TDR Targets

Basic information

Technical information

TDR Targets ID: 621452
Name: 2-furan-2-yl-5-(4-propan-2-ylphenyl)-5,10b-di hydro-1H-pyrazolo[1,5-c][1,3]benzoxazine
MW: 358.433 | Formula: C23H22N2O2
H donors: 0 H acceptors: 0 LogP: 5.36 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(c1ccc(cc1)C1Oc2ccccc2C2N1N=C(C2)c1ccco1)C
InChi: 1S/C23H22N2O2/c1-15(2)16-9-11-17(12-10-16)23-25-20(18-6-3-4-7-21(18)27-23)14-19(24-25)22-8-5-13-26-22/h3-13,15,20,23H,14H2,1-2H3
InChiKey: RWCQBUWGKJOPGW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(2-furyl)-5-(4-isopropylphenyl)-5,10b-dihydro-1H-pyrazolo[1,5-c][1,3]benzoxazine
EU-0077174

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0422	0.0945
Brugia malayi	hypothetical protein	0.0051	0.0374	0.0837
Schistosoma mansoni	hypothetical protein	0.0075	0.0716	0.1317
Schistosoma mansoni	transcription factor LCR-F1	0.0075	0.0716	0.1317
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0073	0.0681	0.1525
Brugia malayi	beta-lactamase family protein	0.0073	0.0681	0.1525
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0073	0.0681	0.1074
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.0681	0.5
Echinococcus granulosus	lamin	0.0113	0.127	0.1139
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0392	0.0877
Echinococcus multilocularis	musashi	0.0113	0.127	0.1139
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.0681	0.1236
Trypanosoma brucei	PAB1-binding protein , putative	0.008	0.0782	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0049	0.0345	0.0773
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0055	0.0422	0.0279
Echinococcus multilocularis	tumor protein p63	0.0717	1	1
Brugia malayi	Latrophilin receptor protein 2	0.0049	0.0345	0.0773
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0049	0.0345	0.0201
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0156	0.1888	0.4229
Loa Loa (eye worm)	intermediate filament protein	0.0113	0.127	0.2844
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0049	0.0345	0.0201
Brugia malayi	cytoplasmic intermediate filament protein	0.0061	0.0509	0.1139
Loa Loa (eye worm)	hypothetical protein	0.0113	0.127	0.2844
Loa Loa (eye worm)	hypothetical protein	0.0111	0.124	0.2776
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0156	0.1888	0.4229
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.0681	0.1236
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0681	0.1525
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0055	0.0422	0.0279
Onchocerca volvulus		0.0113	0.127	1
Echinococcus granulosus	lamin dm0	0.0113	0.127	0.1139
Schistosoma mansoni	lamin	0.0113	0.127	0.26
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0681	0.1525
Mycobacterium leprae	conserved hypothetical protein	0.0073	0.0681	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0113	0.127	0.2844
Brugia malayi	TAR-binding protein	0.0334	0.4465	1
Schistosoma mansoni	tar DNA-binding protein	0.0334	0.4465	1
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0681	0.1074
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0073	0.0681	0.1525
Brugia malayi	RNA binding protein	0.0334	0.4465	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.008	0.0782	1
Brugia malayi	hypothetical protein	0.008	0.0782	0.1751
Schistosoma mansoni	hypothetical protein	0.0107	0.1174	0.2379
Loa Loa (eye worm)	transcription factor SMAD2	0.0259	0.3381	0.7572
Echinococcus granulosus	beta LACTamase domain containing family member	0.0073	0.0681	0.0542
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.0681	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0075	0.0716	0.0577
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0073	0.0681	1
Mycobacterium ulcerans	lipase LipD	0.0073	0.0681	1
Loa Loa (eye worm)	TAR-binding protein	0.0334	0.4465	1
Brugia malayi	MH2 domain containing protein	0.0259	0.3381	0.7572
Brugia malayi	intermediate filament protein	0.0113	0.127	0.2844
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0334	0.4465	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0107	0.1174	0.263
Schistosoma mansoni	tar DNA-binding protein	0.0334	0.4465	1
Schistosoma mansoni	hypothetical protein	0.0049	0.0345	0.0459
Onchocerca volvulus		0.0113	0.127	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0061	0.0509	0.1139
Onchocerca volvulus		0.0073	0.0681	0.5363
Entamoeba histolytica	hypothetical protein	0.0075	0.0716	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0049	0.0345	0.0201
