Detailed information for compound 621038

Basic information

Technical information
  • TDR Targets ID: 621038
  • Name: 4-(6-chloro-2-oxochromen-3-yl)-7-(2-oxopropox y)chromen-2-one
  • MW: 396.777 | Formula: C21H13ClO6
  • H donors: 0 H acceptors: 3 LogP: 3.43 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)COc1ccc2c(c1)oc(=O)cc2c1cc2cc(Cl)ccc2oc1=O
  • InChi: 1S/C21H13ClO6/c1-11(23)10-26-14-3-4-15-16(9-20(24)27-19(15)8-14)17-7-12-6-13(22)2-5-18(12)28-21(17)25/h2-9H,10H2,1H3
  • InChiKey: XWJXMTQPIGLDOQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 7-acetonyloxy-4-(6-chloro-2-oxo-chromen-3-yl)chromen-2-one
  • 7-acetonyloxy-4-(6-chloro-2-oxo-3-chromenyl)-2-chromenone
  • 7-acetonyloxy-4-(6-chloro-2-keto-chromen-3-yl)coumarin
  • 4-(6-chloro-2-oxo-chromen-3-yl)-7-(2-oxopropoxy)chromen-2-one
  • ZINC04340025

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sulfide quinone reductase 0.0053 0.0133 0.0092
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0198 0.0942 0.1557
Brugia malayi MH2 domain containing protein 0.0052 0.0129 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0632 0.6552
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0573 0.3019 0.3716
Trichomonas vaginalis glutamate synthase, putative 0.0053 0.0133 0.1013
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0192 0.0904 0.0866
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0016 0.0039
Echinococcus multilocularis glutamate synthase 0.0053 0.0133 0.0164
Mycobacterium tuberculosis Probable oxidoreductase 0.1452 0.7899 1
Schistosoma mansoni tar DNA-binding protein 0.0345 0.1753 0.1718
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0198 0.0942 0.2803
Loa Loa (eye worm) phosphatidylinositol 3 0.0192 0.0904 0.2227
Schistosoma mansoni glutamate synthase 0.0053 0.0133 0.0092
Trichomonas vaginalis apoptosis inducing factor, putative 0.0053 0.0133 0.1013
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0198 0.0942 1
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0053 0.0133 0.1013
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0053 0.0133 0.1013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192 0.0904 0.9579
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0198 0.0942 0.3024
Brugia malayi Bromodomain containing protein 0.0074 0.0252 0.0621
Brugia malayi RNA recognition motif domain containing protein 0.0345 0.1753 0.4317
Brugia malayi glutamate synthase 0.0053 0.0133 0.0328
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0142
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0192 0.0904 0.2896
Echinococcus granulosus tar DNA binding protein 0.0345 0.1753 0.2954
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.0414 0.4135
Entamoeba histolytica thioredoxin reductase, putative 0.0053 0.0133 0.1058
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0064 0.0198 0.0522
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0198 0.0942 0.3024
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0053 0.0133 0.1013
Loa Loa (eye worm) Smad1 0.0052 0.0129 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0198 0.1727
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0198 0.0942 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0091 0.0344 0.1014
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0167 0.0412
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0192 0.0904 0.1492
Echinococcus granulosus TGF beta signal transducer SmadC 0.0052 0.0129 0.0156
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0133 0.0306
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0064 0.0198 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.0414 0.4135
Schistosoma mansoni microtubule-associated protein tau 0.0788 0.4214 0.419
Echinococcus multilocularis lamin dm0 0.0059 0.0167 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192 0.0904 0.9579
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0053 0.0133 0.1058
Entamoeba histolytica hypothetical protein 0.0074 0.0252 0.2437
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0064 0.0198 0.0522
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0052 0.0129 0.0156
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0198 0.0942 1
Entamoeba histolytica hypothetical protein 0.0074 0.0252 0.2437
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0053 0.0133 0.0164
Echinococcus multilocularis thioredoxin glutathione reductase 0.0577 0.3043 0.5175
Mycobacterium tuberculosis Probable reductase 0.1306 0.709 0.8958
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0198 0.0942 0.3024
Schistosoma mansoni smad1 5 8 and 0.0052 0.0129 0.0087
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0198 0.0942 0.3024
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1306 0.709 0.8958
Schistosoma mansoni intermediate filament proteins 0.0059 0.0167 0.0126
Loa Loa (eye worm) programmed cell death 8 0.0053 0.0133 0.0328
Treponema pallidum NADH oxidase 0.0198 0.0942 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0252 0.0369
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0053 0.0133 0.1058
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0198 0.0942 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0053 0.0133 0.0306
Schistosoma mansoni sulfide quinone reductase 0.0053 0.0133 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0152 0.0687 0.7162
