Detailed information for compound 621078

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 448.539 | Formula: C18H16N4O4S3
  • H donors: 1 H acceptors: 4 LogP: 2.79 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCn1c(=NC(=O)c2nc3c(s2)cccc3)sc2c1ccc(c2)S(=O)(=O)N
  • InChi: 1S/C18H16N4O4S3/c1-26-9-8-22-13-7-6-11(29(19,24)25)10-15(13)28-18(22)21-16(23)17-20-12-4-2-3-5-14(12)27-17/h2-7,10H,8-9H2,1H3,(H2,19,24,25)/b21-18-
  • InChiKey: CMZLTFGNMBTBBL-UZYVYHOESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.025 0.0318
Echinococcus multilocularis mothers against decapentaplegic 5 0.0053 0.0106 0.0134
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0202 0.092 0.2843
Loa Loa (eye worm) phosphatidylinositol 3 0.0151 0.0642 0.1578
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0202 0.092 0.226
Brugia malayi MH2 domain containing protein 0.0779 0.407 1
Echinococcus granulosus lamin dm0 0.0058 0.0135 0.0172
Echinococcus granulosus tar DNA binding protein 0.0542 0.2777 0.3535
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0261 0.2537
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0431 0.4454
Trichomonas vaginalis glutathione reductase, putative 0.0202 0.092 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0093 0.0628
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0054 0.0109 0.0139
Echinococcus granulosus tumor protein p63 0.1473 0.7855 1
Echinococcus multilocularis microtubule associated protein 2 0.0743 0.3874 0.4931
Schistosoma mansoni hypothetical protein 0.0073 0.0214 0.0214
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1331 0.7083 0.8958
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0054 0.0109 0.0055
Brugia malayi RNA recognition motif domain containing protein 0.0542 0.2777 0.6824
Trypanosoma cruzi NADH dehydrogenase, putative 0.0054 0.0109 0.0055
Leishmania major trypanothione reductase 0.0584 0.3002 1
Leishmania major hypothetical protein, conserved 0.0054 0.0109 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0109 0.0055
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0135 0.0332
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0093 0.0228
Schistosoma mansoni smad1 5 8 and 0.0053 0.0106 0.0106
Loa Loa (eye worm) MH2 domain-containing protein 0.0053 0.0106 0.026
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0202 0.092 1
Echinococcus granulosus Smad4 0.0053 0.0106 0.0134
Schistosoma mansoni sulfide quinone reductase 0.0054 0.0109 0.0109
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0202 0.092 1
Brugia malayi hypothetical protein 0.008 0.025 0.0615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0151 0.0642 0.6855
Schistosoma mansoni glutamate synthase 0.0054 0.0109 0.0109
Trypanosoma cruzi trypanothione reductase, putative 0.0584 0.3002 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0054 0.0109 0.0139
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0054 0.0109 0.0267
Schistosoma mansoni tar DNA-binding protein 0.0542 0.2777 0.2777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0431 0.4454
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0149 0.0627 0.154
Onchocerca volvulus 0.0216 0.0993 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0054 0.0109 0.0808
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0473 0.4938
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0051 0.0093 0.0118
Echinococcus granulosus glutamate synthase 0.0054 0.0109 0.0139
Loa Loa (eye worm) hypothetical protein 0.0073 0.0214 0.0525
Loa Loa (eye worm) TAR-binding protein 0.0542 0.2777 0.6824
Loa Loa (eye worm) hypothetical protein 0.0054 0.0109 0.0267
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0054 0.0109 0.0139
Plasmodium falciparum glutathione reductase 0.0202 0.092 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.031 0.3084
Loa Loa (eye worm) hypothetical protein 0.0107 0.0398 0.0978
Echinococcus multilocularis smad 0.0053 0.0106 0.0134
Leishmania major hypothetical protein, conserved 0.0054 0.0109 0.0055
Trypanosoma cruzi target of rapamycin kinase 3 0.0121 0.0474 0.131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0262 0.2545
Schistosoma mansoni disulfide oxidoreductase 0.0054 0.0109 0.0109
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0151 0.0642 0.0642
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0054 0.0109 0.0808
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0202 0.092 1
Trypanosoma cruzi trypanothione reductase, putative 0.0202 0.092 0.2843
Brugia malayi RNA binding protein 0.0542 0.2777 0.6824
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0202 0.092 1
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0054 0.0109 0.0055
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1331 0.7083 0.8958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0352 0.3568
Plasmodium vivax thioredoxin reductase, putative 0.0584 0.3002 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0473 0.4938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0151 0.0642 0.6855
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0054 0.0109 0.0808
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0093 0.0628
Schistosoma mansoni transcription factor LCR-F1 0.008 0.025 0.025
Brugia malayi MH1 domain containing protein 0.0053 0.0106 0.026
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0054 0.0109 0.0808
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0054 0.0109 0.0808
Toxoplasma gondii thioredoxin reductase 0.0584 0.3002 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0202 0.092 0.2843
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0054 0.0109 0.0267
Schistosoma mansoni microtubule-associated protein tau 0.0743 0.3874 0.3874
Schistosoma mansoni tar DNA-binding protein 0.0542 0.2777 0.2777
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0202 0.092 0.2843
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0054 0.0109 0.0055
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0054 0.0109 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0262 0.2545
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0202 0.092 0.2843
Leishmania major NADH dehydrogenase, putative 0.0054 0.0109 0.0055
