Detailed information for compound 621056

Basic information

Technical information
  • TDR Targets ID: 621056
  • Name: 5-[(3-bromophenyl)-morpholin-4-ylmethyl]-2-me thyl-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-ol
  • MW: 409.301 | Formula: C16H17BrN4O2S
  • H donors: 1 H acceptors: 3 LogP: 3.11 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cccc(c1)C(c1sc2n(c1O)nc(n2)C)N1CCOCC1
  • InChi: 1S/C16H17BrN4O2S/c1-10-18-16-21(19-10)15(22)14(24-16)13(20-5-7-23-8-6-20)11-3-2-4-12(17)9-11/h2-4,9,13,22H,5-8H2,1H3
  • InChiKey: QYOSSLGJEIUBJU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(3-bromophenyl)-morpholino-methyl]-2-methyl-thiazolo[2,3-e][1,2,4]triazol-6-ol
  • 5-[(3-bromophenyl)-morpholinomethyl]-2-methyl-6-thiazolo[2,3-e][1,2,4]triazolol
  • 5-[(3-bromophenyl)-morpholin-4-yl-methyl]-2-methyl-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus mothers against decapentaplegic 2 0.0023 0.0071 0.0168
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0114 0.0953 0.315
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0878 0.1258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0089 0.0432
Schistosoma mansoni TGF-beta signal transducer Smad2 0.005 0.034 0.034
Trichomonas vaginalis glutamate synthase, putative 0.003 0.0146 0.0707
Entamoeba histolytica hypothetical protein 0.0037 0.0208 0.431
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.003 0.0146 0.0345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0289 0.1403
Treponema pallidum NADH oxidase 0.0114 0.0953 1
Onchocerca volvulus 0.003 0.0146 0.0375
Trichomonas vaginalis disulfide oxidoreductase, putative 0.003 0.0146 0.0707
Echinococcus multilocularis TGF beta signal transducer SmadC 0.005 0.034 0.0804
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.02 0.0971
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0146 0.0482
Echinococcus multilocularis musashi 0.0028 0.0119 0.0282
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0178 0.0422
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.003 0.0146 0.0482
Loa Loa (eye worm) thioredoxin reductase 0.0329 0.3026 0.4333
Schistosoma mansoni glutamate synthase 0.003 0.0146 0.0146
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.006 0.0198
Giardia lamblia GTOR 0.0045 0.0289 0.1775
Plasmodium vivax glutathione reductase, putative 0.0329 0.3026 1
Trichomonas vaginalis apoptosis inducing factor, putative 0.003 0.0146 0.0707
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0289 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0114 0.0953 1
Schistosoma mansoni glutamate synthase 0.003 0.0146 0.0146
Echinococcus granulosus Smad4 0.005 0.034 0.0804
Loa Loa (eye worm) MH2 domain-containing protein 0.0023 0.0071 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.02 0.0971
Trypanosoma cruzi NADH dehydrogenase, putative 0.003 0.0146 0.0482
Giardia lamblia NADH oxidase lateral transfer candidate 0.0114 0.0953 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0132 0.0132
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0114 0.0953 0.315
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.003 0.0146 0.0482
Echinococcus granulosus tar DNA binding protein 0.0454 0.4227 1
Schistosoma mansoni sulfide quinone reductase 0.003 0.0146 0.0146
Echinococcus granulosus mothers against decapentaplegic 5 0.005 0.034 0.0804
Trichomonas vaginalis glutamate synthase, putative 0.003 0.0146 0.0707
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.003 0.0146 0.0707
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0329 0.3026 0.3716
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0132 0.0313
Echinococcus granulosus intermediate filament protein 0.0028 0.0119 0.0282
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0119 0.0171
Schistosoma mansoni hypothetical protein 0.0034 0.0178 0.0178
Schistosoma mansoni lamin 0.0028 0.0119 0.0119
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0114 0.0953 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0201 0.0663
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0289 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.003 0.0146 0.0482
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0751 0.709 0.8958
Echinococcus multilocularis tar DNA binding protein 0.0454 0.4227 1
Plasmodium falciparum glutathione reductase 0.0329 0.3026 1
Leishmania major hypothetical protein, conserved 0.003 0.0146 0.0482
Loa Loa (eye worm) MH2 domain-containing protein 0.074 0.6984 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0178 0.0422
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.003 0.0146 0.0345
Schistosoma mansoni Smad4 0.0023 0.0071 0.0071
Schistosoma mansoni smad1 5 8 and 0.005 0.034 0.034
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0114 0.0953 0.2837
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0114 0.0953 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0178 0.0255
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.003 0.0146 0.0345
Schistosoma mansoni smad 0.0023 0.0071 0.0071
Leishmania major trypanothione reductase 0.0329 0.3026 1
Schistosoma mansoni tar DNA-binding protein 0.0454 0.4227 0.4227
Loa Loa (eye worm) hypothetical protein 0.0028 0.0119 0.0171
