Detailed information for compound 620949

Basic information

Technical information
  • TDR Targets ID: 620949
  • Name: 5-[[4-(4-fluorophenyl)piperazin-1-yl]-(3-meth ylphenyl)methyl]-2-methyl-[1,3]thiazolo[2,3-e ][1,2,4]triazol-6-ol
  • MW: 437.533 | Formula: C23H24FN5OS
  • H donors: 1 H acceptors: 3 LogP: 4.85 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)C(c1sc2n(c1O)nc(n2)C)N1CCN(CC1)c1ccc(cc1)F
  • InChi: 1S/C23H24FN5OS/c1-15-4-3-5-17(14-15)20(21-22(30)29-23(31-21)25-16(2)26-29)28-12-10-27(11-13-28)19-8-6-18(24)7-9-19/h3-9,14,20,30H,10-13H2,1-2H3
  • InChiKey: CMWQAJQGESCECM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[[4-(4-fluorophenyl)piperazin-1-yl]-(3-methylphenyl)methyl]-2-methyl-thiazolo[2,3-e][1,2,4]triazol-6-ol
  • 5-[[4-(4-fluorophenyl)-1-piperazinyl]-(3-methylphenyl)methyl]-2-methyl-6-thiazolo[2,3-e][1,2,4]triazolol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0006 0.0007
Brugia malayi glutamate synthase 0.0046 0.0129 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0446 0.3163
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0127 0.0645 0.143
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0172 0.0938 0.3016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0165 0.1174
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0076 0.0321 0.0944
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0046 0.0129 0.0387
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0046 0.0129 0.0275
Giardia lamblia NADH oxidase lateral transfer candidate 0.0172 0.0938 1
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0129 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.029 0.2055
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0046 0.0129 0.0387
Schistosoma mansoni hypothetical protein 0.0067 0.0264 0.0258
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0046 0.0129 0.0296
Brugia malayi glutathione reductase 0.0497 0.3014 0.6727
Loa Loa (eye worm) MH2 domain-containing protein 0.0049 0.0153 0.0335
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0046 0.0129 0.0387
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0034 0.0064
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0076 0.0321 0.0944
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0321 0.2279
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0046 0.0129 0.0296
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0172 0.0938 0.2084
Brugia malayi Thioredoxin reductase 0.0497 0.3014 0.6727
Leishmania major hypothetical protein, conserved 0.0046 0.0129 0.0296
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0312 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0446 0.3163
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0046 0.0129 0.0915
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0046 0.0129 0.0387
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0524 0.3186 0.7113
Trichomonas vaginalis glutathione reductase, putative 0.0172 0.0938 0.6657
Schistosoma mansoni hypothetical protein 0.0046 0.0129 0.0123
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.004 0.009 0.0164
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0172 0.0938 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0165 0.1171
Brugia malayi Pre-SET motif family protein 0.0031 0.0035 0.0065
Schistosoma mansoni hypothetical protein 0.0031 0.0034 0.0029
Loa Loa (eye worm) Smad1 0.0049 0.0153 0.0335
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0032 0.0041 0.0035
Plasmodium vivax thioredoxin reductase, putative 0.0497 0.3014 1
Loa Loa (eye worm) programmed cell death 8 0.0046 0.0129 0.0282
Loa Loa (eye worm) hypothetical protein 0.0046 0.0129 0.0282
Trypanosoma cruzi NADH dehydrogenase, putative 0.0046 0.0129 0.0296
Schistosoma mansoni glutamate synthase 0.0046 0.0129 0.0123
Brugia malayi MH2 domain containing protein 0.0726 0.4478 1
Loa Loa (eye worm) thioredoxin reductase 0.0497 0.3014 0.673
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0046 0.0129 0.0296
Schistosoma mansoni smad1 5 8 and 0.0049 0.0153 0.0147
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1134 0.7085 0.8958
Schistosoma mansoni tar DNA-binding protein 0.0524 0.3186 0.3182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.029 0.2055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0197 0.1398
Echinococcus granulosus GPCR family 2 0.0031 0.0034 0.009
Treponema pallidum NADH oxidase 0.0172 0.0938 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0034 0.009
Echinococcus granulosus Smad4 0.0049 0.0153 0.0462
Brugia malayi RNA binding protein 0.0524 0.3186 0.7111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0035 0.0029
Leishmania major trypanothione reductase 0.0497 0.3014 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0172 0.0938 0.3016
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0046 0.0129 0.0275
Brugia malayi Smad1 0.0049 0.0153 0.0329
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0172 0.0938 0.2803
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0095 0.0446 0.1361
