Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0253 | 0.1008 | 0.2945 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0253 | 0.1008 | 0.2945 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase family protein | 0.0067 | 0.0206 | 0.0673 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0253 | 0.1008 | 0.2803 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.003 | 0.0048 | 0.0155 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.1669 | 0.7101 | 0.8958 |
Echinococcus granulosus | sulfide:quinone oxidoreductase | 0.0067 | 0.0206 | 0.0342 |
Schistosoma mansoni | sulfide quinone reductase | 0.0067 | 0.0206 | 0.0206 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0067 | 0.0206 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0057 | 0.0161 | 0.0267 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0253 | 0.1008 | 0.1042 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.003 | 0.0098 |
Echinococcus granulosus | lamin | 0.0057 | 0.0161 | 0.0267 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0253 | 0.1008 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0253 | 0.1008 | 0.2803 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0067 | 0.0206 | 0.0342 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0043 | 0.0103 | 0.0171 |
Loa Loa (eye worm) | intermediate filament protein | 0.0057 | 0.0161 | 0.0525 |
Schistosoma mansoni | smad1 5 8 and | 0.0043 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0043 | 0.0103 | 0.0336 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.1669 | 0.7101 | 0.8958 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0186 | 0.0718 | 0.2343 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0208 | 0.0812 | 0.0812 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0161 | 0.0525 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.1855 | 0.7903 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0732 | 0.3066 | 1 |
Loa Loa (eye worm) | pyridine nucleotide-disufhide oxidoreductase | 0.0067 | 0.0206 | 0.0673 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0812 | 0.2648 |
Brugia malayi | MH2 domain containing protein | 0.0043 | 0.0103 | 0.0336 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0253 | 0.1008 | 0.2803 |
Onchocerca volvulus | 0.0208 | 0.0812 | 1 | |
Schistosoma mansoni | smad1 5 8 and | 0.0043 | 0.0103 | 0.0103 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0253 | 0.1008 | 0.2945 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0035 | 0.0113 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0205 | 0.0205 |
Trypanosoma cruzi | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0067 | 0.0206 | 0.0197 |
Echinococcus multilocularis | glutamate synthase | 0.0067 | 0.0206 | 0.0342 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0253 | 0.1008 | 0.2803 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0741 | 0.3105 | 0.5148 |
Echinococcus granulosus | NADPH:adrenodoxin oxidoreductase | 0.0067 | 0.0206 | 0.0342 |
Leishmania major | trypanothione reductase | 0.0732 | 0.3066 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.0205 | 0.067 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0063 | 0.0187 | 0.0129 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0212 | 0.002 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0253 | 0.1008 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0212 | 0.002 |
Schistosoma mansoni | glutamate synthase | 0.0067 | 0.0206 | 0.0206 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0253 | 0.1008 | 0.2803 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0067 | 0.0206 | 0.0197 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.0212 | 0.002 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0253 | 0.1008 | 0.2803 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0253 | 0.1008 | 1 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0043 | 0.0103 | 0.0171 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0253 | 0.1008 | 0.2945 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0067 | 0.0206 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0732 | 0.3066 | 1 |
Brugia malayi | Smad1 | 0.0043 | 0.0103 | 0.0336 |
Trypanosoma cruzi | 2,4-dienoyl-coa reductase fadh1, putative | 0.0067 | 0.0206 | 0.0197 |
Trypanosoma cruzi | NADH dehydrogenase, putative | 0.0067 | 0.0206 | 0.0197 |
Brugia malayi | RNA binding protein | 0.0067 | 0.0205 | 0.067 |
Onchocerca volvulus | 0.0067 | 0.0206 | 0.2543 | |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0253 | 0.1008 | 0.2803 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0212 | 0.002 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.0205 | 0.067 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0069 | 0.0212 | 0.0217 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0253 | 0.1008 | 0.2945 |
Loa Loa (eye worm) | programmed cell death 8 | 0.0067 | 0.0206 | 0.0673 |
