoma cruzi	hypothetical protein, conserved	0.0063	0.0146	0.0334
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.015	0.0545	0.1673
Schistosoma mansoni	transcription factor LCR-F1	0.0112	0.0372	0.0327
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0239	0.0954	0.3043
Schistosoma mansoni	cellular tumor antigen P53	0.0057	0.0119	0.0072
Echinococcus granulosus	pyridine nucleotide disulfide oxidoreductase	0.0063	0.0146	0.0331
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0119	0.0405	0.12
Brugia malayi	beta-lactamase family protein	0.0042	0.0047	0.0044
Mycobacterium ulcerans	NADPH dependent 2,4-dienoyl-CoA reductase FadH	0.0063	0.0146	0.1096
Brugia malayi	MH2 domain containing protein	0.0068	0.0167	0.0316
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0081	0.0227	0.2262
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0047	0.0467
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.015	0.0545	0.1673
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.1571	0.7092	0.8972
Trichomonas vaginalis	PIKK family atypical protein kinase	0.009	0.0267	0.2664
Echinococcus multilocularis	musashi	0.0054	0.0102	0.0183
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0063	0.0146	0.1458
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0054	0.0102	0.0229
Mycobacterium ulcerans	thioredoxin reductase TrxB2	0.0063	0.0146	0.1096
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.005	0.0086	0.0132
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0063	0.0146	0.0334
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0063	0.0146	0.0331
Echinococcus granulosus	tumor protein p63	0.0392	0.166	0.5365
Trypanosoma cruzi	NADH dehydrogenase, putative	0.0063	0.0146	0.0334
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0239	0.0954	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.015	0.0545	0.0501
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0239	0.0954	0.3043
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.1571	0.7092	0.8972
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0267	0.1084	0.132
Schistosoma mansoni	glutamate synthase	0.0063	0.0146	0.01
Echinococcus granulosus	apoptosis inducing factor 1 mitochondrial	0.0063	0.0146	0.0331
Echinococcus granulosus	thioredoxin glutathione reductase	0.0694	0.3054	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0168	0.0319
Onchocerca volvulus		0.0057	0.0119	0.0752
Onchocerca volvulus		0.0054	0.0102	0.0575
Schistosoma mansoni	tar DNA-binding protein	0.0671	0.2947	0.2914
Plasmodium falciparum	thioredoxin reductase	0.0239	0.0954	0.2803
Echinococcus granulosus	smad	0.0068	0.0167	0.04
Schistosoma mansoni	disulfide oxidoreductase	0.0063	0.0146	0.01
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.005	0.0086	0.0131
Loa Loa (eye worm)	phosphatidylinositol 3	0.015	0.0545	0.1227
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0239	0.0954	0.3043
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0063	0.0146	0.0269
Leishmania major	phosphatidylinositol 3-kinase, putative	0.005	0.0086	0.0132
Mycobacterium ulcerans	monoxygenase	0.0063	0.0146	0.1096
Toxoplasma gondii	thioredoxin reductase	0.0689	0.3027	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.1571	0.7092	0.8972
Loa Loa (eye worm)	MH2 domain-containing protein	0.0996	0.4445	1
Loa Loa (eye worm)	RNA binding protein	0.0671	0.2947	0.6631
Brugia malayi	MH2 domain containing protein	0.0068	0.0167	0.0316
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0063	0.0146	0.1458
Entamoeba histolytica	hypothetical protein	0.0112	0.0372	0.5655
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0089	0.0263	0.2623
Plasmodium vivax	ferrodoxin reductase, putative	0.0063	0.0146	0.0334
Treponema pallidum	NADH oxidase	0.0239	0.0954	1
Mycobacterium tuberculosis	Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase)	0.0063	0.0146	0.0127
Toxoplasma gondii	non-proton pumping type-II NADH dehydrogenase I	0.0063	0.0146	0.0483
Schistosoma mansoni	smad	0.0068	0.0167	0.0121
Echinococcus granulosus	NADPH:adrenodoxin oxidoreductase	0.0063	0.0146	0.0331
Brugia malayi	RNA binding protein	0.0671	0.2947	0.661
Mycobacterium ulcerans	NADH dehydrogenase Ndh1	0.0063	0.0146	0.1096
Mycobacterium ulcerans	glutamate synthase subunit beta	0.0063	0.0146	0.1096
Leishmania major	hypothetical protein, conserved	0.0063	0.0146	0.0334
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.015	0.0545	0.1673
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0047	0.0105
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0063	0.0146	0.1458
Trypanosoma cruzi	trypanothione reductase, putative	0.0689	0.3027	1
Brugia malayi	NADPH:adrenodoxin oxidoreductase, mitochondrial precursor	0.0063	0.0146	0.0269
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0239	0.0954	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0239	0.0954	0.3043
Mycobacterium leprae	Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE)	0.0063	0.0146	0.0127
Loa Loa (eye worm)	phosphatidylinositol 3	0.005	0.0086	0.0194
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0081	0.0227	0.2267
Trypanosoma cruzi	target of rapamycin kinase 3	0.0119	0.0405	0.12
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.004	0.0396
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0112	0.0368	0.3671
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0239	0.0954	0.3043
Trypanosoma brucei	NADH dehydrogenase	0.0063	0.0146	0.0334
Schistosoma mansoni	tar DNA-binding protein	0.0671	0.2947	0.2914
Leishmania major	NADH dehydrogenase, putative	0.0063	0.0146	0.0334
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.005	0.0086	0.0132
Entamoeba histolytica	hypothetical protein	0.0112	0.0372	0.5655
Brugia malayi	MH1 domain containing protein	0.0068	0.0167	0.0316
Echinococcus multilocularis	tar DNA binding protein	0.0671	0.2947	0.9644
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0146	0.0329
Trypanosoma brucei	2,4-dienoyl-coa reductase-like protein	0.0063	0.0146	0.0334
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0047	0.0467
Toxoplasma gondii	ABC1 family protein	0.0042	0.0047	0.0155
Mycobacterium tuberculosis	Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase)	0.0063	0.0146	0.0127
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0119	0.0404	0.4027
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0081	0.0227	0.2262
Loa Loa (eye worm)	programmed cell death 8	0.0063	0.0146	0.0329
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0063	0.0146	0.1096
Brugia malayi	beta-lactamase family protein	0.0042	0.0047	0.0044
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0239	0.0954	0.3016
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.0063	0.0146	0.0334
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.0313	0.0705
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0112	0.0372	0.1081
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0063	0.0146	0.0483
Schistosoma mansoni	lamin	0.0054	0.0102	0.0055
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.015	0.0545	0.1657
Mycobacterium tuberculosis	Probable thioredoxin reductase TrxB2 (TRXR) (TR)	0.0063	0.0146	0.0127
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0239	0.0954	0.3043
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.005	0.0086	0.0133
Brugia malayi	Pre-SET motif family protein	0.0219	0.0864	0.1893
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.0086	0.0858

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 620911