Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0117 | 0.0408 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0021 | 0.0117 | 0.0408 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0642 | 0.2157 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0373 | 0.1207 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0117 | 0.03 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0117 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0117 | 0.0408 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0018 | 0.007 | 0.0244 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.0848 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0117 | 0.0408 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0117 | 0.0408 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0117 | 0.03 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0117 | 0.03 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0062 | 0.0105 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0021 | 0.0117 | 0.0135 |
Trichomonas vaginalis | set domain proteins, putative | 0.0229 | 0.3283 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0018 | 0.007 | 0.002 |
Schistosoma mansoni | lamin | 0.0029 | 0.0239 | 0.0434 |
Loa Loa (eye worm) | fibroinase | 0.0018 | 0.007 | 0.0244 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0726 | 0.1626 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0018 | 0.007 | 0.0062 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0021 | 0.0117 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0062 | 0.0215 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0018 | 0.007 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0117 | 0.0408 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0021 | 0.0117 | 0.0109 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0117 | 0.0408 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0117 | 0.0109 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0117 | 0.0408 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0021 | 0.0117 | 0.0146 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0117 | 0.0408 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0018 | 0.007 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0021 | 0.0117 | 0.03 |
Echinococcus granulosus | FTZ F1 alpha | 0.0021 | 0.0117 | 0.0109 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0233 | 0.0225 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.007 | 0.0134 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0233 | 0.0711 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0117 | 0.03 |
Echinococcus multilocularis | tumor protein p63 | 0.0669 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0117 | 0.03 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.0726 | 0.0719 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.0726 | 0.2456 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0117 | 0.0109 |
Schistosoma mansoni | lamin | 0.0029 | 0.0239 | 0.0434 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.0848 | 1 |
Onchocerca volvulus | 0.0029 | 0.0233 | 0.0507 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0018 | 0.007 | 0.0062 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.0848 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0018 | 0.007 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0117 | 0.0408 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0726 | 0.1626 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0117 | 0.0109 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.0726 | 0.254 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0233 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0062 | 0.0053 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0848 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0021 | 0.0117 | 0.03 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0239 | 0.0231 |
Echinococcus granulosus | cathepsin l1 | 0.0018 | 0.007 | 0.0062 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0018 | 0.007 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.007 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0117 | 0.0408 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0286 | 0.415 | 0.4145 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0018 | 0.007 | 0.0134 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.0726 | 0.254 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0239 | 0.0231 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0021 | 0.0117 | 0.03 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0021 | 0.0117 | 0.0109 |
Echinococcus granulosus | lamin | 0.0029 | 0.0239 | 0.0231 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0239 | 0.0732 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0062 | 0.0053 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0117 | 0.0109 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0062 | 0.0053 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0021 | 0.0117 | 0.0135 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0117 | 0.0109 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0848 | 0.5 |
Loa Loa (eye worm) | cysteine protease | 0.0018 | 0.007 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0642 | 0.2244 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0848 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0117 | 0.03 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0062 | 0.0053 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0726 | 0.1626 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0021 | 0.0117 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.007 | 0.0244 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0069 | 0.0848 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.007 | 0.0134 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0117 | 0.03 |
Brugia malayi | nuclear receptor NHR-88 | 0.0021 | 0.0117 | 0.03 |
Brugia malayi | nuclear hormone receptor | 0.0021 | 0.0117 | 0.03 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0008 | 0.0029 |
Onchocerca volvulus | 0.0021 | 0.0117 | 0.0146 | |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0233 | 0.0419 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0021 | 0.0117 | 0.0109 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0233 | 0.0419 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0054 | 0.0622 | 0.7098 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.0726 | 0.0719 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0117 | 0.0109 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0848 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0117 | 0.03 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0117 | 0.0408 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0239 | 0.0836 |
Onchocerca volvulus | 0.0029 | 0.0239 | 0.0526 | |
Brugia malayi | Pre-SET motif family protein | 0.0201 | 0.286 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0062 | 0.0053 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0233 | 0.0225 |
Schistosoma mansoni | coup transcription factor | 0.0021 | 0.0117 | 0.0135 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0021 | 0.0117 | 0.0408 |
Echinococcus multilocularis | cysteine protease | 0.0018 | 0.007 | 0.0062 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0018 | 0.007 | 0.0062 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0233 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0286 | 0.415 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0264 | 0.3826 | 0.3821 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0264 | 0.3826 | 0.3821 |
Onchocerca volvulus | 0.0229 | 0.3283 | 1 | |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0032 | 0.0111 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0021 | 0.0117 | 0.0146 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0021 | 0.0117 | 0.0109 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0239 | 0.0231 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0018 | 0.007 | 0.0244 |
Schistosoma mansoni | nuclear hormone receptor | 0.0021 | 0.0117 | 0.0135 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0117 | 0.03 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0848 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0117 | 0.0109 |
Loa Loa (eye worm) | ctsf protein | 0.0018 | 0.007 | 0.0244 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0239 | 0.0836 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0117 | 0.0408 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.007 | 0.0134 |
Echinococcus multilocularis | cysteine protease | 0.0018 | 0.007 | 0.0062 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0239 | 0.0434 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0848 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0021 | 0.0117 | 0.0135 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0848 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.007 | 0.0134 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0117 | 0.03 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0726 | 0.1626 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0848 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0021 | 0.0117 | 0.0135 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0848 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0021 | 0.0117 | 0.0109 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0021 | 0.0117 | 0.03 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0233 | 0.0419 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0117 | 0.0408 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0201 | 0.286 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0286 | 0.415 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0021 | 0.0117 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0117 | 0.0408 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.0848 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0117 | 0.0109 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0063 | 0.0756 | 0.8824 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0239 | 0.0836 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0021 | 0.0117 | 0.0135 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0239 | 0.0231 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0021 | 0.0117 | 0.03 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.0848 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0098 | 0.1287 | 0.2997 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.1287 | 0.45 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0021 | 0.0117 | 0.0135 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0021 | 0.0117 | 0.0135 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0726 | 0.1626 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0231 | 0.0807 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0373 | 0.0762 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.007 | 0.0134 |
Schistosoma mansoni | hypothetical protein | 0.0264 | 0.3826 | 0.9208 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0117 | 0.03 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0373 | 0.1305 |
Brugia malayi | RNA binding protein | 0.0061 | 0.0726 | 0.2456 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0018 | 0.007 | 0.0062 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0018 | 0.007 | 0.002 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0642 | 0.2157 |
Onchocerca volvulus | 0.0029 | 0.0239 | 0.0526 | |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0117 | 0.03 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0062 | 0.0105 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.0726 | 0.2456 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0117 | 0.0109 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0018 | 0.007 | 0.0062 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0021 | 0.0117 | 0.0146 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0018 | 0.007 | 0.5 |
Onchocerca volvulus | 0.0098 | 0.1287 | 0.3787 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0233 | 0.0419 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0018 | 0.007 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0062 | 0.0053 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0848 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.0726 | 0.254 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0848 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0233 | 0.0814 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.0848 | 1 |
Brugia malayi | steroid hormone receptor | 0.0021 | 0.0117 | 0.03 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0062 | 0.0215 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0233 | 0.0225 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0239 | 0.0732 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0642 | 0.2244 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0018 | 0.007 | 0.0062 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0217 | 0.0209 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0239 | 0.0231 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.