Onchocerca volvulus | 0.0057 | 0.0161 | 0.1984 | |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0253 | 0.1008 | 0.3288 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0043 | 0.0103 | 0.0103 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0205 | 0.0205 |
Mycobacterium tuberculosis | Probable reductase | 0.1669 | 0.7101 | 0.8958 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.0212 | 0.0217 |
Echinococcus multilocularis | lamin dm0 | 0.0057 | 0.0161 | 0.0267 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0253 | 0.1008 | 0.2945 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0253 | 0.1008 | 0.2945 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0212 | 0.002 |
Echinococcus granulosus | apoptosis inducing factor 1 mitochondrial | 0.0067 | 0.0206 | 0.0342 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.1669 | 0.7101 | 0.8958 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.0205 | 0.067 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0253 | 0.1008 | 1 |
Schistosoma mansoni | lamin | 0.0057 | 0.0161 | 0.0161 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0732 | 0.3066 | 0.3716 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0635 | 0.2651 | 0.8645 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0253 | 0.1008 | 0.1671 |
Entamoeba histolytica | disulphide oxidoreductase, putative | 0.0067 | 0.0206 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0732 | 0.3066 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0253 | 0.1008 | 0.2945 |
Brugia malayi | MH2 domain containing protein | 0.0043 | 0.0103 | 0.0336 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0212 | 0.002 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0212 | 0.002 |
Brugia malayi | MH1 domain containing protein | 0.0043 | 0.0103 | 0.0336 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase family protein | 0.0067 | 0.0206 | 0.0673 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0732 | 0.3066 | 1 |
Entamoeba histolytica | pyridine nucleotide-disulfide oxidoreductase family protein | 0.0067 | 0.0206 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0057 | 0.0161 | 0.0267 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0253 | 0.1008 | 1 |
Brugia malayi | NADPH:adrenodoxin oxidoreductase, mitochondrial precursor | 0.0067 | 0.0206 | 0.0673 |
Toxoplasma gondii | thioredoxin reductase | 0.0732 | 0.3066 | 1 |
Schistosoma mansoni | sulfide quinone reductase | 0.0067 | 0.0206 | 0.0206 |
Echinococcus granulosus | smad | 0.0043 | 0.0103 | 0.0171 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.0205 | 0.067 |
Schistosoma mansoni | Smad4 | 0.0043 | 0.0103 | 0.0103 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0057 | 0.0161 | 0.0525 |
Treponema pallidum | NADH oxidase | 0.0253 | 0.1008 | 1 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0253 | 0.1008 | 0.2803 |
Entamoeba histolytica | thioredoxin reductase, putative | 0.0067 | 0.0206 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.0205 | 0.034 |
Plasmodium falciparum | glutathione reductase | 0.0253 | 0.1008 | 0.2803 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0253 | 0.1008 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0732 | 0.3066 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0253 | 0.1008 | 0.2803 |
Schistosoma mansoni | smad1 5 8 and | 0.0043 | 0.0103 | 0.0103 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.1669 | 0.7101 | 0.8958 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0027 | 0.0035 | 0.0057 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0206 | 0.0206 |
Schistosoma mansoni | glutamate synthase | 0.0067 | 0.0206 | 0.0206 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0253 | 0.1008 | 0.2803 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0186 | 0.0718 | 0.2343 |
Echinococcus multilocularis | lamin | 0.0057 | 0.0161 | 0.0267 |
Loa Loa (eye worm) | glutathione reductase | 0.0732 | 0.3066 | 1 |
Schistosoma mansoni | smad | 0.0043 | 0.0103 | 0.0103 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0212 | 0.002 |
Echinococcus multilocularis | sulfide:quinone oxidoreductase | 0.0067 | 0.0206 | 0.0342 |
Trypanosoma cruzi | 2,4-dienoyl-coa reductase-like protein, putative | 0.0067 | 0.0206 | 0.0197 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0212 | 0.002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0205 | 0.0205 |
Onchocerca volvulus | 0.0057 | 0.0161 | 0.1984 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0212 | 0.002 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0253 | 0.1008 | 0.2945 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0253 | 0.1008 | 0.2803 |
Loa Loa (eye worm) | Smad1 | 0.0043 | 0.0103 | 0.0336 |
Schistosoma mansoni | lamin | 0.0057 | 0.0161 | 0.0161 |
Loa Loa (eye worm) | nuclear factor I | 0.0024 | 0.002 | 0.0064 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0043 | 0.0103 | 0.0171 |
Trypanosoma cruzi | NADPH:adrenodoxin oxidoreductase, mitochondrial, putative | 0.0067 | 0.0206 | 0.0197 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0635 | 0.2651 | 0.8645 |
