Detailed information for compound 620943

Basic information

Technical information
  • TDR Targets ID: 620943
  • Name: 5-[(2-fluorophenyl)-(4-phenylpiperazin-1-yl)m ethyl]-2-methyl-[1,3]thiazolo[2,3-e][1,2,4]tr iazol-6-ol
  • MW: 423.506 | Formula: C22H22FN5OS
  • H donors: 1 H acceptors: 3 LogP: 4.49 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nn2c(n1)sc(c2O)C(c1ccccc1F)N1CCN(CC1)c1ccccc1
  • InChi: 1S/C22H22FN5OS/c1-15-24-22-28(25-15)21(29)20(30-22)19(17-9-5-6-10-18(17)23)27-13-11-26(12-14-27)16-7-3-2-4-8-16/h2-10,19,29H,11-14H2,1H3
  • InChiKey: ZNBGEKURAJYAQD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(2-fluorophenyl)-(4-phenylpiperazin-1-yl)methyl]-2-methyl-thiazolo[2,3-e][1,2,4]triazol-6-ol
  • 5-[(2-fluorophenyl)-(4-phenyl-1-piperazinyl)methyl]-2-methyl-6-thiazolo[2,3-e][1,2,4]triazolol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0141 0.0482 0.1698
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0033 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0382 0.1033
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0166 0.0206
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0067 0.0122 0.0351
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0208 0.0805 0.286
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0208 0.0805 0.11
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0208 0.0805 0.0787
Schistosoma mansoni sulfide quinone reductase 0.0055 0.0066 0.0046
Loa Loa (eye worm) MH2 domain-containing protein 0.0075 0.0163 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0028 0.0023
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0055 0.0066 0.0065
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0097 0.0268 0.084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0148 0.045
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0055 0.0066 0.0046
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1368 0.6426 0.8965
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0148 0.045
Loa Loa (eye worm) TAR-binding protein 0.0523 0.2334 0.4532
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.008 0.0186 0.0361
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0225 0.089 0.0872
Mycobacterium tuberculosis Probable oxidoreductase 0.152 0.7165 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0166 0.0419
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0166 0.0603 0.7433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0242 0.0635
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0055 0.0066 0.0132
Loa Loa (eye worm) phosphatidylinositol 3 0.0141 0.0482 0.0935
Loa Loa (eye worm) hypothetical protein 0.0712 0.3248 0.6305
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0166 0.0419
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0055 0.0066 0.0142
Echinococcus granulosus thioredoxin glutathione reductase 0.0604 0.2726 0.2712
Mycobacterium tuberculosis Probable reductase 0.1368 0.6426 0.8965
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0033 0.0014
Giardia lamblia GTOR 0.0141 0.0482 0.5629
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.0207 0.0534
Echinococcus granulosus GPCR family 2 0.0225 0.089 0.0872
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0208 0.0805 0.0787
Loa Loa (eye worm) hypothetical protein 0.0051 0.0045 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0028 0.0023
Schistosoma mansoni glutamate synthase 0.0055 0.0066 0.0046
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0094 0.0248
Schistosoma mansoni phosphoglycerate kinase 0.0166 0.0603 0.0585
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0307 0.0819
Echinococcus multilocularis tumor protein p63 0.1772 0.8385 0.8382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0307 0.0819
Loa Loa (eye worm) latrophilin receptor protein 2 0.0225 0.089 0.1727
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0342 0.092
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0055 0.0066 0.0078
Onchocerca volvulus 0.0097 0.0268 0.0586
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0307 0.0819
Trichomonas vaginalis glutamate synthase, putative 0.0055 0.0066 0.0132
Echinococcus granulosus histone lysine methyltransferase setb 0.0097 0.0268 0.0249
Schistosoma mansoni smad1 5 8 and 0.0075 0.0163 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0342 0.092
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0208 0.0805 0.2906
Toxoplasma gondii ABC1 family protein 0.0076 0.0166 0.0458
Echinococcus multilocularis GPCR, family 2 0.0225 0.089 0.0872
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0208 0.0805 1
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0166 0.0603 0.2101
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0075 0.0163 0.0144
Plasmodium vivax phosphoglycerate kinase, putative 0.0166 0.0603 0.2101
Loa Loa (eye worm) hypothetical protein 0.0166 0.0603 0.1172
Leishmania major hypothetical protein, conserved 0.0055 0.0066 0.0142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0148 0.045
Plasmodium vivax thioredoxin reductase, putative 0.06 0.2704 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0208 0.0805 0.2906
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0167 0.042
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0166 0.1872
