Detailed information for compound 620984

Basic information

Technical information
  • TDR Targets ID: 620984
  • Name: 6-ethoxy-4-methyl-3-phenylchromen-2-one
  • MW: 280.318 | Formula: C18H16O3
  • H donors: 0 H acceptors: 1 LogP: 3.8 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc2c(c1)c(C)c(c(=O)o2)c1ccccc1
  • InChi: 1S/C18H16O3/c1-3-20-14-9-10-16-15(11-14)12(2)17(18(19)21-16)13-7-5-4-6-8-13/h4-11H,3H2,1-2H3
  • InChiKey: CHIWAOUCHWQWAQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-ethoxy-4-methyl-3-phenyl-chromen-2-one
  • 6-ethoxy-4-methyl-3-phenyl-2-chromenone
  • 6-ethoxy-4-methyl-3-phenyl-coumarin
  • ST5308866
  • ZINC00058021

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0171 0.0913 0.2917
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0045 0.0102 0.0292
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0045 0.0102 0.0158
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0171 0.0913 0.3018
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0275 0.0266
Brugia malayi beta-lactamase family protein 0.0038 0.0056 0.0102
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.014 0.0715 0.2242
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0045 0.0102 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0013 0.0004
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0047 0.0113 0.0194
Schistosoma mansoni tar DNA-binding protein 0.0523 0.3184 0.3178
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0494 0.2995 0.3753
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0047 0.0113 0.0194
Leishmania major phosphatidylinositol 3-kinase, putative 0.0047 0.0113 0.0194
Echinococcus multilocularis mothers against decapentaplegic 5 0.005 0.0131 0.0382
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0045 0.0102 0.0715
Plasmodium vivax ferrodoxin reductase, putative 0.0045 0.0102 0.0299
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0045 0.0102 0.0059
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0275 0.0848
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0443 0.0958
Schistosoma mansoni hypothetical protein 0.0045 0.0102 0.0093
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0171 0.0913 0.0904
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0056 0.0102
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0045 0.0102 0.0225
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1127 0.7077 0.8964
Brugia malayi TAR-binding protein 0.0523 0.3184 0.7021
Leishmania major trypanothione reductase 0.0494 0.2995 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0732 0.4531 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0047 0.0113 0.0194
Onchocerca volvulus 0.0053 0.0148 0.0953
Mycobacterium ulcerans glutamate synthase subunit beta 0.0045 0.0102 0.0541
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0066 0.0237 0.0618
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0056 0.0391
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0045 0.0102 0.0541
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0171 0.0913 0.2855
Giardia lamblia GTOR 0.014 0.0715 0.7556
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0171 0.0913 0.2917
Schistosoma mansoni disulfide oxidoreductase 0.0045 0.0102 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0523 0.3184 0.3178
Trichomonas vaginalis glutamate synthase, putative 0.0045 0.0102 0.0715
Echinococcus multilocularis Smad4 0.005 0.0131 0.0382
Plasmodium vivax thioredoxin reductase, putative 0.0494 0.2995 1
Onchocerca volvulus 0.0038 0.0056 0.0302
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0021
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.014 0.0715 0.2242
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0045 0.0102 0.0059
Trichomonas vaginalis glutamate synthase, putative 0.0045 0.0102 0.0715
Echinococcus granulosus GPCR family 2 0.0031 0.001 0.0013
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0056 0.0146
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0171 0.0913 0.2917
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0171 0.0913 0.2917
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0045 0.0102 0.0541
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0171 0.0913 0.1998
Trichomonas vaginalis PIKK family atypical protein kinase 0.0083 0.0345 0.2416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.035 0.2453
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0045 0.0102 0.0158
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0047 0.0113 0.0337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.053 0.3708
Schistosoma mansoni hypothetical protein 0.0072 0.0275 0.0266
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0056 0.0391
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0045 0.0102 0.0059
Schistosoma mansoni sulfide quinone reductase 0.0045 0.0102 0.0093
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0056 0.0391
Echinococcus multilocularis glutamate synthase 0.0045 0.0102 0.0292
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0056 0.0123
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0058 0.0185 0.0441
Plasmodium falciparum thioredoxin reductase 0.0494 0.2995 1
Brugia malayi Smad1 0.005 0.0131 0.0268
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0045 0.0102 0.0158
Brugia malayi Thioredoxin reductase 0.0494 0.2995 0.6603
Toxoplasma gondii target of rapamycin (TOR), putative 0.0104 0.0483 0.1612
Loa Loa (eye worm) hypothetical protein 0.0038 0.0056 0.0123
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0013 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.053 0.3708
Brugia malayi Pre-SET motif family protein 0.0221 0.1232 0.2703
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0045 0.0102 0.0292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0483 0.3381
