Detailed information for compound 620990

Basic information

Technical information
  • TDR Targets ID: 620990
  • Name: 5-[(4-ethoxy-3-methoxyphenyl)-(4-methylpiperi din-1-yl)methyl]-2-methyl-[1,3]thiazolo[2,3-e ][1,2,4]triazol-6-ol
  • MW: 416.537 | Formula: C21H28N4O3S
  • H donors: 1 H acceptors: 3 LogP: 4.38 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1OC)C(c1sc2n(c1O)nc(n2)C)N1CCC(CC1)C
  • InChi: 1S/C21H28N4O3S/c1-5-28-16-7-6-15(12-17(16)27-4)18(24-10-8-13(2)9-11-24)19-20(26)25-21(29-19)22-14(3)23-25/h6-7,12-13,18,26H,5,8-11H2,1-4H3
  • InChiKey: KVRXRFWNYXMWOO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(4-ethoxy-3-methoxy-phenyl)-(4-methyl-1-piperidyl)methyl]-2-methyl-thiazolo[2,3-e][1,2,4]triazol-6-ol
  • 5-[(4-ethoxy-3-methoxyphenyl)-(4-methyl-1-piperidinyl)methyl]-2-methyl-6-thiazolo[2,3-e][1,2,4]triazolol
  • 5-[(4-ethoxy-3-methoxy-phenyl)-(4-methylpiperidin-1-yl)methyl]-2-methyl-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH2 domain containing protein 0.1225 0.6571 1
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0233 0.0788
Brugia malayi intermediate filament protein 0.0137 0.0574 0.0866
Echinococcus granulosus chromobox protein 1 0.0075 0.0233 0.0406
Leishmania major hypothetical protein, conserved 0.0053 0.011 0.0084
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.02 0.092 0.2899
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0418 0.0396
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1316 0.7078 0.8958
Schistosoma mansoni hypothetical protein 0.0159 0.0693 0.0672
Trypanosoma cruzi target of rapamycin kinase 3 0.0116 0.0454 0.1309
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0502 0.2585 0.3929
Mycobacterium tuberculosis Conserved protein 0.0109 0.0418 0.0396
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.059 0.3071 0.4674
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0145 0.0617 0.1865
Mycobacterium leprae Probable lipase LipE 0.0109 0.0418 0.0396
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0053 0.011 0.0305
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0053 0.011 0.0134
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0028 0.004
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0145 0.0617 0.1091
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.02 0.092 0.2899
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0116 0.0454 0.1309
Schistosoma mansoni tar DNA-binding protein 0.059 0.3071 0.3056
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0049 0.0085 0.0143
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1316 0.7078 0.8958
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0155 0.0671 0.2048
Loa Loa (eye worm) phosphatidylinositol 3 0.0145 0.0617 0.0939
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0049 0.0085 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0337 0.1192
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.02 0.092 0.2864
Mycobacterium ulcerans phosphoglycerate kinase 0.0184 0.0834 0.5401
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.02 0.092 0.2899
Schistosoma mansoni hypothetical protein 0.0072 0.0217 0.0194
Brugia malayi glutamate synthase 0.0053 0.011 0.0159
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0068 0.0142
Brugia malayi Smad1 0.0083 0.0277 0.0414
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0053 0.011 0.0305
Echinococcus multilocularis smad 0.0083 0.0277 0.0485
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0184 0.0834 0.8933
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.02 0.092 0.6047
Mycobacterium ulcerans glutaminase 0.0296 0.145 1
Schistosoma mansoni smad1 5 8 and 0.0083 0.0277 0.0255
Giardia lamblia NADH oxidase lateral transfer candidate 0.02 0.092 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0068 0.019 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0249 0.085
Brugia malayi TAR-binding protein 0.059 0.3071 0.467
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0184 0.0834 0.2509
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0184 0.0834 0.2604
Brugia malayi Thioredoxin reductase 0.0577 0.3 0.4561
Trypanosoma brucei phosphoglycerate kinase 0.0184 0.0834 0.2604
Plasmodium vivax thioredoxin reductase, putative 0.0577 0.3 1
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0184 0.0834 0.2509
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.0418 0.0396
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0053 0.011 0.0305
Brugia malayi beta-lactamase family protein 0.0109 0.0418 0.0629
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0211 0.048
Treponema pallidum NADH oxidase 0.02 0.092 1
Echinococcus multilocularis Smad4 0.0083 0.0277 0.0485
