Detailed information for compound 620964

Basic information

Technical information
  • TDR Targets ID: 620964
  • Name: 2-[3-(4-methoxyphenyl)-4-methyl-2-oxochromen- 7-yl]oxyacetamide
  • MW: 339.342 | Formula: C19H17NO5
  • H donors: 1 H acceptors: 2 LogP: 2.35 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1c(=O)oc2c(c1C)ccc(c2)OCC(=O)N
  • InChi: 1S/C19H17NO5/c1-11-15-8-7-14(24-10-17(20)21)9-16(15)25-19(22)18(11)12-3-5-13(23-2)6-4-12/h3-9H,10H2,1-2H3,(H2,20,21)
  • InChiKey: VUKCMHUMLLHPRV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[3-(4-methoxyphenyl)-4-methyl-2-oxo-chromen-7-yl]oxyacetamide
  • 2-[[3-(4-methoxyphenyl)-4-methyl-2-oxo-7-chromenyl]oxy]acetamide
  • 2-[2-keto-3-(4-methoxyphenyl)-4-methyl-chromen-7-yl]oxyacetamide
  • 2-[3-(4-methoxyphenyl)-4-methyl-2-oxo-chromen-7-yl]oxyethanamide
  • ZINC04340070

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum glutathione reductase 0.0584 0.3001 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1332 0.7083 0.8958
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0072 0.0206 0.0392
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0202 0.0919 0.2841
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0054 0.0108 0.0137
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0054 0.0108 0.0137
Plasmodium vivax glutathione reductase, putative 0.0584 0.3001 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0215 0.0529
Trichomonas vaginalis mercuric reductase, putative 0.0202 0.0919 1
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0054 0.0108 0.0137
Echinococcus granulosus tumor protein p63 0.1472 0.7849 1
Echinococcus granulosus glutamate synthase 0.0054 0.0108 0.0137
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0202 0.0919 0.2841
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0305 0.3036
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0054 0.0108 0.0137
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0108 0.0053
Loa Loa (eye worm) transcription factor SMAD2 0.0779 0.4067 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0152 0.0643 0.0643
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0149 0.0626 0.1539
Onchocerca volvulus 0.0173 0.076 0.7391
Entamoeba histolytica hypothetical protein 0.008 0.0252 0.2692
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0063 0.0159 0.0228
Schistosoma mansoni Smad4 0.0053 0.0104 0.0104
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0202 0.0919 0.1042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0152 0.0643 0.6872
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0054 0.0108 0.0803
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0054 0.0108 0.0265
Brugia malayi RNA binding protein 0.0543 0.2779 0.6833
Brugia malayi glutathione reductase 0.0584 0.3001 0.7379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0431 0.4465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0431 0.4465
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0121 0.0474 0.1312
Plasmodium falciparum thioredoxin reductase 0.0584 0.3001 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0202 0.0919 0.2803
Toxoplasma gondii NADPH-glutathione reductase 0.0202 0.0919 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0092 0.063
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0202 0.0919 0.2841
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0431 0.4465
Echinococcus multilocularis musashi 0.0059 0.0134 0.0171
Schistosoma mansoni lamin 0.0059 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0057 0.0128 0.0315
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0054 0.0108 0.0053
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1481 0.7894 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0401 0.0985
Onchocerca volvulus 0.0059 0.0134 0.0296
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0202 0.0919 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0134 0.0329
Echinococcus multilocularis lamin 0.0059 0.0134 0.0171
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0152 0.0643 0.1893
Brugia malayi MH2 domain containing protein 0.0053 0.0104 0.0256
Brugia malayi Thioredoxin reductase 0.0584 0.3001 0.7379
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0054 0.0108 0.0053
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0054 0.0108 0.0053
Schistosoma mansoni glutamate synthase 0.0054 0.0108 0.0108
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0092 0.0227
Loa Loa (eye worm) glutathione reductase 0.0584 0.3001 0.7379
Echinococcus granulosus intermediate filament protein 0.0059 0.0134 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0121 0.0473 0.495
Onchocerca volvulus 0.0059 0.0134 0.0296
Loa Loa (eye worm) MH2 domain-containing protein 0.0053 0.0104 0.0256
