Detailed information for compound 621266

Basic information

Technical information
  • TDR Targets ID: 621266
  • Name: N-(4-fluorophenyl)-2-[4-oxo-2-[2-(2-oxo-5H-1, 3-thiazol-4-yl)hydrazinyl]-1,3-thiazol-5-yl]a cetamide
  • MW: 381.405 | Formula: C14H12FN5O3S2
  • H donors: 3 H acceptors: 3 LogP: 1.41 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CC1SC(=NC1=O)NN=C1CSC(=O)N1)Nc1ccc(cc1)F
  • InChi: 1S/C14H12FN5O3S2/c15-7-1-3-8(4-2-7)16-11(21)5-9-12(22)18-13(25-9)20-19-10-6-24-14(23)17-10/h1-4,9H,5-6H2,(H,16,21)(H,17,19,23)(H,18,20,22)
  • InChiKey: QDUYPCPXDKIUBA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-fluorophenyl)-2-[4-oxo-2-[N'-(2-oxo-5H-thiazol-4-yl)hydrazino]thiazol-5-yl]acetamide
  • N-(4-fluorophenyl)-2-[4-oxo-2-[N'-(2-oxo-5H-thiazol-4-yl)hydrazino]-5-thiazolyl]acetamide
  • N-(4-fluorophenyl)-2-[4-keto-2-[N'-(2-keto-5H-thiazol-4-yl)hydrazino]thiazol-5-yl]acetamide
  • N-(4-fluorophenyl)-2-[4-oxo-2-[2-(2-oxo-5H-1,3-thiazol-4-yl)hydrazinyl]-1,3-thiazol-5-yl]ethanamide
  • ST5069515

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0251 0.0805
Echinococcus multilocularis protein patched 0.0043 0.0354 0.0339
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0433 0.1374
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0065 0.1211
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0272 0.0304
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0093 0.0257
Loa Loa (eye worm) hypothetical protein 0.0098 0.1062 0.2831
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0023 0.0063
Entamoeba histolytica hypothetical protein 0.0037 0.0272 0.2235
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0354 0.0402
Brugia malayi Importin beta-1 subunit 0.0028 0.0161 0.0479
Echinococcus multilocularis thyroid hormone receptor alpha 0.0135 0.1541 0.1528
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0419 0.1142
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0035 0.0097
Mycobacterium tuberculosis Conserved protein 0.0035 0.0251 0.088
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.1649 0.1636
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0333 0.0925
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0412 0.3562
Plasmodium falciparum glutathione reductase 0.0048 0.0426 1
Schistosoma mansoni importin beta-1 0.0028 0.0161 0.0439
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0257 1
Toxoplasma gondii thioredoxin reductase 0.0048 0.0426 1
Entamoeba histolytica hypothetical protein 0.0023 0.0093 0.0544
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0065 0.005
Loa Loa (eye worm) glutathione reductase 0.0048 0.0426 0.1084
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.1062 0.2892
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.1412 0.1398
Schistosoma mansoni hypothetical protein 0.0299 0.3672 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0251 0.5746
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0426 0.1084
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0016 0.0044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0232 0.0807
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0016 0.0044
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2692 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0412 0.1145
Schistosoma mansoni zinc finger protein 0.002 0.0056 0.0154
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0016 0.0044
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.1229 0.8596
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0093 0.0263
Brugia malayi hypothetical protein 0.0037 0.0272 0.0842
Entamoeba histolytica Ran family GTPase 0.0021 0.0065 0.0287
Echinococcus granulosus survival motor neuron protein 1 0.023 0.2773 0.3277
Mycobacterium tuberculosis Probable reductase 0.011 0.1229 0.4535
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0251 0.0776
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.1389 0.5131
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0412 0.2221
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0095 0.008
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0251 0.028
Loa Loa (eye worm) hypothetical protein 0.0048 0.0419 0.1066
Echinococcus granulosus importin subunit beta 1 0.0028 0.0161 0.0173
Schistosoma mansoni hypothetical protein 0.0041 0.0334 0.091
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.1093 0.1281
Mycobacterium tuberculosis Conserved protein 0.0035 0.0251 0.088
Onchocerca volvulus 0.0035 0.0251 0.0207
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.3598 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0479 0.123
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0065 0.0163
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.1229 0.4535
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.3598 1
Brugia malayi RNA binding protein 0.0251 0.3052 1
Brugia malayi beta-lactamase family protein 0.0035 0.0251 0.0776
Schistosoma mansoni patched 1 0.0043 0.0354 0.0964
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.1389 0.5131
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0035 0.0019
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0272 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0354 0.1156
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0194 0.4358
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0251 0.0805
Echinococcus granulosus tar DNA binding protein 0.0251 0.3052 0.3608
