Detailed information for compound 621337

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 489.608 | Formula: C23H27N3O5S2
  • H donors: 0 H acceptors: 3 LogP: 2.94 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOCCn1c(=NC(=O)c2ccc(cc2)S(=O)(=O)N2CCOCC2)sc2c1ccc(c2)C
  • InChi: 1S/C23H27N3O5S2/c1-3-30-15-12-26-20-9-4-17(2)16-21(20)32-23(26)24-22(27)18-5-7-19(8-6-18)33(28,29)25-10-13-31-14-11-25/h4-9,16H,3,10-15H2,1-2H3/b24-23-
  • InChiKey: SPMFNXZSYJLJCO-VHXPQNKSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.1135 0.2783
Schistosoma mansoni ap endonuclease 0.0037 0.0253 0.0618
Brugia malayi Niemann-Pick C1 protein precursor 0.0106 0.1135 0.3686
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0397 0.2797
Brugia malayi Cytochrome P450 family protein 0.0022 0.0048 0.002
Plasmodium falciparum glutathione reductase 0.0047 0.0371 1
Echinococcus granulosus importin subunit beta 1 0.0029 0.014 0.0289
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0371 0.0347
Mycobacterium ulcerans hypothetical protein 0.0049 0.0397 0.2015
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0048 0.0017
Mycobacterium leprae Probable lipase LipE 0.0035 0.0224 0.1412
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0404 0.0951
Loa Loa (eye worm) glutathione reductase 0.0047 0.0371 0.0997
Mycobacterium ulcerans hypothetical protein 0.0035 0.0224 0.1018
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0397 0.2015
Echinococcus multilocularis protein patched 0.0045 0.0356 0.0332
Schistosoma mansoni cytochrome P450 0.0022 0.0048 0.0064
Schistosoma mansoni ap endonuclease 0.0037 0.0253 0.0618
Schistosoma mansoni hypothetical protein 0.0044 0.0335 0.0839
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0238 0.5959
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0048 0.0017
Entamoeba histolytica hypothetical protein 0.0039 0.0269 0.2072
Brugia malayi Bromodomain containing protein 0.0039 0.0268 0.0762
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0404 0.1087
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.358 1
Toxoplasma gondii ABC1 family protein 0.0035 0.0224 0.5314
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.007 0.0101
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0063 0.0104
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.358 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.1294 0.4748
Loa Loa (eye worm) hypothetical protein 0.0056 0.0488 0.1311
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.1294 0.4748
Mycobacterium tuberculosis Conserved protein 0.0035 0.0224 0.0671
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0397 0.1001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0404 0.1027
Loa Loa (eye worm) hypothetical protein 0.0035 0.0224 0.0603
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0213 0.0627
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0397 0.2015
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.1573 0.4327
Schistosoma mansoni hypothetical protein 0.0021 0.0039 0.0037
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0048 0.0017
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0392 0.0992
Schistosoma mansoni tar DNA-binding protein 0.0251 0.3007 0.8068
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0048 0.0017
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0371 0.0929
Schistosoma mansoni tar DNA-binding protein 0.0251 0.3007 0.8068
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0224 0.0603
Schistosoma mansoni patched 1 0.0045 0.0356 0.0896
Echinococcus multilocularis importin subunit beta 1 0.0029 0.014 0.0116
Trichomonas vaginalis importin beta-1, putative 0.0023 0.007 0.0101
Schistosoma mansoni hypothetical protein 0.0039 0.0269 0.0661
Onchocerca volvulus 0.0035 0.0224 0.0284
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0043 0.0018
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0224 0.0514
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2781 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0224 0.0603
Loa Loa (eye worm) RNA binding protein 0.0251 0.3007 0.8081
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0224 0.0664
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0397 0.1328
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0043 0.0114
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0238 0.0213
Schistosoma mansoni hypothetical protein 0.0044 0.0335 0.0839
Mycobacterium tuberculosis Conserved protein 0.0035 0.0224 0.0671
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1141 0.4165
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0547 0.1308
Mycobacterium tuberculosis Probable reductase 0.0106 0.1141 0.4165
Echinococcus granulosus tumor protein p63 0.0329 0.4015 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.0224 0.1018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0397 0.3241
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0224 0.0514
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0371 0.0938
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1573 0.4327
Onchocerca volvulus 0.0035 0.0224 0.0284
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0379 0.1133
Loa Loa (eye worm) hypothetical protein 0.0106 0.1135 0.3051
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0224 0.0664
Loa Loa (eye worm) hypothetical protein 0.0047 0.0371 0.0998
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.007 0.0101
Entamoeba histolytica hypothetical protein 0.0039 0.0269 0.2072
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1573 0.4327
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0253 0.077
Loa Loa (eye worm) hypothetical protein 0.0035 0.0224 0.0603
Brugia malayi CHE-14 protein 0.0045 0.0356 0.1057
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0224 0.0671
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0356 0.083
Brugia malayi RNA, U transporter 1 0.0082 0.0823 0.2631
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0224 0.02
Loa Loa (eye worm) beta-lactamase 0.0035 0.0224 0.0603
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0371 0.0938
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0306 0.0744
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0224 0.0671
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0048 0.0017
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0397 0.1195
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0397 0.1001
Leishmania major cytochrome p450-like protein 0.0022 0.0048 0.0017
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0397 0.2015
