Detailed information for compound 621122

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 441.523 | Formula: C21H19N3O4S2
  • H donors: 1 H acceptors: 3 LogP: 3.25 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCn1c(=NC(=O)c2ccc3c(c2)cccc3)sc2c1ccc(c2)S(=O)(=O)N
  • InChi: 1S/C21H19N3O4S2/c1-28-11-10-24-18-9-8-17(30(22,26)27)13-19(18)29-21(24)23-20(25)16-7-6-14-4-2-3-5-15(14)12-16/h2-9,12-13H,10-11H2,1H3,(H2,22,26,27)/b23-21-
  • InChiKey: YRAFEKUBFSWGOX-LNVKXUELSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0123 0.0811 0.3141
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0175
Schistosoma mansoni hypothetical protein 0.0182 0.1253 0.1511
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0017 0.0026 0.003
Brugia malayi MH1 domain containing protein 0.0034 0.0153 0.0423
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0449 0.054
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0226 0.0626
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0033 0.0143 0.0142
Brugia malayi RNA recognition motif domain containing protein 0.046 0.3311 0.9237
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0044 0.0232
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0144 0.0398
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0123 0.0811 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0024 0.0082 0.0222
Echinococcus multilocularis dna polymerase eta 0.0019 0.0044 0.0043
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0044 0.0175
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0073
Echinococcus multilocularis cpg binding protein 0.0014 0.0002 0.0001
Schistosoma mansoni smad 0.0015 0.0014 0.0015
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0898 0.6558 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0828 0.0827
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0033 0.0143 0.1492
Echinococcus multilocularis smad 0.0034 0.0153 0.0151
Trichomonas vaginalis glutathione reductase, putative 0.0123 0.0811 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.0559 0.6781
Echinococcus granulosus GPCR family 2 0.0033 0.0144 0.0143
Loa Loa (eye worm) RNA binding protein 0.046 0.3311 0.9237
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0089 0.0559 0.2211
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0506 0.141
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0014 0.0013
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0153 0.0151
Loa Loa (eye worm) MH2 domain-containing protein 0.0497 0.3584 1
Loa Loa (eye worm) glutathione reductase 0.0354 0.2527 0.705
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0033 0.0143 0.0469
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0123 0.0811 0.2803
Echinococcus granulosus glutamate synthase 0.0033 0.0143 0.0142
Onchocerca volvulus 0.0016 0.0021 0.0142
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0033 0.0143 0.0142
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0175
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0122 0.1223
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0033 0.0143 0.0152
Schistosoma mansoni aryl hydrocarbon receptor 0.0022 0.0062 0.0074
Brugia malayi MH1 domain containing protein 0.0019 0.0041 0.011
Schistosoma mansoni tar DNA-binding protein 0.046 0.3311 0.3993
Leishmania major phosphatidylinositol 3-related kinase, putative 0.003 0.0122 0.0314
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0033 0.0143 0.0469
Loa Loa (eye worm) programmed cell death 8 0.0033 0.0143 0.0397
Mycobacterium ulcerans hypothetical protein 0.0033 0.0143 0.1549
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0026 0.0069
Loa Loa (eye worm) hypothetical protein 0.0071 0.0425 0.1182
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0017 0.0026 0.0103
Schistosoma mansoni smad1 5 8 and 0.0034 0.0153 0.0183
Schistosoma mansoni hypothetical protein 0.0033 0.0144 0.0172
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0808 0.589 0.8974
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0122 0.0337
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0123 0.0811 0.2803
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0033 0.0143 0.1291
Schistosoma mansoni hypothetical protein 0.0071 0.0425 0.0511
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0425 0.1182
Echinococcus granulosus smad 0.0034 0.0153 0.0151
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0033 0.0143 0.0469
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0014 0.0013
Trypanosoma cruzi NADH dehydrogenase, putative 0.0033 0.0143 0.0469
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0256 0.2934
Schistosoma mansoni hypothetical protein 0.0033 0.0144 0.0172
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0033 0.0143 0.0397
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0194 0.0192
Entamoeba histolytica hypothetical protein 0.0074 0.0449 0.7933
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0123 0.0811 0.3141
Trichomonas vaginalis mercuric reductase, putative 0.0123 0.0811 1
Trypanosoma brucei unspecified product 0.0019 0.0044 0.0175
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0044 0.012
Onchocerca volvulus 0.0199 0.138 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0123 0.0811 0.2262
Trichomonas vaginalis glutamate synthase, putative 0.0033 0.0143 0.1492
Onchocerca volvulus 0.0033 0.0143 0.103
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0175
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0033 0.0143 0.1549
Trypanosoma brucei NADH dehydrogenase 0.0033 0.0143 0.0567
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0026 0.0069
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0033 0.0143 0.1549
