Detailed information for compound 620970

Basic information

Technical information
  • TDR Targets ID: 620970
  • Name: 3-(3,4-dimethoxyphenyl)-4-methyl-7-(2-oxoprop oxy)chromen-2-one
  • MW: 368.38 | Formula: C21H20O6
  • H donors: 0 H acceptors: 2 LogP: 3.13 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)c1c(=O)oc2c(c1C)ccc(c2)OCC(=O)C
  • InChi: 1S/C21H20O6/c1-12(22)11-26-15-6-7-16-13(2)20(21(23)27-18(16)10-15)14-5-8-17(24-3)19(9-14)25-4/h5-10H,11H2,1-4H3
  • InChiKey: FDZBBZYLKUYPLZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 7-acetonyloxy-3-(3,4-dimethoxyphenyl)-4-methyl-chromen-2-one
  • 7-acetonyloxy-3-(3,4-dimethoxyphenyl)-4-methyl-2-chromenone
  • 7-acetonyloxy-3-(3,4-dimethoxyphenyl)-4-methyl-coumarin
  • ZINC04340113

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Thioredoxin reductase 0.0475 0.2997 0.7609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.056 0.6112
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0311 0.0302
Toxoplasma gondii target of rapamycin (TOR), putative 0.0105 0.0511 0.1688
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0511 0.5572
Plasmodium falciparum glutathione reductase 0.0165 0.0912 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0511 0.5572
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0165 0.0912 0.2803
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0165 0.0912 0.3029
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0165 0.0912 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0165 0.0912 0.2803
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0044 0.01 0.0101
Loa Loa (eye worm) RNA binding protein 0.045 0.2829 0.7187
Plasmodium falciparum thioredoxin reductase 0.0475 0.2997 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1085 0.7083 0.8958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0511 0.5572
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0125 0.0317
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0044 0.01 0.0101
Schistosoma mansoni tar DNA-binding protein 0.045 0.2829 0.2822
Loa Loa (eye worm) MH2 domain-containing protein 0.0615 0.3936 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1206 0.7895 1
Schistosoma mansoni smad1 5 8 and 0.0042 0.0088 0.0079
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0044 0.01 0.1036
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0141 0.0754 0.1896
Schistosoma mansoni sulfide quinone reductase 0.0044 0.01 0.0091
Brugia malayi MH1 domain containing protein 0.0042 0.0088 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0125 0.1303
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0165 0.0912 0.2803
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0044 0.01 0.0314
Loa Loa (eye worm) hypothetical protein 0.0056 0.0181 0.0461
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1206 0.7895 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0047 0.0125 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0442 0.4809
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0165 0.0912 0.2803
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0165 0.0912 0.0904
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0141 0.0754 0.0829
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0754 0.8251
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0044 0.01 0.0101
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0047 0.0125 0.0083
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0047 0.0125 0.0128
Onchocerca volvulus 0.0044 0.01 0.0796
Echinococcus granulosus microtubule associated protein 2 0.0674 0.4329 0.4813
Loa Loa (eye worm) programmed cell death 8 0.0044 0.01 0.0255
Brugia malayi RNA binding protein 0.045 0.2829 0.718
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0318 0.3433
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0044 0.01 0.0314
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0165 0.0912 0.1006
Echinococcus granulosus smad 0.0042 0.0088 0.0088
Mycobacterium tuberculosis Probable oxidoreductase 0.1206 0.7895 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0165 0.0912 0.2299
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0063 0.0136
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0044 0.01 0.1036
Treponema pallidum NADH oxidase 0.0165 0.0912 1
Schistosoma mansoni hypothetical protein 0.0044 0.01 0.0091
Trichomonas vaginalis mercuric reductase, putative 0.0165 0.0912 1
Entamoeba histolytica hypothetical protein 0.0075 0.0311 0.3221
Schistosoma mansoni microtubule-associated protein tau 0.0674 0.4329 0.4324
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0044 0.01 0.0231
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0044 0.01 0.0101
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0165 0.0912 0.2803
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0047 0.0125 0.0083
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0141 0.0754 0.2256
Loa Loa (eye worm) Smad1 0.0042 0.0088 0.0224
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1085 0.7083 0.8958
Toxoplasma gondii thioredoxin reductase 0.0475 0.2997 1
Echinococcus multilocularis Smad4 0.0042 0.0088 0.0088
Leishmania major trypanothione reductase 0.0475 0.2997 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0181 0.0438
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0044 0.01 0.1036
Loa Loa (eye worm) thioredoxin reductase 0.0475 0.2997 0.7614
Plasmodium falciparum glutathione reductase 0.0475 0.2997 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0044 0.01 0.0101
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0311 0.0336
Leishmania major phosphatidylinositol 3-kinase, putative 0.0047 0.0125 0.0083
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0044 0.01 0.0101
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0047 0.0125 0.0115
