Detailed information for compound 620952

Basic information

Technical information
  • TDR Targets ID: 620952
  • Name: methyl 2-[4-(6-bromo-2-oxochromen-3-yl)-2-oxo chromen-7-yl]oxyacetate
  • MW: 457.228 | Formula: C21H13BrO7
  • H donors: 0 H acceptors: 3 LogP: 3.67 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)COc1ccc2c(c1)oc(=O)cc2c1cc2cc(Br)ccc2oc1=O
  • InChi: 1S/C21H13BrO7/c1-26-20(24)10-27-13-3-4-14-15(9-19(23)28-18(14)8-13)16-7-11-6-12(22)2-5-17(11)29-21(16)25/h2-9H,10H2,1H3
  • InChiKey: AUEOLGIBBQNQTQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 2-[4-(6-bromo-2-oxo-chromen-3-yl)-2-oxo-chromen-7-yl]oxyacetate
  • 2-[[4-(6-bromo-2-oxo-3-chromenyl)-2-oxo-7-chromenyl]oxy]acetic acid methyl ester
  • 2-[4-(6-bromo-2-keto-chromen-3-yl)-2-keto-chromen-7-yl]oxyacetic acid methyl ester
  • methyl 2-[4-(6-bromo-2-oxo-chromen-3-yl)-2-oxo-chromen-7-yl]oxyethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0119 0.039
Brugia malayi RNA recognition motif domain containing protein 0.0253 0.1584 0.5154
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0043 0.0162 0.0801
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0162 0.0969 0.2911
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0162 0.0534
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0182 1
Brugia malayi intermediate filament protein 0.008 0.0415 0.1265
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0087 0.0052
Loa Loa (eye worm) hypothetical protein 0.0079 0.0405 0.1232
Schistosoma mansoni lamin 0.008 0.0415 0.0381
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0162 0.0969 0.1042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0123 0.0295
Onchocerca volvulus 0.0253 0.1584 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1185 0.7908 1
Echinococcus multilocularis tumor protein p63 0.0693 0.457 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0468 0.304 0.3716
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0162 0.0969 0.3188
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0107 0.0073
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0087 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0182 0.0928
Brugia malayi Intermediate filament tail domain containing protein 0.008 0.0415 0.1265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0057 0.0118
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0043 0.0162 0.0281
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0043 0.0162 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0102 0.0412
Schistosoma mansoni glutamate synthase 0.0043 0.0162 0.0128
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0087 0.0115
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.1376 0.4462
Giardia lamblia GTOR 0.0046 0.0182 0.0243
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0182 0.0148
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0043 0.0162 0.0425
Brugia malayi MH2 domain containing protein 0.0355 0.2276 0.7457
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0162 0.0969 0.2911
Trichomonas vaginalis glutamate synthase, putative 0.0043 0.0162 0.0801
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0162 0.0969 1
Trypanosoma brucei NADH dehydrogenase 0.0043 0.0162 0.0534
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0043 0.0162 0.7371
Schistosoma mansoni hypothetical protein 0.0035 0.0107 0.0073
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0043 0.0162 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0102 0.0412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0102 0.0412
Entamoeba histolytica disulphide oxidoreductase, putative 0.0043 0.0162 0.7371
Schistosoma mansoni glutamate synthase 0.0043 0.0162 0.0128
Brugia malayi Pre-SET motif family protein 0.0032 0.0087 0.0173
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0043 0.0162 0.7371
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0079 0.0097
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0162 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0079 0.0265
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0107 0.016
Plasmodium vivax thioredoxin reductase, putative 0.0468 0.304 1
Onchocerca volvulus 0.0101 0.0559 0.3152
Mycobacterium tuberculosis Probable dehydrogenase 0.1066 0.7101 0.8958
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0043 0.0162 0.0256
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0162 0.0969 0.3188
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0073 0.0222
Schistosoma mansoni sulfide quinone reductase 0.0043 0.0162 0.0128
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0043 0.0162 0.0801
Trypanosoma cruzi NADH dehydrogenase, putative 0.0043 0.0162 0.015
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0043 0.0162 0.0281
Schistosoma mansoni tar DNA-binding protein 0.0253 0.1584 0.1555
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0043 0.0162 0.015
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0162 0.0969 0.3188
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0102 0.0412
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1066 0.7101 0.8958
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0043 0.0162 0.0534
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0102 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0039 0.0002
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0162 0.0969 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0118 0.0516
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0182 1
Echinococcus granulosus lamin 0.008 0.0415 0.0838
Loa Loa (eye worm) hypothetical protein 0.0101 0.0559 0.1743
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0118 0.0516
Schistosoma mansoni tar DNA-binding protein 0.0253 0.1584 0.1555
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0253 0.1584 0.5154
Brugia malayi glutamate synthase 0.0043 0.0162 0.0425
Echinococcus multilocularis lamin dm0 0.008 0.0415 0.0838