Loa Loa (eye worm) hypothetical protein 0.0199 0.138 0.3848
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0808 0.589 0.8974
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0014 0.0036
Onchocerca volvulus 0.0082 0.0506 0.3664
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0123 0.0811 0.2803
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0033 0.0143 0.2201
Schistosoma mansoni thyroid hormone receptor 0.0138 0.0927 0.1117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0328 0.3847
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0014 0.0013
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0828 0.0827
Echinococcus multilocularis lamin 0.0082 0.0506 0.0505
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0044 0.0297
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.009 0.057 0.1588
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0153 0.0151
Loa Loa (eye worm) hypothetical protein 0.008 0.0495 0.1379
Trichomonas vaginalis apoptosis inducing factor, putative 0.0033 0.0143 0.1492
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0667 0.1857
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0033 0.0143 0.2201
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0089 0.0559 0.1556
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0014 0.0013
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0033 0.0143 0.0152
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0033 0.0143 0.0142
Brugia malayi MH2 domain containing protein 0.0015 0.0014 0.0036
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0044 0.0052
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0123 0.0811 1
Mycobacterium ulcerans dehydrogenase 0.0033 0.0143 0.1549
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.0122 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.039 0.4638
Loa Loa (eye worm) hypothetical protein 0.0033 0.0144 0.0398
Leishmania major hypothetical protein, conserved 0.0033 0.0143 0.0399
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0175
Loa Loa (eye worm) hypothetical protein 0.0039 0.0194 0.0537
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0194 0.0192
Brugia malayi glutathione reductase 0.0354 0.2527 0.705
Echinococcus granulosus cpg binding protein 0.0014 0.0002 0.0001
Brugia malayi Smad1 0.0034 0.0153 0.0423
Schistosoma mansoni tar DNA-binding protein 0.046 0.3311 0.3993
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0143 0.0469
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0033 0.0143 0.0142
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0089 0.0559 0.2072
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0044 0.0043
Brugia malayi hypothetical protein 0.0073 0.0441 0.1228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0078 0.0662
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0033 0.0143 0.2201
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0175
Echinococcus granulosus serine protein kinase ATM 0.0017 0.0026 0.0025
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0123 0.0811 0.309
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0033 0.0143 0.0152
Schistosoma mansoni thyroid hormone receptor 0.0138 0.0927 0.1117
Schistosoma mansoni smad 0.0034 0.0153 0.0183
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0017 0.0026 0.0025
Trypanosoma cruzi trypanothione reductase, putative 0.0354 0.2527 1
Schistosoma mansoni sulfide quinone reductase 0.0033 0.0143 0.0171
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0033 0.0143 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.039 0.4638
Schistosoma mansoni tar DNA-binding protein 0.046 0.3311 0.3993
Schistosoma mansoni hypothetical protein 0.0125 0.0828 0.0998
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0175
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0036
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.009 0.057 0.1588
Echinococcus multilocularis GPCR, family 2 0.0033 0.0144 0.0143
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0033 0.0143 0.0142
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0071 0.0425 0.1681
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0123 0.0811 0.0978
Toxoplasma gondii thioredoxin reductase 0.0354 0.2527 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0424 0.507
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0808 0.589 0.8958
Loa Loa (eye worm) Smad1 0.0034 0.0153 0.0423
Mycobacterium tuberculosis Probable oxidoreductase 0.0898 0.6558 1
Schistosoma mansoni tar DNA-binding protein 0.046 0.3311 0.3993
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0153 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0122 0.1223
Schistosoma mansoni disulfide oxidoreductase 0.0033 0.0143 0.0171
Schistosoma mansoni Smad4 0.0034 0.0153 0.0183
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0175
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0033 0.0143 0.1549
Giardia lamblia NADH oxidase lateral transfer candidate 0.0123 0.0811 1
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0506 0.141
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0449 0.0447
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0033 0.0143 0.0469
Echinococcus granulosus dna polymerase eta 0.0019 0.0044 0.0043
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0033 0.0143 0.0142
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0044 0.0043
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0153 0.0423
Entamoeba histolytica hypothetical protein 0.0074 0.0449 0.7933
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0089 0.0559 0.0673
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0044 0.0175