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0152 0.0643 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0202 0.0919 0.2841
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0202 0.0919 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.037 0.378
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0108 0.0053
Echinococcus multilocularis thioredoxin glutathione reductase 0.0588 0.3025 0.3853
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0401 0.0985
Trypanosoma brucei trypanothione reductase 0.0584 0.3001 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0121 0.0474 0.1312
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0152 0.0643 0.1893
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0054 0.0108 0.0803
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0054 0.0108 0.0137
Schistosoma mansoni smad1 5 8 and 0.0053 0.0104 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0305 0.3036
Loa Loa (eye worm) hypothetical protein 0.0107 0.0401 0.0985
Giardia lamblia GTOR 0.0152 0.0643 0.6599
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0054 0.0108 0.0803
Echinococcus granulosus smad 0.0053 0.0104 0.0133
Echinococcus multilocularis microtubule associated protein 2 0.0738 0.384 0.4892
Trichomonas vaginalis apoptosis inducing factor, putative 0.0054 0.0108 0.0803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0121 0.0473 0.495
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1481 0.7894 1
Trypanosoma brucei NADH dehydrogenase 0.0054 0.0108 0.0053
Echinococcus granulosus TGF beta signal transducer SmadC 0.0053 0.0104 0.0133
Echinococcus granulosus thioredoxin glutathione reductase 0.0588 0.3025 0.3853
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1332 0.7083 0.8958
Trichomonas vaginalis glutathione reductase, putative 0.0202 0.0919 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0092 0.063
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0134 0.0329
Schistosoma mansoni cellular tumor antigen P53 0.0216 0.0991 0.0991
Entamoeba histolytica hypothetical protein 0.008 0.0252 0.2692
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0054 0.0108 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.031 0.3092
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0054 0.0108 0.0137
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0152 0.0643 0.1893
Loa Loa (eye worm) MH2 domain-containing protein 0.0779 0.4067 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0054 0.0108 0.0803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0262 0.2551
Brugia malayi hypothetical protein 0.0173 0.076 0.1869
Schistosoma mansoni intermediate filament proteins 0.0059 0.0134 0.0134
Leishmania major hypothetical protein, conserved 0.0054 0.0108 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0092 0.063
Plasmodium vivax thioredoxin reductase, putative 0.0584 0.3001 1
Schistosoma mansoni lamin 0.0059 0.0134 0.0134
Trypanosoma cruzi NADH dehydrogenase, putative 0.0054 0.0108 0.0053
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0053 0.0104 0.0104
Brugia malayi RNA recognition motif domain containing protein 0.0543 0.2779 0.6833
Trichomonas vaginalis PIKK family atypical protein kinase 0.0121 0.0473 0.495
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0202 0.0919 0.0919
Schistosoma mansoni hypothetical protein 0.0054 0.0108 0.0108
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.0252 0.0321
Schistosoma mansoni smad 0.0053 0.0104 0.0104
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0202 0.0919 0.2841
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0202 0.0919 0.1171
Mycobacterium tuberculosis Probable reductase 0.1332 0.7083 0.8958
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0054 0.0108 0.0053
Trichomonas vaginalis glutamate synthase, putative 0.0054 0.0108 0.0803
Treponema pallidum NADH oxidase 0.0202 0.0919 1
Schistosoma mansoni tar DNA-binding protein 0.0543 0.2779 0.2779
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0202 0.0919 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0152 0.0643 0.6872
Echinococcus multilocularis Smad4 0.0053 0.0104 0.0133
Brugia malayi MH2 domain containing protein 0.0053 0.0104 0.0256
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0202 0.0919 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0054 0.0108 0.0803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0202 0.0919 0.2841
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0054 0.0108 0.0265
Mycobacterium tuberculosis Probable oxidoreductase 0.1481 0.7894 1
Onchocerca volvulus 0.0216 0.0991 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0431 0.4465
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0584 0.3001 0.3716
Brugia malayi MH1 domain containing protein 0.0053 0.0104 0.0256