Schistosoma mansoni hypothetical protein 0.0034 0.0178 0.0178
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0119 0.0171
Brugia malayi intermediate filament protein 0.0028 0.0119 0.0171
Echinococcus multilocularis lamin 0.0028 0.0119 0.0282
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0751 0.709 0.8958
Brugia malayi Pre-SET motif family protein 0.0201 0.1794 0.2568
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.003 0.0146 0.0707
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0114 0.0953 0.315
Trichomonas vaginalis set domain proteins, putative 0.0229 0.2062 1
Brugia malayi MH2 domain containing protein 0.005 0.034 0.0487
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0114 0.0953 0.315
Schistosoma mansoni sulfide quinone reductase 0.003 0.0146 0.0146
Echinococcus granulosus sulfide:quinone oxidoreductase 0.003 0.0146 0.0345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0089 0.0432
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0035 0.0115
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.003 0.0146 0.0209
Brugia malayi hypothetical protein 0.0037 0.0208 0.0297
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.003 0.0146 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0114 0.0553
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0178 0.0862
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.02 0.0971
Loa Loa (eye worm) hypothetical protein 0.0073 0.0554 0.0794
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0751 0.709 0.8958
Trypanosoma brucei NADH dehydrogenase 0.003 0.0146 0.0482
Loa Loa (eye worm) hypothetical protein 0.0029 0.0132 0.0189
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.034 0.0487
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0878 0.1258
Loa Loa (eye worm) hypothetical protein 0.0028 0.0123 0.0176
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.003 0.0146 0.0482
Schistosoma mansoni smad 0.005 0.034 0.034
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0289 0.0684
Schistosoma mansoni Smad4 0.005 0.034 0.034
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0146 0.0482
Entamoeba histolytica hypothetical protein 0.0037 0.0208 0.431
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0114 0.0953 0.2837
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0178 0.0255
Plasmodium falciparum glutathione reductase 0.0114 0.0953 0.2803
Loa Loa (eye worm) hypothetical protein 0.0027 0.0114 0.0164
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0114 0.0953 0.315
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0289 0.0956
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0835 0.7897 1
Toxoplasma gondii NADPH-glutathione reductase 0.0114 0.0953 0.2837
Leishmania major hypothetical protein, conserved 0.003 0.0146 0.0482
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0146 0.0482
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0878 0.1258
Schistosoma mansoni tar DNA-binding protein 0.0454 0.4227 0.4227
Trichomonas vaginalis disulfide oxidoreductase, putative 0.003 0.0146 0.0707
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0114 0.0953 0.315
Brugia malayi mothers against decapentaplegic homolog 3 0.0023 0.0071 0.0102
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.003 0.0146 0.0047
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0208 0.0491
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.003 0.0146 0.0345
Trichomonas vaginalis mercuric reductase, putative 0.0114 0.0953 0.4624
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0114 0.0953 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0178 0.0862
Onchocerca volvulus 0.0028 0.0119 0.0241
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0132 0.0313
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.003 0.0146 0.0707
Echinococcus granulosus mothers against decapentaplegic 6 0.0023 0.0071 0.0168
Trypanosoma cruzi NADH dehydrogenase, putative 0.003 0.0146 0.0482
Schistosoma mansoni tar DNA-binding protein 0.0454 0.4227 0.4227
Trichomonas vaginalis disulfide oxidoreductase, putative 0.003 0.0146 0.0707
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0114 0.0953 0.1042
Plasmodium vivax thioredoxin reductase, putative 0.0329 0.3026 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0023 0.0071 0.0102
Loa Loa (eye worm) hypothetical protein 0.0023 0.0071 0.0102
Echinococcus multilocularis Smad4 0.005 0.034 0.0804
Brugia malayi RNA recognition motif domain containing protein 0.0454 0.4227 0.6053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0289 0.1403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0089 0.0432
Brugia malayi MH2 domain containing protein 0.074 0.6984 1
Echinococcus multilocularis glutamate synthase 0.003 0.0146 0.0345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0226 0.1094
Echinococcus granulosus TGF beta signal transducer SmadC 0.005 0.034 0.0804
Loa Loa (eye worm) glutathione reductase 0.0329 0.3026 0.4333
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0178 0.0255
Plasmodium vivax ferrodoxin reductase, putative 0.003 0.0146 0.0047
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0122 0.0289
Schistosoma mansoni tar DNA-binding protein 0.0454 0.4227 0.4227