Echinococcus granulosus intermediate filament protein 0.0082 0.0506 0.0505
Echinococcus multilocularis glutamate synthase 0.0033 0.0143 0.0142
Loa Loa (eye worm) hypothetical protein 0.0082 0.0506 0.141
Brugia malayi MH1 domain containing protein 0.0034 0.0153 0.0423
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0123 0.0811 0.3141
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.0122 0.0121
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0123 0.0811 0.081
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0033 0.0143 0.0469
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0123 0.0811 0.3141
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0143 0.0567
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0667 0.1857
Toxoplasma gondii selenide, water dikinase 0.0033 0.0143 0.0469
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0033 0.0143 0.0397
Brugia malayi PAS domain containing protein 0.0022 0.0062 0.0171
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.0122 0.0146
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0033 0.0143 0.1492
Echinococcus granulosus dnaJ subfamily B 0.0182 0.1253 0.1252
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0089 0.0559 0.0558
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0122 0.0337
Echinococcus granulosus single minded 2 0.0016 0.0021 0.002
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0089 0.0559 0.213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.011
Schistosoma mansoni lamin 0.0082 0.0506 0.0609
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0033 0.0143 0.0469
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0175
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0103 0.0123
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0033 0.0143 0.1492
Brugia malayi Thioredoxin reductase 0.0354 0.2527 0.705
Giardia lamblia Glutamate synthase 0.0033 0.0143 0.1291
Trypanosoma cruzi NADH dehydrogenase, putative 0.0033 0.0143 0.0469
Plasmodium falciparum thioredoxin reductase 0.0354 0.2527 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0256 0.2927
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0424 0.507
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0033 0.0143 0.0469
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0033 0.0143 0.0567
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0449 0.0447
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.004 0.0181
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0044 0.0232
Mycobacterium ulcerans NADH dehydrogenase 0.0033 0.0143 0.1549
Loa Loa (eye worm) hypothetical protein 0.0103 0.0667 0.1857
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0256 0.2934
Brugia malayi MH2 domain containing protein 0.0497 0.3584 1
Echinococcus multilocularis lamin dm0 0.0082 0.0506 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.039 0.4638
Brugia malayi MH2 domain containing protein 0.0034 0.0153 0.0423
Loa Loa (eye worm) nuclear factor I 0.0019 0.0041 0.011
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0033 0.0143 0.1549
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0123 0.0811 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0069
Mycobacterium ulcerans monoxygenase 0.0033 0.0143 0.1549
Echinococcus multilocularis thyroid hormone receptor alpha 0.0138 0.0927 0.0926
Mycobacterium tuberculosis Probable dehydrogenase 0.0808 0.589 0.8974
Echinococcus granulosus tar DNA binding protein 0.046 0.3311 0.331
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0044 0.0043
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.0122 0.0121
Brugia malayi MH2 domain containing protein 0.0034 0.0153 0.0423
Schistosoma mansoni hypothetical protein 0.0074 0.0449 0.054
Echinococcus multilocularis dnaJ subfamily B 0.0182 0.1253 0.1252
Schistosoma mansoni glutamate synthase 0.0033 0.0143 0.0171
Brugia malayi hypoxia-induced factor 1 0.0067 0.0399 0.1111
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0123 0.0811 0.3211
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0033 0.0143 0.0152
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.003 0.0122 0.0483
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0096
Trypanosoma cruzi target of rapamycin kinase 3 0.0071 0.0425 0.1595
Plasmodium falciparum glutathione reductase 0.0123 0.0811 0.2803
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0175
Schistosoma mansoni smad1 5 8 and 0.0034 0.0153 0.0183
Schistosoma mansoni Smad4 0.0015 0.0014 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0256 0.2934
Mycobacterium tuberculosis Probable reductase 0.0808 0.589 0.8974
Treponema pallidum NADH oxidase 0.0123 0.0811 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0122 0.1223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.039 0.4638
Schistosoma mansoni single-minded 0.0022 0.0062 0.0074
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0033 0.0143 0.1549
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.046 0.3311 0.9237
Loa Loa (eye worm) hypothetical protein 0.0148 0.0995 0.2775
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0033 0.0143 0.1492
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0044 0.0175
Schistosoma mansoni cellular tumor antigen P53 0.0199 0.138 0.1663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.0559 0.6781
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0122 0.0384
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0144 0.0398
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0153 0.0151
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0044 0.0297
Giardia lamblia Thioredoxin reductase 0.0033 0.0143 0.1291
Echinococcus multilocularis thioredoxin glutathione reductase 0.0356 0.2542 0.2542