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0202 0.0919 0.2841
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0261 0.2544
Echinococcus granulosus lamin dm0 0.0059 0.0134 0.0171
Echinococcus granulosus lamin 0.0059 0.0134 0.0171
Giardia lamblia NADH oxidase lateral transfer candidate 0.0202 0.0919 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0053 0.0104 0.0256
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0134 0.0329
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0543 0.2779 0.6833
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0054 0.0108 0.0137
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0152 0.0643 0.0819
Echinococcus granulosus tar DNA binding protein 0.0543 0.2779 0.354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0262 0.2551
Echinococcus granulosus mothers against decapentaplegic 5 0.0053 0.0104 0.0133
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0054 0.0108 0.0053
Loa Loa (eye worm) Smad1 0.0053 0.0104 0.0256
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0202 0.0919 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0152 0.0643 0.1893
Entamoeba histolytica hypothetical protein 0.008 0.0252 0.2692
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0152 0.0643 0.1581
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0054 0.0108 0.0803
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0054 0.0108 0.0053
Trypanosoma cruzi trypanothione reductase, putative 0.0584 0.3001 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0054 0.0108 0.0137
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0202 0.0919 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0202 0.0919 0.2841
Echinococcus granulosus Smad4 0.0053 0.0104 0.0133
Entamoeba histolytica hypothetical protein 0.008 0.0252 0.2692
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0051 0.0092 0.0118
Schistosoma mansoni smad1 5 8 and 0.0053 0.0104 0.0104
Echinococcus multilocularis lamin dm0 0.0059 0.0134 0.0171
Brugia malayi MH1 domain containing protein 0.0053 0.0104 0.0256
Toxoplasma gondii thioredoxin reductase 0.0584 0.3001 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0108 0.0265
Leishmania major hypothetical protein, conserved 0.0054 0.0108 0.0053
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0054 0.0108 0.0803
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0054 0.0108 0.0137
Schistosoma mansoni microtubule-associated protein tau 0.0738 0.384 0.384
Echinococcus multilocularis tumor protein p63 0.1472 0.7849 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0054 0.0108 0.0137
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0215 0.0529
Echinococcus multilocularis tar DNA binding protein 0.0543 0.2779 0.354
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1332 0.7083 0.8958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0431 0.4465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0261 0.2544
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0051 0.0092 0.0092
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0202 0.0919 0.1171
Brugia malayi MH2 domain containing protein 0.0779 0.4067 1
Brugia malayi intermediate filament protein 0.0059 0.0134 0.0329
Schistosoma mansoni tar DNA-binding protein 0.0543 0.2779 0.2779
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0202 0.0919 0.2841
Schistosoma mansoni hypothetical protein 0.008 0.0252 0.0252
Echinococcus multilocularis smad 0.0053 0.0104 0.0133
Loa Loa (eye worm) phosphatidylinositol 3 0.0152 0.0643 0.1581
Plasmodium falciparum thioredoxin reductase 0.0202 0.0919 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0152 0.0643 0.6872
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0054 0.0108 0.0137
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0202 0.0919 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0202 0.0919 0.2841
Trichomonas vaginalis PIKK family atypical protein kinase 0.0121 0.0473 0.495
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0261 0.2544
Leishmania major hypothetical protein, conserved 0.0054 0.0108 0.0053
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0054 0.0108 0.0265
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0202 0.0919 0.2803
Echinococcus multilocularis glutamate synthase 0.0054 0.0108 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.031 0.3092
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0401 0.0985
Echinococcus multilocularis mothers against decapentaplegic 5 0.0053 0.0104 0.0133
Schistosoma mansoni hypothetical protein 0.0073 0.0215 0.0215
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0054 0.0108 0.0053
Loa Loa (eye worm) TAR-binding protein 0.0543 0.2779 0.6833
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0054 0.0108 0.0803
