Detailed information for compound 621012

Basic information

Technical information
  • TDR Targets ID: 621012
  • Name: methyl 2-(4-methyl-2-oxo-3-phenylchromen-6-yl )oxyacetate
  • MW: 324.327 | Formula: C19H16O5
  • H donors: 0 H acceptors: 2 LogP: 3.35 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)COc1ccc2c(c1)c(C)c(c(=O)o2)c1ccccc1
  • InChi: 1S/C19H16O5/c1-12-15-10-14(23-11-17(20)22-2)8-9-16(15)24-19(21)18(12)13-6-4-3-5-7-13/h3-10H,11H2,1-2H3
  • InChiKey: CPROFLKXCPXQFN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 2-(4-methyl-2-oxo-3-phenyl-chromen-6-yl)oxyacetate
  • 2-[(4-methyl-2-oxo-3-phenyl-6-chromenyl)oxy]acetic acid methyl ester
  • 2-(2-keto-4-methyl-3-phenyl-chromen-6-yl)oxyacetic acid methyl ester
  • methyl 2-(4-methyl-2-oxo-3-phenyl-chromen-6-yl)oxyethanoate
  • ZINC04340600

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0086 0.0193
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0062 0.0139
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0045 0.0062 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0062 0.0406
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0045 0.0062 0.0684
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0045 0.0062 0.0966
Schistosoma mansoni tar DNA-binding protein 0.0513 0.3118 0.3118
Plasmodium vivax thioredoxin reductase, putative 0.0489 0.2967 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.017 0.0876 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0003 0.0004
Brugia malayi TAR-binding protein 0.0513 0.3118 0.7016
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.042 0.285
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0002 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.0644 0.4383
Loa Loa (eye worm) transcription factor SMAD2 0.0716 0.4444 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0045 0.0062 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.024 0.1625
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0045 0.0062 0.0202
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.017 0.0876 0.0876
Mycobacterium tuberculosis Probable oxidoreductase 0.1241 0.7879 1
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0045 0.0062 0.0076
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0134 0.0644 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0045 0.0062 0.0202
Loa Loa (eye worm) RNA binding protein 0.0513 0.3118 0.7014
Leishmania major dihydrolipoamide dehydrogenase, putative 0.017 0.0876 0.2949
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.1266 0.1604
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.017 0.0876 0.2949
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0045 0.0062 0.0076
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0045 0.0062 0.0076
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.009 0.009
Trypanosoma cruzi target of rapamycin kinase 3 0.0107 0.0466 0.1562
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0045 0.0062 0.02
Trichomonas vaginalis apoptosis inducing factor, putative 0.0045 0.0062 0.0408
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.017 0.0876 0.2949
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.042 0.285
Mycobacterium ulcerans glutamate synthase subunit beta 0.0045 0.0062 0.0684
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0134 0.0644 0.2165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0241 0.163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.0644 0.4383
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0045 0.0062 0.0684
Trypanosoma cruzi trypanothione reductase, putative 0.017 0.0876 0.2949
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.017 0.0876 0.1972
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0045 0.0062 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0356 0.2413
Leishmania major dihydrolipoamide dehydrogenase, putative 0.017 0.0876 0.2949
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0062 0.0408
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0045 0.0062 0.014
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0062 0.0202
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1116 0.7065 0.8966
Trichomonas vaginalis set domain proteins, putative 0.026 0.1466 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0134 0.0644 0.2165
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.017 0.0876 0.2949
Echinococcus multilocularis tumor protein p63 0.0337 0.1968 0.6312
Plasmodium falciparum glutathione reductase 0.017 0.0876 0.2803
Trypanosoma brucei hypothetical protein, conserved 0.0045 0.0062 0.0202
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0045 0.0062 0.0202
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0045 0.0062 0.0062
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0045 0.0062 0.0202
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0002 0.0002
Echinococcus granulosus smad 0.0049 0.0087 0.0278
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0045 0.0062 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0062 0.0406
Loa Loa (eye worm) phosphatidylinositol 3 0.0134 0.0644 0.1445
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1116 0.7065 0.8966
