Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1567 | 0.1789 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0301 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0179 | 0.0204 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0063 | 0.1099 | 0.433 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.065 | 0.2559 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0753 | 0.2964 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2857 | 0.326 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0753 | 0.2964 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0076 | 0.1361 | 0.3779 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0301 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.006 | 0.1052 | 0.2342 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0553 | 0.0016 |
Brugia malayi | Pre-SET motif family protein | 0.0438 | 0.8764 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0876 | 0.0999 |
Echinococcus granulosus | expressed conserved protein | 0.0093 | 0.171 | 0.5403 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0126 | 0.2383 | 0.8538 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0133 | 0.254 | 0.2645 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0301 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0042 | 0.0681 | 0.0614 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.0179 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.254 | 1 |
Brugia malayi | RNA binding protein | 0.0133 | 0.254 | 0.2645 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.065 | 0.2559 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0179 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0753 | 0.0859 |
Trypanosoma cruzi | ISWI complex protein | 0.0032 | 0.0474 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0099 | 0.1833 | 0.5976 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0753 | 0.0947 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0076 | 0.1361 | 0.3779 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1466 | 0.1672 |
Echinococcus granulosus | zinc finger protein | 0.0041 | 0.0658 | 0.0505 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0438 | 0.8764 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0037 | 0.0576 | 0.0657 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1833 | 0.2091 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0133 | 0.254 | 0.2898 |
Trypanosoma brucei | ISWI complex protein | 0.0032 | 0.0474 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0041 | 0.0658 | 0.259 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0553 | 0.0016 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0043 | 0.0703 | 0.0802 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0179 | 0.0204 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0126 | 0.2383 | 0.8538 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0681 | 0.0777 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0063 | 0.1099 | 0.2562 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0047 | 0.0785 | 0.3092 |
Onchocerca volvulus | 0.0063 | 0.1099 | 0.0823 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0301 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0042 | 0.0681 | 0.0614 |
Schistosoma mansoni | bromodomain containing protein | 0.0133 | 0.2537 | 0.9989 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0099 | 0.1832 | 0.1808 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0099 | 0.1833 | 0.7217 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0047 | 0.0785 | 0.1099 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.01 | 0.1863 | 0.7336 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.165 | 0.1882 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0047 | 0.0785 | 0.1099 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0301 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0553 | 0.1641 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0753 | 0.0947 |
Echinococcus granulosus | tar DNA binding protein | 0.0133 | 0.254 | 0.9268 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0099 | 0.1832 | 0.5972 |
Loa Loa (eye worm) | RNA binding protein | 0.0133 | 0.254 | 0.2898 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0099 | 0.1832 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0081 | 0.1463 | 0.1372 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0553 | 0.1641 |
Brugia malayi | Pre-SET motif family protein | 0.0063 | 0.1099 | 0.0943 |
Echinococcus multilocularis | protein patched | 0.0042 | 0.0681 | 0.0614 |
Brugia malayi | MH2 domain containing protein | 0.013 | 0.2466 | 0.2557 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0063 | 0.1099 | 0.433 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0179 | 0.0204 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0179 | 0.139 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0099 | 0.1833 | 0.5976 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0301 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.254 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0301 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0042 | 0.0681 | 0.0777 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0036 | 0.0549 | 0.2163 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.0803 | 0.1183 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.254 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0158 | 0.3041 | 0.3237 |
Brugia malayi | TAR-binding protein | 0.0133 | 0.254 | 0.2645 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0301 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0141 | 0.2697 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0141 | 0.2697 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.065 | 0.2559 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0099 | 0.1832 | 0.5972 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0036 | 0.0549 | 0.2163 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0553 | 0.0297 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0301 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0301 | 0.0344 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0753 | 0.0533 |
Brugia malayi | PHD-finger family protein | 0.0052 | 0.0887 | 0.0692 |
Plasmodium vivax | SET domain protein, putative | 0.0063 | 0.1099 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.254 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0032 | 0.0474 | 0.1866 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0553 | 0.2176 |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0681 | 0.2682 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0042 | 0.0681 | 0.0614 |
Leishmania major | hypothetical protein, conserved | 0.0032 | 0.0474 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0753 | 0.0947 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.254 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0301 | 0.0344 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0703 | 0.2769 |
Loa Loa (eye worm) | TAR-binding protein | 0.0133 | 0.254 | 0.2898 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 0.2466 | 0.2813 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0753 | 0.2964 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1832 | 0.209 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0179 | 0.0204 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0179 | 0.0204 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0063 | 0.1099 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0133 | 0.254 | 0.9268 |
Echinococcus multilocularis | expressed conserved protein | 0.0093 | 0.171 | 0.5403 |
Trichomonas vaginalis | set domain proteins, putative | 0.0498 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.065 | 0.2559 |
Brugia malayi | CHE-14 protein | 0.0042 | 0.0681 | 0.0449 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 0.2466 | 0.2813 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0099 | 0.1833 | 0.7217 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0753 | 0.0947 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0301 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0553 | 0.2176 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0553 | 0.1641 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0301 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0553 | 0.1641 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0301 | 0.0344 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0301 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0474 | 0.1866 |
Echinococcus multilocularis | zinc finger protein | 0.0041 | 0.0658 | 0.0505 |
Trypanosoma cruzi | ISWI complex protein | 0.0032 | 0.0474 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.