Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | D-aminoacylase, putative | 0.0108 | 0.0613 | 0.5 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0054 | 0.0213 | 0.0141 |
Mycobacterium leprae | conserved hypothetical protein | 0.0108 | 0.0613 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0112 | 0.0642 | 0.2363 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0075 | 0.0374 | 0.1377 |
Brugia malayi | beta-lactamase family protein | 0.0108 | 0.0613 | 0.226 |
Mycobacterium tuberculosis | Conserved protein | 0.0108 | 0.0613 | 0.1246 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0108 | 0.0613 | 0.1246 |
Plasmodium vivax | hypothetical protein, conserved | 0.0108 | 0.0613 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0108 | 0.0613 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0103 | 0.0574 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0108 | 0.0613 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0108 | 0.0613 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0391 | 0.2715 | 1 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.0628 | 0.2102 |
Mycobacterium tuberculosis | Conserved protein | 0.0108 | 0.0613 | 0.1246 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.006 | 0.0257 | 0.0947 |
Toxoplasma gondii | ABC1 family protein | 0.0108 | 0.0613 | 1 |
Onchocerca volvulus | 0.0201 | 0.1305 | 1 | |
Brugia malayi | cytoplasmic intermediate filament protein | 0.006 | 0.0257 | 0.0947 |
Schistosoma mansoni | intermediate filament proteins | 0.0112 | 0.0642 | 0.2152 |
Echinococcus multilocularis | tar DNA binding protein | 0.0391 | 0.2715 | 0.2661 |
Loa Loa (eye worm) | TAR-binding protein | 0.0391 | 0.2715 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0391 | 0.2715 | 1 |
Brugia malayi | TAR-binding protein | 0.0391 | 0.2715 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0046 | 0.0155 | 0.0083 |
Loa Loa (eye worm) | RNA binding protein | 0.0391 | 0.2715 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0108 | 0.0613 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0108 | 0.0613 | 0.1246 |
Brugia malayi | hypothetical protein | 0.0103 | 0.0574 | 0.2116 |
Echinococcus multilocularis | lamin dm0 | 0.0112 | 0.0642 | 0.0573 |
Schistosoma mansoni | lamin | 0.0112 | 0.0642 | 0.2152 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0613 | 0.226 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0574 | 0.2116 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0108 | 0.0613 | 0.0544 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0108 | 0.0613 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0108 | 0.0613 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0213 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0613 | 0.226 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0198 | 0.0729 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0305 | 0.1123 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0259 | 0.1738 | 0.6402 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0112 | 0.0642 | 0.2363 |
Leishmania major | hypothetical protein, conserved | 0.0108 | 0.0613 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0054 | 0.0213 | 0.0141 |
Brugia malayi | MH2 domain containing protein | 0.0259 | 0.1738 | 0.6402 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0613 | 0.226 |
Onchocerca volvulus | 0.0108 | 0.0613 | 0.4702 | |
Echinococcus multilocularis | tumor protein p63 | 0.1373 | 1 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0108 | 0.0613 | 0.1246 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0613 | 0.226 |
Loa Loa (eye worm) | intermediate filament protein | 0.0112 | 0.0642 | 0.2363 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.011 | 0.0628 | 0.0559 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0035 | 0.0073 | 0.0269 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.011 | 0.0628 | 0.0559 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.1305 | 0.4805 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0073 | 0.0269 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0259 | 0.1738 | 0.6402 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0108 | 0.0613 | 0.1246 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0108 | 0.0613 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0108 | 0.0613 | 0.0544 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0046 | 0.0155 | 0.0083 |
Echinococcus granulosus | tar DNA binding protein | 0.0391 | 0.2715 | 0.2661 |
Onchocerca volvulus | 0.0112 | 0.0642 | 0.4917 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0391 | 0.2715 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0108 | 0.0613 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0642 | 0.2363 |
Schistosoma mansoni | tar DNA-binding protein | 0.0391 | 0.2715 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0103 | 0.0574 | 0.9363 |
Schistosoma mansoni | tar DNA-binding protein | 0.0391 | 0.2715 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0613 | 0.226 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.0628 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0103 | 0.0574 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0112 | 0.0642 | 0.0573 |
Loa Loa (eye worm) | beta-lactamase | 0.0108 | 0.0613 | 0.226 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.0628 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0391 | 0.2715 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0108 | 0.0613 | 0.226 |
Onchocerca volvulus | 0.0108 | 0.0613 | 0.4702 | |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0374 | 0.1139 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.011 | 0.0633 | 0.2332 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0108 | 0.0613 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0035 | 0.0073 | 0.0269 |
Mycobacterium ulcerans | beta-lactamase | 0.0108 | 0.0613 | 1 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.0628 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0374 | 0.1377 |
Mycobacterium ulcerans | lipase LipD | 0.0108 | 0.0613 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0626 | 0.2307 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0613 | 0.226 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0689 | 0.4923 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0108 | 0.0613 | 0.2046 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0108 | 0.0613 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.011 | 0.0628 | 0.2102 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0633 | 0.2332 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0108 | 0.0613 | 0.1246 |
Brugia malayi | RNA binding protein | 0.0391 | 0.2715 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0112 | 0.0642 | 0.0573 |
Echinococcus multilocularis | musashi | 0.0112 | 0.0642 | 0.0573 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.011 | 0.0633 | 0.2332 |
Echinococcus granulosus | lamin | 0.0112 | 0.0642 | 0.0573 |
Brugia malayi | hypothetical protein | 0.011 | 0.0628 | 0.2314 |
Brugia malayi | beta-lactamase | 0.0108 | 0.0613 | 0.226 |
Onchocerca volvulus | 0.0108 | 0.0613 | 0.4702 | |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0198 | 0.0729 |
Brugia malayi | intermediate filament protein | 0.0112 | 0.0642 | 0.2363 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0201 | 0.1305 | 0.4662 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0108 | 0.0613 | 1 |
Onchocerca volvulus | 0.0112 | 0.0642 | 0.4917 | |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0108 | 0.0613 | 0.1246 |
Echinococcus multilocularis | lamin | 0.0112 | 0.0642 | 0.0573 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0108 | 0.0613 | 0.2046 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0035 | 0.0073 | 0.0269 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0108 | 0.0613 | 0.226 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.011 | 0.0633 | 0.2332 |
Mycobacterium tuberculosis | Conserved protein | 0.0108 | 0.0613 | 0.1246 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0391 | 0.2715 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0108 | 0.0613 | 0.1246 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0108 | 0.0613 | 0.226 |
Schistosoma mansoni | lamin | 0.0112 | 0.0642 | 0.2152 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.0628 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0108 | 0.0613 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0155 | 0.031 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.