Brugia malayi MH2 domain containing protein 0.0049 0.0087 0.0195
Brugia malayi MH2 domain containing protein 0.0049 0.0087 0.0195
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0045 0.0062 0.02
Treponema pallidum NADH oxidase 0.017 0.0876 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0045 0.0062 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0291 0.1975
Schistosoma mansoni smad1 5 8 and 0.0049 0.0087 0.0087
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0513 0.3118 0.7014
Mycobacterium tuberculosis Probable reductase 0.1116 0.7065 0.8966
Brugia malayi MH2 domain containing protein 0.0716 0.4444 1
Loa Loa (eye worm) thioredoxin reductase 0.0489 0.2967 0.6674
Echinococcus granulosus mothers against decapentaplegic 5 0.0049 0.0087 0.0278
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0045 0.0062 0.02
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0045 0.0062 0.0076
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0045 0.0062 0.0684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.0644 0.4383
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.017 0.0876 0.2949
Brugia malayi MH1 domain containing protein 0.0049 0.0087 0.0195
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0045 0.0062 0.0202
Brugia malayi beta-lactamase family protein 0.0036 0.0002 0.0005
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.017 0.0876 0.2803
Trypanosoma cruzi trypanothione reductase, putative 0.0489 0.2967 1
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0045 0.0062 0.0076
Schistosoma mansoni tar DNA-binding protein 0.0513 0.3118 0.3118
Echinococcus granulosus Smad4 0.0049 0.0087 0.0278
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0045 0.0062 0.0408
Loa Loa (eye worm) MH1 domain-containing protein 0.0049 0.0087 0.019
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0045 0.0062 0.0198
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.017 0.0876 0.2949
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0045 0.0062 0.0684
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.017 0.0876 1
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0045 0.0062 0.0202
Schistosoma mansoni tar DNA-binding protein 0.0513 0.3118 0.3118
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0134 0.0644 0.1449
Plasmodium vivax ferrodoxin reductase, putative 0.0045 0.0062 0.0202
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0045 0.0062 0.0202
Leishmania major hypothetical protein, conserved 0.0045 0.0062 0.0202
Leishmania major trypanothione reductase 0.0489 0.2967 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0045 0.0062 0.02
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0086 0.0193
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0045 0.0062 0.014
Toxoplasma gondii selenide, water dikinase 0.0045 0.0062 0.0202
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0045 0.0062 0.014
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0045 0.0062 0.02
Loa Loa (eye worm) MH2 domain-containing protein 0.0049 0.0087 0.019
Leishmania major hypothetical protein, conserved 0.0045 0.0062 0.0202
Plasmodium vivax glutathione reductase, putative 0.0489 0.2967 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.01 0.042 0.1407
Entamoeba histolytica disulphide oxidoreductase, putative 0.0045 0.0062 0.0966
Trypanosoma brucei trypanothione reductase 0.0489 0.2967 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.126 0.2832
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0045 0.0062 0.0966
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.042 0.285
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0465 0.3159
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0002 0.0008
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.017 0.0876 0.2949
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.017 0.0876 0.2949
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0134 0.0644 0.0644
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0045 0.0062 0.0966
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0045 0.0062 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0241 0.163
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0062 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.024 0.1625
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0045 0.0062 0.0076
Trichomonas vaginalis glutathione reductase, putative 0.017 0.0876 0.5971
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0045 0.0062 0.0966
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0045 0.0062 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0465 0.3159
Loa Loa (eye worm) hypothetical protein 0.0049 0.0086 0.0187
Mycobacterium ulcerans hypothetical protein 0.0045 0.0062 0.0684
Trichomonas vaginalis mercuric reductase, putative 0.017 0.0876 0.5971
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0045 0.0062 0.02
Onchocerca volvulus 0.026 0.1466 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0465 0.3159
Onchocerca volvulus 0.0045 0.0062 0.0408
Schistosoma mansoni smad1 5 8 and 0.0049 0.0087 0.0087
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0045 0.0062 0.0202
Schistosoma mansoni tar DNA-binding protein 0.0513 0.3118 0.3118
