Detailed information for compound 621076

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 467.561 | Formula: C23H21N3O4S2
  • H donors: 1 H acceptors: 3 LogP: 3.62 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCn1c(=NC(=O)c2ccc(cc2)c2ccccc2)sc2c1ccc(c2)S(=O)(=O)N
  • InChi: 1S/C23H21N3O4S2/c1-30-14-13-26-20-12-11-19(32(24,28)29)15-21(20)31-23(26)25-22(27)18-9-7-17(8-10-18)16-5-3-2-4-6-16/h2-12,15H,13-14H2,1H3,(H2,24,28,29)/b25-23-
  • InChiKey: HXWREXXNWPNVBV-BZZOAKBMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0745 0.8151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0122 0.1287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0504 0.5504
Schistosoma mansoni disulfide oxidoreductase 0.0045 0.0101 0.0101
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0144 0.0745 0.2224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0553 0.6038
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.124 0.7895 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0026 0.0065
Echinococcus granulosus microtubule associated protein 2 0.068 0.4246 0.4761
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1115 0.7083 0.8958
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0169 0.0913 0.1023
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0169 0.0913 0.3034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0504 0.5504
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0169 0.0913 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0144 0.0745 0.2224
Entamoeba histolytica hypothetical protein 0.0077 0.0313 0.3292
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0045 0.0101 0.0113
Trichomonas vaginalis glutamate synthase, putative 0.0045 0.0101 0.1056
Schistosoma mansoni glutamate synthase 0.0045 0.0101 0.0101
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0045 0.0101 0.0113
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1115 0.7083 0.8958
Toxoplasma gondii thioredoxin reductase 0.0489 0.2997 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0169 0.0913 0.2803
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0144 0.0745 0.0835
Echinococcus granulosus tumor protein p63 0.1396 0.8918 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0122 0.1287
Plasmodium falciparum thioredoxin reductase 0.0489 0.2997 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0045 0.0101 0.1056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0313 0.34
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0045 0.0101 0.0113
Onchocerca volvulus 0.0045 0.0101 0.0882
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0416 0.4528
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0144 0.0745 0.0835
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0068 0.0251 0.0518
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0169 0.0913 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0313 0.3391
Echinococcus granulosus Smad4 0.0043 0.0089 0.0099
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0144 0.0745 0.1892
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0553 0.6038
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0124 0.0619 0.1573
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0279 0.0708
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0045 0.0101 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0504 0.5504
Mycobacterium tuberculosis Probable reductase 0.1115 0.7083 0.8958
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0101 0.1056
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0101 0.1056
Schistosoma mansoni hypothetical protein 0.0033 0.0026 0.0026
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0045 0.0101 0.0113
Trypanosoma cruzi trypanothione reductase, putative 0.0169 0.0913 0.2803
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0045 0.0101 0.0113
Loa Loa (eye worm) MH2 domain-containing protein 0.0633 0.3935 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0048 0.0122 0.0072
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.124 0.7895 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0048 0.0122 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0553 0.6038
Schistosoma mansoni hypothetical protein 0.0045 0.0101 0.0101
Echinococcus multilocularis smad 0.0043 0.0089 0.0099
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.0089 0.0099
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0169 0.0913 1
Schistosoma mansoni tar DNA-binding protein 0.0464 0.2832 0.2832
Brugia malayi hypothetical protein 0.0077 0.0313 0.0795
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0045 0.0101 0.0113
Loa Loa (eye worm) Smad1 0.0043 0.0089 0.0225
Brugia malayi glutathione reductase 0.0489 0.2997 0.7615
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0144 0.0745 0.2224
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0313 0.0351
Schistosoma mansoni glutamate synthase 0.0045 0.0101 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0059 0.0594
Schistosoma mansoni sulfide quinone reductase 0.0045 0.0101 0.0101
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0045 0.0101 0.1056
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0169 0.0913 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0124 0.0619 0.1573
Loa Loa (eye worm) hypothetical protein 0.0106 0.0497 0.1263
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0144 0.0745 0.2224
Loa Loa (eye worm) hypothetical protein 0.0045 0.0101 0.0256
Echinococcus multilocularis tar DNA binding protein 0.0464 0.2832 0.3176
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0048 0.0122 0.0122
Brugia malayi MH2 domain containing protein 0.0043 0.0089 0.0225
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0169 0.0913 1
Schistosoma mansoni glutamate synthase 0.0045 0.0101 0.0101
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0045 0.0101 0.0113
Brugia malayi MH2 domain containing protein 0.0633 0.3935 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0144 0.0745 0.2224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0367 0.3994