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0046 0.0129 0.0915
Echinococcus granulosus glutamate synthase 0.0046 0.0129 0.0387
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0046 0.0129 0.0387
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0172 0.0938 0.3016
Trichomonas vaginalis set domain proteins, putative 0.0246 0.1409 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0172 0.0938 0.3016
Loa Loa (eye worm) phosphatidylinositol 3 0.0095 0.0446 0.099
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.1218 0.2716
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1134 0.7085 0.8958
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0035 0.0029
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0035 0.0091
Schistosoma mansoni sulfide quinone reductase 0.0046 0.0129 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0165 0.1174
Echinococcus multilocularis mothers against decapentaplegic 5 0.0049 0.0153 0.0462
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1134 0.7085 0.8958
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0095 0.0446 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0035 0.0091
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0046 0.0129 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.02 0.1423
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0006 0.0007
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0046 0.0129 0.0915
Schistosoma mansoni sulfide quinone reductase 0.0046 0.0129 0.0123
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0095 0.0446 0.1383
Loa Loa (eye worm) hypothetical protein 0.0067 0.0264 0.0584
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0095 0.0446 0.1361
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0046 0.0129 0.0316
Schistosoma mansoni hypothetical protein 0.0074 0.0312 0.0307
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0127 0.0645 0.143
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0035 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0041 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0321 0.2279
Brugia malayi MH1 domain containing protein 0.0027 0.0011 0.0013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0172 0.0938 0.3016
Entamoeba histolytica hypothetical protein 0.0074 0.0312 0.5793
Echinococcus granulosus TGF beta signal transducer SmadC 0.0049 0.0153 0.0462
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0172 0.0938 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0172 0.0938 0.3031
Schistosoma mansoni glutamate synthase 0.0046 0.0129 0.0123
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0462 0.1026
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1261 0.7893 1
Plasmodium vivax ferrodoxin reductase, putative 0.0046 0.0129 0.0316
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0172 0.0938 0.2931
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0046 0.0129 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.02 0.1423
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0046 0.0129 0.0387
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0172 0.0938 0.3016
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0172 0.0938 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0172 0.0938 1
Echinococcus granulosus tar DNA binding protein 0.0524 0.3186 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0046 0.0129 0.0915
Brugia malayi TAR-binding protein 0.0524 0.3186 0.7111
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0046 0.0129 0.0915
Schistosoma mansoni glutamate synthase 0.0046 0.0129 0.0123
Trichomonas vaginalis glutamate synthase, putative 0.0046 0.0129 0.0915
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0041 0.029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0035 0.0029
Echinococcus granulosus smad 0.0049 0.0153 0.0462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.029 0.2055
Loa Loa (eye worm) transcription factor SMAD2 0.0726 0.4478 1
Onchocerca volvulus 0.0046 0.0129 0.0877
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0095 0.0446 0.0984
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0312 0.0964
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0007
Brugia malayi RNA recognition motif domain containing protein 0.0524 0.3186 0.7111
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0172 0.0938 0.3016
Plasmodium falciparum glutathione reductase 0.0497 0.3014 1
Echinococcus multilocularis tar DNA binding protein 0.0524 0.3186 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0046 0.0129 0.0387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0041 0.029
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0046 0.0129 0.0387
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0034 0.0064
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0046 0.0129 0.0316
Schistosoma mansoni smad1 5 8 and 0.0049 0.0153 0.0147
Loa Loa (eye worm) glutathione reductase 0.0497 0.3014 0.673
Trypanosoma cruzi target of rapamycin kinase 3 0.0076 0.0321 0.0944
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0049 0.0153 0.0147
