Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0114 | 0.0113 |
Loa Loa (eye worm) | intermediate filament protein | 0.0086 | 0.096 | 0.1999 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0114 | 0.0113 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.1157 | 0.2409 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.1157 | 0.2409 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0456 | 0.0949 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0175 | 0.0365 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0175 | 0.0563 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0175 | 0.0365 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0272 | 0.0567 |
Echinococcus multilocularis | musashi | 0.0086 | 0.096 | 0.0959 |
Onchocerca volvulus | 0.0098 | 0.1149 | 1 | |
Brugia malayi | RNA binding protein | 0.0333 | 0.4802 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0333 | 0.4802 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0333 | 0.4802 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0333 | 0.4802 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0175 | 0.0365 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0175 | 0.0365 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0175 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0114 | 0.0237 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0175 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.1157 | 0.2409 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0175 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0175 | 0.0563 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0175 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0333 | 0.4802 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0456 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0175 | 1 |
Onchocerca volvulus | 0.0035 | 0.0175 | 0.1525 | |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.0456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.096 | 0.1999 |
Echinococcus granulosus | lamin dm0 | 0.0086 | 0.096 | 0.0959 |
Echinococcus granulosus | lamin | 0.0086 | 0.096 | 0.0959 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0163 | 0.034 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0456 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.1157 | 0.2409 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0175 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0248 | 0.0517 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.0717 | 1 |
Onchocerca volvulus | 0.0035 | 0.0175 | 0.1525 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0248 | 0.0517 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0717 | 0.1492 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0175 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0936 | 0.1949 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0175 | 0.3843 |
Echinococcus granulosus | tar DNA binding protein | 0.0333 | 0.4802 | 0.4802 |
Echinococcus multilocularis | lamin | 0.0086 | 0.096 | 0.0959 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0053 | 0.0456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0674 | 0.1404 |
Loa Loa (eye worm) | TAR-binding protein | 0.0333 | 0.4802 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0114 | 0.0235 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0674 | 0.1402 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0086 | 0.096 | 0.1999 |
Echinococcus multilocularis | tar DNA binding protein | 0.0333 | 0.4802 | 0.4802 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0333 | 0.4802 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0175 | 0.0563 |
Schistosoma mansoni | lamin | 0.0086 | 0.096 | 0.1998 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0175 | 0.0563 |
Onchocerca volvulus | 0.0086 | 0.096 | 0.8359 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.0456 | 0.5 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0041 | 0.0272 | 0.0272 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0114 | 0.0237 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0242 | 0.3381 | 0.7041 |
Schistosoma mansoni | tar DNA-binding protein | 0.0333 | 0.4802 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0333 | 0.4802 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0114 | 0.0235 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0114 | 0.0237 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0175 | 0.0563 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0175 | 0.0365 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0114 | 0.0113 |
Echinococcus multilocularis | tumor protein p63 | 0.0668 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.0717 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0086 | 0.096 | 0.1998 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0046 | 0.0343 | 0.0714 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0224 | 0.3108 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0041 | 0.0272 | 0.0272 |
Brugia malayi | MH2 domain containing protein | 0.0242 | 0.3381 | 0.7041 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0175 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0175 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0175 | 0.0365 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0175 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0175 | 0.0174 |
Onchocerca volvulus | 0.0035 | 0.0175 | 0.1525 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0175 | 0.0365 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0175 | 0.0363 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0114 | 0.0113 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0114 | 0.0235 |
Brugia malayi | TAR-binding protein | 0.0333 | 0.4802 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0053 | 0.0456 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0086 | 0.096 | 0.1999 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0175 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0175 | 0.0563 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.0717 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.0674 | 0.1404 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0175 | 0.0365 |
Schistosoma mansoni | lamin | 0.0086 | 0.096 | 0.1998 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0175 | 0.0563 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0175 | 0.0365 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0242 | 0.3381 | 0.7041 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0114 | 0.0113 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0175 | 0.0563 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0053 | 0.0456 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.0456 | 0.5 |
Brugia malayi | hypothetical protein | 0.007 | 0.0717 | 0.1494 |
Echinococcus granulosus | intermediate filament protein | 0.0086 | 0.096 | 0.0959 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0098 | 0.1149 | 0.2391 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0175 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0114 | 0.0237 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0114 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.1149 | 0.2392 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.007 | 0.0717 | 0.1492 |
Onchocerca volvulus | 0.0086 | 0.096 | 0.8359 | |
Echinococcus multilocularis | lamin dm0 | 0.0086 | 0.096 | 0.0959 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0175 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0333 | 0.4802 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.007 | 0.0717 | 0.0716 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0456 | 0.0949 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0175 | 0.0365 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0114 | 0.0113 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0046 | 0.0343 | 0.0714 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0175 | 0.0563 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0175 | 0.0365 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0175 | 0.0365 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.007 | 0.0717 | 0.0716 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0175 | 0.0363 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.0717 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0175 | 0.0563 |
Brugia malayi | intermediate filament protein | 0.0086 | 0.096 | 0.1999 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0175 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.