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0426 0.0487
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.04 0.0385
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0257 0.588
Entamoeba histolytica hypothetical protein 0.0037 0.0272 0.2235
Schistosoma mansoni ran 0.0021 0.0065 0.0178
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0419 0.0404
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0412 0.3562
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0412 0.2221
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.04 0.1089
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.256 0.6945
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0035 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0257 0.062
Brugia malayi TAR-binding protein 0.0251 0.3052 1
Leishmania major hypothetical protein, conserved 0.0035 0.0251 0.0699
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0194 0.0179
Echinococcus multilocularis zinc finger protein 0.002 0.0056 0.0041
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0251 0.0236
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0016 0.0044
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0412 0.3562
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.04 0.0457
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0035 0.0097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.04 0.1089
Plasmodium falciparum importin beta, putative 0.0028 0.0161 0.3547
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0035 0.0023
Echinococcus multilocularis tumor protein p63 0.0666 0.843 0.8427
Loa Loa (eye worm) hypothetical protein 0.0035 0.0257 0.062
Loa Loa (eye worm) hypothetical protein 0.0028 0.0161 0.0357
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0405 0.1282
Brugia malayi Pre-SET motif family protein 0.0031 0.0194 0.0588
Brugia malayi RNA recognition motif domain containing protein 0.0251 0.3052 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0161 0.3547
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0016 0.0044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0016 0.0044
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0065 0.0182
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0251 0.0685
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0251 0.0805
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0093 0.0263
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.2773 0.2762
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0251 0.088
Onchocerca volvulus 0.0047 0.0412 0.0792
Loa Loa (eye worm) hypothetical protein 0.0035 0.0257 0.062
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.18 0.6665
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0412 0.2221
Brugia malayi PHD-finger family protein 0.0025 0.0127 0.0365
Toxoplasma gondii exonuclease III APE 0.0018 0.0035 0.047
Schistosoma mansoni hypothetical protein 0.0037 0.0272 0.074
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.04 0.1013
Onchocerca volvulus 0.0098 0.1062 0.3158
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0035 0.0066
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0585 0.057
Mycobacterium ulcerans hypothetical protein 0.0155 0.18 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0412 0.1412
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.1649 0.1941
Plasmodium vivax SET domain protein, putative 0.0031 0.0194 0.4358
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0412 0.1412
Brugia malayi beta-lactamase family protein 0.0035 0.0251 0.0776
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0433 0.1374
Schistosoma mansoni hypothetical protein 0.0021 0.007 0.0191
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0412 0.1305
Schistosoma mansoni ran 0.0021 0.0065 0.0178
Brugia malayi glutathione reductase 0.0048 0.0426 0.135
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.1093 0.3549
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0065 1
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0426 1
Brugia malayi hypothetical protein 0.023 0.2773 0.9082
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0035 0.0108
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0412 0.2221
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0412 0.1145
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0257 0.1351
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0251 0.0805
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0035 0.0011
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0272 0.0304
Onchocerca volvulus 0.0035 0.0251 0.0207
Trypanosoma brucei trypanothione reductase 0.0048 0.0426 0.1183
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0272 0.0256
Brugia malayi RNA, U transporter 1 0.008 0.083 0.2682
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0251 0.0805
Echinococcus multilocularis snurportin 1 0.0299 0.3672 0.3662
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0251 0.088
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0412 0.1145
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0251 0.088
Schistosoma mansoni tar DNA-binding protein 0.0251 0.3052 0.8312
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0333 0.0925
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.045 0.1249
Loa Loa (eye worm) hypothetical protein 0.0035 0.0257 0.062
Loa Loa (eye worm) hypothetical protein 0.0039 0.0304 0.0749