Plasmodium vivax glutathione reductase, putative 0.0468 0.304 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0043 0.0162 0.0425
Echinococcus multilocularis lamin 0.008 0.0415 0.0838
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0043 0.0162 0.0256
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0043 0.0162 0.0256
Plasmodium falciparum glutathione reductase 0.0162 0.0969 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0162 0.0801
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0162 0.0969 0.2988
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0182 0.0217
Echinococcus multilocularis musashi 0.008 0.0415 0.0838
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0087 0.0052
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0162 0.0969 0.2911
Echinococcus multilocularis thioredoxin glutathione reductase 0.0471 0.3061 0.6673
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0162 0.0969 1
Echinococcus multilocularis glutamate synthase 0.0043 0.0162 0.0281
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0162 0.0424
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0162 0.0969 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0118 0.0516
Loa Loa (eye worm) intermediate filament protein 0.008 0.0415 0.1265
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0162 0.0969 0.206
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0162 0.0969 0.2911
Treponema pallidum NADH oxidase 0.0162 0.0969 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0182 0.0325
Plasmodium falciparum thioredoxin reductase 0.0162 0.0969 0.2803
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0162 0.0424
Trichomonas vaginalis set domain proteins, putative 0.0253 0.1584 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0182 0.049
Plasmodium vivax ferrodoxin reductase, putative 0.0043 0.0162 0.0256
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0162 0.015
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0043 0.0162 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0102 0.0412
Schistosoma mansoni tar DNA-binding protein 0.0253 0.1584 0.1555
Trichomonas vaginalis apoptosis inducing factor, putative 0.0043 0.0162 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0136 0.0634
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0043 0.0162 0.015
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0162 0.0969 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0162 0.0534
Loa Loa (eye worm) transcription factor SMAD2 0.0355 0.2276 0.7457
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0133 0.0218
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0162 0.0801
Schistosoma mansoni tar DNA-binding protein 0.0253 0.1584 0.1555
Loa Loa (eye worm) programmed cell death 8 0.0043 0.0162 0.0425
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0182 0.0325
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0119 0.0678 0.2139
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0043 0.0162 0.0256
Brugia malayi RNA binding protein 0.0253 0.1584 0.5154
Toxoplasma gondii NADPH-glutathione reductase 0.0162 0.0969 0.2988
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1066 0.7101 0.8958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0039 0.0002
Trichomonas vaginalis glutamate synthase, putative 0.0043 0.0162 0.0801
Leishmania major NADH dehydrogenase, putative 0.0043 0.0162 0.015
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0043 0.0162 0.0281
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0107 0.016
Mycobacterium tuberculosis Probable oxidoreductase 0.1185 0.7908 1
Loa Loa (eye worm) RNA binding protein 0.0253 0.1584 0.5154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0039 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0055 0.0106
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0043 0.0162 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0118 0.0516
Loa Loa (eye worm) glutathione reductase 0.0468 0.304 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0162 0.0969 0.2911
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0043 0.0162 0.0281
Echinococcus granulosus lamin dm0 0.008 0.0415 0.0838
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0043 0.0162 0.7371
Trichomonas vaginalis glutathione reductase, putative 0.0162 0.0969 0.6022
Trypanosoma cruzi trypanothione reductase, putative 0.0468 0.304 1
Echinococcus granulosus tar DNA binding protein 0.0253 0.1584 0.3416
Trypanosoma cruzi NADH dehydrogenase, putative 0.0043 0.0162 0.015
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1066 0.7101 0.8958
Giardia lamblia NADH oxidase lateral transfer candidate 0.0162 0.0969 1
Schistosoma mansoni intermediate filament proteins 0.008 0.0415 0.0381
Brugia malayi Thioredoxin reductase 0.0468 0.304 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0043 0.0162 0.7371
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0043 0.0162 0.0281
Schistosoma mansoni hypothetical protein 0.0043 0.0162 0.0128
Echinococcus granulosus glutamate synthase 0.0043 0.0162 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0182 0.0928
Onchocerca volvulus 0.0043 0.0162 0.0505
Loa Loa (eye worm) MH2 domain-containing protein 0.0355 0.2276 0.7457
Loa Loa (eye worm) hypothetical protein 0.008 0.0415 0.1265
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0087 0.0052
Loa Loa (eye worm) hypothetical protein 0.0039 0.0133 0.0328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0057 0.0118
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0162 0.0969 0.2911
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0043 0.0162 0.0281
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0162 0.0969 0.2911
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0162 0.0801
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.008 0.0415 0.1265
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0162 0.0969 0.2911
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0133 0.0218
