Detailed information for compound 621014

Basic information

Technical information
  • TDR Targets ID: 621014
  • Name: 3-(3,4-dimethoxyphenyl)-4-methyl-6-(2-oxoprop oxy)chromen-2-one
  • MW: 368.38 | Formula: C21H20O6
  • H donors: 0 H acceptors: 2 LogP: 3.13 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)c1c(=O)oc2c(c1C)cc(cc2)OCC(=O)C
  • InChi: 1S/C21H20O6/c1-12(22)11-26-15-6-8-17-16(10-15)13(2)20(21(23)27-17)14-5-7-18(24-3)19(9-14)25-4/h5-10H,11H2,1-4H3
  • InChiKey: SGOUDXCIMWRURE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-acetonyloxy-3-(3,4-dimethoxyphenyl)-4-methyl-chromen-2-one
  • 6-acetonyloxy-3-(3,4-dimethoxyphenyl)-4-methyl-2-chromenone
  • 6-acetonyloxy-3-(3,4-dimethoxyphenyl)-4-methyl-coumarin
  • ZINC04340633

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0053 0.0141 0.1112
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0136 0.1108
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.02 0.0949 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0088 0.033 0.0855
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.02 0.0949 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.004 0.0039
Echinococcus multilocularis thioredoxin glutathione reductase 0.0584 0.3051 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0041 0.0076 0.0219
Trypanosoma cruzi NADH dehydrogenase, putative 0.0053 0.0141 0.0434
Schistosoma mansoni tar DNA-binding protein 0.0514 0.2669 0.2669
Leishmania major hypothetical protein, conserved 0.0053 0.0141 0.0434
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.007 0.0232 0.0735
Schistosoma mansoni smad1 5 8 and 0.005 0.0122 0.0122
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.02 0.0949 0.311
Loa Loa (eye worm) beta-lactamase 0.0035 0.004 0.0103
Mycobacterium ulcerans NADH dehydrogenase 0.0053 0.0141 0.1112
Mycobacterium tuberculosis Probable reductase 0.1319 0.709 0.8972
Leishmania major trypanothione reductase 0.0578 0.3023 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0053 0.0141 0.0365
Loa Loa (eye worm) hypothetical protein 0.0053 0.0141 0.0365
Schistosoma mansoni tar DNA-binding protein 0.0514 0.2669 0.2669
Brugia malayi MH2 domain containing protein 0.073 0.3857 1
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0053 0.0141 0.0426
Brugia malayi RNA binding protein 0.0514 0.2669 0.692
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0053 0.0141 0.0426
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0053 0.0141 0.0426
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0053 0.0141 0.0434
Brugia malayi MH2 domain containing protein 0.005 0.0122 0.0316
Brugia malayi MH1 domain containing protein 0.005 0.0122 0.0316
Schistosoma mansoni smad1 5 8 and 0.005 0.0122 0.0122
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0001 0.0001
Echinococcus multilocularis Smad4 0.005 0.0122 0.0398
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.02 0.0949 0.3116
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0053 0.0141 0.046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.02 0.0949 0.3116
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0053 0.0141 0.1112
Leishmania major hypothetical protein, conserved 0.0035 0.004 0.0099
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0053 0.0141 0.0426
Giardia lamblia GTOR 0.0088 0.033 0.2336
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0013 0.0012
Trypanosoma cruzi trypanothione reductase, putative 0.0578 0.3023 1
Toxoplasma gondii selenide, water dikinase 0.0053 0.0141 0.0426
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0053 0.0141 0.046
Schistosoma mansoni tar DNA-binding protein 0.0514 0.2669 0.2669
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0231 0.1945
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.004 0.0099
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0013 0.0039
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0088 0.033 1
Brugia malayi Pre-SET motif family protein 0.0208 0.0989 0.2565
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0053 0.0141 0.0129
Entamoeba histolytica hypothetical protein 0.0072 0.0245 0.5526
Schistosoma mansoni hypothetical protein 0.0032 0.0024 0.0023
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0111 0.0111
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0053 0.0141 0.046
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0024 0.0077
Leishmania major NADH dehydrogenase, putative 0.0053 0.0141 0.0434
Trichomonas vaginalis apoptosis inducing factor, putative 0.0053 0.0141 0.115
Schistosoma mansoni tar DNA-binding protein 0.0514 0.2669 0.2669
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0053 0.0141 0.0129
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.02 0.0949 0.3109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0206 0.1727
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0136 0.1108
Loa Loa (eye worm) hypothetical protein 0.0069 0.0227 0.0588
Schistosoma mansoni hypothetical protein 0.0053 0.0141 0.014
Brugia malayi hypothetical protein 0.0072 0.0245 0.0636
Leishmania major hypothetical protein, conserved 0.0053 0.0141 0.0434
Loa Loa (eye worm) hypothetical protein 0.0032 0.0024 0.0062
Schistosoma mansoni disulfide oxidoreductase 0.0053 0.0141 0.014
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.004 0.0261
Loa Loa (eye worm) phosphatidylinositol 3 0.0029 0.001 0.0026
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0088 0.033 0.106
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0053 0.0141 0.0129
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.004 0.0039
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0007 0.002
Leishmania major acetoin dehydrogenase e3 component-like protein 0.02 0.0949 0.3116
Schistosoma mansoni hypothetical protein 0.0032 0.0024 0.0023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.02 0.0949 0.3116
