Detailed information for compound 621080

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 474.51 | Formula: C20H18N4O6S2
  • H donors: 1 H acceptors: 5 LogP: 1.04 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCn1c(=NC(=O)CN2C(=O)c3c(C2=O)cccc3)sc2c1ccc(c2)S(=O)(=O)N
  • InChi: 1S/C20H18N4O6S2/c1-30-9-8-23-15-7-6-12(32(21,28)29)10-16(15)31-20(23)22-17(25)11-24-18(26)13-4-2-3-5-14(13)19(24)27/h2-7,10H,8-9,11H2,1H3,(H2,21,28,29)/b22-20-
  • InChiKey: HBDZWMUWGWMELX-XDOYNYLZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0055 0.0153 0.0361
Loa Loa (eye worm) Smad1 0.0049 0.0125 0.0335
Entamoeba histolytica hypothetical protein 0.0072 0.0247 0.2568
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0123 0.0322
Echinococcus multilocularis glutamate synthase 0.0055 0.0153 0.0203
Loa Loa (eye worm) hypothetical protein 0.0027 0.0003 0.0008
Echinococcus granulosus glutamate synthase 0.0055 0.0153 0.0203
Toxoplasma gondii thioredoxin reductase 0.0593 0.3033 1
Echinococcus granulosus tar DNA binding protein 0.0455 0.2292 0.3104
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0206 0.096 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0045 0.0436
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.004 0.01
Schistosoma mansoni fkbp-rapamycin associated protein 0.0034 0.0045 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0145 0.0634 0.6596
Leishmania major trypanothione reductase 0.0593 0.3033 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0182 0.0833 0.2226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.0584 0.6072
Trypanosoma cruzi NADH dehydrogenase, putative 0.0055 0.0153 0.0361
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1354 0.7098 0.8958
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1505 0.7905 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0206 0.096 0.2803
Schistosoma mansoni glutamate synthase 0.0055 0.0153 0.015
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0206 0.096 0.1042
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0153 0.0361
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0055 0.0153 0.0401
Loa Loa (eye worm) transcription factor SMAD2 0.0726 0.3743 1
Echinococcus multilocularis serine protein kinase ATM 0.0034 0.0045 0.0057
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0206 0.096 0.3063
Treponema pallidum NADH oxidase 0.0206 0.096 1
Brugia malayi RNA binding protein 0.0455 0.2292 0.612
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0055 0.0153 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0436 0.4526
Trichomonas vaginalis glutamate synthase, putative 0.0055 0.0153 0.1563
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0182 0.0833 1
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0055 0.0153 0.1368
Loa Loa (eye worm) MH1 domain-containing protein 0.0049 0.0125 0.0335
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0206 0.096 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0145 0.0634 0.6596
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0182 0.0833 0.2639
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0055 0.0153 0.0361
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.0442 0.4586
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0055 0.0153 0.0203
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0182 0.0833 0.2639
Loa Loa (eye worm) hypothetical protein 0.0219 0.103 0.2751
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0061 0.0187 0.0476
Loa Loa (eye worm) hypothetical protein 0.0206 0.0961 0.2568
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0145 0.0635 0.1976
Loa Loa (eye worm) hypothetical protein 0.0038 0.0066 0.0176
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0206 0.096 0.2803
Echinococcus granulosus smad 0.0049 0.0125 0.0166
Schistosoma mansoni smad 0.0049 0.0125 0.0123
Echinococcus multilocularis tar DNA binding protein 0.0455 0.2292 0.3104
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1354 0.7098 0.8958
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0206 0.096 0.3063
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0182 0.0833 0.2639
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0206 0.096 0.2803
Loa Loa (eye worm) TAR-binding protein 0.0455 0.2292 0.6123
Schistosoma mansoni sulfide quinone reductase 0.0055 0.0153 0.015
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0055 0.0153 0.0203
Schistosoma mansoni disulfide oxidoreductase 0.0055 0.0153 0.015
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0055 0.0153 0.0361
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0003 0.0007
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.0045 0.0113
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0055 0.0153 0.0203
Loa Loa (eye worm) hypothetical protein 0.004 0.0074 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0386 0.4001
Mycobacterium tuberculosis Probable dehydrogenase 0.1354 0.7098 0.8958
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0206 0.096 0.3063
Entamoeba histolytica hypothetical protein 0.0072 0.0247 0.2568
Brugia malayi Bromodomain containing protein 0.0073 0.0254 0.0671
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0055 0.0153 0.1563
Brugia malayi MH1 domain containing protein 0.0027 0.0007 0.0012
Brugia malayi MH1 domain containing protein 0.0049 0.0125 0.0328
