TDR Targets

Basic information

Technical information

TDR Targets ID: 621018
Name: ethyl 2-[3-(3,4-dimethoxyphenyl)-4-methyl-2-o xochromen-6-yl]oxyacetate
MW: 398.406 | Formula: C22H22O7
H donors: 0 H acceptors: 2 LogP: 3.66 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)COc1ccc2c(c1)c(C)c(c(=O)o2)c1ccc(c(c1)OC)OC
InChi: 1S/C22H22O7/c1-5-27-20(23)12-28-15-7-9-17-16(11-15)13(2)21(22(24)29-17)14-6-8-18(25-3)19(10-14)26-4/h6-11H,5,12H2,1-4H3
InChiKey: KTZLVGFBMMXNHV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 2-[3-(3,4-dimethoxyphenyl)-4-methyl-2-oxo-chromen-6-yl]oxyacetate
2-[[3-(3,4-dimethoxyphenyl)-4-methyl-2-oxo-6-chromenyl]oxy]acetic acid ethyl ester
2-[3-(3,4-dimethoxyphenyl)-2-keto-4-methyl-chromen-6-yl]oxyacetic acid ethyl ester
ethyl 2-[3-(3,4-dimethoxyphenyl)-4-methyl-2-oxo-chromen-6-yl]oxyethanoate
ZINC04340681

