Detailed information for compound 621114

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 418.53 | Formula: C20H22N2O4S2
  • H donors: 0 H acceptors: 3 LogP: 2.9 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCn1c(=NC(=O)CCc2ccccc2)sc2c1ccc(c2)S(=O)(=O)C
  • InChi: 1S/C20H22N2O4S2/c1-26-13-12-22-17-10-9-16(28(2,24)25)14-18(17)27-20(22)21-19(23)11-8-15-6-4-3-5-7-15/h3-7,9-10,14H,8,11-13H2,1-2H3/b21-20-
  • InChiKey: MSOUAEYSGKUMPH-MRCUWXFGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0021 0.0052
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0161 0.0914 0.1042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0286 0.2942
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0205 0.046
Echinococcus multilocularis thioredoxin glutathione reductase 0.0468 0.3022 0.4483
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.106 0.708 0.8958
Schistosoma mansoni sulfide quinone reductase 0.0043 0.0102 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0188 0.1846
Schistosoma mansoni tar DNA-binding protein 0.0386 0.2455 0.2437
Echinococcus granulosus tumor protein p63 0.101 0.6741 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0102 0.0263
Trichomonas vaginalis glutamate synthase, putative 0.0043 0.0102 0.088
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0093 0.045 0.1076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0161 0.0914 0.2993
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0192 0.1888
Schistosoma mansoni smad1 5 8 and 0.0042 0.0095 0.0071
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0161 0.0914 0.2993
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0386 0.2455 0.6124
Brugia malayi MH2 domain containing protein 0.0612 0.4009 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0155 0.1474
Schistosoma mansoni lamin 0.0058 0.0205 0.0181
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0095 0.0238
Loa Loa (eye worm) hypothetical protein 0.0156 0.0882 0.2201
Schistosoma mansoni disulfide oxidoreductase 0.0043 0.0102 0.0078
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0161 0.0914 0.1356
Schistosoma mansoni glutamate synthase 0.0043 0.0102 0.0078
Plasmodium vivax glutathione reductase, putative 0.0465 0.2997 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.045 0.4788
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0095 0.0141
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0043 0.0102 0.0204
Brugia malayi glutamate synthase 0.0043 0.0102 0.0204
Echinococcus multilocularis tar DNA binding protein 0.0386 0.2455 0.3642
Echinococcus granulosus Smad4 0.0042 0.0095 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0155 0.1468
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0024 0.0008
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0043 0.0102 0.088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0192 0.1888
Loa Loa (eye worm) RNA binding protein 0.0386 0.2455 0.6124
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0102 0.088
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0306 0.0454
Trichomonas vaginalis apoptosis inducing factor, putative 0.0043 0.0102 0.088
Brugia malayi RNA binding protein 0.0386 0.2455 0.6103
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0161 0.0914 0.2993
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0102 0.088
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0074 0.0319 0.0994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0319 0.3314
Trichomonas vaginalis glutathione reductase, putative 0.0161 0.0914 1
Onchocerca volvulus 0.0148 0.0824 0.9249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.045 0.4788
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0102 0.088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0063 0.0239 0.2416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0286 0.2942
Echinococcus multilocularis Smad4 0.0042 0.0095 0.0141
Leishmania major hypothetical protein, conserved 0.0043 0.0102 0.0263
Toxoplasma gondii NADPH-glutathione reductase 0.0161 0.0914 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0102 0.088
Leishmania major hypothetical protein, conserved 0.0043 0.0102 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0319 0.3314
Echinococcus granulosus lamin dm0 0.0058 0.0205 0.0304
Schistosoma mansoni intermediate filament proteins 0.0058 0.0205 0.0181
Brugia malayi Smad1 0.0042 0.0095 0.0186
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0043 0.0102 0.088
Trypanosoma cruzi NADH dehydrogenase, putative 0.0043 0.0102 0.0263
Schistosoma mansoni glutamate synthase 0.0043 0.0102 0.0078
Brugia malayi Thioredoxin reductase 0.0465 0.2997 0.7462
Schistosoma mansoni tar DNA-binding protein 0.0386 0.2455 0.2437
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0161 0.0914 0.2993
Brugia malayi glutathione reductase 0.0465 0.2997 0.7462
Entamoeba histolytica hypothetical protein 0.0072 0.0306 0.5852
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0093 0.045 0.1433
Echinococcus multilocularis tumor protein p63 0.101 0.6741 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0102 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0286 0.2942
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0161 0.0914 0.2803
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1178 0.7892 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0043 0.0102 0.0152
Loa Loa (eye worm) hypothetical protein 0.0148 0.0824 0.2055
Trypanosoma brucei NADH dehydrogenase 0.0043 0.0102 0.0263
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0095 0.0141
Echinococcus granulosus thioredoxin glutathione reductase 0.0468 0.3022 0.4483
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0161 0.0914 0.2993
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0161 0.0914 0.2239
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0161 0.0914 0.2993
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0043 0.0102 0.0263