Brugia malayi Phosphoglycerate kinase 0.0068 0.019 0.0282
Loa Loa (eye worm) hypothetical protein 0.0046 0.0072 0.0109
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0053 0.011 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0085 0.021
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.02 0.092 0.2899
Echinococcus granulosus mothers against decapentaplegic 2 0.0037 0.0023 0.0031
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.02 0.092 0.2803
Schistosoma mansoni lamin 0.0137 0.0574 0.0552
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0145 0.0617 0.7009
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0053 0.011 0.0186
Brugia malayi mothers against decapentaplegic homolog 3 0.0037 0.0023 0.0026
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0211 0.0367
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0037 0.0023 0.0088
Brugia malayi Phosphoglycerate kinase 0.0184 0.0834 0.1262
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1463 0.7888 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0145 0.0617 0.0596
Echinococcus granulosus intermediate filament protein 0.0137 0.0574 0.1013
Giardia lamblia GTOR 0.0145 0.0617 0.6261
Schistosoma mansoni smad1 5 8 and 0.0083 0.0277 0.0255
Echinococcus granulosus lamin 0.0137 0.0574 0.1013
Onchocerca volvulus 0.0137 0.0574 0.2217
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0053 0.011 0.0186
Chlamydia trachomatis phosphoglycerate kinase 0.0184 0.0834 0.8933
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.005 0.0195
Plasmodium vivax glutathione reductase, putative 0.0577 0.3 1
Echinococcus multilocularis lamin dm0 0.0137 0.0574 0.1013
Echinococcus multilocularis chromobox protein 1 0.0075 0.0233 0.0406
Onchocerca volvulus 0.0109 0.0418 0.1615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.029 0.1012
Brugia malayi MH1 domain containing protein 0.0046 0.0072 0.0101
Onchocerca volvulus 0.0137 0.0574 0.2217
Echinococcus multilocularis mothers against decapentaplegic 6 0.0037 0.0023 0.0031
Brugia malayi jmjC domain containing protein 0.004 0.0039 0.0052
Echinococcus multilocularis glutamate synthase 0.0053 0.011 0.0186
Schistosoma mansoni tar DNA-binding protein 0.059 0.3071 0.3056
Schistosoma mansoni intermediate filament proteins 0.0137 0.0574 0.0552
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.0387 0.0681
Mycobacterium ulcerans hypothetical protein 0.0172 0.0767 0.4906
Schistosoma mansoni jumonji domain containing protein 0.0082 0.027 0.0248
Trichomonas vaginalis glutaminase, putative 0.0296 0.145 0.5546
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0053 0.011 0.0159
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0053 0.011 0.0134
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.02 0.092 0.1631
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0184 0.0834 0.3136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0412 0.1488
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0049 0.0085 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0085 0.021
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0049 0.0085 0.005
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0145 0.0617 0.7009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0248 0.0847
Mycobacterium ulcerans lipase LipD 0.0109 0.0418 0.23
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0418 0.1511
Echinococcus granulosus mothers against decapentaplegic 5 0.0083 0.0277 0.0485
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0069 0.0196 0.0426
Treponema pallidum phosphoglycerate kinase 0.0184 0.0834 0.8933
Plasmodium vivax phosphoglycerate kinase, putative 0.0184 0.0834 0.2504
Echinococcus multilocularis thioredoxin glutathione reductase 0.0583 0.3032 0.5395
Echinococcus multilocularis phosphoglycerate kinase 1 0.0184 0.0834 0.1476
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0053 0.011 0.0305
Brugia malayi Bromodomain containing protein 0.0041 0.0046 0.0062
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0053 0.011 0.0134
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0053 0.011 0.0305
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0049 0.0085 0.0143
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0045 0.0071
Echinococcus granulosus histone lysine methyltransferase setb 0.0082 0.0268 0.0469
Schistosoma mansoni tar DNA-binding protein 0.059 0.3071 0.3056
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0116 0.0454 0.1265
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0217 0.0194
Mycobacterium ulcerans beta-lactamase 0.0109 0.0418 0.23
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0412 0.1488
Leishmania major phosphoglycerate kinase B, cytosolic 0.0184 0.0834 0.2567
