Detailed information for compound 620928

Basic information

Technical information
  • TDR Targets ID: 620928
  • Name: 3-(4-chlorophenyl)-7-hydroxy-4-methylchromen- 2-one
  • MW: 286.71 | Formula: C16H11ClO3
  • H donors: 1 H acceptors: 2 LogP: 3.73 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1c(=O)oc2c(c1C)ccc(c2)O
  • InChi: 1S/C16H11ClO3/c1-9-13-7-6-12(18)8-14(13)20-16(19)15(9)10-2-4-11(17)5-3-10/h2-8,18H,1H3
  • InChiKey: XHEYZPULKRBNFS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(4-chlorophenyl)-7-hydroxy-4-methyl-chromen-2-one
  • 3-(4-chlorophenyl)-7-hydroxy-4-methyl-2-chromenone
  • 3-(4-chlorophenyl)-7-hydroxy-4-methyl-coumarin
  • ST056231
  • ZINC00058102

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Smad1 0.0043 0.0083 0.0201
Plasmodium vivax thioredoxin reductase, putative 0.0486 0.2993 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0742 0.8065
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0304 0.0301
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.002 0.0041
Toxoplasma gondii thioredoxin reductase 0.0486 0.2993 1
Schistosoma mansoni hypothetical protein 0.0033 0.002 0.0016
Trichomonas vaginalis apoptosis inducing factor, putative 0.0045 0.0095 0.0482
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0169 0.0907 0.1042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0742 0.8065
Entamoeba histolytica hypothetical protein 0.0077 0.0304 0.3237
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0169 0.0907 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0309 0.2994
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0048 0.0117 0.0076
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0048 0.0117 0.0076
Trichomonas vaginalis mercuric reductase, putative 0.0169 0.0907 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.002 0.0018
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0048 0.0117 0.0076
Schistosoma mansoni cellular tumor antigen P53 0.0204 0.1137 0.1134
Echinococcus granulosus tar DNA binding protein 0.0521 0.3218 0.3602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0501 0.5241
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0004 0.0009
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0169 0.0907 0.2299
Leishmania major trypanothione reductase 0.0486 0.2993 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0143 0.0742 0.2234
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0169 0.0907 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0009
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0169 0.0907 1
Schistosoma mansoni smad1 5 8 and 0.0043 0.0083 0.0079
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1233 0.7894 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0095 0.0482
Entamoeba histolytica hypothetical protein 0.0077 0.0304 0.3237
Schistosoma mansoni hypothetical protein 0.0033 0.002 0.0016
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0169 0.0907 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.111 0.7081 0.8958
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0169 0.0907 0.2803
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0045 0.0095 0.0102
Echinococcus granulosus glutamate synthase 0.0045 0.0095 0.0102
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0169 0.0907 0.2803
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0521 0.3218 0.818
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0048 0.0117 0.0127
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0045 0.0095 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.055 0.581
Plasmodium falciparum thioredoxin reductase 0.0486 0.2993 1
Treponema pallidum NADH oxidase 0.0169 0.0907 1
Schistosoma mansoni sulfide quinone reductase 0.0045 0.0095 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0363 0.3629
Trichomonas vaginalis glutamate synthase, putative 0.0045 0.0095 0.0482
Echinococcus granulosus microtubule associated protein 2 0.0687 0.431 0.4826
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0143 0.0742 0.0827
Brugia malayi MH1 domain containing protein 0.0043 0.0083 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0308 0.2985
Loa Loa (eye worm) hypothetical protein 0.0159 0.0843 0.2142
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0048 0.0117 0.0076
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0045 0.0095 0.0102
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.111 0.7081 0.8958
Schistosoma mansoni tar DNA-binding protein 0.0521 0.3218 0.3215
Trichomonas vaginalis glutathione reductase, putative 0.0169 0.0907 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0117 0.0288
Schistosoma mansoni hypothetical protein 0.0077 0.0304 0.0301
Onchocerca volvulus 0.0204 0.1137 1
Schistosoma mansoni disulfide oxidoreductase 0.0045 0.0095 0.0091
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.002 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0358 0.3564
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.0492 0.125
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0045 0.0095 0.0102
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0143 0.0742 0.0827
Schistosoma mansoni hypothetical protein 0.0033 0.002 0.0016
Loa Loa (eye worm) MH2 domain-containing protein 0.063 0.3933 1
Echinococcus multilocularis GPCR, family 2 0.0033 0.002 0.0018
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0114 0.055 0.1572
Echinococcus granulosus tumor protein p63 0.1391 0.8928 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0095 0.0482
Schistosoma mansoni smad 0.0043 0.0083 0.0079
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0045 0.0095 0.0241
Schistosoma mansoni tar DNA-binding protein 0.0521 0.3218 0.3215
Brugia malayi RNA recognition motif domain containing protein 0.0521 0.3218 0.8179
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.0492 0.1241
