Detailed information for compound 620934

Basic information

Technical information
  • TDR Targets ID: 620934
  • Name: methyl 2-[3-(3,4-dimethoxyphenyl)-4-methyl-2- oxochromen-6-yl]oxyacetate
  • MW: 384.379 | Formula: C21H20O7
  • H donors: 0 H acceptors: 2 LogP: 3.3 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)COc1ccc2c(c1)c(C)c(c(=O)o2)c1ccc(c(c1)OC)OC
  • InChi: 1S/C21H20O7/c1-12-15-10-14(27-11-19(22)26-4)6-8-16(15)28-21(23)20(12)13-5-7-17(24-2)18(9-13)25-3/h5-10H,11H2,1-4H3
  • InChiKey: JDYKWKHQQIWIHX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl 2-[3-(3,4-dimethoxyphenyl)-4-methyl-2-oxo-chromen-6-yl]oxyacetate
  • 2-[[3-(3,4-dimethoxyphenyl)-4-methyl-2-oxo-6-chromenyl]oxy]acetic acid methyl ester
  • 2-[3-(3,4-dimethoxyphenyl)-2-keto-4-methyl-chromen-6-yl]oxyacetic acid methyl ester
  • methyl 2-[3-(3,4-dimethoxyphenyl)-4-methyl-2-oxo-chromen-6-yl]oxyethanoate
  • ZINC04340622

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0098 0.0228
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.006 0.0221 0.0466
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0048 0.0139 0.0137
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0154 0.0899 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0404 0.4425
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0154 0.0899 0.0896
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0041 0.0086 0.0202
Brugia malayi RNA binding protein 0.0393 0.2628 0.6145
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0098 0.0095
Loa Loa (eye worm) hypothetical protein 0.0054 0.0183 0.0429
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0826 0.9169
Plasmodium falciparum glutathione reductase 0.0443 0.2987 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0041 0.0086 0.0256
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.014
Echinococcus multilocularis glutamate synthase 0.0041 0.0086 0.0084
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0098 0.0095
Mycobacterium tuberculosis Probable oxidoreductase 0.1123 0.7893 1
Trichomonas vaginalis glutamate synthase, putative 0.0041 0.0086 0.0856
Brugia malayi glutamate synthase 0.0041 0.0086 0.0193
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0041 0.0086 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0139 0.1448
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0614 0.6792
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0086 0.0856
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0154 0.0899 0.2803
Onchocerca volvulus 0.0165 0.0983 0.779
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1011 0.708 0.8958
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0041 0.0086 0.0856
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0614 0.6792
Echinococcus multilocularis tar DNA binding protein 0.0393 0.2628 0.2671
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0113 0.0606 0.1409
Schistosoma mansoni disulfide oxidoreductase 0.0041 0.0086 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0614 0.6792
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0154 0.0899 0.2803
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0143 0.0826 0.2549
Loa Loa (eye worm) glutathione reductase 0.0443 0.2987 0.699
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0139 0.0325
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0561 0.6192
Echinococcus multilocularis Smad4 0.0042 0.0098 0.0095
Schistosoma mansoni tar DNA-binding protein 0.0393 0.2628 0.2625
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0154 0.0899 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0086 0.0856
Schistosoma mansoni sulfide quinone reductase 0.0041 0.0086 0.0082
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0024
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0004 0.0009
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1011 0.708 0.8958
Loa Loa (eye worm) MH2 domain-containing protein 0.0621 0.4274 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0154 0.0899 0.2803
Schistosoma mansoni Smad4 0.0042 0.0098 0.0094
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0041 0.0086 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.041 0.4493
Entamoeba histolytica hypothetical protein 0.0076 0.0339 0.3424
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0098 0.0228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0139 0.1448
Brugia malayi MH2 domain containing protein 0.0621 0.4274 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0154 0.0899 0.2803
Trichomonas vaginalis mercuric reductase, putative 0.0154 0.0899 1
Schistosoma mansoni smad 0.0042 0.0098 0.0094
Toxoplasma gondii selenide, water dikinase 0.0041 0.0086 0.0256
Giardia lamblia GTOR 0.0143 0.0826 0.9091
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0154 0.0899 0.2803
Trypanosoma cruzi target of rapamycin kinase 3 0.0114 0.0615 0.1823
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0154 0.0899 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0826 0.9169
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0154 0.0899 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0098 0.0095
Echinococcus granulosus tumor protein p63 0.1391 0.9825 1
Trichomonas vaginalis glutathione reductase, putative 0.0154 0.0899 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.006 0.0131
Schistosoma mansoni hypothetical protein 0.0076 0.0339 0.0336
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0154 0.0899 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0139 0.0316
Toxoplasma gondii thioredoxin reductase 0.0443 0.2987 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0041 0.0086 0.0193
Echinococcus multilocularis thioredoxin glutathione reductase 0.0446 0.3006 0.3057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0404 0.4425
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0143 0.0826 0.0837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0349 0.3815
