Detailed information for compound 621040

Basic information

Technical information
  • TDR Targets ID: 621040
  • Name: (4-methyl-2-oxo-3-phenylchromen-7-yl) acetate
  • MW: 294.301 | Formula: C18H14O4
  • H donors: 0 H acceptors: 2 LogP: 3.21 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Oc1ccc2c(c1)oc(=O)c(c2C)c1ccccc1
  • InChi: 1S/C18H14O4/c1-11-15-9-8-14(21-12(2)19)10-16(15)22-18(20)17(11)13-6-4-3-5-7-13/h3-10H,1-2H3
  • InChiKey: OEIICEKXTCMHPV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4-methyl-2-oxo-3-phenyl-chromen-7-yl) acetate
  • acetic acid (4-methyl-2-oxo-3-phenyl-7-chromenyl) ester
  • acetic acid (2-keto-4-methyl-3-phenyl-chromen-7-yl) ester
  • (4-methyl-2-oxo-3-phenyl-chromen-7-yl) ethanoate
  • Oprea1_013142
  • ZINC01506562

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0964 0.708 0.8958
Echinococcus multilocularis thioredoxin glutathione reductase 0.0425 0.3006 0.3058
Giardia lamblia NADH oxidase lateral transfer candidate 0.0146 0.0899 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0331 0.0333
Loa Loa (eye worm) hypothetical protein 0.0194 0.126 0.2949
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0146 0.0899 1
Brugia malayi glutamate synthase 0.0039 0.0086 0.0192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0137 0.144
Plasmodium falciparum thioredoxin reductase 0.0146 0.0899 0.2803
Echinococcus granulosus tumor protein p63 0.1327 0.9823 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0039 0.0086 0.0865
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0039 0.0086 0.0084
Echinococcus multilocularis microtubule associated protein 2 0.0673 0.4881 0.4967
Trichomonas vaginalis PIKK family atypical protein kinase 0.0136 0.0821 0.9122
Loa Loa (eye worm) MH2 domain-containing protein 0.004 0.0097 0.0228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0348 0.3805
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0146 0.0899 0.2803
Brugia malayi hypothetical protein 0.0071 0.0331 0.0767
Schistosoma mansoni tar DNA-binding protein 0.0376 0.2634 0.2631
Trichomonas vaginalis glutamate synthase, putative 0.0039 0.0086 0.0865
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0347 0.3796
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0039 0.0086 0.0084
Brugia malayi MH1 domain containing protein 0.004 0.0097 0.0219
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0146 0.0899 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0146 0.0899 0.2803
Toxoplasma gondii selenide, water dikinase 0.0039 0.0086 0.0259
Loa Loa (eye worm) MH2 domain-containing protein 0.0593 0.4274 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0039 0.0086 0.0192
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0046 0.0137 0.0177
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0039 0.0086 0.0865
Trypanosoma brucei trypanothione reductase 0.0423 0.2987 1
Trypanosoma cruzi trypanothione reductase, putative 0.0423 0.2987 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0046 0.0137 0.0177
Echinococcus multilocularis tar DNA binding protein 0.0376 0.2634 0.2679
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0611 0.6757
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0039 0.0086 0.0192
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0039 0.0086 0.0192
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0039 0.0086 0.0865
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0039 0.0086 0.0084
Onchocerca volvulus 0.0153 0.0951 0.7539
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0064 0.0279 0.0664
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0401 0.4402
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0964 0.708 0.8958
Loa Loa (eye worm) programmed cell death 8 0.0039 0.0086 0.0201
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0184 0.043
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0146 0.0899 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0611 0.6757
Toxoplasma gondii thioredoxin reductase 0.0423 0.2987 1
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.006 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0136 0.0821 0.9122
Brugia malayi MH2 domain containing protein 0.004 0.0097 0.0219
Mycobacterium tuberculosis Probable dehydrogenase 0.0964 0.708 0.8958
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0146 0.0899 0.2097
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0146 0.0899 0.0896
Brugia malayi RNA recognition motif domain containing protein 0.0376 0.2634 0.616
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0039 0.0086 0.0084
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0146 0.0899 0.2803
Schistosoma mansoni glutamate synthase 0.0039 0.0086 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0136 0.0821 0.9122
Toxoplasma gondii NADPH-glutathione reductase 0.0146 0.0899 0.2989
Schistosoma mansoni tar DNA-binding protein 0.0376 0.2634 0.2631
Echinococcus granulosus glutamate synthase 0.0039 0.0086 0.0084
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0146 0.0899 0.2803
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0146 0.0899 0.2803
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0136 0.0821 0.2534
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0146 0.0899 0.2803
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0039 0.0086 0.0084
Schistosoma mansoni tar DNA-binding protein 0.0376 0.2634 0.2631
Echinococcus granulosus tar DNA binding protein 0.0376 0.2634 0.2679
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1072 0.7893 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0964 0.708 0.8958
Schistosoma mansoni sulfide quinone reductase 0.0039 0.0086 0.0082
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0146 0.0899 1
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0039 0.0086 0.0259
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0039 0.0086 0.0084
