Detailed information for compound 621016

Basic information

Technical information
  • TDR Targets ID: 621016
  • Name: 3-(4-bromophenyl)-6-hydroxy-4-methylchromen-2 -one
  • MW: 331.161 | Formula: C16H11BrO3
  • H donors: 1 H acceptors: 2 LogP: 3.8 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)c1c(=O)oc2c(c1C)cc(cc2)O
  • InChi: 1S/C16H11BrO3/c1-9-13-8-12(18)6-7-14(13)20-16(19)15(9)10-2-4-11(17)5-3-10/h2-8,18H,1H3
  • InChiKey: CIQXJKOAFAITMB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(4-bromophenyl)-6-hydroxy-4-methyl-chromen-2-one
  • 3-(4-bromophenyl)-6-hydroxy-4-methyl-2-chromenone
  • 3-(4-bromophenyl)-6-hydroxy-4-methyl-coumarin
  • ST5309175
  • ZINC00057826

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1027 0.7059 0.8964
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0133 0.0692 0.2339
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0045 0.0063 0.0209
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0045 0.0063 0.0209
Mycobacterium ulcerans hypothetical protein 0.0041 0.0041 0.0463
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0041 0.0041 0.0134
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0002 0.001
Echinococcus multilocularis glutamate synthase 0.0041 0.0041 0.0133
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0097 0.0095
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0156 0.0857 0.29
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0133 0.0692 0.2316
Giardia lamblia NADH oxidase lateral transfer candidate 0.0156 0.0857 1
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0041 0.0041 0.0134
Echinococcus multilocularis tumor protein p63 0.0337 0.2142 0.7183
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0041 0.0041 0.005
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0041 0.0258
Echinococcus granulosus mothers against decapentaplegic 5 0.004 0.0034 0.0108
Brugia malayi MH2 domain containing protein 0.004 0.0034 0.0081
Trichomonas vaginalis set domain proteins, putative 0.026 0.1596 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1027 0.7059 0.8964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.038 0.2384
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0156 0.0857 0.29
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0156 0.0857 0.2871
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0041 0.0041 0.0134
Treponema pallidum NADH oxidase 0.0156 0.0857 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0449 0.2816
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0133 0.0692 0.2316
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0041 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0257 0.1609
Loa Loa (eye worm) phosphatidylinositol 3 0.0133 0.0692 0.1742
Schistosoma mansoni hypothetical protein 0.0041 0.0041 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0498 0.3122
Toxoplasma gondii selenide, water dikinase 0.0041 0.0041 0.0134
Loa Loa (eye worm) MH2 domain-containing protein 0.004 0.0034 0.0081
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0156 0.0857 0.2803
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0156 0.0857 0.2159
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.1377 0.1747
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0041 0.0041 0.0463
Onchocerca volvulus 0.0049 0.0097 0.0598
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0041 0.0041 0.0463
Schistosoma mansoni sulfide quinone reductase 0.0041 0.0041 0.004
Loa Loa (eye worm) thioredoxin reductase 0.045 0.2952 0.7447
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0156 0.0857 0.29
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1142 0.7875 1
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0041 0.0041 0.0134
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0156 0.0857 0.29
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0133 0.0692 0.2339
Trypanosoma brucei NADH dehydrogenase 0.0041 0.0041 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0449 0.2816
Trypanosoma cruzi trypanothione reductase, putative 0.045 0.2952 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0133 0.0692 0.1742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0256 0.1604
Brugia malayi MH2 domain containing protein 0.0593 0.3964 1
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0041 0.0041 0.0134
Schistosoma mansoni tar DNA-binding protein 0.0447 0.293 0.2929
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0156 0.0857 1
Echinococcus granulosus glutamate synthase 0.0041 0.0041 0.0133
Plasmodium falciparum thioredoxin reductase 0.045 0.2952 1
Schistosoma mansoni glutamate synthase 0.0041 0.0041 0.004
Schistosoma mansoni smad1 5 8 and 0.004 0.0034 0.0032
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0045 0.0063 0.0209
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0041 0.0041 0.0134
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0041 0.0041 0.0133
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0041 0.0041 0.0133
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0041 0.0041 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0063 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0498 0.3122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0257 0.1609
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0041 0.0041 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0256 0.1604
Mycobacterium ulcerans ferredoxin reductase 0.0041 0.0041 0.0463
Trichomonas vaginalis mercuric reductase, putative 0.0156 0.0857 0.5372
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0156 0.0857 0.29
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0156 0.0857 0.29
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0041 0.0041 0.0133
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0133 0.0692 0.2339
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0041 0.0041 0.0133
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.1371 0.3457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0449 0.2816
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0106 0.0499 0.1686
Toxoplasma gondii target of rapamycin (TOR), putative 0.0099 0.0449 0.1518
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0041 0.0041 0.0133
Echinococcus granulosus tar DNA binding protein 0.0447 0.293 0.9827
Schistosoma mansoni sulfide quinone reductase 0.0041 0.0041 0.004
Echinococcus multilocularis tar DNA binding protein 0.0447 0.293 0.9827
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0041 0.0041 0.0134
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0045 0.0063 0.0062