Loa Loa (eye worm) hypothetical protein 0.0109 0.0418 0.0636
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1463 0.7888 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0053 0.011 0.0134
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0053 0.011 0.0159
Schistosoma mansoni tar DNA-binding protein 0.059 0.3071 0.3056
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0418 0.0736
Brugia malayi hypothetical protein 0.0072 0.0217 0.0322
Echinococcus granulosus chromobox protein 1 0.0075 0.0233 0.0406
Entamoeba histolytica phosphoglycerate kinase, putative 0.0184 0.0834 1
Loa Loa (eye worm) intermediate filament protein 0.0137 0.0574 0.0873
Schistosoma mansoni phosphoglycerate kinase 0.0184 0.0834 0.0813
Schistosoma mansoni Smad4 0.0083 0.0277 0.0255
Loa Loa (eye worm) hypothetical protein 0.0046 0.0072 0.0109
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0159 0.0693 0.1225
Loa Loa (eye worm) MH1 domain-containing protein 0.0037 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0082 0.0268 0.0408
Mycobacterium ulcerans hypothetical protein 0.0109 0.0418 0.23
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0068 0.0263
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0211 0.048
Trichomonas vaginalis esterase, putative 0.0109 0.0418 0.1511
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0502 0.2585 0.3934
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0159 0.0693 0.1047
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0145 0.0617 0.1824
Loa Loa (eye worm) MH1 domain-containing protein 0.0083 0.0277 0.0422
Brugia malayi MH1 domain containing protein 0.0083 0.0277 0.0414
Brugia malayi latrophilin 2 splice variant baaae 0.0343 0.1709 0.2595
Echinococcus granulosus mothers against decapentaplegic 6 0.0037 0.0023 0.0031
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0039 0.006
Loa Loa (eye worm) RNA binding protein 0.059 0.3071 0.4674
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1316 0.7078 0.8958
Trichomonas vaginalis apoptosis inducing factor, putative 0.0053 0.011 0.0305
Echinococcus multilocularis mothers against decapentaplegic 2 0.0037 0.0023 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.011 0.0134
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0053 0.011 0.0186
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0418 0.1511
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0145 0.0617 0.1091
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.02 0.092 0.2803
Trichomonas vaginalis glutamate synthase, putative 0.0053 0.011 0.0305
Brugia malayi MH2 domain containing protein 0.0083 0.0277 0.0414
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0085 0.021
Echinococcus multilocularis GPCR, family 2 0.0159 0.0693 0.1225
Leishmania major hypothetical protein, conserved 0.0053 0.011 0.0084
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0035
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0053 0.011 0.0006
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.0418 0.23
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0059 0.0096
Leishmania major acetoin dehydrogenase e3 component-like protein 0.02 0.092 0.2864
Echinococcus multilocularis tumor protein p63 0.1051 0.5615 1
Brugia malayi Intermediate filament tail domain containing protein 0.0137 0.0574 0.0866
Schistosoma mansoni hypothetical protein 0.0159 0.0693 0.0672
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0418 0.1511
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0442 0.2252 0.3428
Plasmodium vivax SET domain protein, putative 0.0063 0.0166 0.0196
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0068 0.019 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0354 0.1259
Trichomonas vaginalis set domain proteins, putative 0.0503 0.2589 1
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0184 0.0834 0.3136
Loa Loa (eye worm) hypothetical protein 0.0109 0.0418 0.0636
Loa Loa (eye worm) hypothetical protein 0.0044 0.006 0.0092
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0068 0.019 0.0408
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0145 0.0617 0.1865
Brugia malayi RNA binding protein 0.059 0.3071 0.467
Brugia malayi MH1 domain containing protein 0.0083 0.0277 0.0414
Loa Loa (eye worm) hypothetical protein 0.0066 0.0182 0.0277
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0053 0.011 0.0134
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0327 0.1621 0.5292
Echinococcus granulosus glutamate synthase 0.0053 0.011 0.0186
Onchocerca volvulus 0.0109 0.0418 0.1615
Loa Loa (eye worm) hypothetical protein 0.0137 0.0574 0.0873
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.02 0.092 0.2899