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.004 0.0261
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.004 0.0261
Schistosoma mansoni tar DNA-binding protein 0.0514 0.2669 0.2669
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.02 0.0949 0.3116
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0024 0.0062
Loa Loa (eye worm) transcription factor SMAD2 0.073 0.3857 1
Schistosoma mansoni sulfide quinone reductase 0.0053 0.0141 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0206 0.1727
Brugia malayi Thioredoxin reductase 0.0578 0.3023 0.7838
Brugia malayi beta-lactamase 0.0035 0.004 0.0103
Entamoeba histolytica hypothetical protein 0.0072 0.0245 0.5526
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0088 0.033 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0053 0.0141 0.0434
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.004 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0109 0.0865
Schistosoma mansoni TGF-beta signal transducer Smad2 0.005 0.0122 0.0122
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0053 0.0141 0.1112
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0053 0.0141 0.0129
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0033
Schistosoma mansoni glutamate synthase 0.0053 0.0141 0.014
Loa Loa (eye worm) glutathione reductase 0.0578 0.3023 0.7838
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0029 0.001 0.0032
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.004 0.0103
Leishmania major dihydrolipoamide dehydrogenase, putative 0.02 0.0949 0.3116
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0053 0.0141 0.046
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0578 0.3023 0.3797
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.1068 0.1309
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.02 0.0949 0.246
Mycobacterium ulcerans hypothetical protein 0.0053 0.0141 0.1112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0171 0.1418
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0053 0.0141 0.0129
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0147 0.0657 0.1703
Onchocerca volvulus 0.0053 0.0141 0.1225
Plasmodium falciparum glutathione reductase 0.02 0.0949 0.2803
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1467 0.7897 1
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0053 0.0141 0.1112
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.02 0.0949 0.3116
Trichomonas vaginalis glutathione reductase, putative 0.02 0.0949 0.8257
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0053 0.0141 0.0434
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0231 0.1945
Leishmania major dihydrolipoamide dehydrogenase, putative 0.02 0.0949 0.3116
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.004 0.0129
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0036 0.0049 0.0128
Plasmodium falciparum thioredoxin reductase 0.02 0.0949 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0259 0.2192
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.0122 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0206 0.1727
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0024 0.0077
Mycobacterium ulcerans ferredoxin reductase 0.0053 0.0141 0.1112
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0088 0.033 0.1079
Entamoeba histolytica hypothetical protein 0.0072 0.0245 0.5526
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0053 0.0141 0.046
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0088 0.033 0.106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0161 0.1327
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.004 0.0103
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0053 0.0141 0.046
Trichomonas vaginalis esterase, putative 0.0035 0.004 0.0261
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0053 0.0141 0.115
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.004 0.0099
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0053 0.0141 0.0426
Echinococcus granulosus GPCR family 2 0.0032 0.0024 0.0077
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0402 0.1042
Loa Loa (eye worm) hypothetical protein 0.0028 0.0001 0.0001
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1319 0.709 0.8972
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0053 0.0141 0.046
Mycobacterium ulcerans glutamate synthase subunit beta 0.0053 0.0141 0.1112
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0013 0.0012
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1319 0.709 0.8972
Onchocerca volvulus 0.0237 0.1147 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0111 0.0288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0108 0.0862
Echinococcus multilocularis smad 0.005 0.0122 0.0398
Trypanosoma brucei hypothetical protein, conserved 0.0053 0.0141 0.0434
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0088 0.033 0.106
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.02 0.0949 1
Echinococcus granulosus tumor protein p63 0.0326 0.164 0.5375
Trypanosoma cruzi trypanothione reductase, putative 0.02 0.0949 0.3116
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0053 0.0141 0.1112
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.02 0.0949 0.3116
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0053 0.0141 0.115
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0053 0.0141 0.115
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0013 0.0039
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1467 0.7897 1
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0053 0.0141 0.0434
Trypanosoma cruzi target of rapamycin kinase 3 0.007 0.0232 0.0735
Loa Loa (eye worm) hypothetical protein 0.0101 0.0402 0.1042
Plasmodium vivax hypothetical protein, conserved 0.0035 0.004 0.0091
Brugia malayi glutamate synthase 0.0053 0.0141 0.0365