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0224 0.0664
Onchocerca volvulus 0.0048 0.0392 0.0919
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1141 0.4165
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0423 0.1076
Entamoeba histolytica hypothetical protein 0.0039 0.0269 0.2072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0224 0.0603
Brugia malayi Cytochrome P450 family protein 0.0022 0.0048 0.002
Loa Loa (eye worm) cytochrome P450 family protein 0.0138 0.1549 0.4161
Echinococcus granulosus tar DNA binding protein 0.0251 0.3007 0.7474
Brugia malayi Cytochrome P450 family protein 0.0022 0.0048 0.002
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0253 0.0596
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0048 0.0017
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0136 0.0278
Echinococcus granulosus expressed conserved protein 0.0099 0.1053 0.2576
Loa Loa (eye worm) hypothetical protein 0.0043 0.0325 0.0873
Onchocerca volvulus 0.0047 0.0379 0.087
Loa Loa (eye worm) hypothetical protein 0.0035 0.0224 0.0603
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 0.3722 1
Loa Loa (eye worm) TAR-binding protein 0.0251 0.3007 0.8081
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.1294 0.4748
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0224 0.1018
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0269 0.0612
Schistosoma mansoni tar DNA-binding protein 0.0251 0.3007 0.8068
Brugia malayi beta-lactamase family protein 0.0035 0.0224 0.0613
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0039 0.0104
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0641
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0238 0.1099
Brugia malayi Pre-SET motif family protein 0.0205 0.2415 0.8004
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.015 0.0125
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.015 0.0337
Leishmania major importin beta-1 subunit, putative 0.0023 0.007 0.0078
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0253 0.0229
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0043 0.0044
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0807
Leishmania major hypothetical protein, conserved 0.0035 0.0224 0.0514
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1141 0.4165
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.014 0.0276
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0404 0.1221
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0224 0.0671
Onchocerca volvulus 0.0234 0.2781 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0224 0.0664
Loa Loa (eye worm) hypothetical protein 0.0048 0.0392 0.1052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0404 0.0951
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0397 0.1001
Entamoeba histolytica hypothetical protein 0.0039 0.0269 0.2072
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0224 0.05
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0377
Brugia malayi Cytochrome P450 family protein 0.0138 0.1549 0.508
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.015 0.3128
Schistosoma mansoni hypothetical protein 0.0044 0.0335 0.0839
Echinococcus granulosus Niemann Pick C1 protein 0.0151 0.1721 0.4251
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0224 0.1018
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0397 0.2015
Leishmania major cytochrome p450-like protein 0.0022 0.0048 0.0017
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.014 0.2857
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0253 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0048 0.013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0253 0.0596
Loa Loa (eye worm) hypothetical protein 0.0071 0.069 0.1855
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0253 0.1186
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0404 0.0381
Schistosoma mansoni hypothetical protein 0.0044 0.0335 0.0839
Brugia malayi Importin beta-1 subunit 0.0029 0.014 0.033
Plasmodium falciparum thioredoxin reductase 0.0047 0.0371 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2672 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1141 0.4165
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0048 0.0059
Onchocerca volvulus 0.0035 0.0224 0.0284
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0397 0.3241
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0224 0.0671
Echinococcus multilocularis snurportin 1 0.0306 0.3722 0.3706
Brugia malayi Pre-SET motif family protein 0.0029 0.015 0.0361
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0397 0.1195
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.1294 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0547 0.0523
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0397 0.2015
Plasmodium vivax SET domain protein, putative 0.0029 0.015 0.3257
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0224 0.054
Echinococcus multilocularis expressed conserved protein 0.0099 0.1053 0.103
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0397 0.2797
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.358 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0238 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0213 0.0627
Onchocerca volvulus 0.0049 0.0397 0.0939
Brugia malayi hypothetical protein 0.0039 0.0269 0.0764
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1141 0.8772
Mycobacterium tuberculosis Conserved protein 0.0035 0.0224 0.0671
Loa Loa (eye worm) hypothetical protein 0.0035 0.0224 0.0603
Plasmodium falciparum importin beta, putative 0.0029 0.014 0.2974
Leishmania major trypanothione reductase 0.0047 0.0371 0.0929
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0108 0.1157 0.3061
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0253 0.193
Loa Loa (eye worm) hypothetical protein 0.0231 0.2753 0.7398
Entamoeba histolytica hypothetical protein 0.0023 0.007 0.0254
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0253 0.0782
Mycobacterium ulcerans lipase LipD 0.0035 0.0224 0.1018
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0397 0.3241
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.007 0.0078
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0224 0.5532
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0306 0.0744
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0356 0.083
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0397 0.2015
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0253 0.0711
Brugia malayi RNA recognition motif domain containing protein 0.0251 0.3007 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0224 0.0514