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0045 0.0102 0.0205
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.014 0.0715 0.156
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1253 0.7888 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0045 0.0102 0.0205
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0171 0.0913 1
Onchocerca volvulus 0.0038 0.0056 0.0302
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0171 0.0913 0.2917
Onchocerca volvulus 0.0045 0.0102 0.0629
Schistosoma mansoni tar DNA-binding protein 0.0523 0.3184 0.3178
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0244 0.1385 0.1698
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0171 0.0913 0.2917
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0113 0.079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0297 0.2083
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0045 0.0102 0.0541
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0045 0.0102 0.0205
Brugia malayi beta-lactamase 0.0038 0.0056 0.0102
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0102 0.0715
Echinococcus granulosus glutamate synthase 0.0045 0.0102 0.0304
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0242 0.0515
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0045 0.0102 0.0158
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0013 0.0004
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0045 0.0102 0.0715
Echinococcus multilocularis tar DNA binding protein 0.0523 0.3184 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0038 0.0056 0.0123
Loa Loa (eye worm) beta-lactamase 0.0038 0.0056 0.0123
Loa Loa (eye worm) glutathione reductase 0.0494 0.2995 0.661
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0171 0.0913 0.2917
Loa Loa (eye worm) hypothetical protein 0.0032 0.0013 0.0029
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0045 0.0102 0.0158
Brugia malayi MH2 domain containing protein 0.0732 0.4531 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0083 0.0345 0.2416
Loa Loa (eye worm) TAR-binding protein 0.0523 0.3184 0.7027
Toxoplasma gondii selenide, water dikinase 0.0045 0.0102 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0483 0.3381
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.014 0.0715 0.2232
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1127 0.7077 0.8964
Onchocerca volvulus 0.0251 0.1428 1
Schistosoma mansoni glutamate synthase 0.0045 0.0102 0.0093
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0045 0.0102 0.0304
Mycobacterium ulcerans ferredoxin reductase 0.0045 0.0102 0.0541
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0045 0.0102 0.0158
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.014 0.0715 0.2242
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0171 0.0913 0.2917
Echinococcus multilocularis tumor protein p63 0.0359 0.2124 0.6662
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0045 0.0102 0.0541
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0171 0.0913 0.2917
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0298 0.2088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0113 0.079
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0045 0.0102 0.0299
Brugia malayi beta-lactamase family protein 0.0038 0.0056 0.0102
Schistosoma mansoni smad1 5 8 and 0.005 0.0131 0.0121
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0045 0.0102 0.0341
Leishmania major hypothetical protein, conserved 0.0045 0.0102 0.0158
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0056 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.014 0.0715 0.5006
Mycobacterium tuberculosis Probable dehydrogenase 0.1127 0.7077 0.8964
Schistosoma mansoni hypothetical protein 0.0067 0.0242 0.0233
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0275 0.0837
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0013 0.0011
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0102 0.0715
Treponema pallidum NADH oxidase 0.0171 0.0913 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0112 0.053 0.1614
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0045 0.0102 0.0292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0298 0.2088
Toxoplasma gondii ABC1 family protein 0.0038 0.0056 0.0186
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0045 0.0102 0.0158
Loa Loa (eye worm) phosphatidylinositol 3 0.014 0.0715 0.1578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0483 0.3381
Loa Loa (eye worm) programmed cell death 8 0.0045 0.0102 0.0225
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.014 0.0715 0.2242
Trypanosoma cruzi trypanothione reductase, putative 0.0171 0.0913 0.2917
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0171 0.0913 0.2917
Schistosoma mansoni smad1 5 8 and 0.005 0.0131 0.0121
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0443 0.0977
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0171 0.0913 0.2917
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0045 0.0102 0.0341
Mycobacterium ulcerans hypothetical protein 0.0045 0.0102 0.0541
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1127 0.7077 0.8964
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0171 0.0913 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0047 0.0113 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0298 0.2088
Toxoplasma gondii NADPH-glutathione reductase 0.0171 0.0913 0.3049
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0102 0.0158
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0056 0.0391
Loa Loa (eye worm) transcription factor SMAD2 0.0732 0.4531 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0047 0.0113 0.0325