Echinococcus multilocularis tar DNA binding protein 0.0345 0.1753 0.2954
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0133 0.0306
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0198 0.0942 0.2803
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0052 0.0129 0.0087
Brugia malayi glutathione reductase 0.0573 0.3019 0.7435
Loa Loa (eye worm) phosphatidylinositol 3 0.0064 0.0198 0.0487
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0198 0.0942 0.0904
Toxoplasma gondii non-specific serine/threonine protein kinase 0.004 0.0065 0.0077
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0198 0.0942 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0476 0.4824
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0064 0.0198 0.0522
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0036 0.0042 0.0007
Schistosoma mansoni glutamate synthase 0.0053 0.0133 0.0092
Loa Loa (eye worm) hypothetical protein 0.0156 0.0705 0.1736
Plasmodium vivax glutathione reductase, putative 0.0573 0.3019 1
Echinococcus multilocularis lamin 0.0059 0.0167 0.0222
Trypanosoma cruzi target of rapamycin kinase 3 0.0153 0.0688 0.2169
Trypanosoma brucei trypanothione reductase 0.0573 0.3019 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0053 0.0133 0.0164
Onchocerca volvulus 0.0059 0.0167 0.0577
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0167 0.0412
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0053 0.0133 0.0306
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0053 0.0133 0.0328
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0016 0.0039
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0053 0.0133 0.0164
Brugia malayi MH2 domain containing protein 0.076 0.4061 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0053 0.0133 0.1058
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1452 0.7899 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0053 0.0133 0.1013
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0053 0.0133 0.0306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0152 0.0687 0.7162
Loa Loa (eye worm) hypothetical protein 0.004 0.0065 0.016
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0053 0.0133 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.0414 0.4135
Loa Loa (eye worm) MH2 domain-containing protein 0.0052 0.0129 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0476 0.4824
Loa Loa (eye worm) hypothetical protein 0.0158 0.072 0.1772
Echinococcus granulosus intermediate filament protein 0.0059 0.0167 0.0222
Brugia malayi MH1 domain containing protein 0.0052 0.0129 0.0316
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0053 0.0133 0.0306
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0053 0.0133 0.0306
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0146 0.036
Echinococcus granulosus thioredoxin glutathione reductase 0.0577 0.3043 0.5175
Loa Loa (eye worm) hypothetical protein 0.004 0.0064 0.0159
Plasmodium falciparum glutathione reductase 0.0573 0.3019 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0531 0.5435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0152 0.0687 0.7162
Schistosoma mansoni cellular tumor antigen P53 0.0158 0.072 0.0681
Entamoeba histolytica hypothetical protein 0.0074 0.0252 0.2437
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0064 0.0198 0.0487
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0053 0.0133 0.1013
Brugia malayi Smad1 0.0052 0.0129 0.0316
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0192 0.0904 0.2672
Brugia malayi hypothetical protein 0.0156 0.0705 0.1736
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0192 0.0904 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0198 0.0942 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0133 0.0328
Mycobacterium tuberculosis Probable dehydrogenase 0.1306 0.709 0.8958
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0198 0.0942 0.2803
Trypanosoma cruzi NADH dehydrogenase, putative 0.0053 0.0133 0.0306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.0415 0.4144
Loa Loa (eye worm) hypothetical protein 0.0058 0.0161 0.0397
Echinococcus granulosus lamin 0.0059 0.0167 0.0222
Echinococcus multilocularis microtubule associated protein 2 0.0788 0.4214 0.7192
Brugia malayi Thioredoxin reductase 0.0573 0.3019 0.7435
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1306 0.709 0.8958
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0064 0.0198 0.0522
Loa Loa (eye worm) hypothetical protein 0.0055 0.0146 0.036
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0198 0.0942 0.2803
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0053 0.0133 0.0306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0198 0.1727
Trypanosoma cruzi trypanothione reductase, putative 0.0573 0.3019 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1452 0.7899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0554 0.569
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0064 0.0198 0.0156
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0168 0.0224
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0198 0.0942 0.3024
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0064 0.0198 0.0275
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0192 0.0904 0.2672
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0167 0.0412
Brugia malayi intermediate filament protein 0.0059 0.0167 0.0412