Treponema pallidum oxidoreductase 0.0055 0.0066 0.0587
Trypanosoma cruzi trypanothione reductase, putative 0.06 0.2704 1
Entamoeba histolytica phosphoglycerate kinase, putative 0.0166 0.0603 1
Loa Loa (eye worm) thioredoxin reductase 0.06 0.2704 0.5249
Schistosoma mansoni smad1 5 8 and 0.0075 0.0163 0.0144
Mycobacterium ulcerans glutamate synthase subunit beta 0.0055 0.0066 0.0587
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0208 0.0805 0.2906
Mycobacterium ulcerans dehydrogenase 0.0055 0.0066 0.0587
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0166 0.0603 0.2152
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0055 0.0066 0.0046
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0225 0.089 0.0872
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0148 0.045
Loa Loa (eye worm) hypothetical protein 0.0225 0.089 0.1727
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0055 0.0066 0.0142
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0045 0.0064
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0166 0.0147
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0208 0.0805 0.2906
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0307 0.0819
Entamoeba histolytica hypothetical protein 0.0072 0.0149 0.1546
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0033 0.0014
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0045 0.0064
Trypanosoma cruzi trypanothione reductase, putative 0.0208 0.0805 0.2906
Plasmodium falciparum thioredoxin reductase 0.06 0.2704 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0105 0.0307 0.0985
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0167 0.042
Mycobacterium tuberculosis Conserved protein 0.0076 0.0166 0.0206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0148 0.045
Echinococcus multilocularis thioredoxin glutathione reductase 0.0604 0.2726 0.2712
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0055 0.0066 0.0142
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0166 0.0519
Brugia malayi Pre-SET motif family protein 0.0097 0.0268 0.0521
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0028 0.0023
Plasmodium vivax SET domain protein, putative 0.0097 0.0268 0.084
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0066 0.0142
Trichomonas vaginalis glutamate synthase, putative 0.0055 0.0066 0.0132
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0166 0.0206
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0061 0.0094 0.0248
Schistosoma mansoni microtubule-associated protein tau 0.2105 1 1
Onchocerca volvulus 0.008 0.0186 0.0348
Leishmania major phosphoglycerate kinase C, glycosomal 0.0166 0.0603 0.2152
Mycobacterium tuberculosis Conserved protein 0.0076 0.0166 0.0206
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0166 0.0206
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0148 0.045
Trichomonas vaginalis set domain proteins, putative 0.0769 0.3527 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0028 0.0023
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0166 0.0603 0.1665
Brugia malayi MH1 domain containing protein 0.0075 0.0163 0.0316
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0208 0.0805 0.2906
Brugia malayi hypothetical protein 0.0072 0.0149 0.0289
Loa Loa (eye worm) hypothetical protein 0.0097 0.0268 0.0521
Echinococcus granulosus mothers against decapentaplegic 5 0.0075 0.0163 0.0144
Onchocerca volvulus 0.0076 0.0166 0.0291
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0033 0.0014
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0166 0.0603 0.0817
Mycobacterium leprae Probable lipase LipE 0.0076 0.0166 0.0206
Echinococcus granulosus intermediate filament protein 0.008 0.0186 0.0167
Echinococcus multilocularis Smad4 0.0075 0.0163 0.0144
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0055 0.0066 0.0065
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0166 0.0603 0.1665
Leishmania major trypanothione reductase 0.06 0.2704 1
Schistosoma mansoni glutamate synthase 0.0055 0.0066 0.0046
Echinococcus granulosus phosphoglycerate kinase 1 0.0166 0.0603 0.0585
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0208 0.0805 0.2906
Onchocerca volvulus 0.0769 0.3527 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.0207 0.0534
Trypanosoma brucei NADH dehydrogenase 0.0055 0.0066 0.0142
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0033 0.0014
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0055 0.0066 0.0132
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0149 0.013
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0055 0.0066 0.0046
Trypanosoma cruzi target of rapamycin kinase 3 0.0112 0.0343 0.1177
Brugia malayi intermediate filament protein 0.008 0.0186 0.0361
Trichomonas vaginalis glutathione reductase, putative 0.0208 0.0805 0.224
Trichomonas vaginalis apoptosis inducing factor, putative 0.0055 0.0066 0.0132
Brugia malayi hypothetical protein 0.0051 0.0045 0.0087
Echinococcus multilocularis mothers against decapentaplegic 5 0.0075 0.0163 0.0144
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0166 0.1872
Echinococcus multilocularis glutamate synthase 0.0055 0.0066 0.0046
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0055 0.0066 0.0046