Trichomonas vaginalis disulfide oxidoreductase, putative 0.003 0.0146 0.0707
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.003 0.0146 0.0209
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0289 0.0956
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0114 0.0953 0.2255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0089 0.0432
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0114 0.0953 0.315
Onchocerca volvulus 0.0029 0.0132 0.0307
Brugia malayi MH2 domain containing protein 0.005 0.034 0.0487
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0178 0.0422
Echinococcus multilocularis mothers against decapentaplegic 2 0.0023 0.0071 0.0168
Schistosoma mansoni glutamate synthase 0.003 0.0146 0.0146
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.003 0.0146 0.0345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0114 0.0553
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0289 0.0956
Toxoplasma gondii thioredoxin reductase 0.0329 0.3026 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0289 0.0956
Brugia malayi MH1 domain containing protein 0.005 0.034 0.0487
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.003 0.0146 0.0047
Loa Loa (eye worm) TAR-binding protein 0.0454 0.4227 0.6053
Brugia malayi MH2 domain containing protein 0.0023 0.0071 0.0102
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.003 0.0146 0.0345
Brugia malayi MH1 domain containing protein 0.005 0.034 0.0487
Leishmania major NADH dehydrogenase, putative 0.003 0.0146 0.0482
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0835 0.7897 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0132 0.0132
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.003 0.0146 0.0345
Loa Loa (eye worm) RNA binding protein 0.0454 0.4227 0.6053
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0289 0.0956
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0089 0.043
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.034 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0146 0.0708
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0089 0.043
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.003 0.0146 0.0345
Entamoeba histolytica hypothetical protein 0.0037 0.0208 0.431
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.003 0.0146 0.0047
Loa Loa (eye worm) transcription factor SMAD2 0.074 0.6984 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0114 0.0953 0.2255
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.003 0.0146 0.0345
Trichomonas vaginalis disulfide oxidoreductase, putative 0.003 0.0146 0.0707
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0114 0.0953 0.315
Mycobacterium tuberculosis Probable reductase 0.0751 0.709 0.8958
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.003 0.0146 0.0482
Schistosoma mansoni hypothetical protein 0.0037 0.0208 0.0208
Brugia malayi RNA binding protein 0.0454 0.4227 0.6053
Schistosoma mansoni hypothetical protein 0.003 0.0146 0.0146
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0178 0.0422
Echinococcus multilocularis thioredoxin glutathione reductase 0.0332 0.3056 0.723
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0751 0.709 0.8958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0178 0.0862
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0114 0.0953 1
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.003 0.0146 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.02 0.0971
Echinococcus granulosus GPCR family 2 0.0034 0.0178 0.0422
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0119 0.0171
Brugia malayi Smad1 0.005 0.034 0.0487
Loa Loa (eye worm) Smad1 0.005 0.034 0.0487
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0084 0.0662 0.0947
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0111 0.0541
Brugia malayi MH1 domain containing protein 0.0028 0.0123 0.0176
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0114 0.0953 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0114 0.0953 0.315
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0114 0.0953 0.315
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0289 0.0414
Echinococcus granulosus lamin 0.0028 0.0119 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0289 0.1403
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0289 0.0289
Echinococcus granulosus thioredoxin glutathione reductase 0.0332 0.3056 0.723
Echinococcus multilocularis mothers against decapentaplegic 6 0.0023 0.0071 0.0168
Leishmania major hypothetical protein, conserved 0.003 0.0146 0.0482
Schistosoma mansoni smad1 5 8 and 0.005 0.034 0.034
Schistosoma mansoni disulfide oxidoreductase 0.003 0.0146 0.0146
Trypanosoma cruzi trypanothione reductase, putative 0.0329 0.3026 1
Trypanosoma brucei trypanothione reductase 0.0329 0.3026 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0289 0.0414
Loa Loa (eye worm) nuclear factor I 0.0028 0.0123 0.0176
Trypanosoma cruzi trypanothione reductase, putative 0.0114 0.0953 0.315
Schistosoma mansoni hypothetical protein 0.0073 0.0554 0.0554
Schistosoma mansoni hypothetical protein 0.0034 0.0178 0.0178
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0835 0.7897 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0289 0.0684