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0143 0.0742 0.2234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.055 0.581
Schistosoma mansoni glutamate synthase 0.0045 0.0095 0.0091
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.0083 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0117 0.0739
Brugia malayi Latrophilin receptor protein 2 0.0033 0.002 0.0041
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0143 0.0742 0.2234
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0169 0.0907 0.2803
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0169 0.0907 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0432 0.4436
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0045 0.0095 0.0102
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0004 0.0009
Brugia malayi TAR-binding protein 0.0521 0.3218 0.8179
Onchocerca volvulus 0.0045 0.0095 0.0803
Echinococcus granulosus smad 0.0043 0.0083 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0117 0.0739
Echinococcus multilocularis thioredoxin glutathione reductase 0.049 0.3013 0.3373
Trypanosoma cruzi target of rapamycin kinase 3 0.0114 0.055 0.1572
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0117 0.0297
Schistosoma mansoni hypothetical protein 0.0045 0.0095 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0117 0.0739
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0045 0.0095 0.0232
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1233 0.7894 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.0492 0.125
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0048 0.0117 0.0113
Leishmania major phosphatidylinositol 3-kinase, putative 0.0048 0.0117 0.0076
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0048 0.0117 0.0127
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0169 0.0907 0.2803
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0143 0.0742 0.2234
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0169 0.0907 0.2803
Brugia malayi MH2 domain containing protein 0.0043 0.0083 0.0201
Schistosoma mansoni glutamate synthase 0.0045 0.0095 0.0091
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0143 0.0742 0.0739
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0501 0.5241
Echinococcus granulosus thioredoxin glutathione reductase 0.049 0.3013 0.3373
Plasmodium vivax glutathione reductase, putative 0.0486 0.2993 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0114 0.055 0.1572
Toxoplasma gondii target of rapamycin (TOR), putative 0.0107 0.0501 0.1402
Schistosoma mansoni tar DNA-binding protein 0.0521 0.3218 0.3215
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0169 0.0907 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0169 0.0907 0.2803
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0169 0.0907 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0501 0.5241
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0124 0.0614 0.1552
Onchocerca volvulus 0.0159 0.0843 0.7402
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0143 0.0742 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.006 0.0192 0.0335
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0304 0.0337
Mycobacterium tuberculosis Probable reductase 0.111 0.7081 0.8958
Echinococcus multilocularis tar DNA binding protein 0.0521 0.3218 0.3602
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0169 0.0907 0.2803
Echinococcus multilocularis glutamate synthase 0.0045 0.0095 0.0102
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0068 0.0246 0.0522
Schistosoma mansoni smad1 5 8 and 0.0043 0.0083 0.0079
Loa Loa (eye worm) TAR-binding protein 0.0521 0.3218 0.818
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0273 0.0686
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0095 0.0482
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0169 0.0907 0.1012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0358 0.3564
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0045 0.0095 0.0102
Schistosoma mansoni smad1 5 8 and 0.0043 0.0083 0.0079
Mycobacterium tuberculosis Probable oxidoreductase 0.1233 0.7894 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0169 0.0907 0.2803
Loa Loa (eye worm) hypothetical protein 0.0045 0.0095 0.0241
Schistosoma mansoni microtubule-associated protein tau 0.0687 0.431 0.4308
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0169 0.0907 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0501 0.5241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0117 0.0739
Plasmodium falciparum glutathione reductase 0.0169 0.0907 0.2803
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0169 0.0907 0.0904
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0143 0.0742 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0045 0.0095 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0363 0.3629
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0742 0.8065
Brugia malayi glutamate synthase 0.0045 0.0095 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0501 0.5241
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0169 0.0907 0.2803
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.002 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0604 0.6453
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0045 0.0095 0.0102
Entamoeba histolytica hypothetical protein 0.0077 0.0304 0.3237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0308 0.2985
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.111 0.7081 0.8958
Brugia malayi hypothetical protein 0.0159 0.0843 0.2135
Loa Loa (eye worm) programmed cell death 8 0.0045 0.0095 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0308 0.2985
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0045 0.0095 0.0102
Schistosoma mansoni Smad4 0.0043 0.0083 0.0079
Echinococcus granulosus GPCR family 2 0.0033 0.002 0.0018
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0169 0.0907 0.2803