Echinococcus multilocularis lamin dm0 0.0058 0.0205 0.0304
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0102 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0319 0.3314
Loa Loa (eye worm) Smad1 0.0042 0.0095 0.0238
Onchocerca volvulus 0.0156 0.0882 1
Entamoeba histolytica hypothetical protein 0.0072 0.0306 0.5852
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0043 0.0102 0.0263
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0093 0.045 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0205 0.051
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0093 0.045 0.1433
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0043 0.0102 0.0152
Treponema pallidum NADH oxidase 0.0161 0.0914 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0161 0.0914 0.2803
Trichomonas vaginalis glutamate synthase, putative 0.0043 0.0102 0.088
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0306 0.0454
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0161 0.0914 1
Mycobacterium tuberculosis Probable dehydrogenase 0.106 0.708 0.8958
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0161 0.0914 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0093 0.045 0.0668
Trypanosoma cruzi trypanothione reductase, putative 0.0161 0.0914 0.2993
Schistosoma mansoni tar DNA-binding protein 0.0386 0.2455 0.2437
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0161 0.0914 0.2993
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0043 0.0102 0.0152
Schistosoma mansoni Smad4 0.0042 0.0095 0.0071
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0043 0.0102 0.088
Echinococcus multilocularis glutamate synthase 0.0043 0.0102 0.0152
Onchocerca volvulus 0.0058 0.0205 0.131
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0102 0.0263
Giardia lamblia GTOR 0.0093 0.045 0.4285
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.106 0.708 0.8958
Echinococcus granulosus lamin 0.0058 0.0205 0.0304
Loa Loa (eye worm) hypothetical protein 0.0057 0.0197 0.0492
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0043 0.0102 0.0263
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0306 0.0282
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0161 0.0914 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0161 0.0914 0.2993
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0161 0.0914 0.2993
Plasmodium falciparum glutathione reductase 0.0465 0.2997 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0286 0.2942
Entamoeba histolytica hypothetical protein 0.0072 0.0306 0.5852
Echinococcus granulosus tar DNA binding protein 0.0386 0.2455 0.3642
Brugia malayi RNA recognition motif domain containing protein 0.0386 0.2455 0.6103
Schistosoma mansoni hypothetical protein 0.0072 0.0306 0.0282
Echinococcus granulosus glutamate synthase 0.0043 0.0102 0.0152
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0093 0.045 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0095 0.0141
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0161 0.0914 0.2993
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0093 0.045 0.0427
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0161 0.0914 0.2803
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0043 0.0102 0.088
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0155 0.1468
Loa Loa (eye worm) programmed cell death 8 0.0043 0.0102 0.0255
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1178 0.7892 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0286 0.2942
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0043 0.0102 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0155 0.1474
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0043 0.0102 0.0152
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0043 0.0102 0.0263
Loa Loa (eye worm) transcription factor SMAD2 0.0612 0.4009 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0102 0.0263
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0161 0.0914 0.2993
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0043 0.0102 0.0152
Mycobacterium tuberculosis Probable reductase 0.106 0.708 0.8958
Echinococcus multilocularis musashi 0.0058 0.0205 0.0304
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0043 0.0102 0.0204
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0161 0.0914 1
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0043 0.0102 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0188 0.1846
Loa Loa (eye worm) thioredoxin reductase 0.0465 0.2997 0.7476
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0043 0.0102 0.0152
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0166 0.0364
Schistosoma mansoni hypothetical protein 0.0043 0.0102 0.0078
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0161 0.0914 0.2993
Plasmodium falciparum thioredoxin reductase 0.0465 0.2997 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.106 0.708 0.8958
Schistosoma mansoni lamin 0.0058 0.0205 0.0181
Loa Loa (eye worm) hypothetical protein 0.0052 0.0166 0.0414
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0024 0.006
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0093 0.045 0.1433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0319 0.3314
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0118 0.0621 0.1504
Schistosoma mansoni smad1 5 8 and 0.0042 0.0095 0.0071
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0102 0.0263
Entamoeba histolytica hypothetical protein 0.0072 0.0306 0.5852
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0093 0.045 0.1433
Trypanosoma brucei trypanothione reductase 0.0465 0.2997 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0069 0.0286 0.0634
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0043 0.0102 0.0204
Plasmodium vivax thioredoxin reductase, putative 0.0465 0.2997 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0095 0.0141
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1178 0.7892 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0319 0.3314