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0169 0.0913 0.2803
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0045 0.0101 0.0256
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0114 0.0554 0.1564
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0026 0.0065
Entamoeba histolytica hypothetical protein 0.0077 0.0313 0.3292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0122 0.1287
Plasmodium vivax glutathione reductase, putative 0.0489 0.2997 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0169 0.0913 0.2803
Leishmania major phosphatidylinositol 3-kinase, putative 0.0048 0.0122 0.0072
Toxoplasma gondii target of rapamycin (TOR), putative 0.0107 0.0504 0.167
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0497 0.1263
Echinococcus granulosus tar DNA binding protein 0.0464 0.2832 0.3176
Giardia lamblia NADH oxidase lateral transfer candidate 0.0169 0.0913 1
Schistosoma mansoni hypothetical protein 0.0033 0.0026 0.0026
Plasmodium vivax thioredoxin reductase, putative 0.0489 0.2997 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0026 0.0029
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.124 0.7895 1
Schistosoma mansoni hypothetical protein 0.0072 0.0279 0.0279
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0169 0.0913 0.2803
Brugia malayi glutamate synthase 0.0045 0.0101 0.0256
Brugia malayi MH1 domain containing protein 0.0043 0.0089 0.0225
Entamoeba histolytica hypothetical protein 0.0077 0.0313 0.3292
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0045 0.0101 0.032
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0464 0.2832 0.7196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0504 0.5504
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0497 0.1263
Entamoeba histolytica hypothetical protein 0.0077 0.0313 0.3292
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1115 0.7083 0.8958
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0045 0.0101 0.032
Loa Loa (eye worm) TAR-binding protein 0.0464 0.2832 0.7196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0313 0.3391
Trichomonas vaginalis glutathione reductase, putative 0.0169 0.0913 1
Onchocerca volvulus 0.0204 0.1141 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0169 0.0913 0.2803
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0048 0.0122 0.0072
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0101 0.1056
Onchocerca volvulus 0.0169 0.0907 0.7954
Schistosoma mansoni tar DNA-binding protein 0.0464 0.2832 0.2832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0504 0.5504
Schistosoma mansoni cellular tumor antigen P53 0.0204 0.1141 0.1141
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0144 0.0745 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0504 0.5504
Trypanosoma cruzi trypanothione reductase, putative 0.0489 0.2997 1
Plasmodium falciparum glutathione reductase 0.0169 0.0913 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0362 0.3933
Schistosoma mansoni sulfide quinone reductase 0.0045 0.0101 0.0101
Schistosoma mansoni hypothetical protein 0.0033 0.0026 0.0026
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.0089 0.0099
Schistosoma mansoni smad 0.0043 0.0089 0.0089
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0114 0.0554 0.1564
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0026 0.0029
Echinococcus multilocularis tumor protein p63 0.1396 0.8918 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0367 0.3994
Brugia malayi Smad1 0.0043 0.0089 0.0225
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0169 0.0913 0.1023
Brugia malayi TAR-binding protein 0.0464 0.2832 0.7196
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0169 0.0913 0.2803
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.006 0.0197 0.0331
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0045 0.0101 0.032
Echinococcus multilocularis Smad4 0.0043 0.0089 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0313 0.34
Brugia malayi MH2 domain containing protein 0.0043 0.0089 0.0225
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0101 0.1056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0504 0.5504
Echinococcus multilocularis glutamate synthase 0.0045 0.0101 0.0113
Echinococcus granulosus thioredoxin glutathione reductase 0.0492 0.3018 0.3384
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0048 0.0122 0.0072
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0101 0.1056
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0169 0.0913 0.2803
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.0089 0.0099
Loa Loa (eye worm) phosphatidylinositol 3 0.0144 0.0745 0.1892
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0045 0.0101 0.1056
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0045 0.0101 0.0113
Brugia malayi RNA recognition motif domain containing protein 0.0464 0.2832 0.7196
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0313 0.0313
Loa Loa (eye worm) thioredoxin reductase 0.0489 0.2997 0.7615
Echinococcus granulosus smad 0.0043 0.0089 0.0099
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0045 0.0101 0.032
Loa Loa (eye worm) hypothetical protein 0.0169 0.0907 0.2306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0313 0.34
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0169 0.0913 1
Giardia lamblia GTOR 0.0144 0.0745 0.7932
Echinococcus multilocularis thioredoxin glutathione reductase 0.0492 0.3018 0.3384
Schistosoma mansoni Smad4 0.0043 0.0089 0.0089
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0048 0.0122 0.0072
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0045 0.0101 0.1056
Loa Loa (eye worm) transcription factor SMAD2 0.0633 0.3935 1
Trichomonas vaginalis glutamate synthase, putative 0.0045 0.0101 0.1056
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0169 0.0913 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0436 0.4751