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0206 0.096 0.3063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.0584 0.6072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0386 0.4001
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1354 0.7098 0.8958
Brugia malayi RNA recognition motif domain containing protein 0.0455 0.2292 0.612
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0055 0.0153 0.1563
Entamoeba histolytica hypothetical protein 0.0072 0.0247 0.2568
Echinococcus granulosus tumor protein p63 0.1406 0.7378 1
Brugia malayi MH2 domain containing protein 0.0726 0.3743 1
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0153 0.0361
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.0045 0.0113
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0055 0.0153 0.0203
Trichomonas vaginalis mercuric reductase, putative 0.0206 0.096 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.0833 0.8675
Loa Loa (eye worm) hypothetical protein 0.0034 0.0045 0.012
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0055 0.0153 0.0401
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0247 0.0245
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0206 0.096 0.256
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0455 0.2292 0.6123
Brugia malayi Smad1 0.0049 0.0125 0.0328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0187 0.1922
Echinococcus granulosus mothers against decapentaplegic 5 0.0049 0.0125 0.0166
Echinococcus granulosus microtubule associated protein 2 0.0755 0.3896 0.5278
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0086 0.0321 0.0924
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0045 0.0436
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0055 0.0153 0.1368
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0206 0.096 0.3063
Giardia lamblia NADH oxidase lateral transfer candidate 0.0206 0.096 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0055 0.0153 0.0203
Trypanosoma cruzi trypanothione reductase, putative 0.0593 0.3033 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0153 0.0408
Trichomonas vaginalis glutamate synthase, putative 0.0055 0.0153 0.1563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.0833 0.8675
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0055 0.0153 0.1368
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0055 0.0153 0.1563
Trypanosoma brucei trypanothione reductase 0.0593 0.3033 1
Echinococcus multilocularis smad 0.0049 0.0125 0.0166
Leishmania major phosphatidylinositol 3-kinase, putative 0.0061 0.0187 0.0119
Echinococcus granulosus TGF beta signal transducer SmadC 0.0049 0.0125 0.0166
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0049 0.0125 0.0123
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0123 0.0322
Loa Loa (eye worm) nuclear factor I 0.0027 0.0007 0.0019
Schistosoma mansoni glutamate synthase 0.0055 0.0153 0.015
Brugia malayi TAR-binding protein 0.0455 0.2292 0.612
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0174 0.0232
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0247 0.0332
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0145 0.0635 0.1675
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0019
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0055 0.0153 0.0361
Schistosoma mansoni tar DNA-binding protein 0.0455 0.2292 0.229
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0055 0.0153 0.0203
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0428 0.2148 0.5735
Loa Loa (eye worm) hypothetical protein 0.015 0.0662 0.1768
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0182 0.0833 0.2363
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.0107
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0206 0.096 0.2803
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0206 0.096 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0003 0.0007
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0055 0.0153 0.1563
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0182 0.0833 0.2363
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0049 0.0063
Toxoplasma gondii target of rapamycin (TOR), putative 0.0135 0.0584 0.1805
Entamoeba histolytica thioredoxin reductase, putative 0.0055 0.0153 0.1368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0513 0.533
Trypanosoma brucei hypothetical protein, conserved 0.0055 0.0153 0.0361
Trichomonas vaginalis glutathione reductase, putative 0.0206 0.096 1
Trypanosoma brucei NADH dehydrogenase 0.0055 0.0153 0.0361
Brugia malayi glutamate synthase 0.0055 0.0153 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0386 0.4001
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0151 0.0668 0.178
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0055 0.0153 0.0203
Trypanosoma brucei C-8 sterol isomerase, putative 0.0428 0.2148 0.7038
Schistosoma mansoni tar DNA-binding protein 0.0455 0.2292 0.229
Onchocerca volvulus 0.015 0.0662 0.6877
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0123 0.0328
Schistosoma mansoni sulfide quinone reductase 0.0055 0.0153 0.015
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0061 0.0187 0.0476
Schistosoma mansoni Smad4 0.0049 0.0125 0.0123
Brugia malayi glutathione reductase 0.0593 0.3033 0.8102
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0206 0.096 0.0958
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0055 0.0153 0.0203
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0055 0.0153 0.1563