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0041 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0357 0.2531
Trypanosoma cruzi trypanothione reductase, putative 0.0172 0.0938 0.3016
Plasmodium falciparum thioredoxin reductase 0.0172 0.0938 0.2803
Toxoplasma gondii target of rapamycin (TOR), putative 0.0071 0.029 0.0855
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0046 0.0129 0.0387
Schistosoma mansoni tar DNA-binding protein 0.0524 0.3186 0.3182
Trypanosoma brucei trypanothione reductase 0.0497 0.3014 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.029 0.2055
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0095 0.0446 0.1383
Entamoeba histolytica hypothetical protein 0.0074 0.0312 0.5793
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0034 0.0071
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0046 0.0129 0.0296
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0046 0.0129 0.0275
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0046 0.0129 0.0387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0245 0.174
Loa Loa (eye worm) nuclear factor I 0.0027 0.0011 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.029 0.2055
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0046 0.0129 0.0915
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0446 0.3163
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0046 0.0129 0.0387
Schistosoma mansoni tar DNA-binding protein 0.0524 0.3186 0.3182
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0032 0.0041 0.011
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1261 0.7893 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0321 0.2279
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0046 0.0129 0.0296
Leishmania major hypothetical protein, conserved 0.0046 0.0129 0.0296
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1134 0.7085 0.8958
Echinococcus granulosus thioredoxin glutathione reductase 0.0502 0.3044 0.9555
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0172 0.0938 0.3016
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0046 0.0129 0.0296
Echinococcus multilocularis smad 0.0049 0.0153 0.0462
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0046 0.0129 0.0316
Schistosoma mansoni smad1 5 8 and 0.0049 0.0153 0.0147
Schistosoma mansoni tar DNA-binding protein 0.0524 0.3186 0.3182
Leishmania major NADH dehydrogenase, putative 0.0046 0.0129 0.0296
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0172 0.0938 0.3031
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0129 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0232 0.1646
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0172 0.0938 0.3016
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0129 0.0296
Mycobacterium tuberculosis Probable dehydrogenase 0.1134 0.7085 0.8958
Trypanosoma brucei NADH dehydrogenase 0.0046 0.0129 0.0296
Loa Loa (eye worm) MH2 domain-containing protein 0.0726 0.4478 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0027 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0321 0.2279
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0462 0.1019
Giardia lamblia GTOR 0.0095 0.0446 0.3916
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0034 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0165 0.1174
Echinococcus multilocularis Smad4 0.0049 0.0153 0.0462
Loa Loa (eye worm) hypothetical protein 0.0031 0.0035 0.0072
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0172 0.0938 0.3016
Trichomonas vaginalis apoptosis inducing factor, putative 0.0046 0.0129 0.0915
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0046 0.0129 0.0296
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0095 0.0446 0.1361
Brugia malayi hypothetical protein 0.0074 0.0312 0.0686
Plasmodium vivax glutathione reductase, putative 0.0497 0.3014 1
Plasmodium falciparum thioredoxin reductase 0.0497 0.3014 1
Entamoeba histolytica hypothetical protein 0.0074 0.0312 0.5793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.029 0.2055
Echinococcus multilocularis thioredoxin glutathione reductase 0.0502 0.3044 0.9555
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0172 0.0938 0.3016
Plasmodium falciparum glutathione reductase 0.0172 0.0938 0.2803
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0172 0.0938 0.1042
Onchocerca volvulus 0.0031 0.0035 0.0206
Schistosoma mansoni hypothetical protein 0.0031 0.0034 0.0029
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0312 0.0964
Echinococcus multilocularis glutamate synthase 0.0046 0.0129 0.0387
Brugia malayi MH2 domain containing protein 0.0049 0.0153 0.0329
Trichomonas vaginalis glutamate synthase, putative 0.0046 0.0129 0.0915
Brugia malayi MH1 domain containing protein 0.0027 0.0011 0.0013
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0046 0.0129 0.0282
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1261 0.7893 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.029 0.2055
Schistosoma mansoni smad 0.0049 0.0153 0.0147