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.017 0.0876 0.2949
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0045 0.0062 0.02
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0045 0.0062 0.0408
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.017 0.0876 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1116 0.7065 0.8966
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.017 0.0876 0.2949
Schistosoma mansoni glutamate synthase 0.0045 0.0062 0.0062
Loa Loa (eye worm) Smad1 0.0049 0.0087 0.019
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0045 0.0062 0.0076
Brugia malayi Pre-SET motif family protein 0.0228 0.126 0.2835
Schistosoma mansoni Smad4 0.0049 0.0087 0.0087
Echinococcus multilocularis smad 0.0049 0.0087 0.0278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0062 0.0406
Brugia malayi glutamate synthase 0.0045 0.0062 0.014
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.017 0.0876 0.2949
Loa Loa (eye worm) TAR-binding protein 0.0513 0.3118 0.7014
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1116 0.7065 0.8966
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0045 0.0062 0.02
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0086 0.0187
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0134 0.0644 0.2165
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0045 0.0062 0.0202
Echinococcus multilocularis mothers against decapentaplegic 5 0.0049 0.0087 0.0278
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0045 0.0062 0.0202
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0045 0.0062 0.02
Schistosoma mansoni tar DNA-binding protein 0.0513 0.3118 0.3118
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0134 0.0644 0.2165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0241 0.163
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0049 0.0087 0.0087
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0045 0.0062 0.0076
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0045 0.0062 0.0202
Toxoplasma gondii NADPH-glutathione reductase 0.017 0.0876 0.2949
Leishmania major NADH dehydrogenase, putative 0.0045 0.0062 0.0202
Loa Loa (eye worm) hypothetical protein 0.0045 0.0062 0.0135
Loa Loa (eye worm) hypothetical protein 0.0049 0.009 0.0197
Leishmania major acetoin dehydrogenase e3 component-like protein 0.017 0.0876 0.2949
Echinococcus multilocularis Smad4 0.0049 0.0087 0.0278
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0134 0.0644 0.2165
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.017 0.0876 0.2949
Echinococcus multilocularis glutamate synthase 0.0045 0.0062 0.02
Schistosoma mansoni sulfide quinone reductase 0.0045 0.0062 0.0062
Schistosoma mansoni glutamate synthase 0.0045 0.0062 0.0062
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0056 0.0132 0.0437
Brugia malayi Thioredoxin reductase 0.0489 0.2967 0.6675
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0134 0.0644 0.2165
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0002 0.0005
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0489 0.2967 0.3764
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0045 0.0062 0.0684
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0045 0.0062 0.0684
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1241 0.7879 1
Entamoeba histolytica thioredoxin reductase, putative 0.0045 0.0062 0.0966
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.017 0.0876 0.2811
Echinococcus granulosus glutamate synthase 0.0045 0.0062 0.02
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.017 0.0876 0.111
Giardia lamblia GTOR 0.0134 0.0644 0.7146
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0045 0.0062 0.0408
Echinococcus granulosus tumor protein p63 0.0337 0.1968 0.6312
Plasmodium falciparum thioredoxin reductase 0.017 0.0876 0.2803
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0045 0.0062 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.042 0.285
Brugia malayi glutathione reductase 0.0489 0.2967 0.6675
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0062 0.0408
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.017 0.0876 0.2949
Trypanosoma cruzi NADH dehydrogenase, putative 0.0045 0.0062 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.0337 0.2284
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.017 0.0876 0.2949
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0062 0.0408
Giardia lamblia NADH oxidase lateral transfer candidate 0.017 0.0876 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.017 0.0876 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0494 0.2997 0.9613
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0291 0.1975
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.042 0.285
Toxoplasma gondii thioredoxin reductase 0.0489 0.2967 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.042 0.285
Loa Loa (eye worm) glutathione reductase 0.0489 0.2967 0.6674
Mycobacterium ulcerans monoxygenase 0.0045 0.0062 0.0684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0516 0.3508
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0045 0.0062 0.0202
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.017 0.0876 1