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0054 0.0109 0.0808
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0202 0.092 0.2803
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.148 0.7894 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0202 0.092 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0202 0.092 0.2803
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0135 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0431 0.4454
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0202 0.092 0.2843
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0202 0.092 0.1042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0521 0.5485
Echinococcus granulosus TGF beta signal transducer SmadC 0.0053 0.0106 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0305 0.3029
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0054 0.0109 0.0808
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0151 0.0642 0.1889
Toxoplasma gondii target of rapamycin (TOR), putative 0.0113 0.0431 0.1112
Trichomonas vaginalis glutamate synthase, putative 0.0054 0.0109 0.0808
Giardia lamblia GTOR 0.0151 0.0642 0.6578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0261 0.2537
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0054 0.0109 0.0055
Brugia malayi glutamate synthase 0.0054 0.0109 0.0267
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0054 0.0109 0.0055
Loa Loa (eye worm) hypothetical protein 0.0172 0.0755 0.1855
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1331 0.7083 0.8958
Entamoeba histolytica hypothetical protein 0.008 0.025 0.2648
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.025 0.0318
Mycobacterium tuberculosis Probable dehydrogenase 0.1331 0.7083 0.8958
Schistosoma mansoni tar DNA-binding protein 0.0542 0.2777 0.2777
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0093 0.0228
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0051 0.0093 0.0118
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0053 0.0106 0.0106
Schistosoma mansoni glutamate synthase 0.0054 0.0109 0.0109
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0151 0.0642 0.1889
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0202 0.092 0.2843
Echinococcus multilocularis tar DNA binding protein 0.0542 0.2777 0.3535
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0202 0.092 0.2843
Schistosoma mansoni glutamate synthase 0.0054 0.0109 0.0109
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0202 0.092 0.2843
Onchocerca volvulus 0.0058 0.0135 0.0297
Loa Loa (eye worm) hypothetical protein 0.0058 0.0135 0.0332
Schistosoma mansoni lamin 0.0058 0.0135 0.0135
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.148 0.7894 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0398 0.0978
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0151 0.0642 0.0818
Echinococcus multilocularis lamin 0.0058 0.0135 0.0172
Loa Loa (eye worm) hypothetical protein 0.0057 0.0129 0.0318
Echinococcus granulosus intermediate filament protein 0.0058 0.0135 0.0172
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0054 0.0109 0.0055
Loa Loa (eye worm) glutathione reductase 0.0584 0.3002 0.7376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0431 0.4454
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0473 0.4938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0431 0.4454
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0202 0.092 0.2843
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0093 0.0628
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0202 0.092 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0202 0.092 0.2843
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0202 0.092 0.2843
Loa Loa (eye worm) RNA binding protein 0.0542 0.2777 0.6824
Plasmodium falciparum thioredoxin reductase 0.0584 0.3002 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0431 0.4454
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0151 0.0642 0.1889
Trichomonas vaginalis glutamate synthase, putative 0.0054 0.0109 0.0808
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0054 0.0109 0.0267
Entamoeba histolytica hypothetical protein 0.008 0.025 0.2648
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0063 0.0159 0.0227
Schistosoma mansoni Smad4 0.0053 0.0106 0.0106
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0151 0.0642 0.1889
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0149 0.0627 0.154
Brugia malayi hypothetical protein 0.0172 0.0755 0.1855
Schistosoma mansoni hypothetical protein 0.0054 0.0109 0.0109
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0202 0.092 0.2843
Echinococcus multilocularis tumor protein p63 0.1473 0.7855 1
Leishmania major hypothetical protein, conserved 0.0054 0.0109 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.031 0.3084
Trichomonas vaginalis mercuric reductase, putative 0.0202 0.092 1
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0054 0.0109 0.0055
Loa Loa (eye worm) transcription factor SMAD2 0.0779 0.407 1
Trypanosoma brucei hypothetical protein, conserved 0.0054 0.0109 0.0055
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0072 0.0207 0.0391
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0109 0.0055
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0202 0.092 0.1171
Brugia malayi glutathione reductase 0.0584 0.3002 0.7376
Mycobacterium tuberculosis Probable reductase 0.1331 0.7083 0.8958
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0054 0.0109 0.0139
Plasmodium vivax glutathione reductase, putative 0.0584 0.3002 1
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0214 0.0525
Echinococcus granulosus microtubule associated protein 2 0.0743 0.3874 0.4931
Schistosoma mansoni smad1 5 8 and 0.0053 0.0106 0.0106
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0054 0.0109 0.0808
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0121 0.0474 0.131
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0053 0.0106 0.0134
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.148 0.7894 1
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0054 0.0109 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0305 0.3029