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0121 0.0619 0.1552
Onchocerca volvulus 0.0158 0.0866 0.7505
Loa Loa (eye worm) intermediate filament protein 0.003 0.001 0.0024
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0141 0.0754 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0044 0.01 0.0314
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0088 0.0224
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0044 0.01 0.0231
Echinococcus granulosus thioredoxin glutathione reductase 0.0479 0.3017 0.3351
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0141 0.0754 0.0829
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0112 0.0561 0.159
Echinococcus granulosus Smad4 0.0042 0.0088 0.0088
Echinococcus granulosus tar DNA binding protein 0.045 0.2829 0.314
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0044 0.01 0.0101
Trypanosoma brucei trypanothione reductase 0.0475 0.2997 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0422 0.4583
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0181 0.0438
Brugia malayi MH2 domain containing protein 0.0615 0.3936 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0088 0.0079
Schistosoma mansoni smad 0.0042 0.0088 0.0079
Echinococcus multilocularis tar DNA binding protein 0.045 0.2829 0.314
Echinococcus granulosus tumor protein p63 0.1368 0.8986 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.056 0.6112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0511 0.5572
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0044 0.01 0.1036
Brugia malayi Smad1 0.0042 0.0088 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0318 0.3433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0061 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0121 0.0615 0.6722
Loa Loa (eye worm) hypothetical protein 0.0044 0.01 0.0255
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0088 0.0088
Loa Loa (eye worm) phosphatidylinositol 3 0.0141 0.0754 0.1916
Onchocerca volvulus 0.02 0.1151 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.056 0.6112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.0373 0.4044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0125 0.1303
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0475 0.2997 0.3716
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0112 0.0561 0.159
Echinococcus multilocularis glutamate synthase 0.0044 0.01 0.0101
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0088 0.0224
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0141 0.0754 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0044 0.01 0.0231
Plasmodium vivax thioredoxin reductase, putative 0.0475 0.2997 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0165 0.0912 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0165 0.0912 0.2803
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0044 0.01 0.0101
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0165 0.0912 1
Schistosoma mansoni glutamate synthase 0.0044 0.01 0.0091
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0165 0.0912 0.2803
Toxoplasma gondii NADPH-glutathione reductase 0.0165 0.0912 0.3029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.0373 0.4044
Schistosoma mansoni Smad4 0.0042 0.0088 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0083 0.0367 0.3982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.0373 0.4044
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0044 0.01 0.0314
Brugia malayi hypothetical protein 0.0075 0.0311 0.0768
Trypanosoma cruzi target of rapamycin kinase 3 0.0112 0.0561 0.159
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0047 0.0125 0.0128
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0141 0.0754 0.0745
Brugia malayi MH1 domain containing protein 0.0042 0.0088 0.0201
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0024
Schistosoma mansoni tar DNA-binding protein 0.045 0.2829 0.2822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.056 0.6112
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0044 0.01 0.1036
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0044 0.01 0.1036
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0165 0.0912 0.2803
Echinococcus granulosus glutamate synthase 0.0044 0.01 0.0101
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0088 0.0088
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0067 0.0255 0.0533
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0088 0.0088
Loa Loa (eye worm) glutathione reductase 0.0475 0.2997 0.7614
Brugia malayi glutathione reductase 0.0475 0.2997 0.7609
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0047 0.0125 0.0083
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0044 0.01 0.0255
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1085 0.7083 0.8958
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0165 0.0912 0.2803
Plasmodium falciparum thioredoxin reductase 0.0165 0.0912 0.2803
Brugia malayi TAR-binding protein 0.045 0.2829 0.718
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0044 0.01 0.1036
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0165 0.0912 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0083 0.0367 0.3982
Schistosoma mansoni disulfide oxidoreductase 0.0044 0.01 0.0091
Mycobacterium tuberculosis Probable dehydrogenase 0.1085 0.7083 0.8958
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0181 0.0461
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.056 0.6112
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0165 0.0912 1
Plasmodium vivax glutathione reductase, putative 0.0475 0.2997 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0754 0.8251
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.016
Entamoeba histolytica hypothetical protein 0.0075 0.0311 0.3221
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0044 0.01 0.1036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0165 0.0912 0.2803
