Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0607 | 0.7863 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0242 | 0.2956 | 0.9427 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0083 | 0.0819 | 0.2803 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0546 | 0.7044 | 0.8958 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0134 | 0.0429 |
Plasmodium falciparum | thioredoxin reductase | 0.0239 | 0.2922 | 1 |
Entamoeba histolytica | thioredoxin reductase, putative | 0.0022 | 0 | 0.5 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0083 | 0.0819 | 0.2803 |
Brugia malayi | MH2 domain containing protein | 0.0237 | 0.2888 | 0.9208 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0237 | 0.2888 | 0.9208 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0083 | 0.0819 | 0.2803 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0255 | 0.3136 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0083 | 0.0819 | 0.2612 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0083 | 0.0819 | 1 |
Onchocerca volvulus | 0.0254 | 0.3119 | 1 | |
Loa Loa (eye worm) | TAR-binding protein | 0.0255 | 0.3136 | 1 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0083 | 0.0819 | 0.2803 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.3136 | 0.3136 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0083 | 0.0819 | 0.2626 |
Loa Loa (eye worm) | glutathione reductase | 0.0239 | 0.2922 | 0.9316 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0083 | 0.0819 | 0.2803 |
Brugia malayi | Pre-SET motif family protein | 0.0223 | 0.2704 | 0.8624 |
Entamoeba histolytica | pyridine nucleotide-disulfide oxidoreductase family protein | 0.0022 | 0 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0083 | 0.0819 | 0.2803 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0032 | 0.0134 | 0.0429 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0607 | 0.7863 | 1 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0083 | 0.0819 | 0.2803 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0546 | 0.7044 | 0.8958 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0083 | 0.0819 | 0.2803 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0239 | 0.2922 | 0.9316 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0022 | 0 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0083 | 0.0819 | 0.2626 |
Echinococcus granulosus | tar DNA binding protein | 0.0255 | 0.3136 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0083 | 0.0819 | 0.2612 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0237 | 0.2888 | 0.9208 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0134 | 0.0134 |
Treponema pallidum | NADH oxidase | 0.0083 | 0.0819 | 1 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0083 | 0.0819 | 0.2803 |
Brugia malayi | Thioredoxin reductase | 0.0239 | 0.2922 | 0.9316 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0255 | 0.3136 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0239 | 0.2922 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0083 | 0.0819 | 0.2803 |
Brugia malayi | RNA binding protein | 0.0255 | 0.3136 | 1 |
Leishmania major | trypanothione reductase | 0.0239 | 0.2922 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0242 | 0.2956 | 0.9427 |
Plasmodium falciparum | thioredoxin reductase | 0.0083 | 0.0819 | 0.2803 |
Onchocerca volvulus | 0.0032 | 0.0134 | 0.0431 | |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0083 | 0.0819 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0239 | 0.2922 | 0.3716 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0083 | 0.0819 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.3136 | 0.3136 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0083 | 0.0819 | 0.2803 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0083 | 0.0819 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0239 | 0.2922 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0083 | 0.0819 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0083 | 0.0819 | 0.2803 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.0134 | 0.046 |
Trichomonas vaginalis | set domain proteins, putative | 0.0254 | 0.3119 | 1 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0083 | 0.0819 | 0.1042 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0083 | 0.0819 | 0.0819 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0061 | 0.0523 | 0.1668 |
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.0134 | 0.0429 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0083 | 0.0819 | 0.2803 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0083 | 0.0819 | 0.2803 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0031 | 0.0119 | 0.0378 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0083 | 0.0819 | 0.2803 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0083 | 0.0819 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0083 | 0.0819 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0546 | 0.7044 | 0.8958 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.0134 | 0.0429 |
Plasmodium vivax | glutathione reductase, putative | 0.0239 | 0.2922 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0032 | 0.0134 | 0.0429 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0022 | 0 | 0.5 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0083 | 0.0819 | 0.2803 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0546 | 0.7044 | 0.8958 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0607 | 0.7863 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0546 | 0.7044 | 0.8958 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0546 | 0.7044 | 0.8958 |
Mycobacterium tuberculosis | Probable reductase | 0.0546 | 0.7044 | 0.8958 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0083 | 0.0819 | 0.2612 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0083 | 0.0819 | 0.2803 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0134 | 0.0134 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0239 | 0.2922 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.3136 | 0.3136 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0022 | 0 | 0.5 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0083 | 0.0819 | 0.2803 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.0134 | 0.046 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0032 | 0.0134 | 0.0134 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0134 | 0.0134 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0061 | 0.0523 | 0.1668 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0022 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0083 | 0.0819 | 1 |
Entamoeba histolytica | disulphide oxidoreductase, putative | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0255 | 0.3136 | 1 |
Brugia malayi | glutathione reductase | 0.0239 | 0.2922 | 0.9316 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0607 | 0.7863 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0083 | 0.0819 | 0.2803 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0083 | 0.0819 | 0.2803 |
Toxoplasma gondii | thioredoxin reductase | 0.0239 | 0.2922 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0223 | 0.2704 | 0.8624 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.3136 | 0.3136 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0239 | 0.2922 | 1 |
Brugia malayi | TAR-binding protein | 0.0255 | 0.3136 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0255 | 0.3136 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0083 | 0.0819 | 0.2803 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0083 | 0.0819 | 0.2803 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.3136 | 0.3136 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0083 | 0.0819 | 0.2803 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.