Onchocerca volvulus 0.0194 0.126 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0964 0.708 0.8958
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0146 0.0899 0.2803
Brugia malayi glutathione reductase 0.0423 0.2987 0.6987
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0057 0.0219 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0557 0.616
Entamoeba histolytica hypothetical protein 0.0071 0.0331 0.3336
Echinococcus multilocularis Smad4 0.004 0.0097 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0347 0.3796
Echinococcus granulosus smad 0.004 0.0097 0.0095
Schistosoma mansoni hypothetical protein 0.0071 0.0331 0.0327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0348 0.3805
Schistosoma mansoni glutamate synthase 0.0039 0.0086 0.0082
Loa Loa (eye worm) phosphatidylinositol 3 0.0136 0.0821 0.1921
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0146 0.0899 0.2803
Echinococcus granulosus TGF beta signal transducer SmadC 0.004 0.0097 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0557 0.616
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0136 0.0821 0.0832
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0039 0.0086 0.0084
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0146 0.0899 0.2803
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0046 0.0137 0.0177
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0146 0.0899 0.0912
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0108 0.0611 0.1811
Leishmania major phosphatidylinositol 3-kinase, putative 0.0046 0.0137 0.0177
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0021
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0136 0.0821 0.2534
Trichomonas vaginalis glutamate synthase, putative 0.0039 0.0086 0.0865
Brugia malayi RNA binding protein 0.0376 0.2634 0.616
Schistosoma mansoni hypothetical protein 0.0035 0.006 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0347 0.3796
Brugia malayi TAR-binding protein 0.0376 0.2634 0.616
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0557 0.616
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0146 0.0899 0.2803
Brugia malayi hypothetical protein 0.0153 0.0951 0.2218
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0201
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0046 0.0137 0.0177
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0146 0.0899 0.0912
Entamoeba histolytica hypothetical protein 0.0071 0.0331 0.3336
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0146 0.0899 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0136 0.0821 0.2534
Echinococcus multilocularis mothers against decapentaplegic 5 0.004 0.0097 0.0095
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0146 0.0899 0.2803
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0136 0.0821 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0137 0.144
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0039 0.0086 0.0259
Mycobacterium tuberculosis Probable reductase 0.0964 0.708 0.8958
Plasmodium falciparum thioredoxin reductase 0.0423 0.2987 1
Plasmodium vivax thioredoxin reductase, putative 0.0423 0.2987 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0184 0.0421
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0039 0.0086 0.0084
Leishmania major trypanothione reductase 0.0423 0.2987 1
Schistosoma mansoni smad1 5 8 and 0.004 0.0097 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0348 0.3805
Brugia malayi Smad1 0.004 0.0097 0.0219
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1072 0.7893 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0146 0.0899 0.2803
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0146 0.0899 1
Schistosoma mansoni disulfide oxidoreductase 0.0039 0.0086 0.0082
Echinococcus multilocularis glutamate synthase 0.0039 0.0086 0.0084
Treponema pallidum NADH oxidase 0.0146 0.0899 1
Trichomonas vaginalis apoptosis inducing factor, putative 0.0039 0.0086 0.0865
Loa Loa (eye worm) hypothetical protein 0.0153 0.0951 0.2225
Echinococcus granulosus microtubule associated protein 2 0.0673 0.4881 0.4967
Entamoeba histolytica hypothetical protein 0.0071 0.0331 0.3336
Schistosoma mansoni TGF-beta signal transducer Smad2 0.004 0.0097 0.0094
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0046 0.0137 0.0136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0146 0.0899 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0116 0.0671 0.7432
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0004 0.0009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0136 0.0821 0.1914
Brugia malayi Thioredoxin reductase 0.0423 0.2987 0.6987
Echinococcus multilocularis smad 0.004 0.0097 0.0095
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0046 0.0137 0.0136
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0331 0.0333
Schistosoma mansoni smad1 5 8 and 0.004 0.0097 0.0094
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0146 0.0899 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0039 0.0086 0.0865
Loa Loa (eye worm) glutathione reductase 0.0423 0.2987 0.699
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0137 0.0321
Schistosoma mansoni tar DNA-binding protein 0.0376 0.2634 0.2631
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0557 0.616
Onchocerca volvulus 0.0039 0.0086 0.0654
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0964 0.708 0.8958
Mycobacterium tuberculosis Probable oxidoreductase 0.1072 0.7893 1
Loa Loa (eye worm) TAR-binding protein 0.0376 0.2634 0.6164
Brugia malayi MH2 domain containing protein 0.0593 0.4274 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0039 0.0086 0.0084
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0039 0.0086 0.0865
Giardia lamblia GTOR 0.0136 0.0821 0.9039
Schistosoma mansoni glutamate synthase 0.0039 0.0086 0.0082