Mycobacterium tuberculosis Probable reductase 0.1354 0.7098 0.8958
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0206 0.096 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0206 0.096 0.3063
Toxoplasma gondii selenide, water dikinase 0.0055 0.0153 0.0361
Entamoeba histolytica hypothetical protein 0.0072 0.0247 0.2568
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0055 0.0153 0.1563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0386 0.4001
Loa Loa (eye worm) hypothetical protein 0.0428 0.2148 0.5738
Brugia malayi Bromodomain containing protein 0.0038 0.0061 0.0157
Loa Loa (eye worm) hypothetical protein 0.0069 0.0231 0.0618
Brugia malayi MH2 domain containing protein 0.0049 0.0125 0.0328
Toxoplasma gondii NADPH-glutathione reductase 0.0206 0.096 0.3063
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1354 0.7098 0.8958
Echinococcus granulosus thioredoxin glutathione reductase 0.0597 0.3055 0.4139
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0055 0.0153 0.0203
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0061 0.0187 0.025
Schistosoma mansoni smad1 5 8 and 0.0049 0.0125 0.0123
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0206 0.096 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0385 0.3993
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0055 0.0153 0.1563
Echinococcus multilocularis microtubule associated protein 2 0.0755 0.3896 0.5278
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0182 0.0833 0.1126
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0174 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0118 0.0492 0.5111
Schistosoma mansoni bromodomain containing protein 0.0062 0.0192 0.019
Loa Loa (eye worm) hypothetical protein 0.0042 0.0084 0.0225
Echinococcus multilocularis Smad4 0.0049 0.0125 0.0166
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0206 0.096 0.3063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0187 0.1922
Loa Loa (eye worm) phosphatidylinositol 3 0.0061 0.0187 0.05
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0385 0.3993
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0206 0.096 0.1298
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0076 0.0265 0.0736
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0182 0.0833 0.0831
Trypanosoma cruzi trypanothione reductase, putative 0.0206 0.096 0.3063
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0055 0.0153 0.1368
Schistosoma mansoni hypothetical protein 0.0055 0.0153 0.015
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0055 0.0153 0.0361
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0436 0.4526
Schistosoma mansoni tar DNA-binding protein 0.0455 0.2292 0.229
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0034 0.0045 0.0042
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0206 0.096 0.3063
Schistosoma mansoni glutamate synthase 0.0055 0.0153 0.015
Loa Loa (eye worm) RNA binding protein 0.0455 0.2292 0.6123
Mycobacterium tuberculosis Probable oxidoreductase 0.1505 0.7905 1
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0055 0.0153 0.0203
Loa Loa (eye worm) hypothetical protein 0.0027 0.0003 0.0007
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0206 0.096 0.2803
Entamoeba histolytica disulphide oxidoreductase, putative 0.0055 0.0153 0.1368
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0206 0.096 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0049 0.0125 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0122 0.1241
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0206 0.096 0.3063
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0206 0.096 0.1298
Schistosoma mansoni tar DNA-binding protein 0.0455 0.2292 0.229
Schistosoma mansoni smad1 5 8 and 0.0049 0.0125 0.0123
Plasmodium vivax thioredoxin reductase, putative 0.0593 0.3033 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0145 0.0634 0.6596
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0038 0.0066 0.007
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0428 0.2148 0.7038
Trypanosoma cruzi target of rapamycin kinase 3 0.0145 0.0635 0.1976
Loa Loa (eye worm) hypothetical protein 0.0049 0.0123 0.0328
Onchocerca volvulus 0.0206 0.0961 1
Brugia malayi MH1 domain containing protein 0.0049 0.0125 0.0328
Plasmodium falciparum thioredoxin reductase 0.0206 0.096 0.2803
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0206 0.096 0.2803
Plasmodium vivax glutathione reductase, putative 0.0593 0.3033 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0045 0.0436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0145 0.0634 0.6596
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.0584 0.6072
Plasmodium falciparum thioredoxin reductase 0.0593 0.3033 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0145 0.0634 0.6596
Schistosoma mansoni tar DNA-binding protein 0.0455 0.2292 0.229
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0055 0.0153 0.1563
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0055 0.0153 0.0361
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.0833 0.8675
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0206 0.096 0.2803
Schistosoma mansoni smad1 5 8 and 0.0049 0.0125 0.0123
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0206 0.096 0.3063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0187 0.1922
