Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | musashi | 0.0112 | 0.0642 | 0.0573 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0108 | 0.0613 | 0.2046 |
Echinococcus granulosus | tar DNA binding protein | 0.0391 | 0.2715 | 0.2661 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0054 | 0.0213 | 0.0141 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.011 | 0.0628 | 0.2102 |
Brugia malayi | beta-lactamase | 0.0108 | 0.0613 | 0.226 |
Brugia malayi | intermediate filament protein | 0.0112 | 0.0642 | 0.2363 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0613 | 0.226 |
Brugia malayi | RNA binding protein | 0.0391 | 0.2715 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0112 | 0.0642 | 0.0573 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0108 | 0.0613 | 0.226 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0108 | 0.0613 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0103 | 0.0574 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0613 | 0.226 |
Mycobacterium ulcerans | lipase LipD | 0.0108 | 0.0613 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0035 | 0.0073 | 0.0269 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.011 | 0.0628 | 0.0559 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0046 | 0.0155 | 0.0083 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0108 | 0.0613 | 0.0544 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0391 | 0.2715 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.011 | 0.0633 | 0.2332 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.011 | 0.0633 | 0.2332 |
Brugia malayi | beta-lactamase family protein | 0.0108 | 0.0613 | 0.226 |
Brugia malayi | hypothetical protein | 0.0103 | 0.0574 | 0.2116 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0642 | 0.2363 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0613 | 0.226 |
Onchocerca volvulus | 0.0108 | 0.0613 | 0.4702 | |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0198 | 0.0729 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0108 | 0.0613 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.011 | 0.0633 | 0.2332 |
Schistosoma mansoni | tar DNA-binding protein | 0.0391 | 0.2715 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0626 | 0.2307 |
Brugia malayi | MH2 domain containing protein | 0.0259 | 0.1738 | 0.6402 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0108 | 0.0613 | 0.1246 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0108 | 0.0613 | 0.1246 |
Loa Loa (eye worm) | intermediate filament protein | 0.0112 | 0.0642 | 0.2363 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0613 | 0.226 |
Schistosoma mansoni | tar DNA-binding protein | 0.0391 | 0.2715 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0054 | 0.0213 | 0.0141 |
Onchocerca volvulus | 0.0108 | 0.0613 | 0.4702 | |
Echinococcus granulosus | lamin dm0 | 0.0112 | 0.0642 | 0.0573 |
Leishmania major | hypothetical protein, conserved | 0.0103 | 0.0574 | 0.9363 |
Onchocerca volvulus | 0.0108 | 0.0613 | 0.4702 | |
Leishmania major | hypothetical protein, conserved | 0.0108 | 0.0613 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0108 | 0.0613 | 0.1246 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.0628 | 0.2102 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.006 | 0.0257 | 0.0947 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0108 | 0.0613 | 0.1246 |
Mycobacterium tuberculosis | Conserved protein | 0.0108 | 0.0613 | 0.1246 |
Schistosoma mansoni | intermediate filament proteins | 0.0112 | 0.0642 | 0.2152 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0198 | 0.0729 |
Brugia malayi | beta-lactamase family protein | 0.0108 | 0.0613 | 0.226 |
Echinococcus granulosus | lamin | 0.0112 | 0.0642 | 0.0573 |
Mycobacterium tuberculosis | Conserved protein | 0.0108 | 0.0613 | 0.1246 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0112 | 0.0642 | 0.2363 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0108 | 0.0613 | 0.1246 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0108 | 0.0613 | 0.1246 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0108 | 0.0613 | 0.0544 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0108 | 0.0613 | 0.226 |
Loa Loa (eye worm) | RNA binding protein | 0.0391 | 0.2715 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0259 | 0.1738 | 0.6402 |
Schistosoma mansoni | tar DNA-binding protein | 0.0391 | 0.2715 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.1305 | 0.4805 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0574 | 0.2116 |
Onchocerca volvulus | 0.0112 | 0.0642 | 0.4917 | |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0108 | 0.0613 | 0.1246 |
Plasmodium vivax | hypothetical protein, conserved | 0.0108 | 0.0613 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0374 | 0.1377 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0035 | 0.0073 | 0.0269 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0613 | 0.226 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0689 | 0.4923 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0108 | 0.0613 | 0.1246 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0374 | 0.1139 |
Schistosoma mansoni | lamin | 0.0112 | 0.0642 | 0.2152 |
Mycobacterium leprae | conserved hypothetical protein | 0.0108 | 0.0613 | 1 |
Schistosoma mansoni | lamin | 0.0112 | 0.0642 | 0.2152 |
Loa Loa (eye worm) | beta-lactamase | 0.0108 | 0.0613 | 0.226 |
Brugia malayi | hypothetical protein | 0.011 | 0.0628 | 0.2314 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0112 | 0.0642 | 0.2363 |
Brugia malayi | TAR-binding protein | 0.0391 | 0.2715 | 1 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.0628 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0108 | 0.0613 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0633 | 0.2332 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0075 | 0.0374 | 0.1377 |
Schistosoma mansoni | tar DNA-binding protein | 0.0391 | 0.2715 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0112 | 0.0642 | 0.0573 |
Echinococcus multilocularis | lamin | 0.0112 | 0.0642 | 0.0573 |
Onchocerca volvulus | 0.0112 | 0.0642 | 0.4917 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0259 | 0.1738 | 0.6402 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0046 | 0.0155 | 0.0083 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0201 | 0.1305 | 0.4662 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0103 | 0.0574 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0108 | 0.0613 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0108 | 0.0613 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0108 | 0.0613 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0613 | 0.226 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0073 | 0.0269 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.011 | 0.0628 | 0.0559 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.0628 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0108 | 0.0613 | 1 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0305 | 0.1123 |
Onchocerca volvulus | 0.0201 | 0.1305 | 1 | |
Mycobacterium leprae | Probable lipase LipE | 0.0108 | 0.0613 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0108 | 0.0613 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0213 | 0.0785 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.0628 | 1 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.0628 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0391 | 0.2715 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0391 | 0.2715 | 0.2661 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0108 | 0.0613 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.006 | 0.0257 | 0.0947 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0108 | 0.0613 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0108 | 0.0613 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0108 | 0.0613 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0035 | 0.0073 | 0.0269 |
Schistosoma mansoni | tar DNA-binding protein | 0.0391 | 0.2715 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0108 | 0.0613 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0108 | 0.0613 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0108 | 0.0613 | 0.2046 |
Loa Loa (eye worm) | TAR-binding protein | 0.0391 | 0.2715 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0155 | 0.031 |
Echinococcus multilocularis | tumor protein p63 | 0.1373 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.