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1316 0.7078 0.8958
Plasmodium falciparum glutathione reductase 0.02 0.092 0.2803
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0211 0.048
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0418 0.0396
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.011 0.0134
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0147 0.0627 0.0947
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0053 0.011 0.0167
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0053 0.011 0.0186
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0418 0.1511
Mycobacterium tuberculosis Probable oxidoreductase 0.1463 0.7888 1
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.0418 0.0396
Trichomonas vaginalis glutathione reductase, putative 0.02 0.092 0.3474
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0053 0.011 0.0006
Schistosoma mansoni chromobox protein 0.0075 0.0233 0.0211
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.0387 0.0681
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.02 0.092 0.2808
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.02 0.092 0.2899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.0295 0.103
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0577 0.3 0.3716
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0053 0.011 0.0134
Schistosoma mansoni glutaminase 0.0296 0.145 0.143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0085 0.021
Brugia malayi jmjC domain containing protein 0.0103 0.0387 0.0582
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0154 0.0264
Entamoeba histolytica hypothetical protein 0.0072 0.0217 0.1475
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0184 0.0834 0.2604
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0053 0.011 0.0186
Brugia malayi RNA recognition motif domain containing protein 0.059 0.3071 0.467
Schistosoma mansoni smad1 5 8 and 0.0083 0.0277 0.0255
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0053 0.011 0.0186
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0059 0.0096
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0217 0.0377
Brugia malayi Calcitonin receptor-like protein seb-1 0.0502 0.2585 0.3929
Trypanosoma brucei hypothetical protein, conserved 0.0053 0.011 0.0134
Echinococcus granulosus TGF beta signal transducer SmadC 0.0083 0.0277 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0145 0.0617 0.229
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0039 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0412 0.1488
Entamoeba histolytica hypothetical protein 0.0072 0.0217 0.1475
Loa Loa (eye worm) glutaminase 2 0.0296 0.145 0.2207
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0045 0.0071
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0068 0.0142
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0145 0.0617 0.1865
Schistosoma mansoni lamin 0.0137 0.0574 0.0552
Brugia malayi Latrophilin receptor protein 2 0.0159 0.0693 0.1047
Toxoplasma gondii selenide, water dikinase 0.0053 0.011 0.0006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.02 0.092 0.2899
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.0671 0.2008
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0053 0.011 0.0186
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0211 0.0432
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.02 0.092 0.2899
Toxoplasma gondii NADPH-glutathione reductase 0.02 0.092 0.2808
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0454 0.1649
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0053 0.011 0.0305
Toxoplasma gondii target of rapamycin (TOR), putative 0.0108 0.0412 0.1052
Brugia malayi MH2 domain containing protein 0.0037 0.0023 0.0026
Loa Loa (eye worm) thioredoxin reductase 0.0577 0.3 0.4566
Echinococcus granulosus GPCR family 2 0.0159 0.0693 0.1225
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.0418 0.23
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0053 0.011 0.0134
Brugia malayi Bromodomain containing protein 0.0081 0.0265 0.0396
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.02 0.092 0.2803
Leishmania major trypanothione reductase 0.0577 0.3 1
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0418 0.1066
Trichomonas vaginalis glutamate synthase, putative 0.0053 0.011 0.0305
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.0671 0.2048
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0068 0.019 0.0408
Onchocerca volvulus 0.0076 0.0235 0.0906
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0053 0.011 0.0084
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.02 0.092 0.1393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0412 0.1488