Brugia malayi MH1 domain containing protein 0.0052 0.0129 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0198 0.1727
Echinococcus granulosus lamin dm0 0.0059 0.0167 0.0222
Toxoplasma gondii target of rapamycin (TOR), putative 0.0143 0.0632 0.1981
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0146 0.065 0.1601
Plasmodium falciparum thioredoxin reductase 0.0573 0.3019 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.005 0.0122
Echinococcus multilocularis Smad4 0.0052 0.0129 0.0156
Trichomonas vaginalis glutathione reductase, putative 0.0198 0.0942 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0198 0.0942 0.3024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0198 0.0942 0.3024
Echinococcus multilocularis mothers against decapentaplegic 5 0.0052 0.0129 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0632 0.6552
Echinococcus multilocularis smad 0.0052 0.0129 0.0156
Trypanosoma cruzi trypanothione reductase, putative 0.0198 0.0942 0.3024
Onchocerca volvulus 0.0156 0.0705 0.9751
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0053 0.0133 0.0306
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0053 0.0133 0.1013
Loa Loa (eye worm) RNA binding protein 0.0345 0.1753 0.4317
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0632 0.6552
Plasmodium vivax thioredoxin reductase, putative 0.0573 0.3019 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.0415 0.4144
Schistosoma mansoni lamin 0.0059 0.0167 0.0126
Loa Loa (eye worm) MH1 domain-containing protein 0.0052 0.0129 0.0316
Loa Loa (eye worm) hypothetical protein 0.0042 0.0075 0.0184
Schistosoma mansoni lamin 0.0059 0.0167 0.0126
Echinococcus granulosus serine protein kinase ATM 0.0036 0.0042 0.0007
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0053 0.0133 0.0328
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0252 0.0369
Brugia malayi hypothetical protein 0.0074 0.0252 0.0621
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0192 0.0904 0.1492
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1306 0.709 0.8958
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1306 0.709 0.8958
Brugia malayi TAR-binding protein 0.0345 0.1753 0.4317
Schistosoma mansoni smad1 5 8 and 0.0052 0.0129 0.0087
Echinococcus granulosus smad 0.0052 0.0129 0.0156
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0053 0.0133 0.0306
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0053 0.0133 0.1058
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0053 0.0133 0.0164
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0345 0.1753 0.4317
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0198 0.0942 0.2803
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0192 0.0904 0.2896
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0198 0.0942 0.3024
Trichomonas vaginalis mercuric reductase, putative 0.0198 0.0942 1
Schistosoma mansoni bromodomain containing protein 0.0063 0.0188 0.0146
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0198 0.0942 0.2803
Brugia malayi MH2 domain containing protein 0.0052 0.0129 0.0316
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0198 0.0942 0.3024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0632 0.6552
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0198 0.0942 0.3024
Echinococcus granulosus mothers against decapentaplegic 5 0.0052 0.0129 0.0156
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0053 0.0133 0.1013
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0153 0.0688 0.2169
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0192 0.0904 0.2896
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0053 0.0133 0.0328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.0415 0.4144
Trypanosoma brucei NADH dehydrogenase 0.0053 0.0133 0.0306
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0192 0.0904 0.2227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0632 0.6552
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0198 0.0942 0.3024
Echinococcus multilocularis serine protein kinase ATM 0.0036 0.0042 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.076 0.4061 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0053 0.0133 0.0306
Onchocerca volvulus 0.0059 0.0167 0.0577
Schistosoma mansoni hypothetical protein 0.0053 0.0133 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.0415 0.4144
Schistosoma mansoni tar DNA-binding protein 0.0345 0.1753 0.1718
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0198 0.0942 0.2803
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0053 0.0133 0.0306
Giardia lamblia GTOR 0.0192 0.0904 0.9531
Giardia lamblia NADH oxidase lateral transfer candidate 0.0198 0.0942 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1452 0.7899 1
Trypanosoma brucei hypothetical protein, conserved 0.0053 0.0133 0.0306
Loa Loa (eye worm) hypothetical protein 0.0038 0.0051 0.0127
Brugia malayi Bromodomain containing protein 0.0038 0.0051 0.0126
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0198 0.0942 0.1042
Schistosoma mansoni tar DNA-binding protein 0.0345 0.1753 0.1718
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0053 0.0133 0.0306
Echinococcus granulosus tumor protein p63 0.1082 0.5845 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.047 0.4754
Onchocerca volvulus 0.0158 0.072 1
