Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.0456 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0175 | 0.0366 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0175 | 0.0368 |
Schistosoma mansoni | tar DNA-binding protein | 0.0337 | 0.4757 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0086 | 0.0937 | 0.0936 |
Brugia malayi | hypothetical protein | 0.0071 | 0.0717 | 0.1507 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0717 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0175 | 0.3842 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0175 | 0.0563 |
Echinococcus granulosus | intermediate filament protein | 0.0086 | 0.0937 | 0.0936 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0175 | 0.0174 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0175 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0175 | 0.0368 |
Onchocerca volvulus | 0.0086 | 0.0937 | 0.8154 | |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0717 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0681 | 1 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0041 | 0.0261 | 0.026 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0346 | 0.0725 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0164 | 0.0344 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0246 | 0.3381 | 0.7107 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0346 | 0.0345 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.3108 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.0346 | 0.0726 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0175 | 0.0366 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0175 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0175 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0175 | 0.0563 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0175 | 0.5 |
Onchocerca volvulus | 0.0036 | 0.0175 | 0.1525 | |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0175 | 0.0563 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0175 | 1 |
Brugia malayi | hypothetical protein | 0.0054 | 0.0456 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0913 | 0.1919 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0175 | 0.0368 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0175 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0175 | 0.0563 |
Loa Loa (eye worm) | RNA binding protein | 0.0337 | 0.4757 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0175 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.0346 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0261 | 0.0549 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0175 | 0.0563 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0086 | 0.0937 | 0.1969 |
Echinococcus multilocularis | musashi | 0.0086 | 0.0937 | 0.0936 |
Onchocerca volvulus | 0.0036 | 0.0175 | 0.1525 | |
Schistosoma mansoni | cellular tumor antigen P53 | 0.01 | 0.1149 | 0.2413 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0346 | 0.0725 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0046 | 0.033 | 0.0694 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0054 | 0.0456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0175 | 0.0368 |
Onchocerca volvulus | 0.0036 | 0.0175 | 0.1525 | |
Brugia malayi | MH2 domain containing protein | 0.0246 | 0.3381 | 0.7107 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0175 | 0.0563 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0175 | 0.0368 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0101 | 0.1175 | 0.247 |
Onchocerca volvulus | 0.0086 | 0.0937 | 0.8154 | |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0717 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0054 | 0.0456 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1175 | 0.2469 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0175 | 0.0368 |
Schistosoma mansoni | intermediate filament proteins | 0.0086 | 0.0937 | 0.1967 |
Echinococcus granulosus | lamin dm0 | 0.0086 | 0.0937 | 0.0936 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0717 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0337 | 0.4757 | 1 |
Brugia malayi | RNA binding protein | 0.0337 | 0.4757 | 1 |
Brugia malayi | TAR-binding protein | 0.0337 | 0.4757 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0337 | 0.4757 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0175 | 0.0368 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0148 | 0.189 | 0.3972 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0175 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0175 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0346 | 0.0725 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0175 | 0.0563 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0054 | 0.0456 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0337 | 0.4757 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.0346 | 0.0345 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0346 | 0.0345 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0175 | 0.0563 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0046 | 0.033 | 0.0694 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0175 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0175 | 0.0368 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0175 | 0.0368 |
Loa Loa (eye worm) | intermediate filament protein | 0.0086 | 0.0937 | 0.1969 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0148 | 0.189 | 0.3972 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0054 | 0.0456 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0175 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.189 | 0.3972 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0175 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0041 | 0.0261 | 0.026 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1175 | 0.247 |
Schistosoma mansoni | lamin | 0.0086 | 0.0937 | 0.1967 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0346 | 0.0345 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.0717 | 0.1505 |
Leishmania major | hypothetical protein, conserved | 0.0054 | 0.0456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0937 | 0.1969 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0086 | 0.0937 | 0.1969 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0175 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0717 | 0.1505 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0337 | 0.4757 | 1 |
Echinococcus granulosus | lamin | 0.0086 | 0.0937 | 0.0936 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.0456 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0237 | 0.0498 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0337 | 0.4757 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0175 | 0.0563 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.1149 | 0.2414 |
Schistosoma mansoni | tar DNA-binding protein | 0.0337 | 0.4757 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0337 | 0.4757 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0175 | 0.0368 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0175 | 0.0368 |
Echinococcus granulosus | tar DNA binding protein | 0.0337 | 0.4757 | 0.4757 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0246 | 0.3381 | 0.7107 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0175 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0346 | 0.0726 |
Onchocerca volvulus | 0.01 | 0.1149 | 1 | |
Echinococcus multilocularis | lamin | 0.0086 | 0.0937 | 0.0936 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0456 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0237 | 0.0498 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.0346 | 0.0726 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.0346 | 0.0345 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.0717 | 0.0716 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0346 | 0.0725 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0148 | 0.189 | 0.3972 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0175 | 0.0174 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0054 | 0.0456 | 1 |
Schistosoma mansoni | lamin | 0.0086 | 0.0937 | 0.1967 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.0717 | 0.0716 |
Echinococcus multilocularis | tar DNA binding protein | 0.0337 | 0.4757 | 0.4757 |
Brugia malayi | intermediate filament protein | 0.0086 | 0.0937 | 0.1969 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0175 | 0.0563 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0346 | 0.0345 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.