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0141 0.0482 0.0463
Trypanosoma brucei phosphoglycerate kinase 0.0166 0.0603 0.2152
Toxoplasma gondii NADPH-glutathione reductase 0.0208 0.0805 0.286
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0047 0.0028 0.0008
Mycobacterium tuberculosis Probable dehydrogenase 0.1368 0.6426 0.8965
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0097 0.0268 0.0249
Loa Loa (eye worm) intermediate filament protein 0.008 0.0186 0.0361
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0073 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0342 0.092
Schistosoma mansoni Smad4 0.0075 0.0163 0.0144
Brugia malayi TAR-binding protein 0.0523 0.2334 0.4532
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0482 0.1318
Brugia malayi latrophilin 2 splice variant baaae 0.0487 0.2156 0.4186
Loa Loa (eye worm) hypothetical protein 0.0076 0.0166 0.0323
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0055 0.0066 0.0132
Brugia malayi Calcitonin receptor-like protein seb-1 0.0712 0.3248 0.6305
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.152 0.7165 1
Mycobacterium ulcerans hypothetical protein 0.0055 0.0066 0.0587
Echinococcus multilocularis lamin 0.008 0.0186 0.0167
Schistosoma mansoni sulfide quinone reductase 0.0055 0.0066 0.0046
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0055 0.0066 0.0046
Schistosoma mansoni cellular tumor antigen P53 0.0259 0.1055 0.1038
Schistosoma mansoni hypothetical protein 0.0225 0.089 0.0872
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1368 0.6426 0.8965
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0268 0.0249
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0055 0.0066 0.0587
Onchocerca volvulus 0.0076 0.0166 0.0291
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0208 0.0805 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0482 0.1318
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0055 0.0066 0.0142
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0055 0.0066 0.0127
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0166 0.0419
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0523 0.2334 0.4532
Loa Loa (eye worm) hypothetical protein 0.008 0.0186 0.0361
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0028 0.0053
Mycobacterium ulcerans monoxygenase 0.0055 0.0066 0.0587
Leishmania major hypothetical protein, conserved 0.0076 0.0166 0.0519
Trypanosoma brucei phosphoglycerate kinase 0.0166 0.0603 0.2152
Schistosoma mansoni tar DNA-binding protein 0.0523 0.2334 0.232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0342 0.092
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0055 0.0066 0.0065
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0676 0.3075 0.5969
Echinococcus multilocularis smad 0.0075 0.0163 0.0144
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0055 0.0066 0.0587
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0045 0.0064
Loa Loa (eye worm) hypothetical protein 0.0076 0.0166 0.0323
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0166 0.0603 0.0817
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0055 0.0066 0.0132
Loa Loa (eye worm) glutathione reductase 0.06 0.2704 0.5249
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0094 0.0248
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0055 0.0066 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0028 0.0023
Leishmania major cathepsin L-like protease 0.0072 0.0148 0.045
Schistosoma mansoni tar DNA-binding protein 0.0523 0.2334 0.232
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0055 0.0066 0.0132
Loa Loa (eye worm) MH1 domain-containing protein 0.0075 0.0163 0.0316
Treponema pallidum thioredoxin reductase (trxB) 0.0055 0.0066 0.0587
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0055 0.0066 0.0142
Brugia malayi beta-lactamase family protein 0.0076 0.0166 0.0323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0148 0.045
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0055 0.0066 0.0046
Plasmodium falciparum glutathione reductase 0.0208 0.0805 0.286
Loa Loa (eye worm) hypothetical protein 0.0079 0.0179 0.0347
Echinococcus granulosus tumor protein p63 0.1772 0.8385 0.8382
Loa Loa (eye worm) hypothetical protein 0.0076 0.0166 0.0323
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0208 0.0805 0.286
Brugia malayi RNA binding protein 0.0523 0.2334 0.4532
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0055 0.0066 0.0065
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0225 0.089 0.0872
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0208 0.0805 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0166 0.0147
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0094 0.0248
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0208 0.0805 0.2906
Treponema pallidum NADH oxidase 0.0208 0.0805 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0141 0.0482 0.1698
Leishmania major NADH dehydrogenase, putative 0.0055 0.0066 0.0142
Loa Loa (eye worm) hypothetical protein 0.0055 0.0066 0.0127
Echinococcus multilocularis lamin dm0 0.008 0.0186 0.0167
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0166 0.0206