Loa Loa (eye worm) hypothetical protein 0.0038 0.0056 0.0123
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0148 0.0139
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0047 0.0113 0.0194
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0171 0.0913 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0499 0.3025 0.95
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1127 0.7077 0.8964
Schistosoma mansoni tar DNA-binding protein 0.0523 0.3184 0.3178
Mycobacterium ulcerans monoxygenase 0.0045 0.0102 0.0541
Loa Loa (eye worm) hypothetical protein 0.0053 0.0148 0.0327
Entamoeba histolytica hypothetical protein 0.0072 0.0275 0.2826
Echinococcus granulosus smad 0.005 0.0131 0.0394
Schistosoma mansoni sulfide quinone reductase 0.0045 0.0102 0.0093
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0045 0.0102 0.0059
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.014 0.0715 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0112 0.053 0.1614
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.014 0.0715 0.2222
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0056 0.0391
Echinococcus multilocularis thioredoxin glutathione reductase 0.0499 0.3025 0.95
Onchocerca volvulus 0.0038 0.0056 0.0302
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0443 0.0958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0483 0.3381
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0045 0.0102 0.0304
Loa Loa (eye worm) hypothetical protein 0.0098 0.0443 0.0977
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0045 0.0102 0.0304
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0171 0.0913 0.2917
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0171 0.0913 0.3018
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0171 0.0913 0.2803
Giardia lamblia NADH oxidase lateral transfer candidate 0.0171 0.0913 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.001 0.0013
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0102 0.0715
Plasmodium falciparum glutathione reductase 0.0494 0.2995 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0483 0.3381
Toxoplasma gondii thioredoxin reductase 0.0494 0.2995 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0583 0.4079
Brugia malayi glutamate synthase 0.0045 0.0102 0.0205
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0045 0.0102 0.0059
Schistosoma mansoni Smad4 0.005 0.0131 0.0121
Plasmodium falciparum thioredoxin reductase 0.0171 0.0913 0.2803
Brugia malayi MH2 domain containing protein 0.005 0.0131 0.0268
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0013 0.0004
Schistosoma mansoni smad1 5 8 and 0.005 0.0131 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0417 0.2918
Mycobacterium tuberculosis Probable oxidoreductase 0.1253 0.7888 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.014 0.0715 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0045 0.0102 0.0304
Echinococcus granulosus mothers against decapentaplegic 5 0.005 0.0131 0.0394
Brugia malayi MH1 domain containing protein 0.005 0.0131 0.0268
Schistosoma mansoni smad 0.005 0.0131 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0113 0.079
Loa Loa (eye worm) thioredoxin reductase 0.0494 0.2995 0.661
Brugia malayi MH1 domain containing protein 0.005 0.0131 0.0268
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0112 0.053 0.1614
Schistosoma mansoni TGF-beta signal transducer Smad2 0.005 0.0131 0.0121
Loa Loa (eye worm) RNA binding protein 0.0523 0.3184 0.7027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0113 0.079
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0102 0.0715
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0056 0.0046
Trypanosoma cruzi NADH dehydrogenase, putative 0.0045 0.0102 0.0158
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0045 0.0102 0.0299
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0045 0.0102 0.0341
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0171 0.0913 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0171 0.0913 0.2917
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.035 0.2453
Echinococcus granulosus TGF beta signal transducer SmadC 0.005 0.0131 0.0394
Trichomonas vaginalis esterase, putative 0.0038 0.0056 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.053 0.3708
Trypanosoma brucei NADH dehydrogenase 0.0045 0.0102 0.0158
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0045 0.0102 0.0341
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0045 0.0102 0.0292
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0102 0.0158
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0045 0.0102 0.0059
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0047 0.0113 0.0194
Brugia malayi RNA recognition motif domain containing protein 0.0523 0.3184 0.7021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0483 0.3381
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0126 0.062 0.135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0397 0.2781
Plasmodium vivax glutathione reductase, putative 0.0494 0.2995 1
Schistosoma mansoni tar DNA-binding protein 0.0523 0.3184 0.3178
Loa Loa (eye worm) hypothetical protein 0.0038 0.0056 0.0123
Mycobacterium ulcerans dehydrogenase 0.0045 0.0102 0.0541
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0045 0.0102 0.0158
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0013 0.0024
Leishmania major hypothetical protein, conserved 0.0045 0.0102 0.0158
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0045 0.0102 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.053 0.3708
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1253 0.7888 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0298 0.2088
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0102 0.0715