Schistosoma mansoni smad1 5 8 and 0.0053 0.0106 0.0106
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0151 0.0642 0.1578
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0054 0.0109 0.0055
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0398 0.0978
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0054 0.0109 0.0808
Trichomonas vaginalis apoptosis inducing factor, putative 0.0054 0.0109 0.0808
Trypanosoma cruzi NADH dehydrogenase, putative 0.0054 0.0109 0.0055
Echinococcus multilocularis thioredoxin glutathione reductase 0.0588 0.3025 0.3851
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0473 0.4938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0151 0.0642 0.6855
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0584 0.3002 0.3716
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0398 0.0978
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0202 0.092 0.092
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0202 0.092 0.2843
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.037 0.3771
Echinococcus multilocularis lamin dm0 0.0058 0.0135 0.0172
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0151 0.0642 0.1889
Loa Loa (eye worm) Smad1 0.0053 0.0106 0.026
Plasmodium falciparum glutathione reductase 0.0584 0.3002 1
Onchocerca volvulus 0.0058 0.0135 0.0297
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0121 0.0474 0.131
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0054 0.0109 0.0267
Loa Loa (eye worm) thioredoxin reductase 0.0584 0.3002 0.7376
Trypanosoma brucei NADH dehydrogenase 0.0054 0.0109 0.0055
Brugia malayi Smad1 0.0053 0.0106 0.026
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0054 0.0109 0.0139
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0051 0.0093 0.0093
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0054 0.0109 0.0055
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0202 0.092 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1331 0.7083 0.8958
Toxoplasma gondii NADPH-glutathione reductase 0.0202 0.092 0.2803
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0054 0.0109 0.0139
Entamoeba histolytica hypothetical protein 0.008 0.025 0.2648
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0202 0.092 0.2803
Echinococcus granulosus smad 0.0053 0.0106 0.0134
Schistosoma mansoni smad 0.0053 0.0106 0.0106
Schistosoma mansoni tar DNA-binding protein 0.0542 0.2777 0.2777
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0473 0.4938
Loa Loa (eye worm) programmed cell death 8 0.0054 0.0109 0.0267
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0054 0.0109 0.0139
Treponema pallidum NADH oxidase 0.0202 0.092 1
Brugia malayi Thioredoxin reductase 0.0584 0.3002 0.7376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0093 0.0628
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0135 0.0332
Onchocerca volvulus 0.0172 0.0755 0.7314
Echinococcus granulosus lamin 0.0058 0.0135 0.0172
Echinococcus multilocularis glutamate synthase 0.0054 0.0109 0.0139
Loa Loa (eye worm) MH2 domain-containing protein 0.0779 0.407 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0054 0.0109 0.0139
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0151 0.0642 0.1889
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.031 0.3084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0261 0.2537
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0054 0.0109 0.0139
Schistosoma mansoni cellular tumor antigen P53 0.0216 0.0993 0.0993
Schistosoma mansoni hypothetical protein 0.008 0.025 0.025
Brugia malayi intermediate filament protein 0.0058 0.0135 0.0332
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0054 0.0109 0.0055
Echinococcus granulosus thioredoxin glutathione reductase 0.0588 0.3025 0.3851
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1331 0.7083 0.8958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0093 0.0628
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0202 0.092 0.1171
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0054 0.0109 0.0139
Brugia malayi MH2 domain containing protein 0.0053 0.0106 0.026
Entamoeba histolytica hypothetical protein 0.008 0.025 0.2648
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0202 0.092 0.2843
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0151 0.0642 0.0818
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0151 0.0642 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0542 0.2777 0.6824
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0054 0.0109 0.0139
Echinococcus granulosus mothers against decapentaplegic 5 0.0053 0.0106 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0262 0.2545
Brugia malayi TAR-binding protein 0.0542 0.2777 0.6824
Plasmodium falciparum thioredoxin reductase 0.0202 0.092 0.2803
Schistosoma mansoni lamin 0.0058 0.0135 0.0135
Echinococcus multilocularis musashi 0.0058 0.0135 0.0172
Loa Loa (eye worm) MH1 domain-containing protein 0.0053 0.0106 0.026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0262 0.2545
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0202 0.092 0.2803
Schistosoma mansoni intermediate filament proteins 0.0058 0.0135 0.0135
Brugia malayi MH2 domain containing protein 0.0053 0.0106 0.026
Loa Loa (eye worm) hypothetical protein 0.0216 0.0993 0.2439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0431 0.4454
Trypanosoma brucei trypanothione reductase 0.0584 0.3002 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0054 0.0109 0.0808
Mycobacterium tuberculosis Probable oxidoreductase 0.148 0.7894 1
Schistosoma mansoni sulfide quinone reductase 0.0054 0.0109 0.0109
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0202 0.092 0.2843
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0151 0.0642 1
Echinococcus multilocularis Smad4 0.0053 0.0106 0.0134
Schistosoma mansoni tar DNA-binding protein 0.0542 0.2777 0.2777
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0202 0.092 0.2843
Brugia malayi MH1 domain containing protein 0.0053 0.0106 0.026
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0202 0.092 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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