Plasmodium falciparum ferrodoxin reductase-like protein 0.0055 0.0066 0.0078
Plasmodium falciparum glutathione reductase 0.06 0.2704 1
Onchocerca volvulus 0.0076 0.0166 0.0291
Schistosoma mansoni phosphoglycerate kinase 0.0166 0.0603 0.0585
Brugia malayi glutathione reductase 0.06 0.2704 0.5249
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0166 0.0147
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0055 0.0066 0.0132
Trichomonas vaginalis mercuric reductase, putative 0.0208 0.0805 0.224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0148 0.045
Brugia malayi beta-lactamase 0.0076 0.0166 0.0323
Echinococcus granulosus Smad4 0.0075 0.0163 0.0144
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0112 0.0343 0.1177
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0055 0.0066 0.0142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0033 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0307 0.0819
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0094 0.0248
Brugia malayi Latrophilin receptor protein 2 0.0225 0.089 0.1727
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0307 0.0819
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0208 0.0805 0.2906
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0055 0.0066 0.0078
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0141 0.0482 0.7739
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0257 0.0677
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0093 0.0251 0.0232
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0055 0.0066 0.0078
Plasmodium vivax glutathione reductase, putative 0.06 0.2704 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0055 0.0066 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0166 0.0519
Loa Loa (eye worm) hypothetical protein 0.0076 0.0166 0.0323
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0166 0.0147
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0047 0.0028 0.0008
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0112 0.0343 0.1177
Entamoeba histolytica hypothetical protein 0.0072 0.0149 0.1546
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0055 0.0066 0.0587
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0141 0.0482 0.0463
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0166 0.0419
Loa Loa (eye worm) RNA binding protein 0.0523 0.2334 0.4532
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0166 0.0519
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0208 0.0805 0.2906
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0055 0.0066 0.0046
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0055 0.0066 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0083 0.0203 0.0523
Brugia malayi Pre-SET motif family protein 0.0676 0.3075 0.5969
Trypanosoma cruzi NADH dehydrogenase, putative 0.0055 0.0066 0.0142
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0055 0.0066 0.0587
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0208 0.0805 0.2906
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0166 0.0206
Trypanosoma brucei phosphoglycerate kinase 0.0061 0.0094 0.0248
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0208 0.0805 0.286
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0055 0.0066 0.0078
Loa Loa (eye worm) hypothetical protein 0.0487 0.2156 0.4186
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0055 0.0066 0.0065
Schistosoma mansoni hypothetical protein 0.0225 0.089 0.0872
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0141 0.0482 0.1698
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0148 0.045
Mycobacterium ulcerans hypothetical protein 0.0076 0.0166 0.1872
Toxoplasma gondii thioredoxin reductase 0.06 0.2704 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0055 0.0066 0.0142
Loa Loa (eye worm) MH2 domain-containing protein 0.1105 0.5151 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.0342 0.092
Echinococcus granulosus smad 0.0075 0.0163 0.0144
Schistosoma mansoni smad1 5 8 and 0.0075 0.0163 0.0144
Loa Loa (eye worm) hypothetical protein 0.0076 0.0166 0.0323
Onchocerca volvulus 0.0259 0.1055 0.2858
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0141 0.0482 0.0935
Brugia malayi Phosphoglycerate kinase 0.0166 0.0603 0.1172
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0033 0.0014
Brugia malayi Intermediate filament tail domain containing protein 0.008 0.0186 0.0361
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.152 0.7165 1
Brugia malayi MH2 domain containing protein 0.1105 0.5151 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1368 0.6426 0.8965
Trichomonas vaginalis PIKK family atypical protein kinase 0.0083 0.0203 0.0523
Echinococcus granulosus tar DNA binding protein 0.0523 0.2334 0.232
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0141 0.0482 0.7739
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0055 0.0066 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0167 0.0422
Schistosoma mansoni glutamate synthase 0.0055 0.0066 0.0046
Entamoeba histolytica hypothetical protein 0.0072 0.0149 0.1546
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0055 0.0066 0.0065
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0028 0.0053
Plasmodium falciparum phosphoglycerate kinase 0.0166 0.0603 0.2101