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0174 0.03
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.0418 0.0396
Schistosoma mansoni hypothetical protein 0.0343 0.1709 0.169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0454 0.1649
Echinococcus multilocularis tar DNA binding protein 0.059 0.3071 0.5466
Schistosoma mansoni glutamate synthase 0.0053 0.011 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0418 0.1186
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.02 0.092 0.2899
Entamoeba histolytica hypothetical protein 0.0072 0.0217 0.1475
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0177 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.05 0.1832
Loa Loa (eye worm) hypothetical protein 0.0064 0.0168 0.0256
Loa Loa (eye worm) hypothetical protein 0.0135 0.056 0.0852
Echinococcus granulosus thioredoxin glutathione reductase 0.0583 0.3032 0.5395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0412 0.1488
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0068 0.019 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.005 0.0073
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0145 0.0617 0.0932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.029 0.1012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.0295 0.103
Leishmania major mitochondrial DNA polymerase beta 0.0327 0.1621 0.5268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.0295 0.103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0085 0.021
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0159 0.0693 0.1225
Trypanosoma brucei phosphoglycerate kinase 0.0184 0.0834 0.2604
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1316 0.7078 0.8958
Echinococcus granulosus tar DNA binding protein 0.059 0.3071 0.5466
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0454 0.1649
Loa Loa (eye worm) MH2 domain-containing protein 0.1225 0.6571 1
Plasmodium falciparum thioredoxin reductase 0.0577 0.3 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0145 0.0617 0.1824
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.0418 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0248 0.0847
Trypanosoma brucei phosphoglycerate kinase 0.0068 0.019 0.0408
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0053 0.011 0.0186
Loa Loa (eye worm) hypothetical protein 0.0109 0.0418 0.0636
Loa Loa (eye worm) hypothetical protein 0.0053 0.011 0.0167
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.02 0.092 0.2899
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0166 0.0202
Schistosoma mansoni sulfide quinone reductase 0.0053 0.011 0.0087
Loa Loa (eye worm) hypothetical protein 0.0343 0.1709 0.2601
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0147 0.0627 0.0947
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0249 0.085
Brugia malayi beta-lactamase 0.0109 0.0418 0.0629
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.02 0.092 1
Leishmania major NADH dehydrogenase, putative 0.0053 0.011 0.0084
Trypanosoma brucei trypanothione reductase 0.0577 0.3 1
Echinococcus granulosus Smad4 0.0083 0.0277 0.0485
Echinococcus granulosus tumor protein p63 0.1051 0.5615 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0083 0.0277 0.0422
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0145 0.0617 0.1865
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0248 0.0847
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0211 0.1402
Loa Loa (eye worm) hypothetical protein 0.0042 0.0046 0.007
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0174 0.03
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0211 0.0314
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.02 0.092 1
Schistosoma mansoni chromobox protein 0.0075 0.0233 0.0211
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.02 0.092 0.6047
Leishmania major dihydrolipoamide dehydrogenase, putative 0.02 0.092 0.2864
Leishmania major hypothetical protein, conserved 0.0109 0.0418 0.1141
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0082 0.0268 0.0246
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0159 0.0693 0.1225
Mycobacterium tuberculosis Conserved protein 0.0109 0.0418 0.0396
Loa Loa (eye worm) programmed cell death 8 0.0053 0.011 0.0167
Mycobacterium tuberculosis Conserved hypothetical protein 0.0172 0.0767 0.0845
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0053 0.011 0.0006
Loa Loa (eye worm) nuclear factor I 0.0046 0.0072 0.0109
Loa Loa (eye worm) beta-lactamase 0.0109 0.0418 0.0636
Brugia malayi glutaminase DH11.1 0.0296 0.145 0.22
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0073 0.0222 0.0339
Loa Loa (eye worm) hypothetical protein 0.0064 0.0168 0.0256
Brugia malayi beta-lactamase family protein 0.0109 0.0418 0.0629