Schistosoma mansoni smad1 5 8 and 0.004 0.0034 0.0032
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0041 0.0041 0.0134
Leishmania major NADH dehydrogenase, putative 0.0041 0.0041 0.0134
Echinococcus granulosus smad 0.004 0.0034 0.0108
Echinococcus multilocularis smad 0.004 0.0034 0.0108
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0041 0.0041 0.0134
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0041 0.0041 0.0133
Brugia malayi RNA binding protein 0.0447 0.293 0.7391
Brugia malayi glutathione reductase 0.045 0.2952 0.7447
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0041 0.0041 0.005
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0133 0.0692 0.2339
Schistosoma mansoni glutamate synthase 0.0041 0.0041 0.004
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0045 0.0063 0.0207
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0041 0.0041 0.01
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0156 0.0857 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0156 0.0857 0.29
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0041 0.0041 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0447 0.293 0.2929
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0002 0.001
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0041 0.0041 0.0463
Schistosoma mansoni smad 0.004 0.0034 0.0032
Echinococcus multilocularis thioredoxin glutathione reductase 0.0455 0.2982 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0156 0.0857 1
Giardia lamblia GTOR 0.0133 0.0692 0.7971
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0041 0.0041 0.01
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0045 0.0063 0.0207
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0156 0.0857 0.29
Loa Loa (eye worm) transcription factor SMAD2 0.0593 0.3964 1
Schistosoma mansoni tar DNA-binding protein 0.0447 0.293 0.2929
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0041 0.0041 0.005
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0045 0.0063 0.0209
Mycobacterium tuberculosis Probable reductase 0.1027 0.7059 0.8964
Plasmodium vivax thioredoxin reductase, putative 0.045 0.2952 1
Mycobacterium ulcerans monoxygenase 0.0041 0.0041 0.0463
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0041 0.0041 0.0134
Brugia malayi Smad1 0.004 0.0034 0.0081
Toxoplasma gondii NADPH-glutathione reductase 0.0156 0.0857 0.29
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0063 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0306 0.1915
Schistosoma mansoni tar DNA-binding protein 0.0447 0.293 0.2929
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0449 0.2816
Trichomonas vaginalis esterase, putative 0.0036 0.0002 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0156 0.0857 0.29
Echinococcus multilocularis mothers against decapentaplegic 5 0.004 0.0034 0.0108
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0156 0.0857 0.29
Brugia malayi MH2 domain containing protein 0.004 0.0034 0.0081
Echinococcus multilocularis TGF beta signal transducer SmadC 0.004 0.0034 0.0108
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0133 0.0692 1
Plasmodium falciparum glutathione reductase 0.0156 0.0857 0.2803
Echinococcus granulosus tumor protein p63 0.0337 0.2142 0.7183
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1142 0.7875 1
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0041 0.0041 0.005
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0156 0.0857 0.1087
Schistosoma mansoni disulfide oxidoreductase 0.0041 0.0041 0.004
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0055 0.0139 0.0466
Brugia malayi TAR-binding protein 0.0447 0.293 0.7391
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0041 0.0041 0.0133
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0133 0.0692 0.2339
Plasmodium vivax ferrodoxin reductase, putative 0.0041 0.0041 0.0134
Brugia malayi RNA recognition motif domain containing protein 0.0447 0.293 0.7391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0063 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0133 0.0692 0.4334
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0156 0.0857 0.29
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0041 0.0258
Onchocerca volvulus 0.0041 0.0041 0.0248
Trichomonas vaginalis glutamate synthase, putative 0.0041 0.0041 0.0258
Loa Loa (eye worm) hypothetical protein 0.0049 0.0097 0.0241
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0156 0.0857 0.29
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0041 0.0041 0.0134
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0002 0.001
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0041 0.0041 0.01
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0156 0.0857 0.0856
Leishmania major hypothetical protein, conserved 0.0041 0.0041 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0063 0.0397
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0041 0.0041 0.0134
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0133 0.0692 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0041 0.0041 0.01
Echinococcus granulosus thioredoxin glutathione reductase 0.0455 0.2982 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0257 0.1609
Leishmania major hypothetical protein, conserved 0.0041 0.0041 0.0134
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0041 0.0041 0.0134
Schistosoma mansoni smad1 5 8 and 0.004 0.0034 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0133 0.0692 0.4334
Loa Loa (eye worm) Smad1 0.004 0.0034 0.0081
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0156 0.0857 0.29
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1027 0.7059 0.8964
Plasmodium vivax glutathione reductase, putative 0.045 0.2952 1
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0041 0.0041 0.0463
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0063 0.0156
Brugia malayi Pre-SET motif family protein 0.0228 0.1371 0.3457
Loa Loa (eye worm) programmed cell death 8 0.0041 0.0041 0.01
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0156 0.0857 1
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0041 0.0041 0.005
Leishmania major phosphatidylinositol 3-kinase, putative 0.0045 0.0063 0.0209
Trichomonas vaginalis glutathione reductase, putative 0.0156 0.0857 0.5372
Mycobacterium ulcerans NADH dehydrogenase 0.0041 0.0041 0.0463
Trypanosoma cruzi NADH dehydrogenase, putative 0.0041 0.0041 0.0134
Mycobacterium tuberculosis Probable dehydrogenase 0.1027 0.7059 0.8964