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0213	0.1596
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0261	0.3149	0.5145
Echinococcus multilocularis	tar DNA binding protein	0.0261	0.3149	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0033	0.0221	0.0139
Brugia malayi	MH1 domain containing protein	0.0018	0.0028	0.0046
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0086	0.0896	1
Loa Loa (eye worm)	pyridine nucleotide-disufhide oxidoreductase	0.0023	0.0083	0.0136
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0083	0.0194
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0107	0.1164	0.1901
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.0313	0.0232
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0044	0.0359	0.0898
Brugia malayi	RNA recognition motif domain containing protein	0.0261	0.3149	0.5145
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0086	0.0896	0.2943
Trypanosoma cruzi	target of rapamycin kinase 3	0.0035	0.0243	0.055
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0033	0.0221	0.045
Loa Loa (eye worm)	MH2 domain-containing protein	0.0491	0.6122	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0097	0.0168
Echinococcus granulosus	GPCR family 2	0.0034	0.0224	0.0461
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0086	0.0896	0.2943
Trypanosoma brucei	NADH dehydrogenase	0.0023	0.0083	0.0194
Plasmodium falciparum	glutathione reductase	0.0247	0.2981	1
Plasmodium falciparum	glutathione reductase	0.0086	0.0896	0.2803
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0086	0.0896	0.2803
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0564	0.7069	0.8958
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0171	0.1085
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0086	0.0896	1
Schistosoma mansoni	tar DNA-binding protein	0.0261	0.3149	0.3092
Mycobacterium tuberculosis	Probable dehydrogenase	0.0564	0.7069	0.8958
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0023	0.0083	0.0194
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0627	0.7881	1
Treponema pallidum	NADH oxidase	0.0086	0.0896	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0213	0.1596
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0086	0.0896	1
Brugia malayi	NADPH:adrenodoxin oxidoreductase, mitochondrial precursor	0.0023	0.0083	0.0136
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0063	0.0602	0.0983
Echinococcus multilocularis	smad	0.0033	0.0221	0.045
Echinococcus granulosus	lamin	0.003	0.0182	0.0323
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0023	0.0083	0.0194
Loa Loa (eye worm)	Smad1	0.0033	0.0221	0.0361
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0086	0.0896	0.2803
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0086	0.0896	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0213	0.1596
Schistosoma mansoni	hypothetical protein	0.0034	0.0224	0.0142
Schistosoma mansoni	tar DNA-binding protein	0.0261	0.3149	0.3092
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0044	0.0359	0.1126
Loa Loa (eye worm)	hypothetical protein	0.003	0.0182	0.0298
Schistosoma mansoni	smad	0.0033	0.0221	0.0139
Loa Loa (eye worm)	TAR-binding protein	0.0261	0.3149	0.5145
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0083	0.0136
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0086	0.0896	0.2803
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0063	0.0602	0.0983
Brugia malayi	glutamate synthase	0.0023	0.0083	0.0136
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0044	0.0359	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0035	0.0243	0.055
Echinococcus multilocularis	lamin	0.003	0.0182	0.0323
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0086	0.0896	0.2803
Brugia malayi	MH1 domain containing protein	0.0018	0.0028	0.0046
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0044	0.0359	0.0278
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0213	0.1596
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0367
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0213	0.1596
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.0313	0.075
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.0729	0.1191
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0182	0.0298
Trichomonas vaginalis	glutathione reductase, putative	0.0086	0.0896	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0086	0.0896	0.2803
Trypanosoma cruzi	trypanothione reductase, putative	0.0247	0.2981	1
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0033	0.0221	0.045
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0035	0.0243	0.0733
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0247	0.2981	0.3716
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0359	0.339
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0044	0.0359	0.0898
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0086	0.0896	0.2803
Brugia malayi	Smad1	0.0033	0.0221	0.0361
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0086	0.0896	0.0819
Onchocerca volvulus		0.003	0.0182	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0097	0.0168
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0086	0.0896	0.2803
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0086	0.0896	0.2943
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0107	0.1164	0.1901
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.0359	0.0586
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0086	0.0896	0.1042
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0086	0.0896	0.2803
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0107	0.1164	0.1901
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0086	0.0896	0.2803
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0359	0.339
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0729	0.1191
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0564	0.7069	0.8958
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0023	0.0083	0.0136
Mycobacterium tuberculosis	Probable oxidoreductase	0.0627	0.7881	1
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1164	0.1901
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0242	0.1957
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0033	0.0213	0.0447
Schistosoma mansoni	smad1 5 8 and	0.0033	0.0221	0.0139
Trypanosoma brucei	trypanothione reductase	0.0247	0.2981	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0359	0.339
Mycobacterium tuberculosis	Probable reductase	0.0564	0.7069	0.8958
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0086	0.0896	0.2649
Trypanosoma brucei	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.0023	0.0083	0.0194
Schistosoma mansoni	lamin	0.003	0.0182	0.01
Loa Loa (eye worm)	MH1 domain-containing protein	0.0033	0.0221	0.0361
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0159	0.0933
Entamoeba histolytica	hypothetical protein	0.0041	0.0313	0.8355
Loa Loa (eye worm)	nuclear factor I	0.0018	0.0028	0.0046
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0023	0.0083	0.0136
Echinococcus granulosus	tar DNA binding protein	0.0261	0.3149	1
Plasmodium falciparum	thioredoxin reductase	0.0247	0.2981	1
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0564	0.7069	0.8958