Schistosoma mansoni tar DNA-binding protein 0.0251 0.3052 0.8312
Loa Loa (eye worm) hypothetical protein 0.023 0.2773 0.7532
Echinococcus multilocularis tar DNA binding protein 0.0251 0.3052 0.3041
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0016 0.0044
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0016 0.0044
Loa Loa (eye worm) hypothetical protein 0.0035 0.0251 0.0605
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0354 0.0339
Loa Loa (eye worm) hypothetical protein 0.0035 0.0251 0.0605
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.3672 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0585 0.0677
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0251 0.088
Loa Loa (eye worm) hypothetical protein 0.0035 0.0251 0.0605
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.1229 0.4535
Mycobacterium ulcerans hypothetical protein 0.0047 0.0412 0.2221
Leishmania major trypanothione reductase 0.0048 0.0426 0.1183
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0426 0.0411
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0023 0.0007
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0035 0.3878
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0095 0.026
Entamoeba histolytica hypothetical protein 0.0037 0.0272 0.2235
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0354 0.0887
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0412 0.1305
Loa Loa (eye worm) hypothetical protein 0.0047 0.0412 0.1046
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0251 0.0685
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.04 0.1265
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0251 0.0699
Toxoplasma gondii hypothetical protein 0.0047 0.0411 0.9645
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0016 0.0044
Onchocerca volvulus 0.0047 0.0405 0.0767
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0161 0.0448
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0065 0.1211
Plasmodium vivax glutathione reductase, putative 0.0048 0.0426 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0412 0.2221
Echinococcus multilocularis protein dispatched 1 0.0049 0.0433 0.0417
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0035 0.0066
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.1229 0.4535
Mycobacterium tuberculosis Conserved protein 0.0035 0.0251 0.088
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.1113 0.3032
Loa Loa (eye worm) hypothetical protein 0.0049 0.0433 0.1103
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0426 0.1532
Schistosoma mansoni hypothetical protein 0.0125 0.1412 0.3845
Echinococcus granulosus expressed conserved protein 0.0094 0.1015 0.1187
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0257 0.0901
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0161 0.0146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0232 0.0807
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0065 0.0182
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0065 0.0059
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.1412 0.1659
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.3598 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.3598 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0419 0.0479
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0333 0.0925
Schistosoma mansoni hypothetical protein 0.0041 0.0334 0.091
Loa Loa (eye worm) hypothetical protein 0.0035 0.0257 0.062
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0016 0.0044
Onchocerca volvulus 0.0035 0.0251 0.0207
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0016 0.0044
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0035 0.047
Echinococcus granulosus zinc finger protein 0.002 0.0056 0.0048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0251 0.0605
Brugia malayi CHE-14 protein 0.0043 0.0354 0.1114
Loa Loa (eye worm) hypothetical protein 0.0033 0.0232 0.0552
Onchocerca volvulus 0.0243 0.2941 1
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0257 0.588
Leishmania major importin beta-1 subunit, putative 0.0023 0.0093 0.0257
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0333 0.0925
Trichomonas vaginalis ran, putative 0.0021 0.0065 0.017
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0251 0.0699
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0016 0.0044
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0412 0.148
Schistosoma mansoni ap endonuclease 0.0018 0.0035 0.0095
Loa Loa (eye worm) RNA binding protein 0.0251 0.3052 0.8298
Loa Loa (eye worm) hypothetical protein 0.0047 0.0412 0.1046
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.04 0.0457
Schistosoma mansoni tar DNA-binding protein 0.0251 0.3052 0.8312
Loa Loa (eye worm) beta-lactamase 0.0035 0.0251 0.0605
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.1597 0.4438
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0016 0.0044
Loa Loa (eye worm) hypothetical protein 0.0072 0.073 0.192
Schistosoma mansoni ap endonuclease 0.0018 0.0035 0.0095
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0035 0.0097
Echinococcus granulosus tumor protein p63 0.0666 0.843 1
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.1093 0.1079
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0251 0.0699
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0251 0.0605
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0426 0.1183