Schistosoma mansoni | intermediate filament proteins | 0.0057 | 0.0161 | 0.0161 |
Echinococcus multilocularis | apoptosis inducing factor 1 mitochondrial | 0.0067 | 0.0206 | 0.0342 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0157 | 0.0511 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.1669 | 0.7101 | 0.8958 |
Echinococcus multilocularis | smad | 0.0043 | 0.0103 | 0.0171 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0253 | 0.1008 | 0.2803 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0206 | 0.0673 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0067 | 0.0206 | 0.0342 |
Echinococcus multilocularis | tumor protein p63 | 0.142 | 0.6032 | 1 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.0212 | 0.002 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0253 | 0.1008 | 1 |
Schistosoma mansoni | glutamate synthase | 0.0067 | 0.0206 | 0.0206 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0043 | 0.0103 | 0.0336 |
Brugia malayi | intermediate filament protein | 0.0057 | 0.0161 | 0.0525 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0253 | 0.1008 | 0.2803 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.0212 | 0.0217 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0253 | 0.1008 | 0.1008 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.0212 | 0.0217 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.1669 | 0.7101 | 0.8958 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0741 | 0.3105 | 0.5148 |
Trypanosoma cruzi | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0067 | 0.0206 | 0.0197 |
Brugia malayi | Thioredoxin reductase | 0.0732 | 0.3066 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0067 | 0.0206 | 0.0197 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0027 | 0.0035 | 0.0057 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0253 | 0.1008 | 0.2803 |
Schistosoma mansoni | disulfide oxidoreductase | 0.0067 | 0.0206 | 0.0206 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.1855 | 0.7903 | 1 |
Echinococcus multilocularis | Smad4 | 0.0043 | 0.0103 | 0.0171 |
Trypanosoma cruzi | NADH dehydrogenase, putative | 0.0067 | 0.0206 | 0.0197 |
Echinococcus multilocularis | NADPH:adrenodoxin oxidoreductase | 0.0067 | 0.0206 | 0.0342 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.1855 | 0.7903 | 1 |
Echinococcus multilocularis | pyridine nucleotide disulfide oxidoreductase | 0.0067 | 0.0206 | 0.0342 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0253 | 0.1008 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.003 | 0.0098 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0212 | 0.002 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0067 | 0.0206 | 0.0342 |
Brugia malayi | glutamate synthase | 0.0067 | 0.0206 | 0.0673 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.0212 | 0.002 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0067 | 0.0206 | 0.0342 |
Brugia malayi | glutathione reductase | 0.0732 | 0.3066 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0043 | 0.0103 | 0.0336 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0253 | 0.1008 | 0.2803 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.1855 | 0.7903 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.003 | 0.0048 | 0.0155 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0212 | 0.002 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0067 | 0.0206 | 0.5 |
Echinococcus granulosus | pyridine nucleotide disulfide oxidoreductase | 0.0067 | 0.0206 | 0.0342 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0043 | 0.0103 | 0.0171 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0057 | 0.0161 | 0.0525 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0732 | 0.3066 | 1 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.0205 | 0.067 |
Echinococcus granulosus | glutamate synthase | 0.0067 | 0.0206 | 0.0342 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0205 | 0.0205 |
Brugia malayi | MH1 domain containing protein | 0.0024 | 0.002 | 0.0064 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0205 | 0.0205 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0253 | 0.1008 | 0.1671 |
Echinococcus multilocularis | musashi | 0.0057 | 0.0161 | 0.0267 |
Plasmodium falciparum | thioredoxin reductase | 0.0732 | 0.3066 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0635 | 0.2651 | 0.8645 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.0205 | 0.034 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0253 | 0.1008 | 1 |
Echinococcus granulosus | Smad4 | 0.0043 | 0.0103 | 0.0171 |
Brugia malayi | MH1 domain containing protein | 0.0024 | 0.002 | 0.0064 |
Echinococcus granulosus | tumor protein p63 | 0.142 | 0.6032 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.002 | 0.0064 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0067 | 0.0206 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.