Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable lipase LipD | 0.0074 | 0.07 | 0.1085 |
Mycobacterium ulcerans | beta-lactamase | 0.0074 | 0.07 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0716 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.011 | 0.1221 | 0.2178 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.1167 | 0.2251 |
Onchocerca volvulus | 0.0109 | 0.121 | 1 | |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.0118 | 0.0228 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.0118 | 0.0228 |
Echinococcus granulosus | intermediate filament protein | 0.0109 | 0.121 | 0.1105 |
Onchocerca volvulus | 0.0074 | 0.07 | 0.5786 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0248 | 0.3223 | 0.6219 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.1221 | 1 |
Onchocerca volvulus | 0.0074 | 0.07 | 0.5786 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0248 | 0.3223 | 0.6219 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0394 | 0.076 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0074 | 0.07 | 0.1085 |
Loa Loa (eye worm) | beta-lactamase | 0.0074 | 0.07 | 0.1351 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0074 | 0.07 | 0.1085 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.07 | 0.1351 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0365 | 0.0705 |
Brugia malayi | hypothetical protein | 0.0065 | 0.0567 | 0.1094 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0074 | 0.07 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0074 | 0.07 | 0.1351 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0053 | 0.0394 | 0.0279 |
Brugia malayi | beta-lactamase | 0.0074 | 0.07 | 0.1351 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.07 | 0.1351 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0074 | 0.07 | 1 |
Onchocerca volvulus | 0.0109 | 0.121 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.1221 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0384 | 0.5183 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0384 | 0.5183 | 1 |
Brugia malayi | TAR-binding protein | 0.0384 | 0.5183 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0282 | 0.0323 |
Loa Loa (eye worm) | TAR-binding protein | 0.0384 | 0.5183 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0384 | 0.5183 | 0.5125 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.01 | 0.108 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0074 | 0.07 | 0.0589 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0074 | 0.07 | 0.0589 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0058 | 0.0478 | 0.0922 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.1221 | 0.2178 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0058 | 0.0478 | 0.0922 |
Echinococcus multilocularis | musashi | 0.0109 | 0.121 | 0.1105 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.07 | 0.1351 |
Mycobacterium ulcerans | hypothetical protein | 0.0074 | 0.07 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.07 | 0.1085 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.07 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0074 | 0.07 | 0.1351 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1167 | 0.2251 |
Echinococcus multilocularis | tar DNA binding protein | 0.0384 | 0.5183 | 0.5125 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.01 | 0.108 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0074 | 0.07 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.0682 | 0.1315 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.07 | 0.5 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0053 | 0.0394 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.121 | 0.2335 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0074 | 0.07 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.07 | 0.1085 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0384 | 0.5183 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0074 | 0.07 | 0.6484 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.07 | 0.5 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0045 | 0.0282 | 0.0166 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.01 | 0.108 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.011 | 0.1221 | 0.1116 |
Schistosoma mansoni | lamin | 0.0109 | 0.121 | 0.2156 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.01 | 0.108 | 1 |
Echinococcus multilocularis | lamin | 0.0109 | 0.121 | 0.1105 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0074 | 0.07 | 0.1085 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0365 | 0.0705 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.1221 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0109 | 0.121 | 0.1105 |
Onchocerca volvulus | 0.0105 | 0.115 | 0.9507 | |
Leishmania major | hypothetical protein, conserved | 0.01 | 0.108 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.1167 | 0.2251 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0074 | 0.07 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0074 | 0.07 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0118 | 0.0228 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.07 | 0.1351 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.011 | 0.1221 | 0.1116 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.07 | 0.1351 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0105 | 0.115 | 0.2038 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.1221 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0074 | 0.07 | 0.1085 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.115 | 0.2219 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0074 | 0.07 | 0.1351 |
Brugia malayi | intermediate filament protein | 0.0109 | 0.121 | 0.2335 |
Echinococcus multilocularis | lamin dm0 | 0.0109 | 0.121 | 0.1105 |
Schistosoma mansoni | tar DNA-binding protein | 0.0384 | 0.5183 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0109 | 0.121 | 0.2335 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0109 | 0.121 | 0.2335 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.01 | 0.108 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0471 | 0.6451 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0074 | 0.07 | 0.1149 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0682 | 0.1112 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.01 | 0.108 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.01 | 0.108 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.1167 | 0.2251 |
Brugia malayi | RNA binding protein | 0.0384 | 0.5183 | 1 |
Onchocerca volvulus | 0.0074 | 0.07 | 0.5786 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0074 | 0.07 | 0.1351 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.108 | 0.2084 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.0118 | 0.0228 |
Schistosoma mansoni | intermediate filament proteins | 0.0109 | 0.121 | 0.2156 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0682 | 0.1315 |
Schistosoma mansoni | tar DNA-binding protein | 0.0384 | 0.5183 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.07 | 0.1351 |
Trichomonas vaginalis | esterase, putative | 0.0074 | 0.07 | 0.5 |
Schistosoma mansoni | lamin | 0.0109 | 0.121 | 0.2156 |
Schistosoma mansoni | tar DNA-binding protein | 0.0384 | 0.5183 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0074 | 0.07 | 0.1149 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0109 | 0.121 | 0.2335 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1181 | 0.2279 |
Brugia malayi | hypothetical protein | 0.01 | 0.108 | 0.2084 |
Mycobacterium leprae | conserved hypothetical protein | 0.0074 | 0.07 | 1 |
Echinococcus granulosus | lamin | 0.0109 | 0.121 | 0.1105 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0074 | 0.07 | 0.1085 |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.07 | 0.1085 |
Brugia malayi | MH2 domain containing protein | 0.0248 | 0.3223 | 0.6219 |
Schistosoma mansoni | tar DNA-binding protein | 0.0384 | 0.5183 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0074 | 0.07 | 0.1085 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0045 | 0.0282 | 0.0166 |
Schistosoma mansoni | tar DNA-binding protein | 0.0384 | 0.5183 | 1 |
Brugia malayi | hypothetical protein | 0.011 | 0.1221 | 0.2356 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.