Echinococcus multilocularis expressed conserved protein 0.0094 0.1015 0.1001
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.1389 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.036 0.0904
Loa Loa (eye worm) hypothetical protein 0.0035 0.0251 0.0605
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0251 0.132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0194 0.053
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0251 0.3052 0.8298
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0035 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0433 0.1103
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0016 0.0044
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0251 0.088
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0251 0.088
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1597 0.4438
Schistosoma mansoni hypothetical protein 0.0041 0.0334 0.091
Leishmania major GTP-binding protein, putative 0.0021 0.0065 0.0182
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0016 0.0044
Schistosoma mansoni hypothetical protein 0.0033 0.0232 0.0632
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.1389 0.5131
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0412 0.148
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0412 0.2221
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0412 0.1305
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0023 0.0009
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0232 0.0713
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1597 0.4438
Plasmodium falciparum thioredoxin reductase 0.0048 0.0426 1
Schistosoma mansoni bromodomain containing protein 0.0064 0.0632 0.1722
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0016 0.0043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0232 0.0807
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0419 0.1142
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0035 0.0072
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0035 0.047
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0016 0.0044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0232 0.0807
Mycobacterium ulcerans beta-lactamase 0.0035 0.0251 0.132
Loa Loa (eye worm) hypothetical protein 0.0043 0.0354 0.0887
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0412 0.2221
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.018 0.0195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.04 0.1089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.04 0.0385
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0251 0.088
Loa Loa (eye worm) hypothetical protein 0.01 0.1093 0.2917
Brugia malayi Bromodomain containing protein 0.0039 0.0303 0.0946
Schistosoma mansoni thyroid hormone receptor 0.0135 0.1541 0.4198
Trichomonas vaginalis esterase, putative 0.0035 0.0251 0.0805
Schistosoma mansoni tar DNA-binding protein 0.0251 0.3052 0.8312
Echinococcus granulosus snurportin 1 0.0299 0.3672 0.4345
Schistosoma mansoni tar DNA-binding protein 0.0251 0.3052 0.8312
Loa Loa (eye worm) hypothetical protein 0.0035 0.0251 0.0605
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0035 0.0063
Toxoplasma gondii ABC1 family protein 0.0035 0.0251 0.5746
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0065 0.1211
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.1093 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0412 0.1046
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0354 0.0402
Schistosoma mansoni thyroid hormone receptor 0.0135 0.1541 0.4198
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.007 0.0107
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0065 0.0094
Entamoeba histolytica hypothetical protein 0.0037 0.0272 0.2235
Loa Loa (eye worm) TAR-binding protein 0.0251 0.3052 0.8298
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.1229 0.4535
Schistosoma mansoni survival motor neuron protein 0.0047 0.0405 0.1104
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0035 0.0097
Plasmodium vivax importin-beta 2, putative 0.0028 0.0161 0.3547
Schistosoma mansoni hypothetical protein 0.0041 0.0334 0.091
Brugia malayi Bromodomain containing protein 0.0076 0.0787 0.2539
Trichomonas vaginalis set domain proteins, putative 0.0243 0.2941 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0251 0.132
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0023 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0194 0.053
Schistosoma mansoni hypothetical protein 0.0047 0.0405 0.1104
Loa Loa (eye worm) hypothetical protein 0.0041 0.0335 0.0835
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0016 0.0044
Brugia malayi Thioredoxin reductase 0.0048 0.0426 0.135
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0161 0.0448
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.1229 0.4535
Brugia malayi beta-lactamase 0.0035 0.0251 0.0776
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0095 0.0095
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0272 0.074
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0093 0.0263
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0065 0.0182
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0251 0.132
Mycobacterium ulcerans lipase LipD 0.0035 0.0251 0.132
Brugia malayi Pre-SET motif family protein 0.0213 0.256 0.8379

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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