Echinococcus multilocularis Smad4 0.0043 0.0083 0.0089
Plasmodium falciparum glutathione reductase 0.0486 0.2993 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0169 0.0907 0.2803
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0143 0.0742 0.2234
Trypanosoma cruzi trypanothione reductase, putative 0.0486 0.2993 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.111 0.7081 0.8958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0412 0.4198
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0095 0.0482
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.111 0.7081 0.8958
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0143 0.0742 0.1879
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.055 0.581
Brugia malayi RNA binding protein 0.0521 0.3218 0.8179
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0169 0.0907 0.2803
Trypanosoma brucei trypanothione reductase 0.0486 0.2993 1
Loa Loa (eye worm) RNA binding protein 0.0521 0.3218 0.818
Echinococcus granulosus Smad4 0.0043 0.0083 0.0089
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0045 0.0095 0.0482
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.0083 0.0089
Schistosoma mansoni hypothetical protein 0.0033 0.002 0.0016
Entamoeba histolytica hypothetical protein 0.0077 0.0304 0.3237
Schistosoma mansoni glutamate synthase 0.0045 0.0095 0.0091
Brugia malayi hypothetical protein 0.0077 0.0304 0.0765
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0045 0.0095 0.0102
Trypanosoma cruzi trypanothione reductase, putative 0.0169 0.0907 0.2803
Brugia malayi Thioredoxin reductase 0.0486 0.2993 0.7606
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0169 0.0907 0.2803
Loa Loa (eye worm) transcription factor SMAD2 0.063 0.3933 1
Brugia malayi MH1 domain containing protein 0.0043 0.0083 0.0201
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0169 0.0907 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0095 0.0482
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.0083 0.0089
Echinococcus multilocularis tumor protein p63 0.1391 0.8928 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0169 0.0907 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0124 0.0614 0.1552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.055 0.581
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.0083 0.0089
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.2891
Loa Loa (eye worm) glutathione reductase 0.0486 0.2993 0.7608
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.0083 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0501 0.5241
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0045 0.0095 0.0482
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0486 0.2993 0.3716
Loa Loa (eye worm) hypothetical protein 0.0072 0.0273 0.0694
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.0083 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0309 0.2994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.055 0.581
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0045 0.0095 0.0232
Echinococcus multilocularis smad 0.0043 0.0083 0.0089
Toxoplasma gondii NADPH-glutathione reductase 0.0169 0.0907 0.2803
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0045 0.0095 0.0102
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.0083 0.021
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.0492 0.1241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0363 0.3629
Loa Loa (eye worm) Smad1 0.0043 0.0083 0.021
Giardia lamblia GTOR 0.0143 0.0742 0.7967
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0169 0.0907 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0169 0.0907 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0117 0.0739
Echinococcus multilocularis microtubule associated protein 2 0.0687 0.431 0.4826
Loa Loa (eye worm) thioredoxin reductase 0.0486 0.2993 0.7608
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0169 0.0907 0.2803
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.002 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0309 0.2994
Plasmodium falciparum thioredoxin reductase 0.0169 0.0907 0.2803
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0143 0.0742 0.2234
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0095 0.0482
Trichomonas vaginalis glutamate synthase, putative 0.0045 0.0095 0.0482
Schistosoma mansoni sulfide quinone reductase 0.0045 0.0095 0.0091
Mycobacterium tuberculosis Probable dehydrogenase 0.111 0.7081 0.8958
Schistosoma mansoni hypothetical protein 0.0072 0.0273 0.0269
Brugia malayi glutathione reductase 0.0486 0.2993 0.7606
Brugia malayi MH2 domain containing protein 0.063 0.3933 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1233 0.7894 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0309 0.2994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0501 0.5241
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0169 0.0907 0.2803
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0048 0.0117 0.0076
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.002 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0521 0.3218 0.3215
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0045 0.0095 0.0102
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0045 0.0095 0.0232
Loa Loa (eye worm) phosphatidylinositol 3 0.0143 0.0742 0.1886
Brugia malayi MH2 domain containing protein 0.0043 0.0083 0.0201
Schistosoma mansoni tar DNA-binding protein 0.0521 0.3218 0.3215
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0045 0.0095 0.0102
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0169 0.0907 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0045 0.0095 0.0482
Loa Loa (eye worm) hypothetical protein 0.0033 0.002 0.005
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0169 0.0907 0.1012
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0304 0.0337

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.