Loa Loa (eye worm) thioredoxin reductase 0.0423 0.2987 0.699
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0557 0.616
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0108 0.0611 0.1811
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0331 0.0327
Toxoplasma gondii target of rapamycin (TOR), putative 0.0101 0.0557 0.1842
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0557 0.616
Trichomonas vaginalis mercuric reductase, putative 0.0146 0.0899 1
Trypanosoma cruzi trypanothione reductase, putative 0.0146 0.0899 0.2803
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0146 0.0899 0.2989
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0146 0.0899 0.1042
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0046 0.0137 0.0133
Loa Loa (eye worm) Smad1 0.004 0.0097 0.0228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0137 0.144
Echinococcus granulosus Smad4 0.004 0.0097 0.0095
Schistosoma mansoni microtubule-associated protein tau 0.0673 0.4881 0.4879
Schistosoma mansoni Smad4 0.004 0.0097 0.0094
Schistosoma mansoni tar DNA-binding protein 0.0376 0.2634 0.2631
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0046 0.0137 0.0177
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0039 0.0086 0.0865
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0146 0.0899 0.2803
Loa Loa (eye worm) hypothetical protein 0.0052 0.0184 0.043
Echinococcus multilocularis TGF beta signal transducer SmadC 0.004 0.0097 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0482 0.5317
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1072 0.7893 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0137 0.144
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0146 0.0899 0.2803
Plasmodium falciparum glutathione reductase 0.0146 0.0899 0.2803
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0136 0.0821 0.0832
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0136 0.0821 0.2534
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0039 0.0086 0.0259
Echinococcus granulosus mothers against decapentaplegic 5 0.004 0.0097 0.0095
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0136 0.0821 0.0818
Brugia malayi MH1 domain containing protein 0.004 0.0097 0.0219
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0423 0.2987 0.3716
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0146 0.0899 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0039 0.0086 0.0865
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0146 0.0899 0.2803
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0137 0.0312
Plasmodium vivax glutathione reductase, putative 0.0423 0.2987 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0108 0.0605 0.1409
Schistosoma mansoni smad 0.004 0.0097 0.0094
Entamoeba histolytica hypothetical protein 0.0071 0.0331 0.3336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0137 0.144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0611 0.6757
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0136 0.0821 0.2534
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0039 0.0086 0.0259
Loa Loa (eye worm) hypothetical protein 0.0028 0.0004 0.0009
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0146 0.0899 1
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0039 0.0086 0.0084
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0146 0.0899 0.2803
Trichomonas vaginalis glutathione reductase, putative 0.0146 0.0899 1
Schistosoma mansoni sulfide quinone reductase 0.0039 0.0086 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0401 0.4402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0407 0.447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0407 0.447
Echinococcus granulosus thioredoxin glutathione reductase 0.0425 0.3006 0.3058
Schistosoma mansoni smad1 5 8 and 0.004 0.0097 0.0094
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0136 0.0821 0.2534
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0039 0.0086 0.0084
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0108 0.0605 0.1409
Loa Loa (eye worm) RNA binding protein 0.0376 0.2634 0.6164
Loa Loa (eye worm) MH1 domain-containing protein 0.004 0.0097 0.0228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.046 0.5067
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0184 0.0421
Plasmodium falciparum glutathione reductase 0.0423 0.2987 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0039 0.0086 0.0865
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0039 0.0086 0.0259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0348 0.3805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0068 0.0665
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0611 0.6757
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0039 0.0086 0.0865
Brugia malayi MH2 domain containing protein 0.004 0.0097 0.0219
Schistosoma mansoni cellular tumor antigen P53 0.0194 0.126 0.1257
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0136 0.0821 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0407 0.447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0611 0.6757
Loa Loa (eye worm) transcription factor SMAD2 0.0593 0.4274 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0039 0.0086 0.0865
Schistosoma mansoni hypothetical protein 0.0039 0.0086 0.0082
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0376 0.2634 0.6164
Echinococcus multilocularis tumor protein p63 0.1327 0.9823 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0557 0.616
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0039 0.0086 0.0084
Trypanosoma cruzi target of rapamycin kinase 3 0.0108 0.0611 0.1811
Loa Loa (eye worm) hypothetical protein 0.0028 0.0002 0.0004
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0039 0.0086 0.0201

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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