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.003 0.0146 0.0209
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0114 0.0953 0.2803
Schistosoma mansoni hypothetical protein 0.0034 0.0178 0.0178
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.003 0.0146 0.0047
Brugia malayi glutamate synthase 0.003 0.0146 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0178 0.0862
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0089 0.043
Loa Loa (eye worm) programmed cell death 8 0.003 0.0146 0.0209
Trichomonas vaginalis disulfide oxidoreductase, putative 0.003 0.0146 0.0707
Loa Loa (eye worm) hypothetical protein 0.0106 0.0878 0.1258
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.003 0.0146 0.0482
Mycobacterium tuberculosis Probable oxidoreductase 0.0835 0.7897 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0137 0.0662
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0114 0.0953 0.315
Onchocerca volvulus 0.0229 0.2062 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0114 0.0953 1
Schistosoma mansoni smad1 5 8 and 0.005 0.034 0.034
Echinococcus multilocularis lamin dm0 0.0028 0.0119 0.0282
Brugia malayi Pre-SET motif family protein 0.0029 0.0132 0.0189
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0289 0.0956
Brugia malayi glutathione reductase 0.0329 0.3026 0.4333
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0114 0.0953 0.1365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0114 0.0553
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0132 0.0132
Brugia malayi MH1 domain containing protein 0.0028 0.0123 0.0176
Echinococcus multilocularis GPCR, family 2 0.0034 0.0178 0.0422
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0178 0.0157
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0114 0.0953 0.315
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.003 0.0146 0.0209
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0114 0.0953 0.315
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0208 0.0491
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0114 0.0953 0.315
Echinococcus multilocularis mothers against decapentaplegic 5 0.005 0.034 0.0804
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.02 0.0971
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.003 0.0146 0.0345
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0132 0.0313
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.003 0.0146 0.0707
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0208 0.0208
Plasmodium falciparum thioredoxin reductase 0.0329 0.3026 1
Brugia malayi Thioredoxin reductase 0.0329 0.3026 0.4333
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.003 0.0146 0.0482
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0554 0.0794
Schistosoma mansoni Smad4 0.0023 0.0071 0.0071
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.003 0.0146 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0178 0.0862
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0111 0.0541
Plasmodium falciparum thioredoxin reductase 0.0114 0.0953 0.2803
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0201 0.0663
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0114 0.0953 0.0953
Echinococcus granulosus lamin dm0 0.0028 0.0119 0.0282
Brugia malayi TAR-binding protein 0.0454 0.4227 0.6053
Mycobacterium tuberculosis Probable dehydrogenase 0.0751 0.709 0.8958
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.003 0.0146 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0178 0.0862
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0084 0.0662 0.0947
Schistosoma mansoni intermediate filament proteins 0.0028 0.0119 0.0119
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.003 0.0146 0.0047
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0201 0.0663
Entamoeba histolytica hypothetical protein 0.0037 0.0208 0.431
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.003 0.0146 0.0209
Echinococcus multilocularis smad 0.005 0.034 0.0804
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0454 0.4227 0.6053
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.003 0.0146 0.0345
Trichomonas vaginalis glutathione reductase, putative 0.0114 0.0953 0.4624
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.003 0.0146 0.0482
Onchocerca volvulus 0.0028 0.0119 0.0241
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.1794 0.2568
Echinococcus granulosus smad 0.005 0.034 0.0804
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0178 0.0862
Schistosoma mansoni tar DNA-binding protein 0.0454 0.4227 0.4227
Schistosoma mansoni lamin 0.0028 0.0119 0.0119
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.003 0.0146 0.0482
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0114 0.0953 0.2837
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0114 0.0953 0.315
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0751 0.709 0.8958
Toxoplasma gondii selenide, water dikinase 0.003 0.0146 0.0047
Echinococcus granulosus glutamate synthase 0.003 0.0146 0.0345
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0114 0.0953 0.315
Loa Loa (eye worm) hypothetical protein 0.0034 0.0178 0.0255

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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