Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0194 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0085 | 0.0978 | 0.2507 |
Schistosoma mansoni | tar DNA-binding protein | 0.0272 | 0.39 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0054 | 0.0481 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0272 | 0.39 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0171 | 0.0437 |
Echinococcus granulosus | intermediate filament protein | 0.0085 | 0.0978 | 0.0963 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0195 | 0.061 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0054 | 0.0481 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0195 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0194 | 0.0457 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0194 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0195 | 0.0499 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0194 | 0.0178 |
Brugia malayi | hypothetical protein | 0.0054 | 0.0481 | 0.1234 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0194 | 0.0457 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0195 | 0.061 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0195 | 0.5 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0195 | 0.061 |
Onchocerca volvulus | 0.0035 | 0.0195 | 0.1684 | |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0195 | 0.061 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0417 | 0.1068 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0171 | 0.0437 |
Onchocerca volvulus | 0.0085 | 0.0978 | 0.8462 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0272 | 0.39 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0195 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0195 | 0.0178 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0194 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0195 | 0.061 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0171 | 0.0396 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0097 | 0.1155 | 0.2932 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0195 | 0.0499 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0195 | 0.4045 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0481 | 0.1234 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0183 | 0.0468 |
Echinococcus multilocularis | lamin | 0.0085 | 0.0978 | 0.0963 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0195 | 0.0499 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0041 | 0.0285 | 0.0269 |
Brugia malayi | intermediate filament protein | 0.0085 | 0.0978 | 0.2507 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0046 | 0.0356 | 0.0913 |
Onchocerca volvulus | 0.0097 | 0.1155 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0195 | 0.0499 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0195 | 0.0499 |
Echinococcus multilocularis | tumor protein p63 | 0.066 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0085 | 0.0978 | 0.2507 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0195 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0195 | 0.0458 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0195 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.0481 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0195 | 0.0499 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0054 | 0.0481 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0046 | 0.0356 | 0.0913 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0417 | 0.1068 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0417 | 0.1068 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0194 | 0.0498 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0195 | 0.0499 |
Brugia malayi | TAR-binding protein | 0.0272 | 0.39 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0194 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0261 | 0.0668 |
Echinococcus granulosus | tar DNA binding protein | 0.0272 | 0.39 | 0.389 |
Schistosoma mansoni | tar DNA-binding protein | 0.0272 | 0.39 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0272 | 0.39 | 0.389 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0085 | 0.0978 | 0.2507 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0195 | 0.061 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0272 | 0.39 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1155 | 0.2962 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0195 | 0.0499 |
Schistosoma mansoni | lamin | 0.0085 | 0.0978 | 0.2475 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0285 | 0.0731 |
Echinococcus granulosus | lamin | 0.0085 | 0.0978 | 0.0963 |
Echinococcus multilocularis | lamin dm0 | 0.0085 | 0.0978 | 0.0963 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0195 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0195 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0239 | 0.3388 | 0.8686 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0239 | 0.3388 | 0.8686 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0195 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0195 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.0195 | 0.1684 | |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0195 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0054 | 0.0481 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0195 | 0.0458 |
Onchocerca volvulus | 0.0085 | 0.0978 | 0.8462 | |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0054 | 0.0481 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0195 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0195 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0195 | 0.0178 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0261 | 0.0668 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0417 | 0.1068 |
Schistosoma mansoni | intermediate filament proteins | 0.0085 | 0.0978 | 0.2475 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0195 | 0.061 |
Schistosoma mansoni | lamin | 0.0085 | 0.0978 | 0.2475 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0195 | 0.0499 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0978 | 0.2507 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0054 | 0.0481 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0272 | 0.39 | 1 |
Echinococcus multilocularis | musashi | 0.0085 | 0.0978 | 0.0963 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0226 | 0.3189 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0272 | 0.39 | 1 |
Brugia malayi | RNA binding protein | 0.0272 | 0.39 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0272 | 0.39 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0195 | 0.061 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0195 | 0.061 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0195 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0041 | 0.0285 | 0.0269 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0194 | 0.0178 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0195 | 0.061 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0195 | 0.0499 |
Onchocerca volvulus | 0.0035 | 0.0195 | 0.1684 | |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0953 | 0.2444 |
Brugia malayi | MH2 domain containing protein | 0.0239 | 0.3388 | 0.8686 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0272 | 0.39 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0195 | 0.0499 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.0481 | 0.5 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0195 | 0.0499 |
Echinococcus granulosus | lamin dm0 | 0.0085 | 0.0978 | 0.0963 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.