Schistosoma mansoni lamin 0.0082 0.0506 0.0609
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0044 0.0073
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0033 0.0143 0.2201
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0017 0.0026 0.0025
Onchocerca volvulus 0.0148 0.0995 0.721
Schistosoma mansoni sulfide quinone reductase 0.0033 0.0143 0.0171
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0033 0.0143 0.0399
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0123 0.0811 0.309
Leishmania major hypothetical protein, conserved 0.0033 0.0143 0.0399
Leishmania major hypothetical protein, conserved 0.0033 0.0143 0.0399
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0123 0.0811 0.3141
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0123 0.0811 0.3141
Plasmodium vivax thioredoxin reductase, putative 0.0354 0.2527 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0175
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0014 0.0036
Echinococcus multilocularis transfer RNA-Lys 0.0016 0.0021 0.002
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0898 0.6558 1
Echinococcus multilocularis Smad4 0.0034 0.0153 0.0151
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0044 0.0341
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0123 0.0811 0.3211
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0033 0.0143 0.1492
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0033 0.0143 0.0142
Trypanosoma brucei trypanothione reductase 0.0354 0.2527 1
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0033 0.0143 0.0152
Brugia malayi hypothetical protein 0.0074 0.0449 0.1249
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0044 0.0175
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0123 0.0811 0.309
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0144 0.0143
Brugia malayi bHLH-PAS transcription factor 0.0016 0.0021 0.0055
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0033 0.0143 0.1492
Plasmodium falciparum glutathione reductase 0.0354 0.2527 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0424 0.507
Schistosoma mansoni Smad4 0.0015 0.0014 0.0015
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0123 0.0811 0.309
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0667 0.1857
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0033 0.0143 0.0469
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0033 0.0143 0.0142
Echinococcus granulosus Smad4 0.0034 0.0153 0.0151
Schistosoma mansoni cpg binding protein 0.0014 0.0002 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0294 0.3415
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.012
Entamoeba histolytica hypothetical protein 0.0074 0.0449 0.7933
Plasmodium falciparum thioredoxin reductase 0.0123 0.0811 0.2803
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0044 0.012
Loa Loa (eye worm) hypoxia-induced factor 1 0.0067 0.0399 0.1111
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0144 0.0398
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0033 0.0143 0.1492
Trypanosoma cruzi trypanothione reductase, putative 0.0123 0.0811 0.3141
Entamoeba histolytica thioredoxin reductase, putative 0.0033 0.0143 0.2201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.039 0.4638
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0089 0.0559 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0123 0.0811 0.1178
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0123 0.0811 0.3211
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0033 0.0143 0.2201
Schistosoma mansoni cpg binding protein 0.0014 0.0002 0.0001
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0033 0.0143 0.0469
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0033 0.0143 0.0399
Loa Loa (eye worm) hypothetical protein 0.0073 0.0441 0.1228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0424 0.507
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0014 0.0036
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0071 0.0425 0.1533
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0033 0.0143 0.1492
Echinococcus multilocularis tar DNA binding protein 0.046 0.3311 0.331
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0073
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0123 0.0811 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0037 0.0175 0.0691
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0424 0.507
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0808 0.589 0.8974
Brugia malayi RNA binding protein 0.046 0.3311 0.9237
Loa Loa (eye worm) transcription factor SMAD2 0.0497 0.3584 1
Schistosoma mansoni hypothetical protein 0.0033 0.0144 0.0172
Brugia malayi MH1 domain containing protein 0.0019 0.0041 0.011
Schistosoma mansoni hypothetical protein 0.0033 0.0143 0.0171
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0042 0.0212 0.0841
Entamoeba histolytica hypothetical protein 0.0074 0.0449 0.7933
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0506
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0033 0.0143 0.1492
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0123 0.0811 0.081
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0808 0.589 0.8974
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0153 0.0423
Brugia malayi hypothetical protein 0.0148 0.0995 0.2775
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0226 0.0626
Schistosoma mansoni hypothetical protein 0.0033 0.0144 0.0172
Toxoplasma gondii target of rapamycin (TOR), putative 0.0066 0.039 0.1457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.029 0.3366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.029 0.3366