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0166 0.0323
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0055 0.0066 0.0046
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0055 0.0066 0.0142
Mycobacterium ulcerans phosphoglycerate kinase 0.0166 0.0603 0.7433
Loa Loa (eye worm) hypothetical protein 0.0259 0.1055 0.2048
Echinococcus granulosus lamin 0.008 0.0186 0.0167
Mycobacterium ulcerans NADH dehydrogenase 0.0055 0.0066 0.0587
Mycobacterium ulcerans beta-lactamase 0.0076 0.0166 0.1872
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0055 0.0066 0.0127
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0148 0.045
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0208 0.0805 0.2906
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0141 0.0482 0.1698
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.0207 0.0534
Mycobacterium ulcerans ferredoxin reductase 0.0055 0.0066 0.0587
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0006 0.0012
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0055 0.0066 0.0078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0148 0.045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0148 0.045
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0225 0.089 0.0872
Giardia lamblia NADH oxidase lateral transfer candidate 0.0208 0.0805 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0055 0.0066 0.0078
Brugia malayi MH2 domain containing protein 0.0075 0.0163 0.0316
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0208 0.0805 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0166 0.0323
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0149 0.013
Leishmania major phosphoglycerate kinase B, cytosolic 0.0166 0.0603 0.2152
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.06 0.2704 0.3756
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0167 0.042
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0055 0.0066 0.0065
Brugia malayi glutamate synthase 0.0055 0.0066 0.0127
Chlamydia trachomatis phosphoglycerate kinase 0.0166 0.0603 0.7273
Schistosoma mansoni tar DNA-binding protein 0.0523 0.2334 0.232
Loa Loa (eye worm) beta-lactamase 0.0076 0.0166 0.0323
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0055 0.0066 0.0065
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0208 0.0805 0.286
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0055 0.0066 0.0132
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0059 0.0082 0.0204
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0149 0.013
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0166 0.0458
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0141 0.0482 0.1698
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0268 0.0249
Brugia malayi Thioredoxin reductase 0.06 0.2704 0.5249
Trichomonas vaginalis esterase, putative 0.0076 0.0166 0.0419
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0148 0.045
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0055 0.0066 0.0587
Loa Loa (eye worm) transcription factor SMAD2 0.1105 0.5151 1
Mycobacterium ulcerans lipase LipD 0.0076 0.0166 0.1872
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0055 0.0066 0.0587
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0208 0.0805 0.0787
Leishmania major cathepsin L-like protease 0.0072 0.0148 0.045
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0097 0.0268 0.0249
Schistosoma mansoni lamin 0.008 0.0186 0.0167
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0153 0.0538 0.1044
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0055 0.0066 0.0132
Schistosoma mansoni tar DNA-binding protein 0.0523 0.2334 0.232
Schistosoma mansoni hypothetical protein 0.0225 0.089 0.0872
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0066 0.0142
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0485 0.215 0.2982
Echinococcus multilocularis microtubule associated protein 2 0.2105 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0167 0.0422
Plasmodium falciparum thioredoxin reductase 0.0208 0.0805 0.286
Echinococcus granulosus lamin dm0 0.008 0.0186 0.0167
Schistosoma mansoni disulfide oxidoreductase 0.0055 0.0066 0.0046
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0055 0.0066 0.0142
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0047 0.0028 0.0008
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0055 0.0066 0.0587
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0055 0.0066 0.0078
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0055 0.0066 0.0078
Schistosoma mansoni hypothetical protein 0.0225 0.089 0.0872
Trypanosoma brucei phosphoglycerate kinase, putative 0.0061 0.0094 0.0248
Trypanosoma brucei trypanothione reductase 0.06 0.2704 1
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0006 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0148 0.045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0148 0.045
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0055 0.0066 0.0132
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0208 0.0805 0.2906
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0712 0.3248 0.6305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0033 0.0014