Leishmania major trypanothione reductase 0.0573 0.3019 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0065 0.0255
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0146 0.065 0.1601
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0036 0.0042 0.0007
Trypanosoma cruzi NADH dehydrogenase, putative 0.0053 0.0133 0.0306
Schistosoma mansoni smad 0.0052 0.0129 0.0087
Entamoeba histolytica hypothetical protein 0.0074 0.0252 0.2437
Schistosoma mansoni disulfide oxidoreductase 0.0053 0.0133 0.0092
Echinococcus granulosus glutamate synthase 0.0053 0.0133 0.0164
Loa Loa (eye worm) glutathione reductase 0.0573 0.3019 0.7435
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0053 0.0133 0.0306
Toxoplasma gondii NADPH-glutathione reductase 0.0198 0.0942 0.3024
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0053 0.0133 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.047 0.4754
Schistosoma mansoni glutamate synthase 0.0053 0.0133 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0476 0.4824
Trichomonas vaginalis PIKK family atypical protein kinase 0.0152 0.0687 0.7162
Schistosoma mansoni hypothetical protein 0.0074 0.0252 0.0211
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0146 0.036
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0053 0.0133 0.0164
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.005 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0126 0.0935
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0192 0.0904 0.2896
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0053 0.0133 0.1013
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0198 0.0942 0.3024
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0192 0.0904 1
Brugia malayi RNA binding protein 0.0345 0.1753 0.4317
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0053 0.0133 0.0306
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0042 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0632 0.6552
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0153 0.0688 0.1921
Trichomonas vaginalis PIKK family atypical protein kinase 0.0152 0.0687 0.7162
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0198 0.0942 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0053 0.0133 0.0164
Schistosoma mansoni Smad4 0.0052 0.0129 0.0087
Leishmania major phosphatidylinositol 3-kinase, putative 0.0064 0.0198 0.0223
Schistosoma mansoni tar DNA-binding protein 0.0345 0.1753 0.1718
Echinococcus multilocularis musashi 0.0059 0.0167 0.0222
Trichomonas vaginalis glutamate synthase, putative 0.0053 0.0133 0.1013
Toxoplasma gondii thioredoxin reductase 0.0573 0.3019 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0168 0.0224
Loa Loa (eye worm) hypothetical protein 0.0059 0.0167 0.0412
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0053 0.0133 0.0164
Toxoplasma gondii selenide, water dikinase 0.0053 0.0133 0.0306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0198 0.1727
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0053 0.0133 0.0328
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0053 0.0133 0.0306
Plasmodium falciparum thioredoxin reductase 0.0198 0.0942 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0053 0.0133 0.1013
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0198 0.0942 0.1557
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0042 0.0104
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0252 0.0211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0164 0.0749 0.7852
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0053 0.0133 0.1058
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0146 0.036
Loa Loa (eye worm) thioredoxin reductase 0.0573 0.3019 0.7435
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0198 0.0942 0.3024
Loa Loa (eye worm) hypothetical protein 0.007 0.0229 0.0563
Schistosoma mansoni hypothetical protein 0.0038 0.005 0.0008
Entamoeba histolytica disulphide oxidoreductase, putative 0.0053 0.0133 0.1058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192 0.0904 0.9579
Plasmodium falciparum glutathione reductase 0.0198 0.0942 0.2803
Echinococcus granulosus microtubule associated protein 2 0.0788 0.4214 0.7192
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0064 0.0198 0.0223
Schistosoma mansoni smad1 5 8 and 0.0052 0.0129 0.0087
Echinococcus granulosus Smad4 0.0052 0.0129 0.0156
Schistosoma mansoni tar DNA-binding protein 0.0345 0.1753 0.1718
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0632 0.6552
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.008 0.0283 0.0808
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0053 0.0133 0.1013
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0198 0.0942 0.232
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0053 0.0133 0.0164
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0104
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0053 0.0133 0.0164
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1306 0.709 0.8958
Loa Loa (eye worm) transcription factor SMAD2 0.076 0.4061 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0053 0.0133 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0198 0.1727
Loa Loa (eye worm) TAR-binding protein 0.0345 0.1753 0.4317
Echinococcus multilocularis tumor protein p63 0.1082 0.5845 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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