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0073
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0019 0.004 0.0057
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0123 0.0811 0.3211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.039 0.4638
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0123 0.0811 0.3141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0294 0.3415
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0506 0.141
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0898 0.6558 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0342 0.4028
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0033 0.0143 0.0469
Onchocerca volvulus 0.0082 0.0506 0.3664
Loa Loa (eye worm) thioredoxin reductase 0.0354 0.2527 0.705
Leishmania major trypanothione reductase 0.0354 0.2527 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0144 0.0143
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0015 0.0014 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0143 0.0469
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.0559 0.6781
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.003 0.0122 0.0483
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0123 0.0811 0.3141
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0122 0.0384
Mycobacterium ulcerans glutamate synthase subunit beta 0.0033 0.0143 0.1549
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0033 0.0143 0.1549
Echinococcus multilocularis musashi 0.0082 0.0506 0.0505
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0123 0.0811 1
Toxoplasma gondii NADPH-glutathione reductase 0.0123 0.0811 0.3141
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0123 0.0811 1
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0033 0.0143 0.1549
Echinococcus granulosus thioredoxin glutathione reductase 0.0356 0.2542 0.2542
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0033 0.0143 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0122 0.1223
Giardia lamblia GTOR 0.0089 0.0559 0.6705
Schistosoma mansoni intermediate filament proteins 0.0082 0.0506 0.0609
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0089 0.0559 0.0558
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0033 0.0143 0.0567
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0033 0.0143 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.039 0.4638
Brugia malayi intermediate filament protein 0.0082 0.0506 0.141
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0123 0.0811 0.3141
Schistosoma mansoni DNA polymerase eta 0.0019 0.0044 0.0052
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0033 0.0143 0.0142
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0123 0.0811 0.2803
Echinococcus granulosus dna polymerase kappa 0.0019 0.0044 0.0043
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0033 0.0143 0.1492
Loa Loa (eye worm) hypothetical protein 0.0033 0.0143 0.0397
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0033 0.0143 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0256 0.2927
Leishmania major NADH dehydrogenase, putative 0.0033 0.0143 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0256 0.2927
Loa Loa (eye worm) TAR-binding protein 0.046 0.3311 0.9237
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0044 0.012
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0089 0.0559 0.2072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0294 0.3415
Plasmodium vivax glutathione reductase, putative 0.0354 0.2527 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0256 0.2934
Trichomonas vaginalis glutamate synthase, putative 0.0033 0.0143 0.1492
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0089 0.0559 1
Entamoeba histolytica disulphide oxidoreductase, putative 0.0033 0.0143 0.2201
Echinococcus granulosus lamin dm0 0.0082 0.0506 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0463 0.5558
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0033 0.0143 0.0152
Schistosoma mansoni glutamate synthase 0.0033 0.0143 0.0171
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0033 0.0143 0.0567
Echinococcus multilocularis tumor protein p63 0.1363 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0089 0.0559 0.1556
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0153 0.0151
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0144 0.0143
Mycobacterium ulcerans ferredoxin reductase 0.0033 0.0143 0.1549
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0044 0.0052
Schistosoma mansoni fkbp-rapamycin associated protein 0.0017 0.0026 0.003
Schistosoma mansoni tar DNA-binding protein 0.046 0.3311 0.3993
Schistosoma mansoni glutamate synthase 0.0033 0.0143 0.0171
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0033 0.0143 0.0142
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0089 0.0559 0.2211
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0089 0.0559 0.213
Echinococcus granulosus lamin 0.0082 0.0506 0.0505
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0354 0.2527 0.3811
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0033 0.0143 0.0142
Echinococcus multilocularis serine protein kinase ATM 0.0017 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0109
Brugia malayi TAR-binding protein 0.046 0.3311 0.9237
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0506
Schistosoma mansoni smad1 5 8 and 0.0034 0.0153 0.0183
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0144 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0122 0.1223
Brugia malayi glutamate synthase 0.0033 0.0143 0.0397

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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