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0162 0.0801
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0043 0.0162 0.0281
Loa Loa (eye worm) hypothetical protein 0.0043 0.0162 0.0425
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0018 0.0059
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0043 0.0162 0.0281
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0162 0.0969 0.2988
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0039 0.0002
Loa Loa (eye worm) TAR-binding protein 0.0253 0.1584 0.5154
Leishmania major hypothetical protein, conserved 0.0043 0.0162 0.015
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0182 0.049
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0182 0.0217
Echinococcus granulosus intermediate filament protein 0.008 0.0415 0.0838
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0119 0.0678 0.2139
Echinococcus multilocularis tar DNA binding protein 0.0253 0.1584 0.3416
Trichomonas vaginalis mercuric reductase, putative 0.0162 0.0969 0.6022
Leishmania major trypanothione reductase 0.0468 0.304 1
Brugia malayi Pre-SET motif family protein 0.0222 0.1376 0.4462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0102 0.0412
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0182 0.0598
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0182 0.0598
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0162 0.0969 0.3109
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0162 0.0969 0.0938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0182 0.0928
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1066 0.7101 0.8958
Loa Loa (eye worm) thioredoxin reductase 0.0468 0.304 1
Leishmania major hypothetical protein, conserved 0.0043 0.0162 0.015
Brugia malayi glutathione reductase 0.0468 0.304 1
Plasmodium falciparum thioredoxin reductase 0.0468 0.304 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1185 0.7908 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0043 0.0162 0.0281
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0162 0.015
Echinococcus granulosus thioredoxin glutathione reductase 0.0471 0.3061 0.6673
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0087 0.0052
Schistosoma mansoni disulfide oxidoreductase 0.0043 0.0162 0.0128
Brugia malayi hypothetical protein 0.0035 0.0107 0.0242
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0043 0.0162 0.0281
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0043 0.0162 0.0425
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0162 0.0969 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0162 0.0969 0.3188
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0162 0.0534
Mycobacterium tuberculosis Probable reductase 0.1066 0.7101 0.8958
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0162 0.0969 0.2911
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0162 0.0969 0.2911
Schistosoma mansoni lamin 0.008 0.0415 0.0381
Schistosoma mansoni sulfide quinone reductase 0.0043 0.0162 0.0128
Plasmodium falciparum glutathione reductase 0.0468 0.304 1
Trypanosoma cruzi trypanothione reductase, putative 0.0162 0.0969 0.2911
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0043 0.0162 0.015
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0043 0.0162 0.0801
Schistosoma mansoni cellular tumor antigen P53 0.0101 0.0559 0.0526
Toxoplasma gondii thioredoxin reductase 0.0468 0.304 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0162 0.015
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0162 0.0969 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0162 0.0969 0.2911
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0043 0.0162 0.015
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0043 0.0162 0.7371
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0162 0.015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0162 0.0969 0.2911
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0043 0.0162 0.0801
Trypanosoma brucei trypanothione reductase 0.0468 0.304 1
Schistosoma mansoni tar DNA-binding protein 0.0253 0.1584 0.1555
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0043 0.0162 0.0534
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0162 0.0969 0.2988
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1066 0.7101 0.8958
Onchocerca volvulus 0.008 0.0415 0.2192
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1185 0.7908 1
Toxoplasma gondii selenide, water dikinase 0.0043 0.0162 0.0256
Loa Loa (eye worm) hypothetical protein 0.0037 0.0123 0.0295
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0043 0.0162 0.0425
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0182 0.0217
Entamoeba histolytica thioredoxin reductase, putative 0.0043 0.0162 0.7371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0055 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0118 0.0516
Brugia malayi TAR-binding protein 0.0253 0.1584 0.5154
Leishmania major hypothetical protein, conserved 0.0043 0.0162 0.015
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0087 0.0115
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0162 0.0969 0.206
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0162 0.0969 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0173
Onchocerca volvulus 0.008 0.0415 0.2192
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0162 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0102 0.0412
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0043 0.0162 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0057 0.0118
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0182 0.0217
Echinococcus granulosus tumor protein p63 0.0693 0.457 1
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0043 0.0162 0.0281
Schistosoma mansoni glutamate synthase 0.0043 0.0162 0.0128

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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