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0053 0.0141 0.115
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0053 0.0141 0.115
Plasmodium vivax ferrodoxin reductase, putative 0.0053 0.0141 0.0426
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0001 0.0001
Plasmodium vivax thioredoxin reductase, putative 0.0578 0.3023 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0103
Trypanosoma brucei target of rapamycin kinase 3, putative 0.007 0.0232 0.0735
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0245 0.0802
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0108 0.0862
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0231 0.1945
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0109 0.0865
Giardia lamblia NADH oxidase lateral transfer candidate 0.02 0.0949 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.02 0.0949 0.3109
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.02 0.0949 0.3116
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.02 0.0949 0.3116
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0013 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0109 0.0865
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0001 0.0001
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0514 0.2669 0.692
Loa Loa (eye worm) TAR-binding protein 0.0514 0.2669 0.692
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0231 0.1945
Mycobacterium ulcerans dehydrogenase 0.0053 0.0141 0.1112
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0088 0.033 0.106
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0053 0.0141 0.0434
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0053 0.0141 0.1112
Echinococcus granulosus glutamate synthase 0.0053 0.0141 0.046
Brugia malayi MH2 domain containing protein 0.005 0.0122 0.0316
Toxoplasma gondii ABC1 family protein 0.0035 0.004 0.0091
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0088 0.033 0.0329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.033 0.281
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0402 0.1042
Schistosoma mansoni hypothetical protein 0.0032 0.0024 0.0023
Mycobacterium ulcerans monoxygenase 0.0053 0.0141 0.1112
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1319 0.709 0.8972
Mycobacterium ulcerans flavoprotein disulfide reductase 0.02 0.0949 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0206 0.1727
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0053 0.0141 0.0426
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.02 0.0949 0.0948
Schistosoma mansoni glutamate synthase 0.0053 0.0141 0.014
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0024 0.0062
Loa Loa (eye worm) MH2 domain-containing protein 0.073 0.3857 1
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0053 0.0141 0.0434
Schistosoma mansoni hypothetical protein 0.0032 0.0024 0.0023
Loa Loa (eye worm) programmed cell death 8 0.0053 0.0141 0.0365
Schistosoma mansoni glutamate synthase 0.0053 0.0141 0.014
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.02 0.0949 0.3116
Plasmodium vivax glutathione reductase, putative 0.0578 0.3023 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1319 0.709 0.8972
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0053 0.0141 0.0365
Loa Loa (eye worm) thioredoxin reductase 0.0578 0.3023 0.7838
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0053 0.0141 0.046
Plasmodium falciparum glutathione reductase 0.0578 0.3023 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0024 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0133 0.1083
Onchocerca volvulus 0.003 0.0013 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0133 0.1083
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1467 0.7897 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0053 0.0141 0.0426
Echinococcus multilocularis mothers against decapentaplegic 5 0.005 0.0122 0.0398
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0245 0.0245
Toxoplasma gondii target of rapamycin (TOR), putative 0.0065 0.0206 0.0644
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0103
Loa Loa (eye worm) Smad1 0.005 0.0122 0.0316
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0024 0.0062
Loa Loa (eye worm) phosphatidylinositol 3 0.0088 0.033 0.0855
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0053 0.0141 0.115
Onchocerca volvulus 0.0035 0.004 0.0343
Schistosoma mansoni hypothetical protein 0.0069 0.0227 0.0226
Onchocerca volvulus 0.0035 0.004 0.0343
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0029 0.001 0.001
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0053 0.0141 0.046
Schistosoma mansoni sulfide quinone reductase 0.0053 0.0141 0.014
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.004 0.0261
Echinococcus multilocularis glutamate synthase 0.0053 0.0141 0.046
Plasmodium falciparum thioredoxin reductase 0.0578 0.3023 1
Entamoeba histolytica hypothetical protein 0.0072 0.0245 0.5526
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0088 0.033 0.106
Brugia malayi TAR-binding protein 0.0514 0.2669 0.692
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0227 0.0588
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0103
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.02 0.0949 0.311
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.02 0.0949 0.3116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0206 0.1727
Trypanosoma cruzi NADH dehydrogenase, putative 0.0053 0.0141 0.0434
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.033 0.281
Schistosoma mansoni smad1 5 8 and 0.005 0.0122 0.0122
Loa Loa (eye worm) RNA binding protein 0.0514 0.2669 0.692
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0141 0.0434
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0245 0.0802