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0053 0.011 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0454 0.1649
Giardia lamblia Phosphoglycerate kinase 0.0184 0.0834 0.8933
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0159 0.0693 0.1225
Brugia malayi MH2 domain containing protein 0.0083 0.0277 0.0414
Echinococcus multilocularis chromobox protein 1 0.0075 0.0233 0.0406
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0039 0.0017
Loa Loa (eye worm) hypothetical protein 0.0109 0.0418 0.0636
Brugia malayi cytoplasmic intermediate filament protein 0.0073 0.0222 0.0331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0145 0.0617 0.229
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0137 0.0574 0.0873
Toxoplasma gondii thioredoxin reductase 0.0577 0.3 1
Schistosoma mansoni phosphoglycerate kinase 0.0184 0.0834 0.0813
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0233 0.0788
Toxoplasma gondii ABC1 family protein 0.0109 0.0418 0.1072
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0068 0.019 0.0408
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0166 0.0287
Trypanosoma cruzi trypanothione reductase, putative 0.0577 0.3 1
Loa Loa (eye worm) hypothetical protein 0.0502 0.2585 0.3934
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.0418 0.0396
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0184 0.0834 0.093
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0053 0.011 0.0305
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0211 0.0367
Leishmania major hypothetical protein, conserved 0.0053 0.011 0.0084
Leishmania major phosphoglycerate kinase C, glycosomal 0.0184 0.0834 0.2567
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0418 0.0736
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1463 0.7888 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0327 0.1621 0.5292
Mycobacterium tuberculosis Conserved protein 0.0109 0.0418 0.0396
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.02 0.092 0.1631
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0032 0.0047
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0126 0.0189
Brugia malayi MH1 domain containing protein 0.0046 0.0072 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.005 0.0073
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0053 0.011 0.0006
Trypanosoma brucei NADH dehydrogenase 0.0053 0.011 0.0134
Schistosoma mansoni hypothetical protein 0.0053 0.011 0.0087
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0053 0.011 0.0305
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0418 0.0629
Loa Loa (eye worm) hypothetical protein 0.0054 0.0116 0.0176
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0696 0.3657 0.456
Loa Loa (eye worm) hypothetical protein 0.0077 0.024 0.0365
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0066 0.0182 0.0315
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.02 0.092 0.0899
Onchocerca volvulus 0.0503 0.2589 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0053 0.011 0.0305
Loa Loa (eye worm) glutaminase 0.0296 0.145 0.2207
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0053 0.011 0.0159
Echinococcus multilocularis musashi 0.0137 0.0574 0.1013
Loa Loa (eye worm) MH2 domain-containing protein 0.0037 0.0023 0.0035
Schistosoma mansoni hypothetical protein 0.0159 0.0693 0.0672
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.0418 0.0396
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0053 0.011 0.0186
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0083 0.0277 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0412 0.1488
Schistosoma mansoni cellular tumor antigen P53 0.0154 0.0666 0.0644
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0211 0.0189
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.0418 0.0396
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0053 0.011 0.0134
Loa Loa (eye worm) hypothetical protein 0.0109 0.0418 0.0636
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0076 0.0235 0.0212
Schistosoma mansoni bromodomain containing protein 0.0069 0.0195 0.0173
Onchocerca volvulus 0.0053 0.011 0.0425
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0066 0.0182 0.0315
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0418 0.0396
Schistosoma mansoni tar DNA-binding protein 0.059 0.3071 0.3056
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0053 0.011 0.0186
Brugia malayi glutathione reductase 0.0577 0.3 0.4561
Brugia malayi chromobox protein homolog 3 0.0042 0.005 0.0069
Trichomonas vaginalis mercuric reductase, putative 0.02 0.092 0.3474
Entamoeba histolytica hypothetical protein 0.0072 0.0217 0.1475