Toxoplasma gondii exonuclease III APE 0.0037 0.0253 0.6165
Loa Loa (eye worm) cytochrome P450 0.0022 0.0048 0.013
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0106 0.1135 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0306 0.0744
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.1135 0.1113
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0063 0.0097
Brugia malayi RNA binding protein 0.0251 0.3007 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.358 1
Brugia malayi beta-lactamase family protein 0.0035 0.0224 0.0613
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.014 0.0276
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0371 0.0997
Echinococcus multilocularis tumor protein p63 0.0329 0.4015 0.4
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0224 0.0671
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0213 0.0627
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0251 0.3007 0.8081
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0048 0.0017
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0356 0.0957
Toxoplasma gondii hypothetical protein 0.0048 0.0385 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0238 0.0724
Schistosoma mansoni hypothetical protein 0.0022 0.0048 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0213 0.0627
Loa Loa (eye worm) hypothetical protein 0.0045 0.0356 0.0957
Brugia malayi beta-lactamase 0.0035 0.0224 0.0613
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0224 0.054
Brugia malayi cytochrome P450 0.0022 0.0048 0.002
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2415 0.6491
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0371 0.123
Brugia malayi Thioredoxin reductase 0.0047 0.0371 0.1108
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0371 0.0868
Echinococcus multilocularis tar DNA binding protein 0.0251 0.3007 0.299
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0238 0.5959
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0048 0.013
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0356 0.0332
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0397 0.2015
Leishmania major cytochrome p450-like protein 0.0022 0.0048 0.0017
Schistosoma mansoni bromodomain containing protein 0.0064 0.0593 0.1538
Schistosoma mansoni importin beta-1 0.0029 0.014 0.0312
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0371 0.0347
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0253 0.5
Schistosoma mansoni ran 0.0021 0.0043 0.0048
Schistosoma mansoni survival motor neuron protein 0.0047 0.0379 0.0957
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.1777 0.6589
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0253 0.6418
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0224 0.0671
Brugia malayi PHD-finger family protein 0.0025 0.0094 0.0174
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.015 0.0337
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0641
Brugia malayi hypothetical protein 0.0231 0.2753 0.9143
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0253 0.6418
Loa Loa (eye worm) hypothetical protein 0.0049 0.0397 0.1066
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0253 0.0681
Trypanosoma brucei trypanothione reductase 0.0047 0.0371 0.0929
Schistosoma mansoni hypothetical protein 0.0306 0.3722 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0253 0.0596
Echinococcus multilocularis protein dispatched 1 0.0052 0.0439 0.0415
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0253 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0641
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0253 0.0573
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0048 0.0017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0253 0.0596
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0253 0.077
Brugia malayi Bromodomain containing protein 0.0076 0.0746 0.2372
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0063 0.0039
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0397 0.1328
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0404 0.1027
Echinococcus multilocularis 0.0022 0.0048 0.0024
Plasmodium vivax glutathione reductase, putative 0.0047 0.0371 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0371 0.0869
Brugia malayi glutathione reductase 0.0047 0.0371 0.1108
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.2753 0.6837
Schistosoma mansoni ran 0.0021 0.0043 0.0048
Toxoplasma gondii thioredoxin reductase 0.0047 0.0371 0.9605
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0224 0.1412
Trichomonas vaginalis esterase, putative 0.0035 0.0224 0.0664
Echinococcus multilocularis Niemann Pick C1 protein 0.0151 0.1721 0.1701
Mycobacterium ulcerans hypothetical protein 0.0156 0.1777 1
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0371 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0048 0.0171
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0404 0.1027
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0269 0.0245
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0306 0.0744
Plasmodium vivax importin-beta 2, putative 0.0029 0.014 0.2974
Loa Loa (eye worm) hypothetical protein 0.0049 0.0397 0.1066
Loa Loa (eye worm) hypothetical protein 0.0049 0.0397 0.1066
Schistosoma mansoni hypothetical protein 0.0047 0.0379 0.0957
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0048 0.013
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0641
Brugia malayi TAR-binding protein 0.0251 0.3007 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1141 0.4165
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0224 0.0671
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0224 0.0613
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0404 0.0381
Echinococcus granulosus snurportin 1 0.0306 0.3722 0.9264
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0641
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0356 0.1145
Schistosoma mansoni tar DNA-binding protein 0.0251 0.3007 0.8068
Loa Loa (eye worm) hypothetical protein 0.0039 0.0269 0.0724
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0224 0.0664
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.2753 0.2735
Schistosoma mansoni tar DNA-binding protein 0.0251 0.3007 0.8068
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0269 0.0661
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0238 0.0533
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0397 0.1195

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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