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0045 0.0101 0.0256
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0169 0.0913 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0169 0.0913 0.2803
Trypanosoma brucei trypanothione reductase 0.0489 0.2997 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0169 0.0913 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0745 0.8151
Schistosoma mansoni tar DNA-binding protein 0.0464 0.2832 0.2832
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0169 0.0913 0.2803
Echinococcus granulosus GPCR family 2 0.0033 0.0026 0.0029
Schistosoma mansoni smad1 5 8 and 0.0043 0.0089 0.0089
Schistosoma mansoni smad1 5 8 and 0.0043 0.0089 0.0089
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0026 0.0029
Treponema pallidum NADH oxidase 0.0169 0.0913 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1115 0.7083 0.8958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0553 0.6038
Trichomonas vaginalis apoptosis inducing factor, putative 0.0045 0.0101 0.1056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0553 0.6038
Toxoplasma gondii NADPH-glutathione reductase 0.0169 0.0913 0.3034
Loa Loa (eye worm) RNA binding protein 0.0464 0.2832 0.7196
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0122 0.0309
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0169 0.0913 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0367 0.3994
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0045 0.0101 0.032
Schistosoma mansoni smad1 5 8 and 0.0043 0.0089 0.0089
Mycobacterium tuberculosis Probable oxidoreductase 0.124 0.7895 1
Schistosoma mansoni hypothetical protein 0.0033 0.0026 0.0026
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0045 0.0101 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0313 0.34
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0026 0.0065
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0026 0.0029
Brugia malayi MH1 domain containing protein 0.0043 0.0089 0.0225
Loa Loa (eye worm) hypothetical protein 0.0072 0.0279 0.0708
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0362 0.3933
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0169 0.0913 0.2319
Schistosoma mansoni tar DNA-binding protein 0.0464 0.2832 0.2832
Brugia malayi RNA binding protein 0.0464 0.2832 0.7196
Trypanosoma cruzi target of rapamycin kinase 3 0.0114 0.0554 0.1564
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0045 0.0101 0.0113
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.0089 0.0089
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0169 0.0913 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0122 0.1287
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.0089 0.0099
Plasmodium falciparum thioredoxin reductase 0.0169 0.0913 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0122 0.1287
Schistosoma mansoni microtubule-associated protein tau 0.068 0.4246 0.4246
Brugia malayi Thioredoxin reductase 0.0489 0.2997 0.7615
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0489 0.2997 0.3716
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0045 0.0101 0.0113
Mycobacterium tuberculosis Probable dehydrogenase 0.1115 0.7083 0.8958
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0169 0.0913 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.0089 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0745 0.8151
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0169 0.0913 0.0913
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0169 0.0913 0.2803
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1115 0.7083 0.8958
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0045 0.0101 0.0113
Schistosoma mansoni hypothetical protein 0.0077 0.0313 0.0313
Loa Loa (eye worm) programmed cell death 8 0.0045 0.0101 0.0256
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0169 0.0913 0.2803
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0122 0.0309
Loa Loa (eye worm) glutathione reductase 0.0489 0.2997 0.7615
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0169 0.0913 0.2803
Plasmodium falciparum glutathione reductase 0.0489 0.2997 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0048 0.0122 0.0136
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0144 0.0745 0.2224
Brugia malayi hypothetical protein 0.0169 0.0907 0.2306
Echinococcus granulosus glutamate synthase 0.0045 0.0101 0.0113
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.0089 0.0225
Schistosoma mansoni tar DNA-binding protein 0.0464 0.2832 0.2832
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0045 0.0101 0.1056
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0497 0.1263
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0169 0.0913 0.1042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0169 0.0913 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0313 0.3391
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0012
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0169 0.0913 0.2803
Leishmania major trypanothione reductase 0.0489 0.2997 1
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0026 0.0065
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0144 0.0745 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0045 0.0101 0.0256
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0144 0.0745 0.0745
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0048 0.0122 0.0136
Trichomonas vaginalis mercuric reductase, putative 0.0169 0.0913 1
Loa Loa (eye worm) hypothetical protein 0.0204 0.1141 0.2899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0123 0.0608 0.6641
Echinococcus multilocularis GPCR, family 2 0.0033 0.0026 0.0029
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0313 0.0351
Toxoplasma gondii selenide, water dikinase 0.0045 0.0101 0.032
Echinococcus multilocularis microtubule associated protein 2 0.068 0.4246 0.4761

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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