Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0152 | 0.1907 | 0.4235 |
Loa Loa (eye worm) | intermediate filament protein | 0.0087 | 0.0936 | 0.2063 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0188 | 0.0391 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0188 | 0.0391 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1907 | 0.4235 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0188 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0438 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0042 | 0.0267 | 0.0267 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0188 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.036 | 0.036 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1191 | 0.2635 |
Schistosoma mansoni | lamin | 0.0087 | 0.0936 | 0.2086 |
Schistosoma mansoni | tar DNA-binding protein | 0.0325 | 0.4486 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0325 | 0.4486 | 1 |
Brugia malayi | TAR-binding protein | 0.0325 | 0.4486 | 1 |
Brugia malayi | RNA binding protein | 0.0325 | 0.4486 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.036 | 0.0803 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0188 | 0.5 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0188 | 0.0564 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0188 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0152 | 0.1907 | 0.4235 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0188 | 0.0391 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.036 | 0.036 |
Echinococcus multilocularis | GPCR, family 2 | 0.0048 | 0.036 | 0.036 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0188 | 0.0564 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0438 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0325 | 0.4486 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0188 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0046 | 0.0336 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0438 | 0.095 |
Echinococcus multilocularis | lamin | 0.0087 | 0.0936 | 0.0936 |
Onchocerca volvulus | 0.0102 | 0.116 | 1 | |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0188 | 0.0188 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0053 | 0.0438 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.036 | 0.0803 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0152 | 0.1907 | 0.4235 |
Schistosoma mansoni | lamin | 0.0087 | 0.0936 | 0.2086 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0048 | 0.036 | 0.0777 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0244 | 0.0517 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0073 | 0.0728 | 0.0728 |
Echinococcus granulosus | GPCR family 2 | 0.0048 | 0.036 | 0.036 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0073 | 0.0728 | 0.0728 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0188 | 0.0564 |
Brugia malayi | intermediate filament protein | 0.0087 | 0.0936 | 0.2063 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.036 | 0.036 |
Echinococcus multilocularis | tar DNA binding protein | 0.0325 | 0.4486 | 0.4486 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.0438 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0936 | 0.2063 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0073 | 0.0728 | 0.1623 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0325 | 0.4486 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0087 | 0.0936 | 0.2063 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.0728 | 0.1623 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0188 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.116 | 0.2564 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0188 | 0.0564 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0325 | 0.4486 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0325 | 0.4486 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.0438 | 0.5 |
Echinococcus granulosus | lamin | 0.0087 | 0.0936 | 0.0936 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0244 | 0.0517 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0251 | 0.3389 | 0.7548 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.036 | 0.0777 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0188 | 0.0391 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0188 | 0.0391 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0188 | 0.0391 |
Schistosoma mansoni | tar DNA-binding protein | 0.0325 | 0.4486 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0325 | 0.4486 | 0.4486 |
Echinococcus multilocularis | tumor protein p63 | 0.0695 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0156 | 0.0321 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.036 | 0.0803 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0042 | 0.0267 | 0.0267 |
Onchocerca volvulus | 0.0087 | 0.0936 | 0.8047 | |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0728 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0233 | 0.3117 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0048 | 0.036 | 0.0777 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0251 | 0.3389 | 0.7548 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.036 | 0.036 |
Onchocerca volvulus | 0.0036 | 0.0188 | 0.1525 | |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0188 | 0.0564 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0188 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0188 | 0.0564 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0188 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0188 | 0.0418 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0188 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0188 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0325 | 0.4486 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0188 | 0.0391 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0188 | 0.0418 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.0438 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0087 | 0.0936 | 0.0936 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0188 | 0.0564 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0188 | 0.4116 |
Brugia malayi | hypothetical protein | 0.0073 | 0.0728 | 0.1599 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0728 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0188 | 0.0188 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0188 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0087 | 0.0936 | 0.0936 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0188 | 0.0391 |
Brugia malayi | MH2 domain containing protein | 0.0251 | 0.3389 | 0.7548 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0053 | 0.0438 | 1 |
Onchocerca volvulus | 0.0036 | 0.0188 | 0.1525 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0188 | 0.0391 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0728 | 1 |
Onchocerca volvulus | 0.0087 | 0.0936 | 0.8047 | |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0053 | 0.0438 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0188 | 0.0391 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0104 | 0.1191 | 0.2635 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0188 | 0.0564 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0188 | 0.0391 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.1191 | 0.2655 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0728 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0087 | 0.0936 | 0.2086 |
Echinococcus granulosus | lamin dm0 | 0.0087 | 0.0936 | 0.0936 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0188 | 0.0391 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0188 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0912 | 0.201 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0438 | 0.095 |
Loa Loa (eye worm) | RNA binding protein | 0.0325 | 0.4486 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0188 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0267 | 0.0569 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0048 | 0.036 | 0.0777 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0188 | 1 |
Onchocerca volvulus | 0.0036 | 0.0188 | 0.1525 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0087 | 0.0936 | 0.2063 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0188 | 0.0564 |
Echinococcus multilocularis | musashi | 0.0087 | 0.0936 | 0.0936 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0046 | 0.0336 | 0.0723 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.036 | 0.0803 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0102 | 0.116 | 0.2585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.