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0045 0.0062 0.0202
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0134 0.0644 0.2066
Leishmania major hypothetical protein, conserved 0.0045 0.0062 0.0202
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.017 0.0876 0.2811
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0049 0.0087 0.0278
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0291 0.1975
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0045 0.0062 0.0202
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1241 0.7879 1
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0062 0.0202
Loa Loa (eye worm) programmed cell death 8 0.0045 0.0062 0.0135
Onchocerca volvulus 0.0049 0.009 0.0598
Trichomonas vaginalis glutamate synthase, putative 0.0045 0.0062 0.0408
Leishmania major phosphatidylinositol 3-kinase, putative 0.0045 0.0062 0.02
Loa Loa (eye worm) MH2 domain-containing protein 0.0716 0.4444 1
Trichomonas vaginalis glutamate synthase, putative 0.0045 0.0062 0.0408
Mycobacterium ulcerans ferredoxin reductase 0.0045 0.0062 0.0684
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1116 0.7065 0.8966
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.017 0.0876 0.2949
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0063 0.0182 0.0607
Trypanosoma brucei NADH dehydrogenase 0.0045 0.0062 0.0202
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.017 0.0876 0.2949
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0045 0.0062 0.02
Echinococcus granulosus tar DNA binding protein 0.0513 0.3118 1
Brugia malayi Smad1 0.0049 0.0087 0.0195
Mycobacterium ulcerans NADH dehydrogenase 0.0045 0.0062 0.0684
Schistosoma mansoni smad1 5 8 and 0.0049 0.0087 0.0087
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0045 0.0062 0.0202
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.017 0.0876 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0494 0.2997 0.9613
Mycobacterium tuberculosis Probable dehydrogenase 0.1116 0.7065 0.8966
Schistosoma mansoni smad 0.0049 0.0087 0.0087
Brugia malayi MH1 domain containing protein 0.0049 0.0087 0.0195
Schistosoma mansoni disulfide oxidoreductase 0.0045 0.0062 0.0062
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0134 0.0644 0.2066
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0134 0.0644 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0107 0.0466 0.1562
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0062 0.0406
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0045 0.0062 0.0202
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0045 0.0062 0.0684
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0045 0.0062 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.042 0.285
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0125 0.0582 0.131
Plasmodium falciparum thioredoxin reductase 0.0489 0.2967 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0286 0.1939
Brugia malayi beta-lactamase 0.0036 0.0002 0.0005
Brugia malayi RNA recognition motif domain containing protein 0.0513 0.3118 0.7016
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0045 0.0062 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0062 0.0406
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1241 0.7879 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0465 0.3159
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0045 0.0062 0.0202
Schistosoma mansoni sulfide quinone reductase 0.0045 0.0062 0.0062
Brugia malayi RNA binding protein 0.0513 0.3118 0.7016
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0045 0.0062 0.0966
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0125 0.0582 0.131
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0045 0.0062 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0286 0.1939
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0062 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.024 0.1625
Brugia malayi beta-lactamase family protein 0.0036 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0045 0.0062 0.0062
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0107 0.0466 0.1562
Plasmodium falciparum glutathione reductase 0.0489 0.2967 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0045 0.0062 0.02
Mycobacterium ulcerans dehydrogenase 0.0045 0.0062 0.0684
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0062 0.0408
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0062 0.0134
Trypanosoma cruzi NADH dehydrogenase, putative 0.0045 0.0062 0.0202
Echinococcus multilocularis tar DNA binding protein 0.0513 0.3118 1
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0045 0.0062 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0241 0.163
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0002 0.0002
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.017 0.0876 0.2949
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.017 0.0876 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0465 0.3159
Schistosoma mansoni glutamate synthase 0.0045 0.0062 0.0062
Echinococcus granulosus TGF beta signal transducer SmadC 0.0049 0.0087 0.0278

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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