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0041 0.0086 0.0084
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0041 0.0086 0.0193
Loa Loa (eye worm) Smad1 0.0042 0.0098 0.0228
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0143 0.0826 0.2549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0139 0.1448
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0041 0.0086 0.0856
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0339 0.0342
Echinococcus granulosus glutamate synthase 0.0041 0.0086 0.0084
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0048 0.0139 0.0181
Plasmodium falciparum glutathione reductase 0.0154 0.0899 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0086 0.0856
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0041 0.0086 0.0084
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0041 0.0086 0.0856
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0041 0.0086 0.0193
Brugia malayi MH1 domain containing protein 0.0042 0.0098 0.022
Schistosoma mansoni tar DNA-binding protein 0.0393 0.2628 0.2625
Entamoeba histolytica hypothetical protein 0.0076 0.0339 0.3424
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1011 0.708 0.8958
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0041 0.0086 0.0084
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0143 0.0826 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0041 0.0086 0.0084
Loa Loa (eye worm) thioredoxin reductase 0.0443 0.2987 0.699
Leishmania major trypanothione reductase 0.0443 0.2987 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0154 0.0899 0.2803
Brugia malayi RNA recognition motif domain containing protein 0.0393 0.2628 0.6145
Echinococcus multilocularis microtubule associated protein 2 0.0695 0.4807 0.4891
Mycobacterium tuberculosis Probable dehydrogenase 0.1011 0.708 0.8958
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0041 0.0086 0.0084
Toxoplasma gondii target of rapamycin (TOR), putative 0.0107 0.0561 0.185
Brugia malayi Smad1 0.0042 0.0098 0.022
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0154 0.0899 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0154 0.0899 0.2987
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0048 0.0139 0.0137
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0041 0.0086 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0561 0.6192
Schistosoma mansoni smad1 5 8 and 0.0042 0.0098 0.0094
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0086 0.0856
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0349 0.3815
Plasmodium falciparum thioredoxin reductase 0.0154 0.0899 0.2803
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0143 0.0826 0.2549
Echinococcus granulosus thioredoxin glutathione reductase 0.0446 0.3006 0.3057
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0143 0.0826 0.1924
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0041 0.0086 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0614 0.6792
Echinococcus multilocularis tumor protein p63 0.1391 0.9825 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0048 0.0139 0.0181
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0041 0.0086 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0561 0.6192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.035 0.3825
Giardia lamblia NADH oxidase lateral transfer candidate 0.0154 0.0899 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0114 0.0615 0.1823
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1123 0.7893 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0143 0.0826 0.0837
Loa Loa (eye worm) programmed cell death 8 0.0041 0.0086 0.0202
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0339 0.0336
Onchocerca volvulus 0.0204 0.1261 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0114 0.0615 0.1823
Onchocerca volvulus 0.0041 0.0086 0.0655
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.035 0.3825
Schistosoma mansoni glutamate synthase 0.0041 0.0086 0.0082
Echinococcus granulosus microtubule associated protein 2 0.0695 0.4807 0.4891
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.007 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.041 0.4493
Schistosoma mansoni cellular tumor antigen P53 0.0204 0.1261 0.1257
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0154 0.0899 0.2803
Schistosoma mansoni tar DNA-binding protein 0.0393 0.2628 0.2625
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0086 0.0856
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0561 0.6192
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0068 0.0281 0.0671
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0154 0.0899 0.1042
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0154 0.0899 0.2803
Plasmodium falciparum thioredoxin reductase 0.0443 0.2987 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0561 0.6192
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0143 0.0826 0.2549
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0154 0.0899 1
Brugia malayi MH1 domain containing protein 0.0042 0.0098 0.022
Trypanosoma cruzi trypanothione reductase, putative 0.0443 0.2987 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0143 0.0826 0.1932
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0154 0.0899 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0826 0.9169
Brugia malayi hypothetical protein 0.0165 0.0983 0.2293
Echinococcus granulosus Smad4 0.0042 0.0098 0.0095
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0339 0.0342
Schistosoma mansoni smad1 5 8 and 0.0042 0.0098 0.0094
Mycobacterium tuberculosis Probable reductase 0.1011 0.708 0.8958
Loa Loa (eye worm) TAR-binding protein 0.0393 0.2628 0.6148
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0048 0.0139 0.0181
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0143 0.0826 0.0822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0463 0.5093