Loa Loa (eye worm) MH1 domain-containing protein 0.0049 0.0153 0.0335
Leishmania major hypothetical protein, conserved 0.0046 0.0129 0.0296
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0172 0.0938 0.3016
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0095 0.0446 0.044
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0172 0.0938 0.0932
Onchocerca volvulus 0.0246 0.1409 1
Echinococcus multilocularis GPCR, family 2 0.0031 0.0034 0.009
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0095 0.0446 0.1361
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0172 0.0938 0.3016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0041 0.029
Loa Loa (eye worm) hypothetical protein 0.0098 0.0462 0.1026
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0046 0.0129 0.0915
Mycobacterium tuberculosis Probable oxidoreductase 0.1261 0.7893 1
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0046 0.0129 0.0316
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0172 0.0938 1
Schistosoma mansoni hypothetical protein 0.0031 0.0034 0.0029
Toxoplasma gondii thioredoxin reductase 0.0497 0.3014 1
Entamoeba histolytica hypothetical protein 0.0074 0.0312 0.5793
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0032 0.0041 0.011
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0172 0.0938 0.3016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0197 0.1398
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0046 0.0129 0.0915
Schistosoma mansoni Smad4 0.0049 0.0153 0.0147
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0172 0.0938 0.3031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0041 0.029
Brugia malayi MH1 domain containing protein 0.0049 0.0153 0.0329
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0034 0.009
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0046 0.0129 0.0316
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0497 0.3014 0.3716
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0095 0.0446 1
Trypanosoma cruzi trypanothione reductase, putative 0.0497 0.3014 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0045 0.0125 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.02 0.1423
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0041 0.0078
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0046 0.0129 0.0915
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0095 0.0446 0.1361
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0172 0.0938 0.3016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0165 0.1174
Mycobacterium tuberculosis Probable reductase 0.1134 0.7085 0.8958
Schistosoma mansoni tar DNA-binding protein 0.0524 0.3186 0.3182
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0172 0.0938 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0034 0.009
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.002
Brugia malayi MH2 domain containing protein 0.0049 0.0153 0.0329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0165 0.1171
Trichomonas vaginalis mercuric reductase, putative 0.0172 0.0938 0.6657
Trypanosoma cruzi NADH dehydrogenase, putative 0.0046 0.0129 0.0296
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0264 0.0577
Loa Loa (eye worm) TAR-binding protein 0.0524 0.3186 0.7113
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0046 0.0129 0.0296
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0095 0.0446 0.1361
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0046 0.0129 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0165 0.1171
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0071
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0462 0.1019
Brugia malayi MH1 domain containing protein 0.0049 0.0153 0.0329
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0046 0.0129 0.0387
Schistosoma mansoni hypothetical protein 0.0031 0.0034 0.0029
Loa Loa (eye worm) RNA binding protein 0.0524 0.3186 0.7113
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0049 0.0153 0.0462
Schistosoma mansoni disulfide oxidoreductase 0.0046 0.0129 0.0123
Brugia malayi Pre-SET motif family protein 0.0216 0.1218 0.271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0321 0.2279
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0035 0.0091
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0046 0.0129 0.0296
Toxoplasma gondii NADPH-glutathione reductase 0.0172 0.0938 0.3031
Echinococcus granulosus mothers against decapentaplegic 5 0.0049 0.0153 0.0462
Toxoplasma gondii selenide, water dikinase 0.0046 0.0129 0.0316
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0172 0.0938 0.2803
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1134 0.7085 0.8958
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0172 0.0938 0.3016
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0046 0.0129 0.0915
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0046 0.0129 0.0316
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0172 0.0938 0.2931

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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