Loa Loa (eye worm) hypothetical protein 0.02 0.1151 0.2923
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0125 0.1303
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0044 0.01 0.0101
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0165 0.0912 0.2803
Echinococcus multilocularis tumor protein p63 0.1368 0.8986 1
Trichomonas vaginalis glutamate synthase, putative 0.0044 0.01 0.1036
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1085 0.7083 0.8958
Echinococcus multilocularis thioredoxin glutathione reductase 0.0479 0.3017 0.3351
Trichomonas vaginalis glutathione reductase, putative 0.0165 0.0912 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.0866 0.22
Trypanosoma cruzi trypanothione reductase, putative 0.0165 0.0912 0.2803
Schistosoma mansoni smad1 5 8 and 0.0042 0.0088 0.0079
Schistosoma mansoni glutamate synthase 0.0044 0.01 0.0091
Loa Loa (eye worm) transcription factor SMAD2 0.0615 0.3936 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0125 0.0293
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0141 0.0754 0.2256
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0044 0.01 0.0314
Echinococcus multilocularis microtubule associated protein 2 0.0674 0.4329 0.4813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0318 0.3442
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0311 0.0336
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0165 0.0912 0.2803
Schistosoma mansoni tar DNA-binding protein 0.045 0.2829 0.2822
Schistosoma mansoni smad1 5 8 and 0.0042 0.0088 0.0079
Trichomonas vaginalis apoptosis inducing factor, putative 0.0044 0.01 0.1036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0318 0.3442
Brugia malayi glutamate synthase 0.0044 0.01 0.0231
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0165 0.0912 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0125 0.1303
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0165 0.0912 0.1042
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0121 0.0619 0.1552
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0047 0.0125 0.0083
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.001 0.0024
Schistosoma mansoni hypothetical protein 0.0075 0.0311 0.0302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0318 0.3433
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0044 0.01 0.1036
Giardia lamblia GTOR 0.0141 0.0754 0.8049
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0165 0.0912 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0511 0.5572
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0044 0.01 0.0101
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0141 0.0754 0.2256
Trichomonas vaginalis glutamate synthase, putative 0.0044 0.01 0.1036
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0017
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0165 0.0912 0.1006
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0044 0.01 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0125 0.1303
Giardia lamblia NADH oxidase lateral transfer candidate 0.0165 0.0912 1
Entamoeba histolytica hypothetical protein 0.0075 0.0311 0.3221
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0165 0.0912 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0141 0.0754 0.2256
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0141 0.0754 0.2256
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0044 0.01 0.1036
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.045 0.2829 0.7187
Schistosoma mansoni tar DNA-binding protein 0.045 0.2829 0.2822
Schistosoma mansoni hypothetical protein 0.0038 0.0063 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0318 0.3442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0511 0.5572
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0165 0.0912 0.2803
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1206 0.7895 1
Schistosoma mansoni tar DNA-binding protein 0.045 0.2829 0.2822
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1085 0.7083 0.8958
Schistosoma mansoni glutamate synthase 0.0044 0.01 0.0091
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0165 0.0912 1
Brugia malayi MH2 domain containing protein 0.0042 0.0088 0.0201
Brugia malayi MH2 domain containing protein 0.0042 0.0088 0.0201
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0141 0.0754 0.2256
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0165 0.0912 0.2803
Echinococcus multilocularis smad 0.0042 0.0088 0.0088
Loa Loa (eye worm) TAR-binding protein 0.045 0.2829 0.7187
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0165 0.0912 0.2803
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0165 0.0912 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0754 0.8251
Brugia malayi RNA recognition motif domain containing protein 0.045 0.2829 0.718
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0088 0.0088
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0165 0.0912 0.2803
Toxoplasma gondii selenide, water dikinase 0.0044 0.01 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0318 0.3442
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0044 0.01 0.0101
Schistosoma mansoni sulfide quinone reductase 0.0044 0.01 0.0091
Schistosoma mansoni cellular tumor antigen P53 0.02 0.1151 0.1142
Mycobacterium tuberculosis Probable reductase 0.1085 0.7083 0.8958
Brugia malayi hypothetical protein 0.0158 0.0866 0.2181
Trypanosoma cruzi trypanothione reductase, putative 0.0475 0.2997 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0059 0.02 0.0345
Entamoeba histolytica hypothetical protein 0.0075 0.0311 0.3221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0511 0.5572

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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