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0053 0.0141 0.115
Brugia malayi glutathione reductase 0.0578 0.3023 0.7838
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0053 0.0141 0.0434
Echinococcus granulosus TGF beta signal transducer SmadC 0.005 0.0122 0.0398
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.004 0.0261
Trypanosoma brucei NADH dehydrogenase 0.0053 0.0141 0.0434
Schistosoma mansoni Smad4 0.005 0.0122 0.0122
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0053 0.0141 0.115
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.02 0.0949 1
Mycobacterium tuberculosis Probable dehydrogenase 0.1319 0.709 0.8972
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.02 0.0949 0.2803
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0053 0.0141 0.0129
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0053 0.0141 0.0365
Trichomonas vaginalis mercuric reductase, putative 0.02 0.0949 0.8257
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0029 0.001 0.0032
Echinococcus multilocularis TGF beta signal transducer SmadC 0.005 0.0122 0.0398
Brugia malayi intermediate filament protein 0.0028 0.0001 0.0001
Echinococcus granulosus mothers against decapentaplegic 5 0.005 0.0122 0.0398
Schistosoma mansoni hypothetical protein 0.0072 0.0245 0.0245
Trichomonas vaginalis set domain proteins, putative 0.0237 0.1147 1
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0053 0.0141 0.0129
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0053 0.0141 0.0434
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.02 0.0949 0.3116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0108 0.0862
Trypanosoma brucei trypanothione reductase 0.0578 0.3023 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0029 0.001 0.0026
Leishmania major hypothetical protein, conserved 0.0053 0.0141 0.0434
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0147 0.0657 0.1703
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0109 0.0865
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0053 0.0141 0.0434
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0053 0.0141 0.0129
Echinococcus granulosus thioredoxin glutathione reductase 0.0584 0.3051 1
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0141 0.0434
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0088 0.033 0.1079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0206 0.1727
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0053 0.0141 0.0434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0136 0.1108
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0989 0.2565
Trichomonas vaginalis glutamate synthase, putative 0.0053 0.0141 0.115
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0053 0.0141 0.0365
Brugia malayi beta-lactamase family protein 0.0035 0.004 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0013 0.0012
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0053 0.0141 0.0129
Toxoplasma gondii thioredoxin reductase 0.0578 0.3023 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1319 0.709 0.8972
Onchocerca volvulus 0.0048 0.0111 0.0965
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.02 0.0949 1
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0053 0.0141 0.046
Echinococcus granulosus smad 0.005 0.0122 0.0398
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0053 0.0141 0.1112
Brugia malayi Pre-SET motif family protein 0.003 0.0013 0.0033
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.02 0.0949 0.1157
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0088 0.033 0.106
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0402 0.1042
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0103
Brugia malayi RNA recognition motif domain containing protein 0.0514 0.2669 0.692
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0053 0.0141 0.046
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.0122 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0206 0.1727
Echinococcus multilocularis tar DNA binding protein 0.0514 0.2669 0.8747
Echinococcus multilocularis GPCR, family 2 0.0032 0.0024 0.0077
Treponema pallidum NADH oxidase 0.02 0.0949 1
Trichomonas vaginalis glutamate synthase, putative 0.0053 0.0141 0.115
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0053 0.0141 0.0434
Onchocerca volvulus 0.0035 0.004 0.0343
Schistosoma mansoni smad 0.005 0.0122 0.0122
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0053 0.0141 0.115
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.02 0.0949 0.3116
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0053 0.0141 0.115
Echinococcus granulosus Smad4 0.005 0.0122 0.0398
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.004 0.0129
Toxoplasma gondii NADPH-glutathione reductase 0.02 0.0949 0.311
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0024 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0013 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0231 0.1945
Echinococcus granulosus tar DNA binding protein 0.0514 0.2669 0.8747
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0053 0.0141 0.046
Mycobacterium tuberculosis Probable oxidoreductase 0.1467 0.7897 1
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0053 0.0141 0.0129
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.02 0.0949 0.2803
Brugia malayi beta-lactamase family protein 0.0035 0.004 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.033 0.281
Brugia malayi MH1 domain containing protein 0.005 0.0122 0.0316
Echinococcus multilocularis tumor protein p63 0.0326 0.164 0.5375
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.02 0.0949 0.311
Brugia malayi Smad1 0.005 0.0122 0.0316
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.02 0.0949 0.3116

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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