Schistosoma mansoni smad 0.0042 0.0095 0.0071
Trypanosoma cruzi NADH dehydrogenase, putative 0.0043 0.0102 0.0263
Loa Loa (eye worm) glutathione reductase 0.0465 0.2997 0.7476
Brugia malayi MH2 domain containing protein 0.0042 0.0095 0.0186
Loa Loa (eye worm) phosphatidylinositol 3 0.0093 0.045 0.1123
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0043 0.0102 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0286 0.2942
Brugia malayi intermediate filament protein 0.0058 0.0205 0.046
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0095 0.0071
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0074 0.0319 0.0994
Schistosoma mansoni tar DNA-binding protein 0.0386 0.2455 0.2437
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0043 0.0102 0.0255
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0102 0.088
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0031 0.0024 0.0036
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0043 0.0102 0.0152
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0039 0.0075 0.0172
Leishmania major trypanothione reductase 0.0465 0.2997 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0102 0.0255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0286 0.2942
Giardia lamblia NADH oxidase lateral transfer candidate 0.0161 0.0914 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0161 0.0914 0.2993
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0356 0.3734
Brugia malayi MH2 domain containing protein 0.0042 0.0095 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0155 0.1474
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0102 0.088
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0161 0.0914 0.0892
Schistosoma mansoni hypothetical protein 0.0036 0.0053 0.0029
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0161 0.0914 0.1356
Trypanosoma cruzi target of rapamycin kinase 3 0.0074 0.0319 0.0994
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0043 0.0102 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0155 0.1474
Toxoplasma gondii thioredoxin reductase 0.0465 0.2997 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0161 0.0914 0.2803
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0102 0.0263
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0043 0.0102 0.0152
Plasmodium falciparum glutathione reductase 0.0161 0.0914 0.2803
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.106 0.708 0.8958
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0161 0.0914 0.2993
Schistosoma mansoni smad1 5 8 and 0.0042 0.0095 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0192 0.1888
Leishmania major NADH dehydrogenase, putative 0.0043 0.0102 0.0263
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0161 0.0914 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0205 0.051
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0166 0.0364
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0161 0.0914 1
Trypanosoma cruzi trypanothione reductase, putative 0.0465 0.2997 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.106 0.708 0.8958
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0155 0.1468
Leishmania major hypothetical protein, conserved 0.0043 0.0102 0.0263
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0118 0.0621 0.1504
Echinococcus granulosus intermediate filament protein 0.0058 0.0205 0.0304
Brugia malayi MH1 domain containing protein 0.0042 0.0095 0.0186
Loa Loa (eye worm) MH2 domain-containing protein 0.0612 0.4009 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.045 0.4788
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0043 0.0102 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0225 0.226
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0166 0.0414
Echinococcus granulosus smad 0.0042 0.0095 0.0141
Trichomonas vaginalis mercuric reductase, putative 0.0161 0.0914 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0044 0.0112 0.0297
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0043 0.0102 0.0152
Echinococcus multilocularis lamin 0.0058 0.0205 0.0304
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0161 0.0914 0.2993
Onchocerca volvulus 0.0058 0.0205 0.131
Brugia malayi hypothetical protein 0.0156 0.0882 0.216
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0093 0.045 0.0668
Schistosoma mansoni glutamate synthase 0.0043 0.0102 0.0078
Brugia malayi MH1 domain containing protein 0.0042 0.0095 0.0186
Schistosoma mansoni tar DNA-binding protein 0.0386 0.2455 0.2437
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0095 0.0238
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0205 0.051
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0093 0.045 0.1433
Brugia malayi TAR-binding protein 0.0386 0.2455 0.6103
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0043 0.0102 0.0152
Schistosoma mansoni sulfide quinone reductase 0.0043 0.0102 0.0078
Mycobacterium tuberculosis Probable oxidoreductase 0.1178 0.7892 1
Echinococcus multilocularis smad 0.0042 0.0095 0.0141
Schistosoma mansoni cellular tumor antigen P53 0.0148 0.0824 0.0802
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0053 0.0081
Plasmodium falciparum thioredoxin reductase 0.0161 0.0914 0.2803
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0093 0.045 0.1433
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0031 0.0024 0.0036
Loa Loa (eye worm) TAR-binding protein 0.0386 0.2455 0.6124
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0161 0.0914 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0053 0.0133
Brugia malayi hypothetical protein 0.0072 0.0306 0.0714
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0465 0.2997 0.3716
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0161 0.0914 0.2993

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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