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0249 0.085
Schistosoma mansoni disulfide oxidoreductase 0.0053 0.011 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0249 0.085
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0085 0.0122
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0032 0.0047
Loa Loa (eye worm) TAR-binding protein 0.059 0.3071 0.4674
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0082 0.0268 0.0246
Echinococcus granulosus phosphoglycerate kinase 1 0.0184 0.0834 0.1476
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.02 0.092 0.2899
Loa Loa (eye worm) transcription factor SMAD2 0.1225 0.6571 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0454 0.1649
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0053 0.011 0.0186
Loa Loa (eye worm) latrophilin receptor protein 2 0.0159 0.0693 0.1054
Schistosoma mansoni glutamate synthase 0.0053 0.011 0.0087
Schistosoma mansoni smad 0.0083 0.0277 0.0255
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0083 0.0277 0.0255
Mycobacterium tuberculosis Probable dehydrogenase 0.1316 0.7078 0.8958
Plasmodium falciparum glutathione reductase 0.0577 0.3 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.02 0.092 0.1042
Trypanosoma cruzi trypanothione reductase, putative 0.02 0.092 0.2899
Loa Loa (eye worm) glutathione reductase 0.0577 0.3 0.4566
Mycobacterium ulcerans flavoprotein disulfide reductase 0.02 0.092 0.6047
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0418 0.1186
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.006 0.0149 0.0269
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0166 0.0144
Loa Loa (eye worm) hypothetical protein 0.0109 0.0418 0.0636
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0418 0.0636
Trypanosoma cruzi NADH dehydrogenase, putative 0.0053 0.011 0.0134
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.0233 0.0355
Echinococcus multilocularis lamin 0.0137 0.0574 0.1013
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0049 0.0085 0.005
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0053 0.011 0.0186
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0082 0.0268 0.0469
Loa Loa (eye worm) hypothetical protein 0.0159 0.0693 0.1054
Echinococcus granulosus lamin dm0 0.0137 0.0574 0.1013
Echinococcus granulosus smad 0.0083 0.0277 0.0485
Leishmania major dihydrolipoamide dehydrogenase, putative 0.02 0.092 0.2864
Mycobacterium tuberculosis Probable reductase 0.1316 0.7078 0.8958
Trypanosoma brucei phosphoglycerate kinase, putative 0.0068 0.019 0.0408
Onchocerca volvulus 0.0154 0.0666 0.2572
Loa Loa (eye worm) hypothetical protein 0.0154 0.0666 0.1013
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0211 0.0322
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0418 0.1511
Brugia malayi Heterochromatin protein 1 0.0075 0.0233 0.0347
Loa Loa (eye worm) hypothetical protein 0.0042 0.005 0.0077
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0085 0.013
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0184 0.0834 0.093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0412 0.1488
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0053 0.011 0.0006
Schistosoma mansoni sulfide quinone reductase 0.0053 0.011 0.0087
Loa Loa (eye worm) Smad1 0.0083 0.0277 0.0422
Plasmodium falciparum thioredoxin reductase 0.02 0.092 0.2803
Brugia malayi Pre-SET motif family protein 0.0063 0.0166 0.0245
Plasmodium falciparum phosphoglycerate kinase 0.0184 0.0834 0.2504
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0418 0.1186
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.02 0.092 0.2899
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0053 0.011 0.0084
Schistosoma mansoni hypothetical protein 0.0159 0.0693 0.0672
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0217 0.0377
Onchocerca volvulus 0.0109 0.0418 0.1615
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.02 0.092 0.2803
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0039 0.0017
Brugia malayi Pre-SET motif family protein 0.0442 0.2252 0.3422
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0327 0.1621 0.5292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0145 0.0617 0.229
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0053 0.011 0.0305
Schistosoma mansoni glutamate synthase 0.0053 0.011 0.0087
Loa Loa (eye worm) hypothetical protein 0.0184 0.0834 0.1269
Echinococcus multilocularis mothers against decapentaplegic 5 0.0083 0.0277 0.0485
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.02 0.092 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0049 0.0085 0.005

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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