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0096	0.0163
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0242	0.1957
Toxoplasma gondii	thioredoxin reductase	0.0247	0.2981	1
Leishmania major	trypanothione reductase	0.0247	0.2981	1
Brugia malayi	MH2 domain containing protein	0.0491	0.6122	1
Echinococcus granulosus	mothers against decapentaplegic 5	0.0033	0.0221	0.045
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0028	0.0046
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0086	0.0896	0.2803
Plasmodium falciparum	thioredoxin reductase	0.0086	0.0896	0.2803
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0086	0.0896	0.2803
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0086	0.0896	0.2803
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0224	0.0461
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0086	0.0896	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0224	0.0461
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0224	0.0367
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0242	0.1957
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0213	0.1596
Echinococcus multilocularis	thioredoxin glutathione reductase	0.025	0.3014	0.9559
Loa Loa (eye worm)	thioredoxin reductase	0.0247	0.2981	0.4869
Loa Loa (eye worm)	hypothetical protein	0.003	0.0175	0.0286
Schistosoma mansoni	tar DNA-binding protein	0.0261	0.3149	0.3092
Echinococcus multilocularis	lamin dm0	0.003	0.0182	0.0323
Brugia malayi	MH1 domain containing protein	0.0033	0.0221	0.0361
Schistosoma mansoni	smad1 5 8 and	0.0033	0.0221	0.0139
Echinococcus granulosus	intermediate filament protein	0.003	0.0182	0.0323
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0044	0.0359	0.1126
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0044	0.0359	0.095
Toxoplasma gondii	NADPH-glutathione reductase	0.0086	0.0896	0.2803
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0086	0.0896	0.2803
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0627	0.7881	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0224	0.0461
Schistosoma mansoni	lamin	0.003	0.0182	0.01
Schistosoma mansoni	smad1 5 8 and	0.0033	0.0221	0.0139
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0086	0.0896	1
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0182	0.0298
Loa Loa (eye worm)	MH2 domain-containing protein	0.0033	0.0221	0.0361
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0096	0.0163
Loa Loa (eye worm)	RNA binding protein	0.0261	0.3149	0.5145
Brugia malayi	TAR-binding protein	0.0261	0.3149	0.5145
Schistosoma mansoni	Smad4	0.0033	0.0221	0.0139
Echinococcus granulosus	thioredoxin glutathione reductase	0.025	0.3014	0.9559
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0564	0.7069	0.8958
Brugia malayi	MH1 domain containing protein	0.0033	0.0221	0.0361
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0044	0.0359	0.095
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0126	0.053
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0086	0.0896	0.2803
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0182	0.0298
Loa Loa (eye worm)	transcription factor SMAD2	0.0491	0.6122	1
Echinococcus multilocularis	Smad4	0.0033	0.0221	0.045
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0086	0.0896	0.1463
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0021	0.0059	0.0111
Trichomonas vaginalis	mercuric reductase, putative	0.0086	0.0896	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0097	0.0168
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0564	0.7069	0.8958
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0086	0.0896	0.2803
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0086	0.0896	0.2943
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.013	0.0572
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0224	0.0461
Giardia lamblia	GTOR	0.0044	0.0359	0.339
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0044	0.0359	0.095
Entamoeba histolytica	hypothetical protein	0.0041	0.0313	0.8355
Brugia malayi	MH2 domain containing protein	0.0033	0.0221	0.0361
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0126	0.053
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0213	0.1596
Brugia malayi	MH2 domain containing protein	0.0033	0.0221	0.0361
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.013	0.0572
Plasmodium vivax	glutathione reductase, putative	0.0247	0.2981	1
Echinococcus granulosus	Smad4	0.0033	0.0221	0.045
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0224	0.0367
Plasmodium vivax	thioredoxin reductase, putative	0.0247	0.2981	1
Brugia malayi	glutathione reductase	0.0247	0.2981	0.4869
Schistosoma mansoni	intermediate filament proteins	0.003	0.0182	0.01
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0242	0.1957
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0044	0.0359	0.095
Schistosoma mansoni	tar DNA-binding protein	0.0261	0.3149	0.3092
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.013	0.0572
Trypanosoma brucei	2,4-dienoyl-coa reductase-like protein	0.0023	0.0083	0.0194
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0275	0.2366
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0224	0.0461
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0044	0.0359	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0086	0.0896	1
Echinococcus granulosus	lamin dm0	0.003	0.0182	0.0323
Entamoeba histolytica	hypothetical protein	0.0041	0.0313	0.8355
Schistosoma mansoni	hypothetical protein	0.0034	0.0224	0.0142
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0627	0.7881	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0242	0.1957
Brugia malayi	hypothetical protein	0.0041	0.0313	0.0512
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0096	0.0163
Brugia malayi	Thioredoxin reductase	0.0247	0.2981	0.4869
Schistosoma mansoni	tar DNA-binding protein	0.0261	0.3149	0.3092
Trypanosoma cruzi	trypanothione reductase, putative	0.0086	0.0896	0.2803
Schistosoma mansoni	hypothetical protein	0.0073	0.0729	0.0651
Brugia malayi	RNA binding protein	0.0261	0.3149	0.5145
Echinococcus multilocularis	musashi	0.003	0.0182	0.0323
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0359	0.0586
Onchocerca volvulus		0.003	0.0182	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0313	0.0232
Loa Loa (eye worm)	glutathione reductase	0.0247	0.2981	0.4869
Brugia malayi	intermediate filament protein	0.003	0.0182	0.0298
Entamoeba histolytica	hypothetical protein	0.0041	0.0313	0.8355
Echinococcus granulosus	smad	0.0033	0.0221	0.045
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.0313	0.075
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0033	0.0221	0.045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0097	0.0168
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0224	0.0367
Schistosoma mansoni	hypothetical protein	0.0034	0.0224	0.0142
Schistosoma mansoni	hypothetical protein	0.0034	0.0224	0.0142
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0086	0.0896	0.2803
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0086	0.0896	0.2803
Loa Loa (eye worm)	programmed cell death 8	0.0023	0.0083	0.0136
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0086	0.0896	0.2649

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 621018