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0156 0.0857 0.29
Loa Loa (eye worm) hypothetical protein 0.0041 0.0041 0.01
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.045 0.2952 0.3747
Loa Loa (eye worm) MH1 domain-containing protein 0.004 0.0034 0.0081
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0156 0.0857 1
Schistosoma mansoni glutamate synthase 0.0041 0.0041 0.004
Onchocerca volvulus 0.026 0.1596 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0106 0.0499 0.1686
Echinococcus granulosus TGF beta signal transducer SmadC 0.004 0.0034 0.0108
Mycobacterium ulcerans dehydrogenase 0.0041 0.0041 0.0463
Trypanosoma cruzi target of rapamycin kinase 3 0.0106 0.0499 0.1686
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0041 0.0258
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0041 0.0041 0.0463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0256 0.1604
Plasmodium falciparum thioredoxin reductase 0.0156 0.0857 0.2803
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0156 0.0857 1
Echinococcus granulosus Smad4 0.004 0.0034 0.0108
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0041 0.0258
Trypanosoma cruzi NADH dehydrogenase, putative 0.0041 0.0041 0.0134
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0041 0.0041 0.0463
Brugia malayi Thioredoxin reductase 0.045 0.2952 0.7447
Schistosoma mansoni TGF-beta signal transducer Smad2 0.004 0.0034 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0498 0.3122
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0041 0.0134
Loa Loa (eye worm) TAR-binding protein 0.0447 0.293 0.7391
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0041 0.0041 0.0134
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0115 0.0562 0.1415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0311 0.195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0257 0.1609
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0041 0.0041 0.005
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0041 0.0041 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0498 0.3122
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1142 0.7875 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0041 0.0041 0.0133
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0041 0.0041 0.0258
Toxoplasma gondii thioredoxin reductase 0.045 0.2952 1
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0041 0.0041 0.005
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0115 0.0562 0.1415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0449 0.2816
Loa Loa (eye worm) RNA binding protein 0.0447 0.293 0.7391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0311 0.195
Leishmania major trypanothione reductase 0.045 0.2952 1
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0041 0.0041 0.005
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0041 0.0041 0.0133
Trichomonas vaginalis glutamate synthase, putative 0.0041 0.0041 0.0258
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0002 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0498 0.3122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0133 0.0692 0.4334
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0133 0.0692 0.2339
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0002 0.001
Brugia malayi MH1 domain containing protein 0.004 0.0034 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0063 0.0397
Leishmania major hypothetical protein, conserved 0.0041 0.0041 0.0134
Loa Loa (eye worm) glutathione reductase 0.045 0.2952 0.7447
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0041 0.0041 0.0258
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0045 0.0063 0.0209
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0041 0.0041 0.005
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0156 0.0857 0.29
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0063 0.0156
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1027 0.7059 0.8964
Plasmodium falciparum glutathione reductase 0.045 0.2952 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0593 0.3964 1
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0041 0.0041 0.0133
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0041 0.0041 0.0133
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0063 0.0193 0.065
Trichomonas vaginalis apoptosis inducing factor, putative 0.0041 0.0041 0.0258
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0156 0.0857 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1027 0.7059 0.8964
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0041 0.0041 0.0134
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0156 0.0857 0.29
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0041 0.0041 0.0463
Brugia malayi glutamate synthase 0.0041 0.0041 0.01
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0041 0.0041 0.0134
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0041 0.0041 0.0134
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0133 0.0692 0.069
Mycobacterium ulcerans glutamate synthase subunit beta 0.0041 0.0041 0.0463
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0041 0.0041 0.0258
Trypanosoma cruzi trypanothione reductase, putative 0.0156 0.0857 0.29
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0306 0.1915
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0041 0.0134
Mycobacterium tuberculosis Probable oxidoreductase 0.1142 0.7875 1
Schistosoma mansoni tar DNA-binding protein 0.0447 0.293 0.2929
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0449 0.2816
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0447 0.293 0.7391
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0041 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0554 0.3468
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0041 0.0258
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0156 0.0857 0.29
Brugia malayi MH1 domain containing protein 0.004 0.0034 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.036 0.2256
Echinococcus multilocularis Smad4 0.004 0.0034 0.0108
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0156 0.0857 0.29
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0156 0.0857 0.2871
Schistosoma mansoni Smad4 0.004 0.0034 0.0032
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0156 0.0857 0.29
Trypanosoma brucei trypanothione reductase 0.045 0.2952 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0449 0.2816
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0311 0.195

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.