Giardia lamblia Phosphoglycerate kinase 0.0166 0.0603 0.7273
Echinococcus granulosus TGF beta signal transducer SmadC 0.0075 0.0163 0.0144
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1368 0.6426 0.8965
Schistosoma mansoni lamin 0.008 0.0186 0.0167
Leishmania major hypothetical protein, conserved 0.0055 0.0066 0.0142
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0166 0.0603 0.2101
Echinococcus granulosus glutamate synthase 0.0055 0.0066 0.0046
Brugia malayi beta-lactamase family protein 0.0076 0.0166 0.0323
Schistosoma mansoni smad 0.0075 0.0163 0.0144
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0055 0.0066 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0482 0.1318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0167 0.0422
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0094 0.0248
Entamoeba histolytica hypothetical protein 0.0072 0.0149 0.1546
Echinococcus multilocularis musashi 0.008 0.0186 0.0167
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0055 0.0066 0.0587
Trypanosoma cruzi NADH dehydrogenase, putative 0.0055 0.0066 0.0142
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0055 0.0066 0.0046
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0712 0.3248 0.6305
Toxoplasma gondii selenide, water dikinase 0.0055 0.0066 0.0078
Mycobacterium tuberculosis Conserved protein 0.0076 0.0166 0.0206
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0075 0.0163 0.0144
Leishmania major cathepsin L-like protease 0.0072 0.0148 0.045
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0097 0.0268 0.0249
Schistosoma mansoni hypothetical protein 0.0055 0.0066 0.0046
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0055 0.0066 0.0127
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0153 0.0538 0.1044
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0268 0.0249
Brugia malayi MH1 domain containing protein 0.0075 0.0163 0.0316
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0141 0.0482 0.0463
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0141 0.0482 0.1698
Brugia malayi Phosphoglycerate kinase 0.0061 0.0094 0.0182
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0208 0.0805 0.2906
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0055 0.0066 0.0587
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.152 0.7165 1
Schistosoma mansoni hypothetical protein 0.0072 0.0149 0.013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0033 0.0064
Onchocerca volvulus 0.008 0.0186 0.0348
Brugia malayi Smad1 0.0075 0.0163 0.0316
Trypanosoma brucei hypothetical protein, conserved 0.0055 0.0066 0.0142
Loa Loa (eye worm) hypothetical protein 0.0076 0.0166 0.0323
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1368 0.6426 0.8965
Brugia malayi RNA recognition motif domain containing protein 0.0523 0.2334 0.4532
Schistosoma mansoni tar DNA-binding protein 0.0523 0.2334 0.232
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0225 0.089 0.1727
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0166 0.0419
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0055 0.0066 0.0587
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0055 0.0066 0.0065
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0208 0.0805 0.286
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0208 0.0805 0.2906
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0167 0.0422
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0055 0.0066 0.0127
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0166 0.0206
Schistosoma mansoni hypothetical protein 0.0487 0.2156 0.2141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0307 0.0819
Leishmania major hypothetical protein, conserved 0.0055 0.0066 0.0142
Echinococcus multilocularis tar DNA binding protein 0.0523 0.2334 0.232
Brugia malayi MH2 domain containing protein 0.0075 0.0163 0.0316
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0208 0.0805 0.1563
Leishmania major hypothetical protein, conserved 0.0051 0.0045 0.0064
Echinococcus multilocularis phosphoglycerate kinase 1 0.0166 0.0603 0.0585
Plasmodium vivax ferrodoxin reductase, putative 0.0055 0.0066 0.0078
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0166 0.0206
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0055 0.0066 0.0142
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0208 0.0805 0.2906
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0208 0.0805 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0055 0.0066 0.0046
Loa Loa (eye worm) Smad1 0.0075 0.0163 0.0316
Loa Loa (eye worm) programmed cell death 8 0.0055 0.0066 0.0127
Schistosoma mansoni intermediate filament proteins 0.008 0.0186 0.0167
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0208 0.0805 0.2906
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0055 0.0066 0.0142
Treponema pallidum phosphoglycerate kinase 0.0166 0.0603 0.7433
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.0118 0.0337
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0208 0.0805 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0166 0.0206
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0166 0.0603 0.2152

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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