Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.351 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0135 | 0.3185 | 0.3185 |
Schistosoma mansoni | hypothetical protein | 0.0135 | 0.3185 | 0.8832 |
Echinococcus multilocularis | tar DNA binding protein | 0.0072 | 0.1297 | 0.1297 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0056 | 0.0815 | 0.6285 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0146 | 0.351 | 0.351 |
Echinococcus granulosus | tar DNA binding protein | 0.0072 | 0.1297 | 0.1297 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0072 | 0.1297 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0891 | 0.6872 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0032 | 0.0095 | 0.0731 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0135 | 0.3185 | 0.3185 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.1297 | 0.2047 |
Schistosoma mansoni | intermediate filament proteins | 0.0059 | 0.0924 | 0.0706 |
Loa Loa (eye worm) | TAR-binding protein | 0.0072 | 0.1297 | 1 |
Echinococcus granulosus | lamin | 0.0059 | 0.0924 | 0.0924 |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.351 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0072 | 0.1297 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.1297 | 0.2047 |
Echinococcus multilocularis | musashi | 0.0059 | 0.0924 | 0.0924 |
Echinococcus granulosus | intermediate filament protein | 0.0059 | 0.0924 | 0.0924 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.1297 | 0.2047 |
Loa Loa (eye worm) | intermediate filament protein | 0.0059 | 0.0924 | 0.7124 |
Brugia malayi | Cytochrome P450 family protein | 0.0056 | 0.0815 | 0.5991 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0059 | 0.0924 | 0.6897 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0728 | 0.561 |
Echinococcus multilocularis | lamin | 0.0059 | 0.0924 | 0.0924 |
Loa Loa (eye worm) | RNA binding protein | 0.0072 | 0.1297 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0362 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0059 | 0.0924 | 0.0924 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.1297 | 0.2047 |
Schistosoma mansoni | lamin | 0.0059 | 0.0924 | 0.0706 |
Brugia malayi | TAR-binding protein | 0.0072 | 0.1297 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0924 | 0.7124 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0059 | 0.0924 | 0.7124 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.1297 | 0.2047 |
Onchocerca volvulus | 0.0059 | 0.0924 | 1 | |
Schistosoma mansoni | lamin | 0.0059 | 0.0924 | 0.0706 |
Echinococcus granulosus | lamin dm0 | 0.0059 | 0.0924 | 0.0924 |
Brugia malayi | RNA binding protein | 0.0072 | 0.1297 | 1 |
Brugia malayi | intermediate filament protein | 0.0059 | 0.0924 | 0.6897 |
Onchocerca volvulus | 0.0059 | 0.0924 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.