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0051 0.0092 0.0118
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0149 0.0626 0.1539
Trichomonas vaginalis PIKK family atypical protein kinase 0.0121 0.0473 0.495
Loa Loa (eye worm) hypothetical protein 0.0216 0.0991 0.2436
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0054 0.0108 0.0803
Brugia malayi TAR-binding protein 0.0543 0.2779 0.6833
Loa Loa (eye worm) programmed cell death 8 0.0054 0.0108 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0431 0.4465
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0054 0.0108 0.0053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0202 0.0919 0.2841
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0202 0.0919 0.2803
Schistosoma mansoni sulfide quinone reductase 0.0054 0.0108 0.0108
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1481 0.7894 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0054 0.0108 0.0053
Trypanosoma cruzi NADH dehydrogenase, putative 0.0054 0.0108 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0262 0.2551
Schistosoma mansoni tar DNA-binding protein 0.0543 0.2779 0.2779
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0202 0.0919 0.2841
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0202 0.0919 0.2841
Echinococcus granulosus microtubule associated protein 2 0.0738 0.384 0.4892
Schistosoma mansoni glutamate synthase 0.0054 0.0108 0.0108
Loa Loa (eye worm) thioredoxin reductase 0.0584 0.3001 0.7379
Schistosoma mansoni sulfide quinone reductase 0.0054 0.0108 0.0108
Brugia malayi glutamate synthase 0.0054 0.0108 0.0265
Brugia malayi Smad1 0.0053 0.0104 0.0256
Brugia malayi hypothetical protein 0.008 0.0252 0.0619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0092 0.063
Schistosoma mansoni disulfide oxidoreductase 0.0054 0.0108 0.0108
Leishmania major NADH dehydrogenase, putative 0.0054 0.0108 0.0053
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1332 0.7083 0.8958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0352 0.3577
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0152 0.0643 0.1893
Leishmania major trypanothione reductase 0.0584 0.3001 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0121 0.0474 0.1312
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0202 0.0919 1
Loa Loa (eye worm) RNA binding protein 0.0543 0.2779 0.6833
Schistosoma mansoni glutamate synthase 0.0054 0.0108 0.0108
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0053 0.0104 0.0133
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0054 0.0108 0.0137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0202 0.0919 0.2841
Schistosoma mansoni tar DNA-binding protein 0.0543 0.2779 0.2779
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0152 0.0643 0.0819
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0202 0.0919 0.2841
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1332 0.7083 0.8958
Schistosoma mansoni tar DNA-binding protein 0.0543 0.2779 0.2779
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0092 0.063
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0092 0.0227
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0054 0.0108 0.0053
Schistosoma mansoni transcription factor LCR-F1 0.008 0.0252 0.0252
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.0252 0.0321
Loa Loa (eye worm) hypothetical protein 0.0173 0.076 0.1869
Mycobacterium tuberculosis Probable dehydrogenase 0.1332 0.7083 0.8958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0262 0.2551
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0054 0.0108 0.0265
Trypanosoma brucei hypothetical protein, conserved 0.0054 0.0108 0.0053
Trichomonas vaginalis glutamate synthase, putative 0.0054 0.0108 0.0803
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0152 0.0643 0.1893
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.031 0.3092
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0054 0.0108 0.0803
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0152 0.0643 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0113 0.0431 0.1116
Trypanosoma cruzi trypanothione reductase, putative 0.0202 0.0919 0.2841
Schistosoma mansoni smad1 5 8 and 0.0053 0.0104 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0522 0.5499
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0202 0.0919 0.2841
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0431 0.4465
Plasmodium falciparum glutathione reductase 0.0202 0.0919 0.2803
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0134 0.0329
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0202 0.0919 0.2259

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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