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0073	0.0681	0.1074
Brugia malayi	hypothetical protein	0.0075	0.0716	0.1603
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0073	0.0681	0.1074
Schistosoma mansoni	lamin	0.0113	0.127	0.26
Echinococcus multilocularis	GPCR, family 2	0.0049	0.0345	0.0201
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0049	0.0345	0.0201
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0049	0.0345	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0681	0.1525
Schistosoma mansoni	tar DNA-binding protein	0.0334	0.4465	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0345	0.0773
Brugia malayi	Intermediate filament tail domain containing protein	0.0113	0.127	0.2844
Plasmodium vivax	ataxin-2 like protein, putative	0.008	0.0782	1
Trichomonas vaginalis	esterase, putative	0.0073	0.0681	0.5
Mycobacterium leprae	Probable lipase LipE	0.0073	0.0681	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0073	0.0681	0.1074
Onchocerca volvulus		0.0105	0.1149	0.9047
Mycobacterium ulcerans	beta-lactamase	0.0073	0.0681	1
Loa Loa (eye worm)	beta-lactamase	0.0073	0.0681	0.1525
Schistosoma mansoni	cellular tumor antigen P53	0.0105	0.1149	0.232
Brugia malayi	beta-lactamase	0.0073	0.0681	0.1525
Loa Loa (eye worm)	RNA binding protein	0.0334	0.4465	1
Schistosoma mansoni	tar DNA-binding protein	0.0334	0.4465	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.1149	0.2572
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0073	0.0681	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1174	0.263
Schistosoma mansoni	hypothetical protein	0.0049	0.0345	0.0459
Mycobacterium tuberculosis	Probable lipase LipE	0.0073	0.0681	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0681	0.1525
Echinococcus multilocularis	lamin dm0	0.0113	0.127	0.1139
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0681	0.5
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0681	0.1074
Plasmodium falciparum	ataxin-2 like protein, putative	0.008	0.0782	0.5
Entamoeba histolytica	hypothetical protein	0.0075	0.0716	1
Schistosoma mansoni	hypothetical protein	0.0049	0.0345	0.0459
Mycobacterium tuberculosis	Probable hydrolase	0.0073	0.0681	0.1074
Leishmania major	hypothetical protein, conserved	0.0073	0.0681	0.8711
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0681	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0392	0.0877
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0075	0.0716	0.0577
Mycobacterium tuberculosis	Probable lipase LipD	0.0073	0.0681	0.1074
Loa Loa (eye worm)	hypothetical protein	0.008	0.0782	0.1751
Mycobacterium ulcerans	hypothetical protein	0.0073	0.0681	1
Echinococcus granulosus	tar DNA binding protein	0.0334	0.4465	0.4382
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0681	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0259	0.3381	0.7572
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0681	0.1525
Onchocerca volvulus		0.0073	0.0681	0.5363
Leishmania major	hypothetical protein, conserved	0.008	0.0782	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0156	0.1888	0.4229
Echinococcus multilocularis	tar DNA binding protein	0.0334	0.4465	0.4382
Entamoeba histolytica	hypothetical protein	0.0075	0.0716	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0464	0.6339	1
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0681	0.1074
Toxoplasma gondii	LsmAD domain-containing protein	0.008	0.0782	1
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1888	0.4229
Schistosoma mansoni	hypothetical protein	0.0049	0.0345	0.0459
Onchocerca volvulus		0.0073	0.0681	0.5363
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0681	0.1525
Schistosoma mansoni	tar DNA-binding protein	0.0334	0.4465	1
Echinococcus multilocularis	lamin	0.0113	0.127	0.1139
Entamoeba histolytica	hypothetical protein	0.0075	0.0716	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0073	0.0681	1
Brugia malayi	beta-lactamase family protein	0.0073	0.0681	0.1525
Brugia malayi	RNA recognition motif domain containing protein	0.0334	0.4465	1
Schistosoma mansoni	intermediate filament proteins	0.0113	0.127	0.26
Echinococcus granulosus	intermediate filament protein	0.0113	0.127	0.1139
Plasmodium falciparum	ataxin-2 like protein, putative	0.008	0.0782	0.5
Trypanosoma cruzi	PAB1-binding protein , putative	0.008	0.0782	1
Echinococcus granulosus	GPCR family 2	0.0049	0.0345	0.0201

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 621452