Toxoplasma gondii NADPH-glutathione reductase 0.0154 0.0899 0.2987
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0041 0.0086 0.0084
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0154 0.0899 0.0912
Entamoeba histolytica hypothetical protein 0.0076 0.0339 0.3424
Loa Loa (eye worm) hypothetical protein 0.0204 0.1261 0.295
Schistosoma mansoni sulfide quinone reductase 0.0041 0.0086 0.0082
Echinococcus granulosus tar DNA binding protein 0.0393 0.2628 0.2671
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0154 0.0899 0.2803
Leishmania major phosphatidylinositol 3-kinase, putative 0.0048 0.0139 0.0181
Loa Loa (eye worm) hypothetical protein 0.0041 0.0086 0.0202
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0183 0.042
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0154 0.0899 0.2803
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0154 0.0899 0.2097
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1123 0.7893 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0041 0.0086 0.0856
Schistosoma mansoni smad1 5 8 and 0.0042 0.0098 0.0094
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0183 0.0429
Entamoeba histolytica hypothetical protein 0.0076 0.0339 0.3424
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1011 0.708 0.8958
Echinococcus granulosus smad 0.0042 0.0098 0.0095
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0098 0.0094
Brugia malayi MH2 domain containing protein 0.0042 0.0098 0.022
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0154 0.0899 0.2803
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0393 0.2628 0.6148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0561 0.6192
Plasmodium vivax thioredoxin reductase, putative 0.0443 0.2987 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0139 0.1448
Brugia malayi Thioredoxin reductase 0.0443 0.2987 0.6987
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0154 0.0899 0.2803
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0443 0.2987 0.3716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0561 0.6192
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0154 0.0899 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0139 0.1448
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0041 0.0086 0.0084
Brugia malayi glutathione reductase 0.0443 0.2987 0.6987
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0041 0.0086 0.0256
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0154 0.0899 1
Brugia malayi TAR-binding protein 0.0393 0.2628 0.6145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0485 0.5344
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1011 0.708 0.8958
Loa Loa (eye worm) hypothetical protein 0.0165 0.0983 0.23
Trypanosoma brucei trypanothione reductase 0.0443 0.2987 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0004 0.0009
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0004 0.0009
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0143 0.0826 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0154 0.0899 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0041 0.0086 0.0256
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0143 0.0826 0.2549
Loa Loa (eye worm) transcription factor SMAD2 0.0621 0.4274 1
Schistosoma mansoni hypothetical protein 0.0037 0.006 0.0056
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0154 0.0899 0.2803
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0098 0.0095
Treponema pallidum NADH oxidase 0.0154 0.0899 1
Trypanosoma cruzi trypanothione reductase, putative 0.0154 0.0899 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.035 0.3825
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0048 0.0139 0.0181
Echinococcus multilocularis smad 0.0042 0.0098 0.0095
Brugia malayi hypothetical protein 0.0076 0.0339 0.0786
Plasmodium vivax glutathione reductase, putative 0.0443 0.2987 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0048 0.0139 0.0135
Schistosoma mansoni microtubule-associated protein tau 0.0695 0.4807 0.4805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0614 0.6792
Schistosoma mansoni tar DNA-binding protein 0.0393 0.2628 0.2625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0674 0.747
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.035 0.3825
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0154 0.0899 0.2803
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0143 0.0826 0.2549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.041 0.4493
Schistosoma mansoni tar DNA-binding protein 0.0393 0.2628 0.2625
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0113 0.0606 0.1409
Schistosoma mansoni hypothetical protein 0.0041 0.0086 0.0082
Loa Loa (eye worm) RNA binding protein 0.0393 0.2628 0.6148
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0048 0.0139 0.0181
Brugia malayi MH2 domain containing protein 0.0042 0.0098 0.022
Trichomonas vaginalis apoptosis inducing factor, putative 0.0041 0.0086 0.0856
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0086 0.0856
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0154 0.0899 0.2803
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0041 0.0086 0.0084
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1123 0.7893 1
Schistosoma mansoni glutamate synthase 0.0041 0.0086 0.0082
Trichomonas vaginalis glutamate synthase, putative 0.0041 0.0086 0.0856
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0349 0.3815
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0041 0.0086 0.0084
Schistosoma mansoni glutamate synthase 0.0041 0.0086 0.0082
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0007
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0154 0.0899 0.0912
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0183 0.042

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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