Mycobacterium ulcerans NADH dehydrogenase 0.0045 0.0102 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0052 0.0365
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0126 0.062 0.135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0113 0.079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.035 0.2453
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0045 0.0102 0.0059
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.1232 0.2718
Entamoeba histolytica hypothetical protein 0.0072 0.0275 0.2826
Echinococcus granulosus Smad4 0.005 0.0131 0.0394
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0045 0.0102 0.0059
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0013 0.0011
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0045 0.0102 0.0541
Echinococcus granulosus tar DNA binding protein 0.0523 0.3184 1
Mycobacterium tuberculosis Probable reductase 0.1127 0.7077 0.8964
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0045 0.0102 0.0292
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0171 0.0913 0.2917
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.014 0.0715 0.0706
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0045 0.0102 0.0304
Echinococcus multilocularis TGF beta signal transducer SmadC 0.005 0.0131 0.0382
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0045 0.0102 0.0541
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.0131 0.0289
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.014 0.0715 0.2242
Brugia malayi RNA binding protein 0.0523 0.3184 0.7021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0297 0.2083
Entamoeba histolytica hypothetical protein 0.0072 0.0275 0.2826
Trypanosoma brucei hypothetical protein, conserved 0.0045 0.0102 0.0158
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0045 0.0102 0.0715
Trichomonas vaginalis set domain proteins, putative 0.0251 0.1428 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.053 0.3708
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0045 0.0102 0.0541
Trichomonas vaginalis mercuric reductase, putative 0.0171 0.0913 0.6394
Trypanosoma cruzi NADH dehydrogenase, putative 0.0045 0.0102 0.0158
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0523 0.3184 0.7027
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0045 0.0102 0.0304
Echinococcus multilocularis smad 0.005 0.0131 0.0382
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0113 0.0249
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0171 0.0913 0.2803
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1127 0.7077 0.8964
Trichomonas vaginalis glutathione reductase, putative 0.0171 0.0913 0.6394
Loa Loa (eye worm) hypothetical protein 0.0045 0.0102 0.0225
Loa Loa (eye worm) hypothetical protein 0.0067 0.0242 0.0535
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0171 0.0913 0.1095
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.001 0.0021
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0045 0.0102 0.0292
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0045 0.0102 0.0158
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1253 0.7888 1
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0045 0.0102 0.0059
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0056 0.0158
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0171 0.0913 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.014 0.0715 0.5006
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0102 0.0715
Echinococcus granulosus tumor protein p63 0.0359 0.2124 0.6666
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0171 0.0913 0.3049
Schistosoma mansoni glutamate synthase 0.0045 0.0102 0.0093
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0171 0.0913 0.2917
Trichomonas vaginalis apoptosis inducing factor, putative 0.0045 0.0102 0.0715
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0045 0.0102 0.0341
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0171 0.0913 0.2917
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0056 0.0046
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0013 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0483 0.3381
Brugia malayi glutathione reductase 0.0494 0.2995 0.6603
Loa Loa (eye worm) hypothetical protein 0.0038 0.0056 0.0123
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0171 0.0913 1
Loa Loa (eye worm) Smad1 0.005 0.0131 0.0289
Schistosoma mansoni glutamate synthase 0.0045 0.0102 0.0093
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.0131 0.0289
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0045 0.0102 0.0715
Brugia malayi hypothetical protein 0.0072 0.0275 0.0588
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0171 0.0913 0.2846
Brugia malayi MH2 domain containing protein 0.005 0.0131 0.0268
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0113 0.0228
Leishmania major NADH dehydrogenase, putative 0.0045 0.0102 0.0158
Entamoeba histolytica hypothetical protein 0.0072 0.0275 0.2826
Brugia malayi Pre-SET motif family protein 0.0032 0.0013 0.0008
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.014 0.0715 0.2242
Plasmodium falciparum glutathione reductase 0.0171 0.0913 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.014 0.0715 0.5006
Loa Loa (eye worm) hypothetical protein 0.0038 0.0056 0.0123
Trypanosoma brucei trypanothione reductase 0.0494 0.2995 1
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0045 0.0102 0.0158
Leishmania major hypothetical protein, conserved 0.0045 0.0102 0.0158
Trypanosoma cruzi trypanothione reductase, putative 0.0494 0.2995 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0297 0.2083

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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