Schistosoma mansoni cellular tumor antigen P53 0.0206 0.0961 0.0959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0187 0.1922
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1505 0.7905 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0187 0.1922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.0584 0.6072
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0055 0.0153 0.1563
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0061 0.0187 0.0184
Loa Loa (eye worm) hypothetical protein 0.0037 0.0059 0.0158
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0061 0.0187 0.0493
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0061 0.0187 0.0476
Schistosoma mansoni microtubule-associated protein tau 0.0755 0.3896 0.3894
Brugia malayi FAT domain containing protein 0.0027 0.0003 0.0001
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0027 0.0003 0.0001
Trypanosoma cruzi NADH dehydrogenase, putative 0.0055 0.0153 0.0361
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0055 0.0153 0.0361
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.0442 0.4586
Echinococcus multilocularis tumor protein p63 0.1406 0.7378 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0206 0.096 0.3063
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0055 0.0153 0.0361
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0055 0.0153 0.0361
Leishmania major C-8 sterol isomerase-like protein 0.0428 0.2148 0.6927
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0247 0.0332
Brugia malayi Thioredoxin reductase 0.0593 0.3033 0.8102
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0055 0.0153 0.0361
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0206 0.096 0.3063
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0055 0.0153 0.0361
Brugia malayi hypothetical protein 0.0072 0.0247 0.0654
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1354 0.7098 0.8958
Loa Loa (eye worm) thioredoxin reductase 0.0593 0.3033 0.8103
Brugia malayi MH2 domain containing protein 0.0049 0.0125 0.0328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0385 0.3993
Schistosoma mansoni hypothetical protein 0.0072 0.0247 0.0245
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0206 0.096 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0182 0.0833 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0182 0.0833 0.1126
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0066 0.0656
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0055 0.0153 0.0361
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0055 0.0153 0.0203
Loa Loa (eye worm) hypothetical protein 0.0038 0.0062 0.0165
Giardia lamblia GTOR 0.0182 0.0833 0.843
Brugia malayi hypothetical protein 0.015 0.0662 0.1762
Plasmodium falciparum glutathione reductase 0.0593 0.3033 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.0584 0.6072
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0034 0.0045 0.0057
Echinococcus multilocularis thioredoxin glutathione reductase 0.0597 0.3055 0.4139
Loa Loa (eye worm) programmed cell death 8 0.0055 0.0153 0.0408
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0151 0.0668 0.178
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1505 0.7905 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0055 0.0153 0.0408
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0055 0.0153 0.1368
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0055 0.0153 0.0203
Loa Loa (eye worm) MH2 domain-containing protein 0.0726 0.3743 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0055 0.0153 0.0361
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0055 0.0153 0.1563
Brugia malayi MH1 domain containing protein 0.0027 0.0007 0.0012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0182 0.0833 0.2221
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0049 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.0584 0.6072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0109 0.0442 0.4586
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0055 0.0153 0.0361
Echinococcus granulosus serine protein kinase ATM 0.0034 0.0045 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0691 0.719
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0061 0.0187 0.0476
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0593 0.3033 0.3716
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0027 0.0003 0.0001
Echinococcus granulosus Smad4 0.0049 0.0125 0.0166
Onchocerca volvulus 0.0055 0.0153 0.1566
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0061 0.0187 0.025
Loa Loa (eye worm) glutathione reductase 0.0593 0.3033 0.8103
Trichomonas vaginalis apoptosis inducing factor, putative 0.0055 0.0153 0.1563
Loa Loa (eye worm) MH2 domain-containing protein 0.0049 0.0125 0.0335
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.0584 0.6072
Plasmodium falciparum glutathione reductase 0.0206 0.096 0.2803
Schistosoma mansoni hypothetical protein 0.0034 0.004 0.0037
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0206 0.096 0.3063
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0182 0.0833 0.2639
Echinococcus multilocularis mothers against decapentaplegic 5 0.0049 0.0125 0.0166
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0034 0.0045 0.0057
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0061 0.0187 0.0119

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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